Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
MY TRIALS
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Register a trial
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01327846
Registration number
NCT01327846
Ethics application status
Date submitted
29/03/2011
Date registered
4/04/2011
Titles & IDs
Public title
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Query!
Scientific title
A Randomized, Double-blind, Placebo-controlled, Event-driven Trial of Quarterly Subcutaneous Canakinumab in the Prevention of Recurrent Cardiovascular Events Among Stable Post-myocardial Infarction Patients With Elevated hsCRP
Query!
Secondary ID [1]
0
0
2010-022970-14
Query!
Secondary ID [2]
0
0
CACZ885M2301
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
CANTOS
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Atherosclerosis
0
0
Query!
Condition category
Condition code
Cardiovascular
0
0
0
0
Query!
Diseases of the vasculature and circulation including the lymphatic system
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - Standard of care
Experimental: Canakinumab Dose 50 mg - Pivotal Phase:
Blinded Canakinumab 50 mg quarterly subcutaneous + standard of care therapy.
Extension Phase:
Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Experimental: Canakinumab Dose 150 mg - Pivotal Phase:
Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Experimental: Canakinumab Dose 300 mg - Pivotal Phase:
Blinded Canakinumab 300 mg quarterly subcutaneous (with one additional dose at week 2) + standard of care therapy.
Extension phase:
Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Placebo comparator: Placebo - Pivotal Phase:
Blinded matching placebo quarterly subcutaneous + standard of care therapy.
Extension Phase:
Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Treatment: Drugs: Standard of care
Standard of care post-MI background therapy includes, but is not limited to, lipid lowering, anti-hypertensive, beta blockers, and anti-platelet therapy as appropriate
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Analysis of Core Phase First CEC Confirmed Major Adverse Cardiovascular Events (MACE) and Its Components
Query!
Assessment method [1]
0
0
Time to occurrence of CEC (Cardiovascular clinical events adjudication committee) confirmed MACE, which was a composite endpoint consisting of CEC confirmed CV death, CEC confirmed non-fatal MI,or CEC confirmed non-fatal stroke. Patients with the CEC adjudicated reason for death of "Unknown" were counted as CV (cardiovascular) death.
Query!
Timepoint [1]
0
0
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Query!
Primary outcome [2]
0
0
Substudy 1 (Core Phase): Change From Baseline in Carotid Plaque Burden in the Bifurcation Region of the Index Carotid Artery
Query!
Assessment method [2]
0
0
Query!
Timepoint [2]
0
0
24 months
Query!
Primary outcome [3]
0
0
Substudy 2 (Core Phase): Change From Baseline of the Insulin Secretion Rate (ISR) Relative to Glucose 0-30 Min Defined as F30 = AUCISR 0-30 / AUCGluc 0-30 Averaged Across the Year 3, 4, 5 Visits
Query!
Assessment method [3]
0
0
Query!
Timepoint [3]
0
0
From randomization up to approximately 6 years
Query!
Secondary outcome [1]
0
0
Patients With Core Phase CEC Confirmed CV Death, Non-fatal MI, Non-fatal Stroke, or Hospitalization for Unstable Angina Requiring Unplanned Revascularization
Query!
Assessment method [1]
0
0
Occurrence of the composite cardiovascular endpoint consisting of cardiovascular death, non-fatal MI, non-fatal stroke or hospitalization for unstable angina requiring unplanned revascularization.
MACE includes CV death, non-fatal MI and non-fatal stroke. CEC = Clinical Endpoints Committee
Query!
Timepoint [1]
0
0
From randomization, to end of treatment pus 30 days, up to approximately 6 years
Query!
Secondary outcome [2]
0
0
Patients With Core Phase New Onset Type 2 Diabetes Among Patients With Pre-diabetes at Randomization
Query!
Assessment method [2]
0
0
Time to CEC confirmed new onset of type 2 diabetes among those with pre-diabetes at randomization (i.e. excluding those that are normoglycemic at baseline)
Query!
Timepoint [2]
0
0
From randomization up to approximately 6 years
Query!
Secondary outcome [3]
0
0
Core Phase All-cause Mortality, Non-fatal MI, or Non-fatal Stroke
Query!
Assessment method [3]
0
0
Occurrence of the composite endpoint consisting of all-cause mortality, non-fatal IM, or non-fatal stroke
Query!
Timepoint [3]
0
0
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Query!
Secondary outcome [4]
0
0
Core Phase All-cause Mortality
Query!
Assessment method [4]
0
0
Number of participant deaths
Query!
Timepoint [4]
0
0
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Query!
Secondary outcome [5]
0
0
Summary of Adverse Events (Core Phase)
Query!
Assessment method [5]
0
0
Summary of Adverse Events (AEs) and Serious Adverse Events (SAEs) occurring during the double-blind Core phase of the study. AEs/SAEs are any signs or symptoms that occur during the study treatment.
Query!
Timepoint [5]
0
0
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Query!
Secondary outcome [6]
0
0
Summary of Adverse Events (Extension Phase)
Query!
Assessment method [6]
0
0
Summary of Adverse Events (AEs) and Serious Adverse Events (SAEs) occurring during the Extension phase of the study. AEs/SAEs are any signs or symptoms that occur during the study treatment.
Query!
Timepoint [6]
0
0
From start of Extension phase, to end of treatment plus 30 days, up to approximately 2 years
Query!
Secondary outcome [7]
0
0
Substudy 1 (Core Phase): Change From Baseline of the Total Vessel Wall Area at Month 3 in the Bifurcation Region of the Index Carotid Artery
Query!
Assessment method [7]
0
0
Query!
Timepoint [7]
0
0
3 months
Query!
Secondary outcome [8]
0
0
Substudy 1 (Core Phase): Mean Total Vessel Wall Area Across the Left and Right Carotid Artery at Month 3 and Month 24
Query!
Assessment method [8]
0
0
Query!
Timepoint [8]
0
0
24 months
Query!
Secondary outcome [9]
0
0
Substudy 1 (Core Phase): Change From Baseline in Corresponding Total Vessel Wall Area in the Left and Right Carotid Arteries
Query!
Assessment method [9]
0
0
Query!
Timepoint [9]
0
0
24 months
Query!
Secondary outcome [10]
0
0
Substudy 1 (Core Phase): The Existence of a Baseline Total Vessel Wall Area by Treatment Interaction as Well as the Consistency of the Treatment Effect Across Subgroups
Query!
Assessment method [10]
0
0
Query!
Timepoint [10]
0
0
24 months
Query!
Secondary outcome [11]
0
0
Substudy 2 (Core Phase): Change From Baseline in Insulin Sensitivity Index
Query!
Assessment method [11]
0
0
Query!
Timepoint [11]
0
0
From randomization up to approximately 6 years
Query!
Secondary outcome [12]
0
0
Substudy 2 (Core Phase): Change From Baseline in OGTT Stimulated Area Under Curve (AUC) 0-120 Min of Glucose Concentration, Insulin Concentration, Pro-insulin Concentration, and Insulin Concentration/Glucose Concentration Ratio
Query!
Assessment method [12]
0
0
Query!
Timepoint [12]
0
0
From randomization up to approximately 6 years
Query!
Secondary outcome [13]
0
0
Substudy 2 (Core Phase): Change From Baseline in Fasting Pro-Insulin Concentration/Insulin Concentration Ratio
Query!
Assessment method [13]
0
0
Query!
Timepoint [13]
0
0
From randomization up to approximately 6 years
Query!
Secondary outcome [14]
0
0
Substudy 2 (Core Phase): Change From Baseline in OGTT Stimulated Area Under the Curve (AUC) 0-120 Min of C-peptide Concentration
Query!
Assessment method [14]
0
0
Query!
Timepoint [14]
0
0
From randomization up to approximately 6 years
Query!
Eligibility
Key inclusion criteria
Main Study
* Written informed consent
* Male, or Female of non-child-bearing potential
* Age = 18 years.
* Spontaneous MI at least 30 days before randomization. hsCRP = 2 mg/L
Substudy 1 Inclusion:
* All Inclusion from Main Study
* Acquisition of evaluable baseline MRI images of bilateral carotid arteries by the imaging core laboratory
Substudy 2 Inclusion:
* All inclusion from Main Study
* T2D at baseline per Main protocol criteria and be on a stable anti-hyperglycemic medication for at least 4 weeks prior to the baseline OGTT test
* Willing to have the OGTT assessment started before 10 am
Main Study
Query!
Minimum age
18
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Pregnant or nursing (lactating) women
* Women of child-bearing potential
* Any of the following concomitant diseases
* Planned coronary revascularization (PCI or CABG)
* Major non-cardiac surgical or endoscopic procedure within past 6 months
* Multi-vessel CABG surgery within the past 3 years
* Symptomatic patients with Class IV heart failure (HF) (New York Heart Association [NYHA].
* Uncontrolled hypertension
* Uncontrolled diabetes
* History or evidence of active tuberculosis (TB) infection Substudy 1 Exclusion
* All Main exclusion
* Patients with prior history of carotid angioplasty, stenting, or carotid atherectomy
* Patients with contraindications to MRI examination (brain aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker, pacemaker wires or defibrillator, prosthetic heart valves, cochlear implant, ocular foreign body or other implanted body, tattoos, implanted insulin pump, metal shrapnel or bullet)
* Patients prone to claustrophobia or known anxiety disorders
* BMI > 40 kg/m2 Substudy 2 Exclusion
* This sub-study does not have any additional exclusion criteria.
Query!
Study design
Purpose of the study
Treatment
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people assessing the outcomes
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
11/04/2011
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
14/04/2019
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
10066
Query!
Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,TAS,VIC,WA
Query!
Recruitment hospital [1]
0
0
Novartis Investigative Site - Garran
Query!
Recruitment hospital [2]
0
0
Novartis Investigative Site - Gosford
Query!
Recruitment hospital [3]
0
0
Novartis Investigative Site - Kogarah
Query!
Recruitment hospital [4]
0
0
Novartis Investigative Site - Liverpool
Query!
Recruitment hospital [5]
0
0
Novartis Investigative Site - Milton
Query!
Recruitment hospital [6]
0
0
Novartis Investigative Site - Southport
Query!
Recruitment hospital [7]
0
0
Novartis Investigative Site - Hobart
Query!
Recruitment hospital [8]
0
0
Novartis Investigative Site - Bundoora
Query!
Recruitment hospital [9]
0
0
Novartis Investigative Site - Geelong
Query!
Recruitment hospital [10]
0
0
Novartis Investigative Site - Bateman
Query!
Recruitment hospital [11]
0
0
Novartis Investigative Site - Joondalup
Query!
Recruitment hospital [12]
0
0
Novartis Investigative Site - Perth
Query!
Recruitment postcode(s) [1]
0
0
2606 - Garran
Query!
Recruitment postcode(s) [2]
0
0
2250 - Gosford
Query!
Recruitment postcode(s) [3]
0
0
2217 - Kogarah
Query!
Recruitment postcode(s) [4]
0
0
2170 - Liverpool
Query!
Recruitment postcode(s) [5]
0
0
4064 - Milton
Query!
Recruitment postcode(s) [6]
0
0
4215 - Southport
Query!
Recruitment postcode(s) [7]
0
0
7000 - Hobart
Query!
Recruitment postcode(s) [8]
0
0
3083 - Bundoora
Query!
Recruitment postcode(s) [9]
0
0
3220 - Geelong
Query!
Recruitment postcode(s) [10]
0
0
6150 - Bateman
Query!
Recruitment postcode(s) [11]
0
0
6027 - Joondalup
Query!
Recruitment postcode(s) [12]
0
0
6000 - Perth
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Alaska
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
Arizona
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Arkansas
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
California
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Colorado
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Connecticut
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Delaware
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
District of Columbia
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Florida
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Georgia
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Hawaii
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Idaho
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Illinois
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Indiana
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Iowa
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Kansas
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Kentucky
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Louisiana
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Maine
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Maryland
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Massachusetts
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Michigan
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
Minnesota
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
Mississippi
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
Missouri
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
Nebraska
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
Nevada
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
New Hampshire
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
New Jersey
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
New Mexico
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
New York
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
North Carolina
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
North Dakota
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
Ohio
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
Oklahoma
Query!
Country [37]
0
0
United States of America
Query!
State/province [37]
0
0
Oregon
Query!
Country [38]
0
0
United States of America
Query!
State/province [38]
0
0
Pennsylvania
Query!
Country [39]
0
0
United States of America
Query!
State/province [39]
0
0
Rhode Island
Query!
Country [40]
0
0
United States of America
Query!
State/province [40]
0
0
South Carolina
Query!
Country [41]
0
0
United States of America
Query!
State/province [41]
0
0
South Dakota
Query!
Country [42]
0
0
United States of America
Query!
State/province [42]
0
0
Tennessee
Query!
Country [43]
0
0
United States of America
Query!
State/province [43]
0
0
Texas
Query!
Country [44]
0
0
United States of America
Query!
State/province [44]
0
0
Utah
Query!
Country [45]
0
0
United States of America
Query!
State/province [45]
0
0
Virginia
Query!
Country [46]
0
0
United States of America
Query!
State/province [46]
0
0
Washington
Query!
Country [47]
0
0
United States of America
Query!
State/province [47]
0
0
Wisconsin
Query!
Country [48]
0
0
Argentina
Query!
State/province [48]
0
0
Buenos Aires
Query!
Country [49]
0
0
Argentina
Query!
State/province [49]
0
0
Capital Federal
Query!
Country [50]
0
0
Argentina
Query!
State/province [50]
0
0
Jujuy
Query!
Country [51]
0
0
Argentina
Query!
State/province [51]
0
0
Misiones
Query!
Country [52]
0
0
Argentina
Query!
State/province [52]
0
0
Rio Negro
Query!
Country [53]
0
0
Argentina
Query!
State/province [53]
0
0
San Miguel De Tucuman
Query!
Country [54]
0
0
Argentina
Query!
State/province [54]
0
0
Santa Fe
Query!
Country [55]
0
0
Argentina
Query!
State/province [55]
0
0
Tucuman
Query!
Country [56]
0
0
Argentina
Query!
State/province [56]
0
0
Caba
Query!
Country [57]
0
0
Argentina
Query!
State/province [57]
0
0
Cordoba
Query!
Country [58]
0
0
Argentina
Query!
State/province [58]
0
0
Corrientes
Query!
Country [59]
0
0
Argentina
Query!
State/province [59]
0
0
Formosa
Query!
Country [60]
0
0
Argentina
Query!
State/province [60]
0
0
Salta
Query!
Country [61]
0
0
Argentina
Query!
State/province [61]
0
0
San Luis
Query!
Country [62]
0
0
Argentina
Query!
State/province [62]
0
0
Santiago del Estero
Query!
Country [63]
0
0
Austria
Query!
State/province [63]
0
0
Graz
Query!
Country [64]
0
0
Austria
Query!
State/province [64]
0
0
Linz
Query!
Country [65]
0
0
Austria
Query!
State/province [65]
0
0
Saint Stefan
Query!
Country [66]
0
0
Austria
Query!
State/province [66]
0
0
Salzburg
Query!
Country [67]
0
0
Austria
Query!
State/province [67]
0
0
Vienna
Query!
Country [68]
0
0
Austria
Query!
State/province [68]
0
0
Wien
Query!
Country [69]
0
0
Belgium
Query!
State/province [69]
0
0
Aalst
Query!
Country [70]
0
0
Belgium
Query!
State/province [70]
0
0
Bonheiden
Query!
Country [71]
0
0
Belgium
Query!
State/province [71]
0
0
Brasschaat
Query!
Country [72]
0
0
Belgium
Query!
State/province [72]
0
0
Brussel
Query!
Country [73]
0
0
Belgium
Query!
State/province [73]
0
0
De Pinte
Query!
Country [74]
0
0
Belgium
Query!
State/province [74]
0
0
Genk
Query!
Country [75]
0
0
Belgium
Query!
State/province [75]
0
0
Gent
Query!
Country [76]
0
0
Belgium
Query!
State/province [76]
0
0
Hasselt
Query!
Country [77]
0
0
Belgium
Query!
State/province [77]
0
0
Huy
Query!
Country [78]
0
0
Belgium
Query!
State/province [78]
0
0
Leuven
Query!
Country [79]
0
0
Belgium
Query!
State/province [79]
0
0
Mechelen
Query!
Country [80]
0
0
Belgium
Query!
State/province [80]
0
0
Ottignies
Query!
Country [81]
0
0
Belgium
Query!
State/province [81]
0
0
Tienen
Query!
Country [82]
0
0
Brazil
Query!
State/province [82]
0
0
BA
Query!
Country [83]
0
0
Brazil
Query!
State/province [83]
0
0
CE
Query!
Country [84]
0
0
Brazil
Query!
State/province [84]
0
0
DF
Query!
Country [85]
0
0
Brazil
Query!
State/province [85]
0
0
GO
Query!
Country [86]
0
0
Brazil
Query!
State/province [86]
0
0
MG
Query!
Country [87]
0
0
Brazil
Query!
State/province [87]
0
0
Minas Gerais
Query!
Country [88]
0
0
Brazil
Query!
State/province [88]
0
0
MS
Query!
Country [89]
0
0
Brazil
Query!
State/province [89]
0
0
PA
Query!
Country [90]
0
0
Brazil
Query!
State/province [90]
0
0
PE
Query!
Country [91]
0
0
Brazil
Query!
State/province [91]
0
0
PR
Query!
Country [92]
0
0
Brazil
Query!
State/province [92]
0
0
Rio Grande Do Sul
Query!
Country [93]
0
0
Brazil
Query!
State/province [93]
0
0
RS
Query!
Country [94]
0
0
Brazil
Query!
State/province [94]
0
0
SC
Query!
Country [95]
0
0
Brazil
Query!
State/province [95]
0
0
SP
Query!
Country [96]
0
0
Bulgaria
Query!
State/province [96]
0
0
Pazardzhik
Query!
Country [97]
0
0
Bulgaria
Query!
State/province [97]
0
0
Pleven
Query!
Country [98]
0
0
Bulgaria
Query!
State/province [98]
0
0
Plovdiv
Query!
Country [99]
0
0
Bulgaria
Query!
State/province [99]
0
0
Sofia
Query!
Country [100]
0
0
Canada
Query!
State/province [100]
0
0
British Columbia
Query!
Country [101]
0
0
Canada
Query!
State/province [101]
0
0
Manitoba
Query!
Country [102]
0
0
Canada
Query!
State/province [102]
0
0
Newfoundland and Labrador
Query!
Country [103]
0
0
Canada
Query!
State/province [103]
0
0
Nova Scotia
Query!
Country [104]
0
0
Canada
Query!
State/province [104]
0
0
Ontario
Query!
Country [105]
0
0
Canada
Query!
State/province [105]
0
0
Quebec
Query!
Country [106]
0
0
Canada
Query!
State/province [106]
0
0
Saskatchewan
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Beijing
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Chongqing
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Fujian
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Guangdong
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Guangxi
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Hebei
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Heilongjiang
Query!
Country [114]
0
0
China
Query!
State/province [114]
0
0
Hubei
Query!
Country [115]
0
0
China
Query!
State/province [115]
0
0
Hunan
Query!
Country [116]
0
0
China
Query!
State/province [116]
0
0
Inner Mongolia
Query!
Country [117]
0
0
China
Query!
State/province [117]
0
0
Jiangsu
Query!
Country [118]
0
0
China
Query!
State/province [118]
0
0
Jilin
Query!
Country [119]
0
0
China
Query!
State/province [119]
0
0
Liaoning
Query!
Country [120]
0
0
China
Query!
State/province [120]
0
0
Shanghai
Query!
Country [121]
0
0
China
Query!
State/province [121]
0
0
Shanxi
Query!
Country [122]
0
0
China
Query!
State/province [122]
0
0
Tianjin
Query!
Country [123]
0
0
China
Query!
State/province [123]
0
0
Zhejiang
Query!
Country [124]
0
0
Colombia
Query!
State/province [124]
0
0
Atlantico
Query!
Country [125]
0
0
Colombia
Query!
State/province [125]
0
0
Bolivar
Query!
Country [126]
0
0
Colombia
Query!
State/province [126]
0
0
Caldas
Query!
Country [127]
0
0
Colombia
Query!
State/province [127]
0
0
Santander
Query!
Country [128]
0
0
Colombia
Query!
State/province [128]
0
0
Armenia
Query!
Country [129]
0
0
Colombia
Query!
State/province [129]
0
0
Baranquilla
Query!
Country [130]
0
0
Colombia
Query!
State/province [130]
0
0
Barranquilla
Query!
Country [131]
0
0
Colombia
Query!
State/province [131]
0
0
Bogota
Query!
Country [132]
0
0
Colombia
Query!
State/province [132]
0
0
Bogotá
Query!
Country [133]
0
0
Colombia
Query!
State/province [133]
0
0
Cali
Query!
Country [134]
0
0
Colombia
Query!
State/province [134]
0
0
Cartegena
Query!
Country [135]
0
0
Colombia
Query!
State/province [135]
0
0
Florida Blanca
Query!
Country [136]
0
0
Croatia
Query!
State/province [136]
0
0
HRV
Query!
Country [137]
0
0
Croatia
Query!
State/province [137]
0
0
Cakovec
Query!
Country [138]
0
0
Croatia
Query!
State/province [138]
0
0
Koprivnica
Query!
Country [139]
0
0
Croatia
Query!
State/province [139]
0
0
Krapinske toplice
Query!
Country [140]
0
0
Croatia
Query!
State/province [140]
0
0
Krapinske Toplice
Query!
Country [141]
0
0
Croatia
Query!
State/province [141]
0
0
Opatija
Query!
Country [142]
0
0
Croatia
Query!
State/province [142]
0
0
Rijeka
Query!
Country [143]
0
0
Croatia
Query!
State/province [143]
0
0
Virovitica
Query!
Country [144]
0
0
Croatia
Query!
State/province [144]
0
0
Zagreb
Query!
Country [145]
0
0
Czechia
Query!
State/province [145]
0
0
Czech Republic
Query!
Country [146]
0
0
Czechia
Query!
State/province [146]
0
0
CZE
Query!
Country [147]
0
0
Czechia
Query!
State/province [147]
0
0
Benesov
Query!
Country [148]
0
0
Czechia
Query!
State/province [148]
0
0
Brno Bohunice
Query!
Country [149]
0
0
Czechia
Query!
State/province [149]
0
0
Broumov
Query!
Country [150]
0
0
Czechia
Query!
State/province [150]
0
0
Kolin
Query!
Country [151]
0
0
Czechia
Query!
State/province [151]
0
0
Marianske lazne
Query!
Country [152]
0
0
Czechia
Query!
State/province [152]
0
0
Pardubice
Query!
Country [153]
0
0
Czechia
Query!
State/province [153]
0
0
Prague 4 - Krc
Query!
Country [154]
0
0
Czechia
Query!
State/province [154]
0
0
Praha
Query!
Country [155]
0
0
Czechia
Query!
State/province [155]
0
0
Slany
Query!
Country [156]
0
0
Czechia
Query!
State/province [156]
0
0
Teplice
Query!
Country [157]
0
0
Czechia
Query!
State/province [157]
0
0
Uherske Hradiste
Query!
Country [158]
0
0
Estonia
Query!
State/province [158]
0
0
Parnu
Query!
Country [159]
0
0
Estonia
Query!
State/province [159]
0
0
Saku
Query!
Country [160]
0
0
Estonia
Query!
State/province [160]
0
0
Tallinn
Query!
Country [161]
0
0
Estonia
Query!
State/province [161]
0
0
Tartu
Query!
Country [162]
0
0
Estonia
Query!
State/province [162]
0
0
Viljandi County
Query!
Country [163]
0
0
Estonia
Query!
State/province [163]
0
0
Võru
Query!
Country [164]
0
0
Germany
Query!
State/province [164]
0
0
NRW
Query!
Country [165]
0
0
Germany
Query!
State/province [165]
0
0
Bad Krozingen
Query!
Country [166]
0
0
Germany
Query!
State/province [166]
0
0
Balve
Query!
Country [167]
0
0
Germany
Query!
State/province [167]
0
0
Berlin
Query!
Country [168]
0
0
Germany
Query!
State/province [168]
0
0
Bochum
Query!
Country [169]
0
0
Germany
Query!
State/province [169]
0
0
Borna
Query!
Country [170]
0
0
Germany
Query!
State/province [170]
0
0
Chemnitz
Query!
Country [171]
0
0
Germany
Query!
State/province [171]
0
0
Dillingen
Query!
Country [172]
0
0
Germany
Query!
State/province [172]
0
0
Dinslaken
Query!
Country [173]
0
0
Germany
Query!
State/province [173]
0
0
Dortmund
Query!
Country [174]
0
0
Germany
Query!
State/province [174]
0
0
Dresden
Query!
Country [175]
0
0
Germany
Query!
State/province [175]
0
0
Duisburg
Query!
Country [176]
0
0
Germany
Query!
State/province [176]
0
0
Düsseldorf
Query!
Country [177]
0
0
Germany
Query!
State/province [177]
0
0
Ebersbach
Query!
Country [178]
0
0
Germany
Query!
State/province [178]
0
0
Elsterwerda
Query!
Country [179]
0
0
Germany
Query!
State/province [179]
0
0
Erlangen
Query!
Country [180]
0
0
Germany
Query!
State/province [180]
0
0
Essen
Query!
Country [181]
0
0
Germany
Query!
State/province [181]
0
0
Falkensee
Query!
Country [182]
0
0
Germany
Query!
State/province [182]
0
0
Frankfurt am Main
Query!
Country [183]
0
0
Germany
Query!
State/province [183]
0
0
Frankfurt
Query!
Country [184]
0
0
Germany
Query!
State/province [184]
0
0
Freiburg
Query!
Country [185]
0
0
Germany
Query!
State/province [185]
0
0
Fulda
Query!
Country [186]
0
0
Germany
Query!
State/province [186]
0
0
Giengen
Query!
Country [187]
0
0
Germany
Query!
State/province [187]
0
0
Goerlitz
Query!
Country [188]
0
0
Germany
Query!
State/province [188]
0
0
Haag
Query!
Country [189]
0
0
Germany
Query!
State/province [189]
0
0
Halle Saale
Query!
Country [190]
0
0
Germany
Query!
State/province [190]
0
0
Hamburg
Query!
Country [191]
0
0
Germany
Query!
State/province [191]
0
0
Heidelberg
Query!
Country [192]
0
0
Germany
Query!
State/province [192]
0
0
Heilbronn
Query!
Country [193]
0
0
Germany
Query!
State/province [193]
0
0
Huy / OT Anderbeck
Query!
Country [194]
0
0
Germany
Query!
State/province [194]
0
0
Jerichow
Query!
Country [195]
0
0
Germany
Query!
State/province [195]
0
0
Kallstadt
Query!
Country [196]
0
0
Germany
Query!
State/province [196]
0
0
Kamp-Lintfort
Query!
Country [197]
0
0
Germany
Query!
State/province [197]
0
0
Kassel
Query!
Country [198]
0
0
Germany
Query!
State/province [198]
0
0
Kiel
Query!
Country [199]
0
0
Germany
Query!
State/province [199]
0
0
Koblenz
Query!
Country [200]
0
0
Germany
Query!
State/province [200]
0
0
Koeln
Query!
Country [201]
0
0
Germany
Query!
State/province [201]
0
0
Kuenzing
Query!
Country [202]
0
0
Germany
Query!
State/province [202]
0
0
Leipzig
Query!
Country [203]
0
0
Germany
Query!
State/province [203]
0
0
Ludwigshafen
Query!
Country [204]
0
0
Germany
Query!
State/province [204]
0
0
Lüneburg
Query!
Country [205]
0
0
Germany
Query!
State/province [205]
0
0
Magdeburg
Query!
Country [206]
0
0
Germany
Query!
State/province [206]
0
0
Mainz
Query!
Country [207]
0
0
Germany
Query!
State/province [207]
0
0
Mayen
Query!
Country [208]
0
0
Germany
Query!
State/province [208]
0
0
Meissen
Query!
Country [209]
0
0
Germany
Query!
State/province [209]
0
0
Meißen
Query!
Country [210]
0
0
Germany
Query!
State/province [210]
0
0
Muehldorf Am Inn
Query!
Country [211]
0
0
Germany
Query!
State/province [211]
0
0
Muehlhausen
Query!
Country [212]
0
0
Germany
Query!
State/province [212]
0
0
Neuhofen
Query!
Country [213]
0
0
Germany
Query!
State/province [213]
0
0
Neunkirchen
Query!
Country [214]
0
0
Germany
Query!
State/province [214]
0
0
Northeim
Query!
Country [215]
0
0
Germany
Query!
State/province [215]
0
0
Nurnberg
Query!
Country [216]
0
0
Germany
Query!
State/province [216]
0
0
Oelde
Query!
Country [217]
0
0
Germany
Query!
State/province [217]
0
0
Oschatz
Query!
Country [218]
0
0
Germany
Query!
State/province [218]
0
0
Paderborn
Query!
Country [219]
0
0
Germany
Query!
State/province [219]
0
0
Potsdam
Query!
Country [220]
0
0
Germany
Query!
State/province [220]
0
0
Rednitzhembach
Query!
Country [221]
0
0
Germany
Query!
State/province [221]
0
0
Reinfeld
Query!
Country [222]
0
0
Germany
Query!
State/province [222]
0
0
Rostock
Query!
Country [223]
0
0
Germany
Query!
State/province [223]
0
0
Rüdersdorf
Query!
Country [224]
0
0
Germany
Query!
State/province [224]
0
0
Siegen
Query!
Country [225]
0
0
Germany
Query!
State/province [225]
0
0
Ulm
Query!
Country [226]
0
0
Germany
Query!
State/province [226]
0
0
Wolmirstedt
Query!
Country [227]
0
0
Greece
Query!
State/province [227]
0
0
GR
Query!
Country [228]
0
0
Greece
Query!
State/province [228]
0
0
Athens
Query!
Country [229]
0
0
Greece
Query!
State/province [229]
0
0
Chalkida
Query!
Country [230]
0
0
Greece
Query!
State/province [230]
0
0
Crete Heraklion
Query!
Country [231]
0
0
Greece
Query!
State/province [231]
0
0
Heraklion Crete
Query!
Country [232]
0
0
Greece
Query!
State/province [232]
0
0
Patras
Query!
Country [233]
0
0
Guatemala
Query!
State/province [233]
0
0
Guatemala City
Query!
Country [234]
0
0
Guatemala
Query!
State/province [234]
0
0
Guatemala
Query!
Country [235]
0
0
Hungary
Query!
State/province [235]
0
0
Zala
Query!
Country [236]
0
0
Hungary
Query!
State/province [236]
0
0
Budapest
Query!
Country [237]
0
0
Hungary
Query!
State/province [237]
0
0
Csongrad
Query!
Country [238]
0
0
Hungary
Query!
State/province [238]
0
0
Debrecen
Query!
Country [239]
0
0
Hungary
Query!
State/province [239]
0
0
Gyula
Query!
Country [240]
0
0
Hungary
Query!
State/province [240]
0
0
Kistarcsa
Query!
Country [241]
0
0
Hungary
Query!
State/province [241]
0
0
Komarom
Query!
Country [242]
0
0
Hungary
Query!
State/province [242]
0
0
Miskolc
Query!
Country [243]
0
0
Hungary
Query!
State/province [243]
0
0
Mosonmagyarovar
Query!
Country [244]
0
0
Hungary
Query!
State/province [244]
0
0
Nyiregyháza
Query!
Country [245]
0
0
Hungary
Query!
State/province [245]
0
0
Pecs
Query!
Country [246]
0
0
Hungary
Query!
State/province [246]
0
0
Szeged
Query!
Country [247]
0
0
Hungary
Query!
State/province [247]
0
0
Szekesfehervar
Query!
Country [248]
0
0
Hungary
Query!
State/province [248]
0
0
Szentes
Query!
Country [249]
0
0
Iceland
Query!
State/province [249]
0
0
Kopavogur
Query!
Country [250]
0
0
Iceland
Query!
State/province [250]
0
0
Reykjavik
Query!
Country [251]
0
0
India
Query!
State/province [251]
0
0
Andhra Pradesh
Query!
Country [252]
0
0
India
Query!
State/province [252]
0
0
Andhrapradesh
Query!
Country [253]
0
0
India
Query!
State/province [253]
0
0
Delhi
Query!
Country [254]
0
0
India
Query!
State/province [254]
0
0
Gujarat
Query!
Country [255]
0
0
India
Query!
State/province [255]
0
0
Karnataka
Query!
Country [256]
0
0
India
Query!
State/province [256]
0
0
Kerala
Query!
Country [257]
0
0
India
Query!
State/province [257]
0
0
Maharashtra
Query!
Country [258]
0
0
India
Query!
State/province [258]
0
0
Punjab
Query!
Country [259]
0
0
India
Query!
State/province [259]
0
0
Rajasthan
Query!
Country [260]
0
0
India
Query!
State/province [260]
0
0
Tamil Nadu
Query!
Country [261]
0
0
India
Query!
State/province [261]
0
0
Tamil NADU
Query!
Country [262]
0
0
India
Query!
State/province [262]
0
0
Tamilnadu
Query!
Country [263]
0
0
India
Query!
State/province [263]
0
0
Telangana
Query!
Country [264]
0
0
India
Query!
State/province [264]
0
0
Uttar Pradesh
Query!
Country [265]
0
0
India
Query!
State/province [265]
0
0
Ahmedabad
Query!
Country [266]
0
0
Italy
Query!
State/province [266]
0
0
AN
Query!
Country [267]
0
0
Italy
Query!
State/province [267]
0
0
AP
Query!
Country [268]
0
0
Italy
Query!
State/province [268]
0
0
AR
Query!
Country [269]
0
0
Italy
Query!
State/province [269]
0
0
BG
Query!
Country [270]
0
0
Italy
Query!
State/province [270]
0
0
BS
Query!
Country [271]
0
0
Italy
Query!
State/province [271]
0
0
CA
Query!
Country [272]
0
0
Italy
Query!
State/province [272]
0
0
CE
Query!
Country [273]
0
0
Italy
Query!
State/province [273]
0
0
CH
Query!
Country [274]
0
0
Italy
Query!
State/province [274]
0
0
CZ
Query!
Country [275]
0
0
Italy
Query!
State/province [275]
0
0
FE
Query!
Country [276]
0
0
Italy
Query!
State/province [276]
0
0
FG
Query!
Country [277]
0
0
Italy
Query!
State/province [277]
0
0
FI
Query!
Country [278]
0
0
Italy
Query!
State/province [278]
0
0
IS
Query!
Country [279]
0
0
Italy
Query!
State/province [279]
0
0
MI
Query!
Country [280]
0
0
Italy
Query!
State/province [280]
0
0
MS
Query!
Country [281]
0
0
Italy
Query!
State/province [281]
0
0
PA
Query!
Country [282]
0
0
Italy
Query!
State/province [282]
0
0
PC
Query!
Country [283]
0
0
Italy
Query!
State/province [283]
0
0
PI
Query!
Country [284]
0
0
Italy
Query!
State/province [284]
0
0
PR
Query!
Country [285]
0
0
Italy
Query!
State/province [285]
0
0
PV
Query!
Country [286]
0
0
Italy
Query!
State/province [286]
0
0
RM
Query!
Country [287]
0
0
Italy
Query!
State/province [287]
0
0
SS
Query!
Country [288]
0
0
Italy
Query!
State/province [288]
0
0
UD
Query!
Country [289]
0
0
Italy
Query!
State/province [289]
0
0
VR
Query!
Country [290]
0
0
Italy
Query!
State/province [290]
0
0
VV
Query!
Country [291]
0
0
Italy
Query!
State/province [291]
0
0
Napoli
Query!
Country [292]
0
0
Italy
Query!
State/province [292]
0
0
Novara
Query!
Country [293]
0
0
Italy
Query!
State/province [293]
0
0
Veruno
Query!
Country [294]
0
0
Japan
Query!
State/province [294]
0
0
Aichi
Query!
Country [295]
0
0
Japan
Query!
State/province [295]
0
0
Chiba
Query!
Country [296]
0
0
Japan
Query!
State/province [296]
0
0
Fukuoka
Query!
Country [297]
0
0
Japan
Query!
State/province [297]
0
0
Gifu
Query!
Country [298]
0
0
Japan
Query!
State/province [298]
0
0
Gunma
Query!
Country [299]
0
0
Japan
Query!
State/province [299]
0
0
Hiroshima
Query!
Country [300]
0
0
Japan
Query!
State/province [300]
0
0
Hyogo
Query!
Country [301]
0
0
Japan
Query!
State/province [301]
0
0
Ibaraki
Query!
Country [302]
0
0
Japan
Query!
State/province [302]
0
0
Kagawa
Query!
Country [303]
0
0
Japan
Query!
State/province [303]
0
0
Kanagawa
Query!
Country [304]
0
0
Japan
Query!
State/province [304]
0
0
Kumamoto
Query!
Country [305]
0
0
Japan
Query!
State/province [305]
0
0
Kyoto
Query!
Country [306]
0
0
Japan
Query!
State/province [306]
0
0
Miyagi
Query!
Country [307]
0
0
Japan
Query!
State/province [307]
0
0
Nagano
Query!
Country [308]
0
0
Japan
Query!
State/province [308]
0
0
Osaka
Query!
Country [309]
0
0
Japan
Query!
State/province [309]
0
0
Saitama
Query!
Country [310]
0
0
Japan
Query!
State/province [310]
0
0
Shiga
Query!
Country [311]
0
0
Japan
Query!
State/province [311]
0
0
Tokushima
Query!
Country [312]
0
0
Japan
Query!
State/province [312]
0
0
Tokyo
Query!
Country [313]
0
0
Korea, Republic of
Query!
State/province [313]
0
0
Gangwon-Do
Query!
Country [314]
0
0
Korea, Republic of
Query!
State/province [314]
0
0
Gyeonggi-do
Query!
Country [315]
0
0
Korea, Republic of
Query!
State/province [315]
0
0
Korea
Query!
Country [316]
0
0
Korea, Republic of
Query!
State/province [316]
0
0
Seocho Gu
Query!
Country [317]
0
0
Korea, Republic of
Query!
State/province [317]
0
0
Busan
Query!
Country [318]
0
0
Korea, Republic of
Query!
State/province [318]
0
0
Daegu
Query!
Country [319]
0
0
Korea, Republic of
Query!
State/province [319]
0
0
Gwangju
Query!
Country [320]
0
0
Korea, Republic of
Query!
State/province [320]
0
0
Seoul
Query!
Country [321]
0
0
Latvia
Query!
State/province [321]
0
0
LV
Query!
Country [322]
0
0
Latvia
Query!
State/province [322]
0
0
Daugavpils
Query!
Country [323]
0
0
Latvia
Query!
State/province [323]
0
0
Riga
Query!
Country [324]
0
0
Latvia
Query!
State/province [324]
0
0
Valmiera
Query!
Country [325]
0
0
Lithuania
Query!
State/province [325]
0
0
LTU
Query!
Country [326]
0
0
Lithuania
Query!
State/province [326]
0
0
Alytus
Query!
Country [327]
0
0
Lithuania
Query!
State/province [327]
0
0
Kaunas
Query!
Country [328]
0
0
Lithuania
Query!
State/province [328]
0
0
Kedainiai
Query!
Country [329]
0
0
Lithuania
Query!
State/province [329]
0
0
Panevezys
Query!
Country [330]
0
0
Lithuania
Query!
State/province [330]
0
0
Siauliai
Query!
Country [331]
0
0
Lithuania
Query!
State/province [331]
0
0
Vilnius
Query!
Country [332]
0
0
Mexico
Query!
State/province [332]
0
0
Jalisco
Query!
Country [333]
0
0
Mexico
Query!
State/province [333]
0
0
San Luis Potosí
Query!
Country [334]
0
0
Mexico
Query!
State/province [334]
0
0
Sinaloa
Query!
Country [335]
0
0
Mexico
Query!
State/province [335]
0
0
Aguascalientes
Query!
Country [336]
0
0
Mexico
Query!
State/province [336]
0
0
Queretaro
Query!
Country [337]
0
0
Mexico
Query!
State/province [337]
0
0
San Luis Potosi
Query!
Country [338]
0
0
Netherlands
Query!
State/province [338]
0
0
AZ
Query!
Country [339]
0
0
Netherlands
Query!
State/province [339]
0
0
DZ
Query!
Country [340]
0
0
Netherlands
Query!
State/province [340]
0
0
The Netherlands
Query!
Country [341]
0
0
Netherlands
Query!
State/province [341]
0
0
Alkmaar
Query!
Country [342]
0
0
Netherlands
Query!
State/province [342]
0
0
Amersfoort
Query!
Country [343]
0
0
Netherlands
Query!
State/province [343]
0
0
Amstelveen
Query!
Country [344]
0
0
Netherlands
Query!
State/province [344]
0
0
Amsterdam
Query!
Country [345]
0
0
Netherlands
Query!
State/province [345]
0
0
Breda
Query!
Country [346]
0
0
Netherlands
Query!
State/province [346]
0
0
Deventer
Query!
Country [347]
0
0
Netherlands
Query!
State/province [347]
0
0
Doetinchem
Query!
Country [348]
0
0
Netherlands
Query!
State/province [348]
0
0
Ede
Query!
Country [349]
0
0
Netherlands
Query!
State/province [349]
0
0
Gouda
Query!
Country [350]
0
0
Netherlands
Query!
State/province [350]
0
0
Groningen
Query!
Country [351]
0
0
Netherlands
Query!
State/province [351]
0
0
Haarlem
Query!
Country [352]
0
0
Netherlands
Query!
State/province [352]
0
0
Heerlen
Query!
Country [353]
0
0
Netherlands
Query!
State/province [353]
0
0
Hoorn
Query!
Country [354]
0
0
Netherlands
Query!
State/province [354]
0
0
Leeuwarden
Query!
Country [355]
0
0
Netherlands
Query!
State/province [355]
0
0
Meppel
Query!
Country [356]
0
0
Netherlands
Query!
State/province [356]
0
0
Nijmegen
Query!
Country [357]
0
0
Netherlands
Query!
State/province [357]
0
0
Rotterdam
Query!
Country [358]
0
0
Netherlands
Query!
State/province [358]
0
0
Tiel
Query!
Country [359]
0
0
Netherlands
Query!
State/province [359]
0
0
Utrecht
Query!
Country [360]
0
0
Netherlands
Query!
State/province [360]
0
0
Venlo
Query!
Country [361]
0
0
Norway
Query!
State/province [361]
0
0
Alesund
Query!
Country [362]
0
0
Norway
Query!
State/province [362]
0
0
Elverum
Query!
Country [363]
0
0
Norway
Query!
State/province [363]
0
0
Hamar
Query!
Country [364]
0
0
Norway
Query!
State/province [364]
0
0
Harstad
Query!
Country [365]
0
0
Norway
Query!
State/province [365]
0
0
Hønefoss
Query!
Country [366]
0
0
Norway
Query!
State/province [366]
0
0
Lillehammer
Query!
Country [367]
0
0
Norway
Query!
State/province [367]
0
0
Moss
Query!
Country [368]
0
0
Norway
Query!
State/province [368]
0
0
Nesttun
Query!
Country [369]
0
0
Norway
Query!
State/province [369]
0
0
Oslo
Query!
Country [370]
0
0
Norway
Query!
State/province [370]
0
0
Sandefjord
Query!
Country [371]
0
0
Norway
Query!
State/province [371]
0
0
Skedsmokorset
Query!
Country [372]
0
0
Norway
Query!
State/province [372]
0
0
Stavanger
Query!
Country [373]
0
0
Norway
Query!
State/province [373]
0
0
Tonsberg
Query!
Country [374]
0
0
Norway
Query!
State/province [374]
0
0
Trondheim
Query!
Country [375]
0
0
Norway
Query!
State/province [375]
0
0
Tynset
Query!
Country [376]
0
0
Peru
Query!
State/province [376]
0
0
Lima
Query!
Country [377]
0
0
Poland
Query!
State/province [377]
0
0
Gdansk
Query!
Country [378]
0
0
Poland
Query!
State/province [378]
0
0
Gdynia
Query!
Country [379]
0
0
Poland
Query!
State/province [379]
0
0
Lublin
Query!
Country [380]
0
0
Poland
Query!
State/province [380]
0
0
Olawa
Query!
Country [381]
0
0
Poland
Query!
State/province [381]
0
0
Ostrow Wielkopolski
Query!
Country [382]
0
0
Poland
Query!
State/province [382]
0
0
Poznan
Query!
Country [383]
0
0
Poland
Query!
State/province [383]
0
0
Pulawy
Query!
Country [384]
0
0
Poland
Query!
State/province [384]
0
0
Rumia
Query!
Country [385]
0
0
Poland
Query!
State/province [385]
0
0
Skierniewice
Query!
Country [386]
0
0
Poland
Query!
State/province [386]
0
0
Torun
Query!
Country [387]
0
0
Poland
Query!
State/province [387]
0
0
Warszawa
Query!
Country [388]
0
0
Poland
Query!
State/province [388]
0
0
Wegrow
Query!
Country [389]
0
0
Poland
Query!
State/province [389]
0
0
Wloclawek
Query!
Country [390]
0
0
Puerto Rico
Query!
State/province [390]
0
0
Manati
Query!
Country [391]
0
0
Puerto Rico
Query!
State/province [391]
0
0
Mayaguez
Query!
Country [392]
0
0
Puerto Rico
Query!
State/province [392]
0
0
Ponce
Query!
Country [393]
0
0
Puerto Rico
Query!
State/province [393]
0
0
San Juan
Query!
Country [394]
0
0
Romania
Query!
State/province [394]
0
0
Arges
Query!
Country [395]
0
0
Romania
Query!
State/province [395]
0
0
District 1
Query!
Country [396]
0
0
Romania
Query!
State/province [396]
0
0
District 2
Query!
Country [397]
0
0
Romania
Query!
State/province [397]
0
0
District 4
Query!
Country [398]
0
0
Romania
Query!
State/province [398]
0
0
Jud Bihor
Query!
Country [399]
0
0
Romania
Query!
State/province [399]
0
0
Jud Cluj
Query!
Country [400]
0
0
Romania
Query!
State/province [400]
0
0
Jud Iasi
Query!
Country [401]
0
0
Romania
Query!
State/province [401]
0
0
Jud Mures
Query!
Country [402]
0
0
Romania
Query!
State/province [402]
0
0
Jud. Constanta
Query!
Country [403]
0
0
Romania
Query!
State/province [403]
0
0
Jud. Dolj
Query!
Country [404]
0
0
Romania
Query!
State/province [404]
0
0
Jud. Iasi
Query!
Country [405]
0
0
Romania
Query!
State/province [405]
0
0
Mures
Query!
Country [406]
0
0
Romania
Query!
State/province [406]
0
0
ROM
Query!
Country [407]
0
0
Romania
Query!
State/province [407]
0
0
Timis
Query!
Country [408]
0
0
Romania
Query!
State/province [408]
0
0
Baia Mare
Query!
Country [409]
0
0
Romania
Query!
State/province [409]
0
0
Brasov
Query!
Country [410]
0
0
Romania
Query!
State/province [410]
0
0
Bucharest
Query!
Country [411]
0
0
Romania
Query!
State/province [411]
0
0
Bucuresti
Query!
Country [412]
0
0
Romania
Query!
State/province [412]
0
0
Cluj Napoca
Query!
Country [413]
0
0
Romania
Query!
State/province [413]
0
0
Cluj-Napoca
Query!
Country [414]
0
0
Romania
Query!
State/province [414]
0
0
Craiova
Query!
Country [415]
0
0
Romania
Query!
State/province [415]
0
0
Oradea
Query!
Country [416]
0
0
Romania
Query!
State/province [416]
0
0
Pitesti
Query!
Country [417]
0
0
Romania
Query!
State/province [417]
0
0
Sibiu
Query!
Country [418]
0
0
Romania
Query!
State/province [418]
0
0
Targu Mures
Query!
Country [419]
0
0
Romania
Query!
State/province [419]
0
0
Targu-Mures
Query!
Country [420]
0
0
Romania
Query!
State/province [420]
0
0
Timisoara
Query!
Country [421]
0
0
Russian Federation
Query!
State/province [421]
0
0
Chelyabinsk
Query!
Country [422]
0
0
Russian Federation
Query!
State/province [422]
0
0
Ekaterinburg
Query!
Country [423]
0
0
Russian Federation
Query!
State/province [423]
0
0
Izhevsk
Query!
Country [424]
0
0
Russian Federation
Query!
State/province [424]
0
0
Kazan
Query!
Country [425]
0
0
Russian Federation
Query!
State/province [425]
0
0
Kemerovo
Query!
Country [426]
0
0
Russian Federation
Query!
State/province [426]
0
0
Kirov
Query!
Country [427]
0
0
Russian Federation
Query!
State/province [427]
0
0
Krasnodar
Query!
Country [428]
0
0
Russian Federation
Query!
State/province [428]
0
0
Moscow
Query!
Country [429]
0
0
Russian Federation
Query!
State/province [429]
0
0
Novosibirsk
Query!
Country [430]
0
0
Russian Federation
Query!
State/province [430]
0
0
Penza
Query!
Country [431]
0
0
Russian Federation
Query!
State/province [431]
0
0
Perm
Query!
Country [432]
0
0
Russian Federation
Query!
State/province [432]
0
0
Petrozavodsk
Query!
Country [433]
0
0
Russian Federation
Query!
State/province [433]
0
0
Ryazan
Query!
Country [434]
0
0
Russian Federation
Query!
State/province [434]
0
0
Saint Petersburg
Query!
Country [435]
0
0
Russian Federation
Query!
State/province [435]
0
0
Saint-Petersburg
Query!
Country [436]
0
0
Russian Federation
Query!
State/province [436]
0
0
Samara
Query!
Country [437]
0
0
Russian Federation
Query!
State/province [437]
0
0
Saratov
Query!
Country [438]
0
0
Russian Federation
Query!
State/province [438]
0
0
Sestroretsk
Query!
Country [439]
0
0
Russian Federation
Query!
State/province [439]
0
0
Smolensk
Query!
Country [440]
0
0
Russian Federation
Query!
State/province [440]
0
0
St-Petersburg
Query!
Country [441]
0
0
Russian Federation
Query!
State/province [441]
0
0
St. Petersburg
Query!
Country [442]
0
0
Russian Federation
Query!
State/province [442]
0
0
St.- Petersburg
Query!
Country [443]
0
0
Russian Federation
Query!
State/province [443]
0
0
St.Petersburg
Query!
Country [444]
0
0
Russian Federation
Query!
State/province [444]
0
0
Syktyvkar
Query!
Country [445]
0
0
Russian Federation
Query!
State/province [445]
0
0
Tomsk
Query!
Country [446]
0
0
Russian Federation
Query!
State/province [446]
0
0
Tyumen
Query!
Country [447]
0
0
Russian Federation
Query!
State/province [447]
0
0
Vladimir
Query!
Country [448]
0
0
Russian Federation
Query!
State/province [448]
0
0
Yaroslavl
Query!
Country [449]
0
0
Russian Federation
Query!
State/province [449]
0
0
Yekaterinburg
Query!
Country [450]
0
0
Serbia
Query!
State/province [450]
0
0
Beograd
Query!
Country [451]
0
0
Serbia
Query!
State/province [451]
0
0
Niska Banja
Query!
Country [452]
0
0
Serbia
Query!
State/province [452]
0
0
Nis
Query!
Country [453]
0
0
Serbia
Query!
State/province [453]
0
0
Sremska Kamenica
Query!
Country [454]
0
0
Slovakia
Query!
State/province [454]
0
0
Slovak Republic
Query!
Country [455]
0
0
Slovakia
Query!
State/province [455]
0
0
Banska Bystrica
Query!
Country [456]
0
0
Slovakia
Query!
State/province [456]
0
0
Bardejov
Query!
Country [457]
0
0
Slovakia
Query!
State/province [457]
0
0
Bratislava
Query!
Country [458]
0
0
Slovakia
Query!
State/province [458]
0
0
Dubnica nad Vahom
Query!
Country [459]
0
0
Slovakia
Query!
State/province [459]
0
0
Dunajska Streda
Query!
Country [460]
0
0
Slovakia
Query!
State/province [460]
0
0
Galanta
Query!
Country [461]
0
0
Slovakia
Query!
State/province [461]
0
0
Kosice
Query!
Country [462]
0
0
Slovakia
Query!
State/province [462]
0
0
Levice
Query!
Country [463]
0
0
Slovakia
Query!
State/province [463]
0
0
Lucenec
Query!
Country [464]
0
0
Slovakia
Query!
State/province [464]
0
0
Martin
Query!
Country [465]
0
0
Slovakia
Query!
State/province [465]
0
0
Nitra
Query!
Country [466]
0
0
Slovakia
Query!
State/province [466]
0
0
Nove Zamky
Query!
Country [467]
0
0
Slovakia
Query!
State/province [467]
0
0
Presov
Query!
Country [468]
0
0
Slovakia
Query!
State/province [468]
0
0
Trnava
Query!
Country [469]
0
0
Slovakia
Query!
State/province [469]
0
0
Zilina
Query!
Country [470]
0
0
Slovenia
Query!
State/province [470]
0
0
Celje
Query!
Country [471]
0
0
Slovenia
Query!
State/province [471]
0
0
Golnik
Query!
Country [472]
0
0
Slovenia
Query!
State/province [472]
0
0
Ljubljana
Query!
Country [473]
0
0
South Africa
Query!
State/province [473]
0
0
Kwa-Zulu Natal
Query!
Country [474]
0
0
South Africa
Query!
State/province [474]
0
0
Western Cape
Query!
Country [475]
0
0
South Africa
Query!
State/province [475]
0
0
Alberton
Query!
Country [476]
0
0
South Africa
Query!
State/province [476]
0
0
Bloemfontein
Query!
Country [477]
0
0
South Africa
Query!
State/province [477]
0
0
Cape Town
Query!
Country [478]
0
0
South Africa
Query!
State/province [478]
0
0
Centurion
Query!
Country [479]
0
0
South Africa
Query!
State/province [479]
0
0
Johannesburg
Query!
Country [480]
0
0
South Africa
Query!
State/province [480]
0
0
Kempton Park
Query!
Country [481]
0
0
South Africa
Query!
State/province [481]
0
0
Pretoria
Query!
Country [482]
0
0
Sweden
Query!
State/province [482]
0
0
Vastra Gotalands Lan
Query!
Country [483]
0
0
Sweden
Query!
State/province [483]
0
0
Boras
Query!
Country [484]
0
0
Sweden
Query!
State/province [484]
0
0
Goteborg
Query!
Country [485]
0
0
Sweden
Query!
State/province [485]
0
0
Kristianstad
Query!
Country [486]
0
0
Sweden
Query!
State/province [486]
0
0
Luleå
Query!
Country [487]
0
0
Sweden
Query!
State/province [487]
0
0
Lund
Query!
Country [488]
0
0
Sweden
Query!
State/province [488]
0
0
Malmö
Query!
Country [489]
0
0
Sweden
Query!
State/province [489]
0
0
Molndal
Query!
Country [490]
0
0
Sweden
Query!
State/province [490]
0
0
Skanör
Query!
Country [491]
0
0
Sweden
Query!
State/province [491]
0
0
Skelleftea
Query!
Country [492]
0
0
Sweden
Query!
State/province [492]
0
0
Stockholm
Query!
Country [493]
0
0
Sweden
Query!
State/province [493]
0
0
Uddevalla
Query!
Country [494]
0
0
Sweden
Query!
State/province [494]
0
0
Vallingby
Query!
Country [495]
0
0
Sweden
Query!
State/province [495]
0
0
Vasteras
Query!
Country [496]
0
0
Sweden
Query!
State/province [496]
0
0
Östersund
Query!
Country [497]
0
0
Taiwan
Query!
State/province [497]
0
0
Taiwan ROC
Query!
Country [498]
0
0
Taiwan
Query!
State/province [498]
0
0
Taiwan, ROC
Query!
Country [499]
0
0
Taiwan
Query!
State/province [499]
0
0
Changhua
Query!
Country [500]
0
0
Taiwan
Query!
State/province [500]
0
0
Kaohsiung City
Query!
Country [501]
0
0
Taiwan
Query!
State/province [501]
0
0
Kaohsiung
Query!
Country [502]
0
0
Taiwan
Query!
State/province [502]
0
0
Taichung
Query!
Country [503]
0
0
Taiwan
Query!
State/province [503]
0
0
Tainan
Query!
Country [504]
0
0
Taiwan
Query!
State/province [504]
0
0
Taipei
Query!
Country [505]
0
0
Taiwan
Query!
State/province [505]
0
0
Taoyuan
Query!
Country [506]
0
0
Taiwan
Query!
State/province [506]
0
0
Yilan
Query!
Country [507]
0
0
Turkey
Query!
State/province [507]
0
0
Meselik
Query!
Country [508]
0
0
Turkey
Query!
State/province [508]
0
0
Aydin
Query!
Country [509]
0
0
Turkey
Query!
State/province [509]
0
0
Istanbul
Query!
Country [510]
0
0
Turkey
Query!
State/province [510]
0
0
Izmir
Query!
Country [511]
0
0
Turkey
Query!
State/province [511]
0
0
Kocaeli
Query!
Country [512]
0
0
Turkey
Query!
State/province [512]
0
0
Mersin
Query!
Country [513]
0
0
Turkey
Query!
State/province [513]
0
0
Sivas
Query!
Country [514]
0
0
United Kingdom
Query!
State/province [514]
0
0
Hampshire
Query!
Country [515]
0
0
United Kingdom
Query!
State/province [515]
0
0
Isle Of Wight
Query!
Country [516]
0
0
United Kingdom
Query!
State/province [516]
0
0
Manchester
Query!
Country [517]
0
0
United Kingdom
Query!
State/province [517]
0
0
North Yorkshire
Query!
Country [518]
0
0
United Kingdom
Query!
State/province [518]
0
0
Perthshire
Query!
Country [519]
0
0
United Kingdom
Query!
State/province [519]
0
0
Somerset
Query!
Country [520]
0
0
United Kingdom
Query!
State/province [520]
0
0
Wales
Query!
Country [521]
0
0
United Kingdom
Query!
State/province [521]
0
0
Barnet
Query!
Country [522]
0
0
United Kingdom
Query!
State/province [522]
0
0
Berkshire
Query!
Country [523]
0
0
United Kingdom
Query!
State/province [523]
0
0
Birmingham
Query!
Country [524]
0
0
United Kingdom
Query!
State/province [524]
0
0
Cardiff
Query!
Country [525]
0
0
United Kingdom
Query!
State/province [525]
0
0
Cheshire
Query!
Country [526]
0
0
United Kingdom
Query!
State/province [526]
0
0
Chesterfield
Query!
Country [527]
0
0
United Kingdom
Query!
State/province [527]
0
0
Chorley
Query!
Country [528]
0
0
United Kingdom
Query!
State/province [528]
0
0
Exeter
Query!
Country [529]
0
0
United Kingdom
Query!
State/province [529]
0
0
Glasgow
Query!
Country [530]
0
0
United Kingdom
Query!
State/province [530]
0
0
Irvine
Query!
Country [531]
0
0
United Kingdom
Query!
State/province [531]
0
0
Leicester
Query!
Country [532]
0
0
United Kingdom
Query!
State/province [532]
0
0
Liverpool
Query!
Country [533]
0
0
United Kingdom
Query!
State/province [533]
0
0
London
Query!
Country [534]
0
0
United Kingdom
Query!
State/province [534]
0
0
Newcastle Upon Tyne
Query!
Country [535]
0
0
United Kingdom
Query!
State/province [535]
0
0
Newport
Query!
Country [536]
0
0
United Kingdom
Query!
State/province [536]
0
0
Norwich
Query!
Country [537]
0
0
United Kingdom
Query!
State/province [537]
0
0
Nottingham
Query!
Country [538]
0
0
United Kingdom
Query!
State/province [538]
0
0
Sheffield
Query!
Country [539]
0
0
United Kingdom
Query!
State/province [539]
0
0
Wiltshire
Query!
Country [540]
0
0
United Kingdom
Query!
State/province [540]
0
0
Worcester
Query!
Country [541]
0
0
United Kingdom
Query!
State/province [541]
0
0
York
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Novartis Pharmaceuticals
Query!
Address
Query!
Country
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated hsCRP could prevent recurrent cardiovascular events. The purpose of the extension phase of the main study is to collect additional long-term safety data on continued exposure to canakinumab in patients who participated in the pivotal phase. Sub-study 1 (CACZ885M2301S1): The purpose of this sub-study was to evaluate the effect of quarterly subcutaneous canakinumab treatment for 24 months comparted with placebo on the carotid plaque burden measured by integrated vascular MRI in patients enrolled in the CACZ885M2301 study (CANTOS). Sub-study 2 (CACZ885M2301S2): The purpose of this CANTOS sub-study was to determine whether, in patients with type 2 diabetes participating in the CANTOS main study, canakinumab compared to placebo, on top of standard of care could increase insulin secretion and insulin sensitivity.
Query!
Trial website
https://clinicaltrials.gov/study/NCT01327846
Query!
Trial related presentations / publications
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG. Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy. Eur Heart J. 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. Svensson EC, Madar A, Campbell CD, He Y, Sultan M, Healey ML, Xu H, D'Aco K, Fernandez A, Wache-Mainier C, Libby P, Ridker PM, Beste MT, Basson CT. TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial. JAMA Cardiol. 2022 May 1;7(5):521-528. doi: 10.1001/jamacardio.2022.0386. Everett BM, MacFadyen JG, Thuren T, Libby P, Glynn RJ, Ridker PM. Inhibition of Interleukin-1beta and Reduction in Atherothrombotic Cardiovascular Events in the CANTOS Trial. J Am Coll Cardiol. 2020 Oct 6;76(14):1660-1670. doi: 10.1016/j.jacc.2020.08.011. Schieker M, Conaghan PG, Mindeholm L, Praestgaard J, Solomon DH, Scotti C, Gram H, Thuren T, Roubenoff R, Ridker PM. Effects of Interleukin-1beta Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2020 Oct 6;173(7):509-515. doi: 10.7326/M20-0527. Epub 2020 Aug 4. Vallurupalli M, MacFadyen JG, Glynn RJ, Thuren T, Libby P, Berliner N, Ridker PM. Effects of Interleukin-1beta Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial. Ann Intern Med. 2020 Apr 21;172(8):523-532. doi: 10.7326/M19-2945. Epub 2020 Mar 24. Erratum In: Ann Intern Med. 2020 Aug 18;173(4):324. doi: 10.7326/L20-0934. Rothman AM, MacFadyen J, Thuren T, Webb A, Harrison DG, Guzik TJ, Libby P, Glynn RJ, Ridker PM. Effects of Interleukin-1beta Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk: A Secondary Analysis of CANTOS. Hypertension. 2020 Feb;75(2):477-482. doi: 10.1161/HYPERTENSIONAHA.119.13642. Epub 2019 Dec 30. Ridker PM, MacFadyen JG, Thuren T, Libby P. Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1beta inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis. Eur Heart J. 2020 Jun 14;41(23):2153-2163. doi: 10.1093/eurheartj/ehz542. Everett BM, Cornel JH, Lainscak M, Anker SD, Abbate A, Thuren T, Libby P, Glynn RJ, Ridker PM. Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure. Circulation. 2019 Mar 5;139(10):1289-1299. doi: 10.1161/CIRCULATIONAHA.118.038010. Solomon DH, Glynn RJ, MacFadyen JG, Libby P, Thuren T, Everett BM, Ridker PM. Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial. Ann Intern Med. 2018 Oct 16;169(8):535-542. doi: 10.7326/M18-1167. Epub 2018 Sep 18. Ridker PM, Libby P, MacFadyen JG, Thuren T, Ballantyne C, Fonseca F, Koenig W, Shimokawa H, Everett BM, Glynn RJ. Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur Heart J. 2018 Oct 7;39(38):3499-3507. doi: 10.1093/eurheartj/ehy310. Ridker PM, MacFadyen JG, Glynn RJ, Koenig W, Libby P, Everett BM, Lefkowitz M, Thuren T, Cornel JH. Inhibition of Interleukin-1beta by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease. J Am Coll Cardiol. 2018 May 29;71(21):2405-2414. doi: 10.1016/j.jacc.2018.03.490. Everett BM, Donath MY, Pradhan AD, Thuren T, Pais P, Nicolau JC, Glynn RJ, Libby P, Ridker PM. Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes. J Am Coll Cardiol. 2018 May 29;71(21):2392-2401. doi: 10.1016/j.jacc.2018.03.002. Epub 2018 Mar 12. Ridker PM, MacFadyen JG, Everett BM, Libby P, Thuren T, Glynn RJ; CANTOS Trial Group. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet. 2018 Jan 27;391(10118):319-328. doi: 10.1016/S0140-6736(17)32814-3. Epub 2017 Nov 13. Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group. Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27. Canada JM, Fronk DT, Cei LF, Carbone S, Erdle CO, Abouzaki NA, Melchior RD, Thomas CS, Christopher S, Turlington JS, Trankle CR, Thurber CJ, Evans RK, Dixon DL, Van Tassell BW, Arena R, Abbate A. Usefulness of C-Reactive Protein Plasma Levels to Predict Exercise Intolerance in Patients With Chronic Systolic Heart Failure. Am J Cardiol. 2016 Jan 1;117(1):116-20. doi: 10.1016/j.amjcard.2015.10.020. Epub 2015 Oct 19. Ridker PM, Thuren T, Zalewski A, Libby P. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011 Oct;162(4):597-605. doi: 10.1016/j.ahj.2011.06.012. Epub 2011 Sep 14.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Novartis Pharmaceuticals
Query!
Address
0
0
Novartis Pharmaceuticals
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
Query!
What data in particular will be shared?
Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.
This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com
Query!
When will data be available (start and end dates)?
Query!
Available to whom?
Query!
Available for what types of analyses?
Query!
How or where can data be obtained?
Query!
What supporting documents are/will be available?
No Supporting Document Provided
Type
Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/46/NCT01327846/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/46/NCT01327846/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT01327846