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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT00483379
Registration number
NCT00483379
Ethics application status
Date submitted
6/06/2007
Date registered
7/06/2007
Date last updated
7/03/2014
Titles & IDs
Public title
High Dose or High Dose Frequency Study of Alglucosidase Alfa
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Scientific title
An Exploratory, Open-Label Study of the Safety and Efficacy of High Dose or High Dosing Frequency Alglucosidase Alfa Treatment in Patients With Pompe Disease Who Do Not Have an Optimal Response to the Standard Dose Regimen
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Secondary ID [1]
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AGLU03306
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Universal Trial Number (UTN)
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Trial acronym
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Pompe Disease
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Glycogen Storage Disease Type II (GSD-II)
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Glycogenesis 2 Acid Maltase Deficiency
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Condition category
Condition code
Metabolic and Endocrine
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Metabolic disorders
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Metabolic and Endocrine
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Other metabolic disorders
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Human Genetics and Inherited Disorders
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Other human genetics and inherited disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Other interventions - alglucosidase alfa
Experimental: alglucosidase alfa 20 mg/kg every week - Participants were treated with alglucosidase alfa 20 mg/kg every week for 52 weeks. This was the 'frequent dose' arm.
Experimental: alglucosidase alfa 40 mg/kg every other week - Participants were treated with alglucosidase alfa 40 mg/kg every other week for 52 weeks. This was the 'high dose' arm.
Other interventions: alglucosidase alfa
intravenous infusion
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Intervention code [1]
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Other interventions
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Participants' Efficacy Response During the Treatment Period as Compared to Baseline for Participants With Respiratory Decline on Standard Treatment
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Assessment method [1]
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Participants were enrolled based on clinical decline or sub-optimal clinical response in cardiac, respiratory and/or motor function parameters pre-study while on standard treatment. Each participant was evaluated at Week 52 for change from baseline in the criteria that declined; respiratory decline as measured by change in ventilator use is summarized in this outcome. Ventilator use might have improved (less use of ventilator support), had no change, or worsened (more use of ventilator support). Each participant served as his or her own control.
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Timepoint [1]
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Baseline, Week 52
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Primary outcome [2]
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Participants' Efficacy Response During the Treatment Period as Compared to Baseline for Participants With Motor Function Decline on Standard Treatment
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Assessment method [2]
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Participants were enrolled based on clinical decline or sub-optimal clinical response in cardiac, respiratory and/or motor function parameters pre-study while on standard treatment. Each participant was evaluated at Week 52 for change from baseline in the criteria that declined; motor function decline primarily based on Gross Motor Function Measure 66 and Pompe Pediatric Evaluation of Disability Inventory results is summarized. Participants could gain motor function (improve), had no change (declined stopped), or continued loss (worsened). Each participant served as his or her own control.
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Timepoint [2]
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Baseline, Week 52
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Primary outcome [3]
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Summary of Participants Reporting Treatment-Emergent Adverse Events During the Treatment Period
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Assessment method [3]
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Overall safety summary of participants experiencing Adverse Events (AEs), Serious Adverse Events (SAEs), treatment-related AEs, and Infusion Associated Reactions (IARs). Summary is based on Treatment-emergent AEs (TEAEs), defined as AEs that occurred following the initiation of study treatment.
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Timepoint [3]
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Day 1 up to Week 52
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Secondary outcome [1]
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Baseline Values for Left Ventricular Mass (LVM) Z-Scores
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Assessment method [1]
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Z-Scores indicate the number of standard deviations (SD) from the mean in a normal distribution. Negative values indicate a smaller than mean LVM and values higher than 0 indicate a larger LVM than the mean. The normal range is -2 to 2 and greater than 2 may indicate left ventricular hypertrophy. The Z-scores for all parameters are calculated with reference to the normative data from the Children's Hospital, Boston, MA (Colan, 1992, J Am Coll Cardiol) based on the reference population with matched body surface area (BSA). Z-scores for LVM were provided by the central cardiologist.
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Timepoint [1]
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Day 0
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Secondary outcome [2]
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Change From Baseline in Left Ventricular Mass (LVM) Z-Score at Week 52
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Assessment method [2]
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Z-Scores indicate the number of standard deviations (SD) from the mean in a normal distribution. A negative change from baseline indicates a decrease and positive change from baseline an increase in LVM Z-score. The normal range is -2 to 2 and greater than 2 may indicate left ventricular hypertrophy. The Z-scores for all parameters are calculated with reference to the normative data from the Children's Hospital, Boston, MA (Colan, 1992, J Am Coll Cardiol) based on the reference population with matched body surface area (BSA). Z-scores for LVM were provided by the central cardiologist.
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Timepoint [2]
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Baseline, Week 52
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Secondary outcome [3]
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Baseline Values for Left Ventricular Mass Index (LVMI)
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Assessment method [3]
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Cardiac pathophysiology was assessed by a central cardiologist using left ventricular mass index (LVMI) measured by echocardiogram at Baseline. Left Ventricular Mass is adjusted to the participant's body surface area in the calculation of LVMI.
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Timepoint [3]
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Day 0
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Secondary outcome [4]
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Change From Baseline in Left Ventricular Mass Index (LVMI) at Week 52
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Assessment method [4]
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Cardiac pathophysiology was assessed by a central cardiologist using left ventricular mass index (LVMI) measured by echocardiogram at Baseline and after 12 months of treatment (Week 52). Left Ventricular Mass is adjusted to the participant's body surface area in the calculation of LVMI.
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Timepoint [4]
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Baseline, Week 52
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Secondary outcome [5]
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Change From Baseline in Ventilator Use at Last Assessment (Approximately Week 52)
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Assessment method [5]
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The change from baseline in ventilator use at the last assessment is summarized as improved (less use of ventilator support), no change, worsened (increased use of ventilator support), and did not use ventilator support.
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Timepoint [5]
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Baseline, approximately Week 52
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Secondary outcome [6]
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Change From Baseline in Body Strength Measured by the Manual Muscle Testing (MMT) Total Score at Week 52
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Assessment method [6]
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Body strength is measured by the MMT score on a scale of 0-10 with higher scores representing greater body strength.
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Timepoint [6]
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Baseline, Week 52
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Secondary outcome [7]
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Baseline Values of Raw Scores for Gross Motor Function Measure 66 (GMFM-66) Results
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Assessment method [7]
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The Gross Motor Function Measure 66 contains sixty-six questions with a total raw score range of 0 - 198. Raw scores are derived from the following dimensions: Lying and rolling = 12; Sitting = 45; Crawling and kneeling = 30; Standing = 39; Walking, running and jumping = 72. Higher scores indicate better gross motor functions.
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Timepoint [7]
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Day 0
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Secondary outcome [8]
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Change From Baseline in Raw Scores for Gross Motor Function Measure 66 (GMFM-66) Results at Week 52
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Assessment method [8]
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The Gross Motor Function Measure 66 contains sixty-six questions with a total raw score range of 0 - 198. Raw scores are derived from the following dimensions: Lying and rolling = 12; Sitting = 45; Crawling and kneeling = 30; Standing = 39; Walking, running and jumping = 72. Higher scores indicate better gross motor functions.
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Timepoint [8]
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Baseline, Week 52
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Secondary outcome [9]
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Baseline Values in Mobility as Measured by the Pompe Pediatric Evaluation of Disability Inventory (Pompe PEDI)
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Assessment method [9]
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The Pompe PEDI is a disease specific version of the PEDI that was developed to assess functional capabilities and performance in children with Pompe disease from 2 months through adolescence. Baseline results for the mobility domain are reported. Scaled scores are used as an evaluative measure of change in performance over time with acquisition of new skills or new levels of independence. The range of scores is from 0-100 with scores near "0" reflecting low capability and scores near "100" reflecting high capability.
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Timepoint [9]
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Day 0
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Secondary outcome [10]
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Change From Baseline in Mobility as Measured by the Pompe Pediatric Evaluation of Disability Inventory (Pompe PEDI) at Week 52
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Assessment method [10]
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The Pompe PEDI is a disease specific version of the PEDI that was developed to assess functional capabilities and performance in children with Pompe disease from 2 months through adolescence. Change from baseline results for the mobility domain are reported. Scaled scores are used as an evaluative measure of change in performance over time with acquisition of new skills or new levels of independence. The range of scores is from 0-100 with scores near "0" reflecting low capability and scores near "100" reflecting high capability.
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Timepoint [10]
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Baseline, Week 52
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Secondary outcome [11]
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Baseline Values for Normative Physical Component Summary of Medical Outcomes Study Short Form Health Survey (SF-36)
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Assessment method [11]
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Health related quality of life is measured using the Physical Component Summary (PCS) score of the Medical Outcomes Study (MOS) Short Form Health Survey (SF-36) for participants =14 years of age. SF-36 normative-based scoring has a mean of 50 and a standard deviation of 10. Higher scores represent better quality of life.
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Timepoint [11]
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Day 0
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Secondary outcome [12]
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Change From Baseline in Normative Physical Component Summary of Medical Outcomes Study Short Form Health Survey (SF-36) at Week 52
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Assessment method [12]
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Health related quality of life is measured using the Physical Component Summary (PCS) score of the Medical Outcomes Study (MOS) Short Form Health Survey (SF-36) for participants =14 years of age. SF-36 normative-based scoring has a mean of 50 and a standard deviation of 10. Higher scores represent better quality of life.
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Timepoint [12]
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Baseline, Week 52
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Eligibility
Key inclusion criteria
- The patient or patient's legal guardian must provide signed, informed consent prior to
performing any study-related procedures;
- The patient must have a clinical diagnosis of Pompe disease as defined by documented
GAA deficiency in skin fibroblasts or blood;
- The patient must have been compliant with the standard dosing regimen of alglucosidase
alfa (20 mg/kg every other week) for a minimum of 6 months immediately prior to study
entry
- The patient must have clinical decline or sub-optimal improvement in at least one of
the following parameters as compared to their condition prior to the beginning
alglucosidase alfa treatment:
1. Cardiac: Left Ventricular Mass (LVM) Z-score =6 or LVM index =150 g/m2 after a
minimum of 6 months of regular treatment with alglucosidase alfa; OR
2. Respiratory: New development of respiratory failure requiring the use of
ventilatory assistance (invasive or non-invasive) after a minimum of 6 months of
regular treatment with alglucosidase alfa. Ventilatory assistance must have been
required for at least 4 weeks prior to study enrollment; OR
3. Motor Skills:
- For patients = 2 years of age at study entry, failure to acquire at least 2 new gross
motor milestones after a minimum of 6 months of regular treatment with alglucosidase
alfa; OR
- For patients > 2 years of age at study entry, worsening of proximal upper extremity
muscle weakness as determined by the Investigator through loss of functional use of
the upper extremities after a minimum of 6 months of regular treatment with
alglucosidase alfa, OR
- For patients > 8 years of age at study entry, worsening of proximal upper extremity
muscle weakness as determined by the Investigator through longitudinal assessments of
manual muscle testing after a minimum of 6 months of regular treatment with
alglucosidase alfa, OR
- For patients previously ambulatory, progression to use of an assistive device for
ambulation due to worsening of proximal lower extremity muscle weakness after a
minimum of 6 months of regular treatment with alglucosidase alfa.
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Minimum age
6
Months
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
- For patients < 18 years of age, negative Cross-Reactive Immunologic Material (CRIM)
assay result (added in protocol amendment #2);
- Any medical condition which, in the opinion of the Investigator, could interfere with
treatment or evaluation of safety and/or efficacy of alglucosidase alfa;
- The patient is not currently receiving alglucosidase alfa;
- The patient has major congenital abnormality;
- The patient has used any investigational product (other than alglucosidase alfa in
those regions where the product is not commercially available) within 30 days prior to
study enrollment;
- The patient is pregnant or lactating.
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Open (masking not used)
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Who is / are masked / blinded?
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 4
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/05/2007
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/07/2010
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Sample size
Target
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Accrual to date
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Final
13
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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- Parkville Victoria
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Recruitment postcode(s) [1]
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- Parkville Victoria
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Recruitment outside Australia
Country [1]
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United States of America
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State/province [1]
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Alabama
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Country [2]
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United States of America
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State/province [2]
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California
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Country [3]
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United States of America
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State/province [3]
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District of Columbia
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Country [4]
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United States of America
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State/province [4]
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Illinois
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Country [5]
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United States of America
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State/province [5]
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Kansas
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Country [6]
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United States of America
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State/province [6]
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Massachusetts
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Country [7]
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United States of America
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State/province [7]
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Michigan
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Country [8]
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United States of America
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State/province [8]
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New York
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Country [9]
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United States of America
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State/province [9]
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North Carolina
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Canada
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State/province [10]
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Alberta
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Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
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Name
Genzyme, a Sanofi Company
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Address
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Country
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Ethics approval
Ethics application status
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Summary
Brief summary
Pompe disease (also known as glycogen storage disease Type II) is caused by a deficiency of a
critical enzyme in the body called acid alpha-glucosidase (GAA). Normally, GAA is used by the
body's cells to break down glycogen (a stored form of sugar) within specialized structures
called lysosomes. In patients with Pompe disease, an excessive amount of glycogen accumulates
and is stored in various tissues, especially heart and skeletal muscle, which prevents their
normal function. The objective of this exploratory study is to evaluate the safety and
efficacy of alternative dosing regimens of alglucosidase alfa in patients with Pompe disease
who have not demonstrated an optimal response to the standard dosing regimen of 20 mg/kg
every other week after a minimum of 6 months treatment immediately prior to study entry.
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Trial website
https://clinicaltrials.gov/ct2/show/NCT00483379
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
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Medical Monitor
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Address
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Genzyme, a Sanofi Company
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Country
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Phone
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Fax
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Email
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Contact person for public queries
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Address
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Country
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Phone
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Fax
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Email
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Contact person for scientific queries
Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT00483379
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