Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT00496769
Registration number
NCT00496769
Ethics application status
Date submitted
2/07/2007
Date registered
4/07/2007
Date last updated
15/06/2018
Titles & IDs
Public title
A Phase III Study of Apixaban in Patients With Atrial Fibrillation
Query!
Scientific title
Apixaban Versus Acetylsalicylic Acid (ASA) to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment: A Randomized Double-blind Trial
Query!
Secondary ID [1]
0
0
CV185-048
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
AVERROES
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Atrial Fibrillation
0
0
Query!
Condition category
Condition code
Cardiovascular
0
0
0
0
Query!
Other cardiovascular diseases
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - Apixaban
Treatment: Drugs - Acetylsalicylic acid
Experimental: Apixaban -
Active comparator: Acetylasalicylic acid -
Treatment: Drugs: Apixaban
Tablets, oral, 5 mg (2.5 mg in patients meeting any 2 of the following criteria: 80 years of age and older, weight of 60 kilograms or less, and a serum creatinine level of 1.5 mg/dL or higher), twice daily, up to 156 weeks
Treatment: Drugs: Acetylsalicylic acid
Tablets, oral, 81-324 mg, once daily, up to 156 weeks
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Event Rate of Stroke/Systemic Embolism During the Intended-treatment Period
Query!
Assessment method [1]
0
0
Event rate=percent of participants with an event divided by the total participants in the arm. Intended-treatment period=date of randomization to the efficacy cutoff date, which was to be the date on which at least 226 unrefuted original primary efficacy events occurred (date revised to May 28, 2010 following cessation of study for superior efficacy.)
Query!
Timepoint [1]
0
0
Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)
Query!
Secondary outcome [1]
0
0
Event Rate for the Composite of Stroke of Any Type, Systemic Embolism, Myocardial Infarction, or Vascular Death During the Double-blind Treatment Period
Query!
Assessment method [1]
0
0
Event rate=percent of participants with an event divided by the total participants in the arm.
Query!
Timepoint [1]
0
0
Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)
Query!
Secondary outcome [2]
0
0
Event Rate of All-cause Death; Net Clinical Benefit-Composite of Stroke, Systemic Embolism, Myocardial Infarction, Vascular Death, and Major Bleeding; and Vascular Death
Query!
Assessment method [2]
0
0
Event rate=percent of participants with an event divided by the total participants in the arm.
Query!
Timepoint [2]
0
0
Randomization to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)
Query!
Secondary outcome [3]
0
0
Event Rates for Major Bleeding, Major or Clinically Relevant Nonmajor (CNRM) Bleeding, and All Bleeding in the Double-blind Period
Query!
Assessment method [3]
0
0
Event rate=percent of participants with an event divided by the total participants in the arm.
Query!
Timepoint [3]
0
0
First dose of study drug (Day 1) to the earlier of a patient's discontinuation of double-blind study drug or the attainment of at least 226 primary efficacy events up to May 28, 2010
Query!
Secondary outcome [4]
0
0
Rate of Unrefuted Bleeding From First Dose of Double-blind Study Drug to First Occurence of Unrefuted Bleeding During the Double-blind Treatment Period
Query!
Assessment method [4]
0
0
Event rate=percent of participants with an event divided by the total participants in the arm.
Query!
Timepoint [4]
0
0
Day 1 to first bleeding event up to efficacy cutoff date of May 28, 2010 (date revised following cessation of study for superior efficacy)
Query!
Secondary outcome [5]
0
0
Number of Participants With Serious Adverse Events (SAEs), Adverse Events (AEs), Bleeding AEs, Discontinuations Due to AEs, and Death as Outcome
Query!
Assessment method [5]
0
0
AE=any new unfavorable symptom, sign, or disease or worsening of a preexisting condition that may not have a causal relationship with treatment. SAE=a medical event that at any dose results in death, persistent or significant disability/incapacity, or drug dependency/abuse; is life-threatening, an important medical event, or a congenital anomaly/birth defect; or requires or prolongs hospitalization.
Query!
Timepoint [5]
0
0
First dose of study drug (Day 1) to 30 days after last dose of blinded study drug
Query!
Secondary outcome [6]
0
0
Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality
Query!
Assessment method [6]
0
0
BL=baseline, LLN=lower limit of normal, ULN=upper limit of normal. Hemoglobin (g/dL), low: BL\>2 or value =8; hematocrit(%), low: \<0.75\*BL; erythrocytes (\*10\^6 cells/µL), low: \<0.75\*BL; platelet count (\*10\^9 cells/L),low: \<100\*10\^9 cells/L; leukocytes (\*10\^3 cells/µL), low if \<0.8\*BL and BL\<LLN or \<LLN and BL \>ULN or \<0.75\*LLN when BL is missing or LLN =BL= ULN, high if \>1.2\*BL and BL\>ULN or \>ULN when BL and BL\<LLN or \>1.25\*ULN when BL is missing or LLN=BL=ULN; neutrophils (absolute), low: \<1.0\*10\^3 cells/µL; eosinophils (absolute), high: \>0.750\*10\^3 cells/µL; basophils (absolute), high: \>0.4\*10\^3 cells/µL; monocytes (absolute), high: 2\*10\^3 cells/µL; lymphocytes (absolute), low if \<0.75\*10\^3 cells/µL, high if \>7.50\*10\^3 cells/µL; ALP (U/L), high: 2\*ULN; AST (U/L), high: 3\*ULN; AST (U/L), high: 3\*ULN; bilirubin, total (mg/dL), high: \>2\*ULN; bilirubin, direct (mg/dL), high: 1.5\*ULN; BUN (mg/dL), high:\>2\*ULN; creatinine (mg/dL), high: \>1.5\*ULN.
Query!
Timepoint [6]
0
0
First dose of study drug (Day 1) to 30 days after last dose of blinded study drug
Query!
Secondary outcome [7]
0
0
Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)
Query!
Assessment method [7]
0
0
LLN=lower limit of normal; ULN=upper limit of normal; BL=baseline. Sodium, serum (mEq/L):low if \<0.95\*BL and BL\<LLN or \<LLN and BL\>ULN or \<0.95\*LLN when BL missing or LLN =BL=ULN, high if \>1.05\*BL and BL\>ULN or \>ULN and BL\<LLN or \>1.05\*ULN when BL missing or LLN=BL=ULN; potassium(mEq/L):low if \<0.90\*BL and BL\<LLN or \<LLN and BL\>ULN or \<0.90\*LLN if BL missing or LLN=BL=ULN, high if \>1.10\*BL and BL\>ULN or\>ULN and BL\<LLN or \>1.10\*ULN when BL missing or LLN=BL=ULN; chloride(mEq/L):low if \<0.90\*BL and BL\<LLN or \<LLN and BL\>ULN or \<0.90\*LLN if BL missing or LLN=BL =ULN, high if \>1.10\*BL and BL\>ULN or \>ULN and BL\<LLN or \>1.10\* ULN if BL missing or LLN=BL=ULN; calcium(mg/dL):low if \<0.75\*BL and BL\<LLN or \<LLN and BL\>ULN or \<0.80\*LLN if BL missing or LLN=BL=ULN, high if \>1.25\*BL and BL\>ULN or \>ULN if BL\<LLN or \>1.20\*ULN if BL missing or LLN=BL=ULN ; bicarbonate(mEq/L):low if \<0.75\*BL when BL\<LLN or \<LLN when BL\>ULN or \<0.75\*LLN if BL missing or LLN=BL=ULN, high if \>1.25\*BL when BL\>ULN or \>ULN
Query!
Timepoint [7]
0
0
First dose of study drug (Day 1) to 30 days after last dose of blinded study drug
Query!
Secondary outcome [8]
0
0
Number of Participants With Laboratory Test Results Meeting the Criteria for Marked Abnormality (Continued)
Query!
Assessment method [8]
0
0
ULN=upper limit of normal; LLN=lower limit of normal; BL=baseline. Creatine kinase (U/L), high:\>5\*ULN; protein, total(g/L):low if \<0.90\*BL when BL\<LLN or \<LLN when B \>ULN or \<0.90\*LLN when BL is missing or LLN=BL=ULN, high if \>1.10\*BL if BL\>ULN or \>ULN when BL\<LLN or \>1.10\*ULN if BL missing or LLN=BL=ULN.Protein,total(g/L): low if \<0.90\*BL if BL\<LLN or \<LLN if BL\>ULN or \<0.90\*LLN if BL missing or LLN=BL=ULN, high if \>1.10\*BL if BL\>ULN or \>ULN if BL\<LLN or \>1.10\*ULN if BL or LLN=BL=ULN; glucose, serum fasting (mg/dL): low if \<0.8\*BL if BL\<LLN or \<LLN when BL\>ULN or \<0.8\*LLN when BL missing or LLN=BL=ULN, high if \>2\*BL when BL\>ULN or \>ULN when BL\<LLN or \>1.5\*ULN if BL missing or LLN=BL=ULN; uric acid (mg/dL), high: \>2\*BL and BL\>ULN or\>1.5\*ULN when BL missing or BL=ULN; glucose, urine, high; protein, urine, high; blood, urine, high; leukocyte esterase, urine, high; RBC count, urine (Hpf), high; WBC count, urine (Hpf), high: =2 if BL=missing,=0 or =0.5 or if =3 if BL=1, or if =4 and BL=2.
Query!
Timepoint [8]
0
0
First dose of study drug (Day 1) to 30 days after last dose of blinded study drug
Query!
Eligibility
Key inclusion criteria
Key
* Male and female
* Age of 50 years or older
* Permanent, paroxysmal, or persistent atrial fibrillation (at screening or within 6 months prior to enrollment) documented by 12-lead electrocardiogram)
* At least 1 of the following risk factors for stroke:
* Prior stroke or transient ischemic attack
* Age of 75 years or older
* Arterial hypertension on treatment
* Diabetes mellitus
* Heart failure (New York Health Authority Class 2 or greater at time of enrollment)
* Left ventricular ejection fraction of 35% or less, documented within 6 months of enrollment
* Peripheral arterial disease (previous arterial revascularization, limb or foot amputation, or current intermittent claudication with ankle-arm systolic blood pressure ratio <0.9)
* Not currently receiving vitamin K antagonist therapy for 1 of the following reasons:
* Previous vitamin K antagonist therapy demonstrated as unsuitable and discontinued
* Vitamin K antagonist therapy not previously used but expected unsuitable
Key
Query!
Minimum age
50
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Women who are pregnant or breast feeding
* Women of child bearing potential who are unwilling to meet the study requirements for pregnancy testing or are unwilling or unable to use an acceptable method to avoid pregnancy
* Atrial fibrillation due to reversible causes, such as thyrotoxicosis or pericarditis
* Valvular disease requiring surgery
* Planned ablation procedure for atrial fibrillation to be performed within 3 months
* Conditions other than atrial fibrillation that require chronic anticoagulation (such as, prosthetic mechanical heart valve, venous thromboembolism)
* Patients with serious bleeding in the last 6 months or at high risk for bleeding, including but not limited to those with:
* Active peptic ulcer disease
* Platelet count <100,000/mm^3 or hemoglobin <10g/dL
* Recent stroke (within 10 days)
* Documented hemorrhagic tendencies or blood dyscrasias
* Current alcohol or drug abuse or psychosocial reasons that make study participation impractical
* Severe comorbid condition with life expectancy <1 year
* Severe renal insufficiency; any patient with a serum creatinine level >2.5 mg/dL or a calculated creatinine clearance <25 mL/min is excluded
* Alanine transaminase or aspartate aminotransferase levels >2 times upper limit of normal (ULN) or a total bilirubin level >1.5 times ULN (unless an alternative causative factor [such as Gilbert's syndrome] is identified)
* Allergy or adverse reaction to acetylsalicylic acid
* Required treatment with a thienopyridine (clopidogrel or ticlopidine)
* Prisoners or participants who are compulsory detained (involuntarily incarcerated)
* Use of an investigational drug or device within the past 30 days or prior randomization into an apixaban clinical study
* Patients who are compulsorily detained for treatment for a psychiatric or physical illness
Query!
Study design
Purpose of the study
Prevention
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
31/08/2007
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
25/05/2017
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
6421
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,VIC,WA
Query!
Recruitment hospital [1]
0
0
Local Institution - Coffs Harbour
Query!
Recruitment hospital [2]
0
0
Local Institution - Concord
Query!
Recruitment hospital [3]
0
0
Local Institution - Gosford
Query!
Recruitment hospital [4]
0
0
Local Institution - Kingswood
Query!
Recruitment hospital [5]
0
0
Local Institution - Auchenflower
Query!
Recruitment hospital [6]
0
0
Local Institution - Kippa Ring
Query!
Recruitment hospital [7]
0
0
Local Institution - Milton
Query!
Recruitment hospital [8]
0
0
Local Institution - Woolloongabba
Query!
Recruitment hospital [9]
0
0
Local Institution - Geelong
Query!
Recruitment hospital [10]
0
0
Local Institution - Joondalup
Query!
Recruitment postcode(s) [1]
0
0
2450 - Coffs Harbour
Query!
Recruitment postcode(s) [2]
0
0
2139 - Concord
Query!
Recruitment postcode(s) [3]
0
0
2250 - Gosford
Query!
Recruitment postcode(s) [4]
0
0
2747 - Kingswood
Query!
Recruitment postcode(s) [5]
0
0
4066 - Auchenflower
Query!
Recruitment postcode(s) [6]
0
0
4021 - Kippa Ring
Query!
Recruitment postcode(s) [7]
0
0
4064 - Milton
Query!
Recruitment postcode(s) [8]
0
0
4102 - Woolloongabba
Query!
Recruitment postcode(s) [9]
0
0
3220 - Geelong
Query!
Recruitment postcode(s) [10]
0
0
6027 - Joondalup
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arizona
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
California
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Connecticut
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Florida
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Georgia
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Illinois
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Indiana
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Kansas
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Louisiana
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Maryland
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Massachusetts
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Michigan
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Mississippi
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Missouri
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Montana
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
New Jersey
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
New York
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
North Carolina
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Ohio
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Oklahoma
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Oregon
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Pennsylvania
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
South Carolina
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
Tennessee
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
Virginia
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
Washington
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
Wisconsin
Query!
Country [29]
0
0
Argentina
Query!
State/province [29]
0
0
Buenos Aires
Query!
Country [30]
0
0
Argentina
Query!
State/province [30]
0
0
Cordoba
Query!
Country [31]
0
0
Argentina
Query!
State/province [31]
0
0
Jujuy
Query!
Country [32]
0
0
Argentina
Query!
State/province [32]
0
0
Provincia Buenos Aires
Query!
Country [33]
0
0
Argentina
Query!
State/province [33]
0
0
Santa FE
Query!
Country [34]
0
0
Argentina
Query!
State/province [34]
0
0
Tucuman
Query!
Country [35]
0
0
Argentina
Query!
State/province [35]
0
0
Corrientes
Query!
Country [36]
0
0
Argentina
Query!
State/province [36]
0
0
Salta
Query!
Country [37]
0
0
Argentina
Query!
State/province [37]
0
0
Santa Fe
Query!
Country [38]
0
0
Austria
Query!
State/province [38]
0
0
Graz
Query!
Country [39]
0
0
Austria
Query!
State/province [39]
0
0
Linz
Query!
Country [40]
0
0
Austria
Query!
State/province [40]
0
0
Oberpullendorf
Query!
Country [41]
0
0
Austria
Query!
State/province [41]
0
0
Salzburg
Query!
Country [42]
0
0
Belgium
Query!
State/province [42]
0
0
Aalst
Query!
Country [43]
0
0
Belgium
Query!
State/province [43]
0
0
Brasschaat
Query!
Country [44]
0
0
Belgium
Query!
State/province [44]
0
0
Brussel
Query!
Country [45]
0
0
Belgium
Query!
State/province [45]
0
0
Bruxelles
Query!
Country [46]
0
0
Belgium
Query!
State/province [46]
0
0
De Pinte
Query!
Country [47]
0
0
Belgium
Query!
State/province [47]
0
0
Genk
Query!
Country [48]
0
0
Belgium
Query!
State/province [48]
0
0
Huy
Query!
Country [49]
0
0
Belgium
Query!
State/province [49]
0
0
Roeselare
Query!
Country [50]
0
0
Belgium
Query!
State/province [50]
0
0
Turnhout
Query!
Country [51]
0
0
Brazil
Query!
State/province [51]
0
0
Bahia
Query!
Country [52]
0
0
Brazil
Query!
State/province [52]
0
0
Minas Gerais
Query!
Country [53]
0
0
Brazil
Query!
State/province [53]
0
0
Parana
Query!
Country [54]
0
0
Brazil
Query!
State/province [54]
0
0
Para
Query!
Country [55]
0
0
Brazil
Query!
State/province [55]
0
0
Rio Grande Do Norte
Query!
Country [56]
0
0
Brazil
Query!
State/province [56]
0
0
Rio Grande Do Sul
Query!
Country [57]
0
0
Brazil
Query!
State/province [57]
0
0
Santa Catarina
Query!
Country [58]
0
0
Brazil
Query!
State/province [58]
0
0
Sao Paulo
Query!
Country [59]
0
0
Brazil
Query!
State/province [59]
0
0
Rio De Janeiro
Query!
Country [60]
0
0
Canada
Query!
State/province [60]
0
0
British Columbia
Query!
Country [61]
0
0
Canada
Query!
State/province [61]
0
0
Manitoba
Query!
Country [62]
0
0
Canada
Query!
State/province [62]
0
0
Ontario
Query!
Country [63]
0
0
Canada
Query!
State/province [63]
0
0
Quebec
Query!
Country [64]
0
0
Canada
Query!
State/province [64]
0
0
Saskatchewan
Query!
Country [65]
0
0
Chile
Query!
State/province [65]
0
0
Araucania
Query!
Country [66]
0
0
Chile
Query!
State/province [66]
0
0
LOS Lagos
Query!
Country [67]
0
0
Chile
Query!
State/province [67]
0
0
Los Rios
Query!
Country [68]
0
0
Chile
Query!
State/province [68]
0
0
Metropolitana
Query!
Country [69]
0
0
Chile
Query!
State/province [69]
0
0
Valparaiso
Query!
Country [70]
0
0
China
Query!
State/province [70]
0
0
Beijing
Query!
Country [71]
0
0
China
Query!
State/province [71]
0
0
Guangdong
Query!
Country [72]
0
0
China
Query!
State/province [72]
0
0
Hebei
Query!
Country [73]
0
0
China
Query!
State/province [73]
0
0
Hubei
Query!
Country [74]
0
0
China
Query!
State/province [74]
0
0
Jiangsu
Query!
Country [75]
0
0
China
Query!
State/province [75]
0
0
Liaoning
Query!
Country [76]
0
0
China
Query!
State/province [76]
0
0
Shandong
Query!
Country [77]
0
0
China
Query!
State/province [77]
0
0
Shanghai
Query!
Country [78]
0
0
China
Query!
State/province [78]
0
0
Sichuan
Query!
Country [79]
0
0
Colombia
Query!
State/province [79]
0
0
Antioquia
Query!
Country [80]
0
0
Colombia
Query!
State/province [80]
0
0
Atlantico
Query!
Country [81]
0
0
Colombia
Query!
State/province [81]
0
0
Santander
Query!
Country [82]
0
0
Colombia
Query!
State/province [82]
0
0
Valle DEL Cauca
Query!
Country [83]
0
0
Colombia
Query!
State/province [83]
0
0
Bogota
Query!
Country [84]
0
0
Czechia
Query!
State/province [84]
0
0
Brno
Query!
Country [85]
0
0
Czechia
Query!
State/province [85]
0
0
Havirov - Mesto
Query!
Country [86]
0
0
Czechia
Query!
State/province [86]
0
0
Jindrichuv Hradec
Query!
Country [87]
0
0
Czechia
Query!
State/province [87]
0
0
Kladno
Query!
Country [88]
0
0
Czechia
Query!
State/province [88]
0
0
Kromeriz
Query!
Country [89]
0
0
Czechia
Query!
State/province [89]
0
0
Mestec Kralove
Query!
Country [90]
0
0
Czechia
Query!
State/province [90]
0
0
Ostrava
Query!
Country [91]
0
0
Czechia
Query!
State/province [91]
0
0
Pisek
Query!
Country [92]
0
0
Czechia
Query!
State/province [92]
0
0
Praha 1
Query!
Country [93]
0
0
Czechia
Query!
State/province [93]
0
0
Praha 2
Query!
Country [94]
0
0
Czechia
Query!
State/province [94]
0
0
Praha 5
Query!
Country [95]
0
0
Czechia
Query!
State/province [95]
0
0
Prelouc
Query!
Country [96]
0
0
Czechia
Query!
State/province [96]
0
0
Pribram
Query!
Country [97]
0
0
Czechia
Query!
State/province [97]
0
0
Slany
Query!
Country [98]
0
0
Czechia
Query!
State/province [98]
0
0
Usti Nad Orlici
Query!
Country [99]
0
0
Denmark
Query!
State/province [99]
0
0
Arhus C
Query!
Country [100]
0
0
Denmark
Query!
State/province [100]
0
0
Esbjerg
Query!
Country [101]
0
0
Denmark
Query!
State/province [101]
0
0
Frederiksberg
Query!
Country [102]
0
0
Finland
Query!
State/province [102]
0
0
Espoo
Query!
Country [103]
0
0
Finland
Query!
State/province [103]
0
0
Helsinki
Query!
Country [104]
0
0
Finland
Query!
State/province [104]
0
0
Jyvaskyla
Query!
Country [105]
0
0
Finland
Query!
State/province [105]
0
0
Kuopio
Query!
Country [106]
0
0
Finland
Query!
State/province [106]
0
0
Tampere
Query!
Country [107]
0
0
France
Query!
State/province [107]
0
0
Abbeville Cedex
Query!
Country [108]
0
0
France
Query!
State/province [108]
0
0
Albi Cedex 09
Query!
Country [109]
0
0
France
Query!
State/province [109]
0
0
Cholet
Query!
Country [110]
0
0
France
Query!
State/province [110]
0
0
Grenoble Cedex 09
Query!
Country [111]
0
0
France
Query!
State/province [111]
0
0
Langres Cedex
Query!
Country [112]
0
0
France
Query!
State/province [112]
0
0
Paris Cedex 18
Query!
Country [113]
0
0
France
Query!
State/province [113]
0
0
Sisteron
Query!
Country [114]
0
0
France
Query!
State/province [114]
0
0
Toulon Cedex 09
Query!
Country [115]
0
0
Germany
Query!
State/province [115]
0
0
Berlin
Query!
Country [116]
0
0
Germany
Query!
State/province [116]
0
0
Bonn
Query!
Country [117]
0
0
Germany
Query!
State/province [117]
0
0
Essen
Query!
Country [118]
0
0
Germany
Query!
State/province [118]
0
0
Frankfurt Am Main
Query!
Country [119]
0
0
Germany
Query!
State/province [119]
0
0
Halle/saale
Query!
Country [120]
0
0
Germany
Query!
State/province [120]
0
0
Hamburg
Query!
Country [121]
0
0
Germany
Query!
State/province [121]
0
0
Heidelberg
Query!
Country [122]
0
0
Germany
Query!
State/province [122]
0
0
Kassel
Query!
Country [123]
0
0
Germany
Query!
State/province [123]
0
0
Koln
Query!
Country [124]
0
0
Germany
Query!
State/province [124]
0
0
Leipzig
Query!
Country [125]
0
0
Germany
Query!
State/province [125]
0
0
Magdeburg
Query!
Country [126]
0
0
Germany
Query!
State/province [126]
0
0
Mainz
Query!
Country [127]
0
0
Germany
Query!
State/province [127]
0
0
Mannheim
Query!
Country [128]
0
0
Germany
Query!
State/province [128]
0
0
Papenburg
Query!
Country [129]
0
0
Germany
Query!
State/province [129]
0
0
Regensburg
Query!
Country [130]
0
0
Germany
Query!
State/province [130]
0
0
Riesa
Query!
Country [131]
0
0
Germany
Query!
State/province [131]
0
0
Witten
Query!
Country [132]
0
0
Germany
Query!
State/province [132]
0
0
Wolmirstedt
Query!
Country [133]
0
0
Greece
Query!
State/province [133]
0
0
Athens
Query!
Country [134]
0
0
Greece
Query!
State/province [134]
0
0
Larissa
Query!
Country [135]
0
0
Greece
Query!
State/province [135]
0
0
Thiva
Query!
Country [136]
0
0
Hong Kong
Query!
State/province [136]
0
0
NEW Territories
Query!
Country [137]
0
0
Hong Kong
Query!
State/province [137]
0
0
Chai Wan
Query!
Country [138]
0
0
Hong Kong
Query!
State/province [138]
0
0
Hong Kong
Query!
Country [139]
0
0
India
Query!
State/province [139]
0
0
Andhra Pradesh
Query!
Country [140]
0
0
India
Query!
State/province [140]
0
0
Karnataka
Query!
Country [141]
0
0
India
Query!
State/province [141]
0
0
Maharashtra
Query!
Country [142]
0
0
India
Query!
State/province [142]
0
0
Nagpur
Query!
Country [143]
0
0
India
Query!
State/province [143]
0
0
Tamil Nadu
Query!
Country [144]
0
0
India
Query!
State/province [144]
0
0
Uttar Pradesh
Query!
Country [145]
0
0
India
Query!
State/province [145]
0
0
Ahmedabad
Query!
Country [146]
0
0
India
Query!
State/province [146]
0
0
Bangalore
Query!
Country [147]
0
0
India
Query!
State/province [147]
0
0
Bikaner
Query!
Country [148]
0
0
India
Query!
State/province [148]
0
0
Indore
Query!
Country [149]
0
0
India
Query!
State/province [149]
0
0
Jaipur
Query!
Country [150]
0
0
India
Query!
State/province [150]
0
0
Kottayam
Query!
Country [151]
0
0
India
Query!
State/province [151]
0
0
Pune
Query!
Country [152]
0
0
Indonesia
Query!
State/province [152]
0
0
Jawa-timur
Query!
Country [153]
0
0
Indonesia
Query!
State/province [153]
0
0
Bandung
Query!
Country [154]
0
0
Indonesia
Query!
State/province [154]
0
0
Denpasar
Query!
Country [155]
0
0
Indonesia
Query!
State/province [155]
0
0
Jakarta Timur
Query!
Country [156]
0
0
Indonesia
Query!
State/province [156]
0
0
Jakarta
Query!
Country [157]
0
0
Indonesia
Query!
State/province [157]
0
0
Padang
Query!
Country [158]
0
0
Indonesia
Query!
State/province [158]
0
0
Palembang
Query!
Country [159]
0
0
Indonesia
Query!
State/province [159]
0
0
Surabaya
Query!
Country [160]
0
0
Indonesia
Query!
State/province [160]
0
0
Yogyakarta
Query!
Country [161]
0
0
Israel
Query!
State/province [161]
0
0
Afula
Query!
Country [162]
0
0
Israel
Query!
State/province [162]
0
0
Ashkelon
Query!
Country [163]
0
0
Israel
Query!
State/province [163]
0
0
Givatayim
Query!
Country [164]
0
0
Israel
Query!
State/province [164]
0
0
Hadera
Query!
Country [165]
0
0
Israel
Query!
State/province [165]
0
0
Haifa
Query!
Country [166]
0
0
Israel
Query!
State/province [166]
0
0
Holon
Query!
Country [167]
0
0
Israel
Query!
State/province [167]
0
0
Nazareth
Query!
Country [168]
0
0
Israel
Query!
State/province [168]
0
0
Petach-tikva
Query!
Country [169]
0
0
Israel
Query!
State/province [169]
0
0
Safed
Query!
Country [170]
0
0
Israel
Query!
State/province [170]
0
0
Tel Aviv
Query!
Country [171]
0
0
Italy
Query!
State/province [171]
0
0
Ascoli Piceno
Query!
Country [172]
0
0
Italy
Query!
State/province [172]
0
0
Chieti
Query!
Country [173]
0
0
Italy
Query!
State/province [173]
0
0
Genova
Query!
Country [174]
0
0
Italy
Query!
State/province [174]
0
0
Isernia
Query!
Country [175]
0
0
Italy
Query!
State/province [175]
0
0
Lido Di Camaiore
Query!
Country [176]
0
0
Italy
Query!
State/province [176]
0
0
Palermo
Query!
Country [177]
0
0
Italy
Query!
State/province [177]
0
0
Perugia
Query!
Country [178]
0
0
Italy
Query!
State/province [178]
0
0
San Daniele De Friuli (ud)
Query!
Country [179]
0
0
Italy
Query!
State/province [179]
0
0
Sassari
Query!
Country [180]
0
0
Korea, Republic of
Query!
State/province [180]
0
0
Gyeonggi-do
Query!
Country [181]
0
0
Korea, Republic of
Query!
State/province [181]
0
0
Kyunggi-do
Query!
Country [182]
0
0
Korea, Republic of
Query!
State/province [182]
0
0
Busan
Query!
Country [183]
0
0
Korea, Republic of
Query!
State/province [183]
0
0
Daegu
Query!
Country [184]
0
0
Korea, Republic of
Query!
State/province [184]
0
0
Daejeon
Query!
Country [185]
0
0
Korea, Republic of
Query!
State/province [185]
0
0
Gwangju
Query!
Country [186]
0
0
Korea, Republic of
Query!
State/province [186]
0
0
Seoul
Query!
Country [187]
0
0
Malaysia
Query!
State/province [187]
0
0
Johor
Query!
Country [188]
0
0
Malaysia
Query!
State/province [188]
0
0
Kuala Lumpur
Query!
Country [189]
0
0
Malaysia
Query!
State/province [189]
0
0
Pinang
Query!
Country [190]
0
0
Malaysia
Query!
State/province [190]
0
0
Sarawak
Query!
Country [191]
0
0
Mexico
Query!
State/province [191]
0
0
Distrito Federal
Query!
Country [192]
0
0
Mexico
Query!
State/province [192]
0
0
Estado De Mexico
Query!
Country [193]
0
0
Mexico
Query!
State/province [193]
0
0
Guerrero
Query!
Country [194]
0
0
Mexico
Query!
State/province [194]
0
0
Jalisco
Query!
Country [195]
0
0
Mexico
Query!
State/province [195]
0
0
Nuevo Leon
Query!
Country [196]
0
0
Mexico
Query!
State/province [196]
0
0
San Luis Potosi
Query!
Country [197]
0
0
Mexico
Query!
State/province [197]
0
0
Sinaloa
Query!
Country [198]
0
0
Mexico
Query!
State/province [198]
0
0
Sonora
Query!
Country [199]
0
0
Mexico
Query!
State/province [199]
0
0
Veracruz
Query!
Country [200]
0
0
Mexico
Query!
State/province [200]
0
0
Aguascalientes
Query!
Country [201]
0
0
Mexico
Query!
State/province [201]
0
0
Chihuahua
Query!
Country [202]
0
0
Mexico
Query!
State/province [202]
0
0
Durango
Query!
Country [203]
0
0
Mexico
Query!
State/province [203]
0
0
Queretaro
Query!
Country [204]
0
0
Norway
Query!
State/province [204]
0
0
Fyllingsdal
Query!
Country [205]
0
0
Norway
Query!
State/province [205]
0
0
Kongsberg
Query!
Country [206]
0
0
Norway
Query!
State/province [206]
0
0
Oslo
Query!
Country [207]
0
0
Philippines
Query!
State/province [207]
0
0
Camarines SUR
Query!
Country [208]
0
0
Philippines
Query!
State/province [208]
0
0
Laguna
Query!
Country [209]
0
0
Philippines
Query!
State/province [209]
0
0
Lanao DEL Norte
Query!
Country [210]
0
0
Philippines
Query!
State/province [210]
0
0
Cagayan De Oro City
Query!
Country [211]
0
0
Philippines
Query!
State/province [211]
0
0
Cavite
Query!
Country [212]
0
0
Philippines
Query!
State/province [212]
0
0
Laoag City
Query!
Country [213]
0
0
Philippines
Query!
State/province [213]
0
0
Manila
Query!
Country [214]
0
0
Philippines
Query!
State/province [214]
0
0
Muntinlupa City
Query!
Country [215]
0
0
Poland
Query!
State/province [215]
0
0
Czestochowa
Query!
Country [216]
0
0
Poland
Query!
State/province [216]
0
0
Elblag
Query!
Country [217]
0
0
Poland
Query!
State/province [217]
0
0
Gdynia
Query!
Country [218]
0
0
Poland
Query!
State/province [218]
0
0
Gliwice
Query!
Country [219]
0
0
Poland
Query!
State/province [219]
0
0
Gniewkowo
Query!
Country [220]
0
0
Poland
Query!
State/province [220]
0
0
Grodzisk Mazowiecki
Query!
Country [221]
0
0
Poland
Query!
State/province [221]
0
0
Inowroclaw
Query!
Country [222]
0
0
Poland
Query!
State/province [222]
0
0
Kielce
Query!
Country [223]
0
0
Poland
Query!
State/province [223]
0
0
Krakow
Query!
Country [224]
0
0
Poland
Query!
State/province [224]
0
0
Lodz
Query!
Country [225]
0
0
Poland
Query!
State/province [225]
0
0
Piotrkow Trybunalski
Query!
Country [226]
0
0
Poland
Query!
State/province [226]
0
0
Plock
Query!
Country [227]
0
0
Poland
Query!
State/province [227]
0
0
Poznan
Query!
Country [228]
0
0
Poland
Query!
State/province [228]
0
0
Pulawy
Query!
Country [229]
0
0
Poland
Query!
State/province [229]
0
0
Siemianowice Slaskie
Query!
Country [230]
0
0
Poland
Query!
State/province [230]
0
0
Skierniewice
Query!
Country [231]
0
0
Poland
Query!
State/province [231]
0
0
Tarnow
Query!
Country [232]
0
0
Poland
Query!
State/province [232]
0
0
Warsaw
Query!
Country [233]
0
0
Poland
Query!
State/province [233]
0
0
Warszawa
Query!
Country [234]
0
0
Poland
Query!
State/province [234]
0
0
Wegrow
Query!
Country [235]
0
0
Poland
Query!
State/province [235]
0
0
Zabrze
Query!
Country [236]
0
0
Poland
Query!
State/province [236]
0
0
Zarow
Query!
Country [237]
0
0
Russian Federation
Query!
State/province [237]
0
0
Anenki
Query!
Country [238]
0
0
Russian Federation
Query!
State/province [238]
0
0
Barnaul
Query!
Country [239]
0
0
Russian Federation
Query!
State/province [239]
0
0
Chelyabinsk
Query!
Country [240]
0
0
Russian Federation
Query!
State/province [240]
0
0
Ekaterinburg
Query!
Country [241]
0
0
Russian Federation
Query!
State/province [241]
0
0
Kazan
Query!
Country [242]
0
0
Russian Federation
Query!
State/province [242]
0
0
Kemerovo
Query!
Country [243]
0
0
Russian Federation
Query!
State/province [243]
0
0
Krasnodar
Query!
Country [244]
0
0
Russian Federation
Query!
State/province [244]
0
0
Moscow
Query!
Country [245]
0
0
Russian Federation
Query!
State/province [245]
0
0
Nizhniy Novgorod
Query!
Country [246]
0
0
Russian Federation
Query!
State/province [246]
0
0
Novosibirsk
Query!
Country [247]
0
0
Russian Federation
Query!
State/province [247]
0
0
Perm
Query!
Country [248]
0
0
Russian Federation
Query!
State/province [248]
0
0
Ryazan
Query!
Country [249]
0
0
Russian Federation
Query!
State/province [249]
0
0
Saint Petersburg
Query!
Country [250]
0
0
Russian Federation
Query!
State/province [250]
0
0
Saint-petersburg
Query!
Country [251]
0
0
Russian Federation
Query!
State/province [251]
0
0
Samara
Query!
Country [252]
0
0
Russian Federation
Query!
State/province [252]
0
0
Saratov
Query!
Country [253]
0
0
Russian Federation
Query!
State/province [253]
0
0
St.petersburg
Query!
Country [254]
0
0
Russian Federation
Query!
State/province [254]
0
0
Tomsk
Query!
Country [255]
0
0
Russian Federation
Query!
State/province [255]
0
0
Tumen
Query!
Country [256]
0
0
Russian Federation
Query!
State/province [256]
0
0
Tver
Query!
Country [257]
0
0
Russian Federation
Query!
State/province [257]
0
0
Yaroslavl
Query!
Country [258]
0
0
Singapore
Query!
State/province [258]
0
0
Singapore
Query!
Country [259]
0
0
South Africa
Query!
State/province [259]
0
0
FREE State
Query!
Country [260]
0
0
South Africa
Query!
State/province [260]
0
0
Gauteng
Query!
Country [261]
0
0
South Africa
Query!
State/province [261]
0
0
Western CAPE
Query!
Country [262]
0
0
South Africa
Query!
State/province [262]
0
0
Pretoria
Query!
Country [263]
0
0
Spain
Query!
State/province [263]
0
0
Alicante
Query!
Country [264]
0
0
Spain
Query!
State/province [264]
0
0
Barcelona
Query!
Country [265]
0
0
Spain
Query!
State/province [265]
0
0
Galicia
Query!
Country [266]
0
0
Spain
Query!
State/province [266]
0
0
Albacete
Query!
Country [267]
0
0
Spain
Query!
State/province [267]
0
0
Madrid
Query!
Country [268]
0
0
Spain
Query!
State/province [268]
0
0
Valencia
Query!
Country [269]
0
0
Sweden
Query!
State/province [269]
0
0
Goteborg
Query!
Country [270]
0
0
Sweden
Query!
State/province [270]
0
0
Molndal
Query!
Country [271]
0
0
Sweden
Query!
State/province [271]
0
0
Stockholm
Query!
Country [272]
0
0
Sweden
Query!
State/province [272]
0
0
Uppsala
Query!
Country [273]
0
0
Taiwan
Query!
State/province [273]
0
0
Kaohsiung
Query!
Country [274]
0
0
Taiwan
Query!
State/province [274]
0
0
Taichung
Query!
Country [275]
0
0
Taiwan
Query!
State/province [275]
0
0
Tainan
Query!
Country [276]
0
0
Taiwan
Query!
State/province [276]
0
0
Taipei
Query!
Country [277]
0
0
Turkey
Query!
State/province [277]
0
0
Isparta
Query!
Country [278]
0
0
Turkey
Query!
State/province [278]
0
0
Istanbul
Query!
Country [279]
0
0
Turkey
Query!
State/province [279]
0
0
Kirikkale
Query!
Country [280]
0
0
Ukraine
Query!
State/province [280]
0
0
Dnipropetrovsk
Query!
Country [281]
0
0
Ukraine
Query!
State/province [281]
0
0
Donetsk
Query!
Country [282]
0
0
Ukraine
Query!
State/province [282]
0
0
Kharkiv
Query!
Country [283]
0
0
Ukraine
Query!
State/province [283]
0
0
Kyiv
Query!
Country [284]
0
0
United Kingdom
Query!
State/province [284]
0
0
Aberdeenshire
Query!
Country [285]
0
0
United Kingdom
Query!
State/province [285]
0
0
Derbyshire
Query!
Country [286]
0
0
United Kingdom
Query!
State/province [286]
0
0
Essex
Query!
Country [287]
0
0
United Kingdom
Query!
State/province [287]
0
0
Fife
Query!
Country [288]
0
0
United Kingdom
Query!
State/province [288]
0
0
Greater London
Query!
Country [289]
0
0
United Kingdom
Query!
State/province [289]
0
0
Lanarkshire
Query!
Country [290]
0
0
United Kingdom
Query!
State/province [290]
0
0
Lancashire
Query!
Country [291]
0
0
United Kingdom
Query!
State/province [291]
0
0
Northamptonshire
Query!
Country [292]
0
0
United Kingdom
Query!
State/province [292]
0
0
Nottinghamshire
Query!
Country [293]
0
0
United Kingdom
Query!
State/province [293]
0
0
Portadown
Query!
Country [294]
0
0
United Kingdom
Query!
State/province [294]
0
0
Renfrewshire
Query!
Country [295]
0
0
United Kingdom
Query!
State/province [295]
0
0
South Yorkshire
Query!
Country [296]
0
0
United Kingdom
Query!
State/province [296]
0
0
Stirlingshire
Query!
Country [297]
0
0
United Kingdom
Query!
State/province [297]
0
0
Tyne And Wear
Query!
Country [298]
0
0
United Kingdom
Query!
State/province [298]
0
0
West Midlands
Query!
Country [299]
0
0
United Kingdom
Query!
State/province [299]
0
0
West Sussex
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Bristol-Myers Squibb
Query!
Address
Query!
Country
Query!
Other collaborator category [1]
0
0
Commercial sector/industry
Query!
Name [1]
0
0
Pfizer
Query!
Address [1]
0
0
Query!
Country [1]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
The purpose of this clinical research study is to determine whether apixaban is more effective than acetylsalicylic acid in the prevention of strokes associated with patients with atrial fibrillation. The safety of this treatment will also be studied.
Query!
Trial website
https://clinicaltrials.gov/study/NCT00496769
Query!
Trial related presentations / publications
Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16. Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4. Bhagirath VC, Eikelboom JW, Hirsh J, Coppens M, Ginsberg J, Vanassche T, Yuan F, Chan N, Yusuf S, Connolly SJ. Apixaban-Calibrated Anti-FXa Activity in Relation to Outcome Events and Clinical Characteristics in Patients with Atrial Fibrillation: Results from the AVERROES Trial. TH Open. 2017 Dec 12;1(2):e139-e145. doi: 10.1055/s-0037-1613679. eCollection 2017 Jul. Ng KH, Shestakovska O, Connolly SJ, Eikelboom JW, Avezum A, Diaz R, Lanas F, Yusuf S, Hart RG. Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial. Age Ageing. 2016 Jan;45(1):77-83. doi: 10.1093/ageing/afv156. Epub 2015 Nov 19. Hohnloser SH, Shestakovska O, Eikelboom J, Franzosi MG, Tan RS, Zhu J, Yusuf S, Connolly SJ. The effects of apixaban on hospitalizations in patients with different types of atrial fibrillation: insights from the AVERROES trial. Eur Heart J. 2013 Sep;34(35):2752-9. doi: 10.1093/eurheartj/eht292. Epub 2013 Jul 25. Lip GY, Connolly S, Yusuf S, Shestakovska O, Flaker G, Hart R, Lanas F, Xavier D, Eikelboom J; ERROES Investigators. Modification of outcomes with aspirin or apixaban in relation to CHADS(2) and CHA(2)DS(2)-VASc scores in patients with atrial fibrillation: a secondary analysis of the AVERROES study. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):31-8. doi: 10.1161/CIRCEP.112.975847. Epub 2013 Feb 6. Flaker GC, Eikelboom JW, Shestakovska O, Connolly SJ, Kaatz S, Budaj A, Husted S, Yusuf S, Lip GY, Hart RG. Bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin: the apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment (AVERROES) trial. Stroke. 2012 Dec;43(12):3291-7. doi: 10.1161/STROKEAHA.112.664144. Epub 2012 Oct 2. Diener HC, Eikelboom J, Connolly SJ, Joyner CD, Hart RG, Lip GY, O'Donnell M, Hohnloser SH, Hankey GJ, Shestakovska O, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol. 2012 Mar;11(3):225-31. doi: 10.1016/S1474-4422(12)70017-0. Epub 2012 Feb 1. Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS, Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806-17. doi: 10.1056/NEJMoa1007432. Epub 2011 Feb 10.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Bristol-Myers Squibb
Query!
Address
0
0
Bristol-Myers Squibb
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT00496769
Download to PDF