Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT00554229
Registration number
NCT00554229
Ethics application status
Date submitted
2/11/2007
Date registered
6/11/2007
Date last updated
8/02/2016
Titles & IDs
Public title
A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Hormone Resistant Prostate Cancer With Bone Metastases
Query!
Scientific title
A Phase III Trial to Test the Efficacy of ZD4054(Zibotentan), an Endothelin A Receptor Antagonist, Versus Placebo in Patients With Hormone Resistant Prostate Cancer (HRPC) and Bone Metastasis Who Are Pain Free and Mildly Symptomatic.
Query!
Secondary ID [1]
0
0
2007-003227-20
Query!
Secondary ID [2]
0
0
D4320C00014
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
ENTHUSE M1
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Prostate Cancer
0
0
Query!
Condition category
Condition code
Cancer
0
0
0
0
Query!
Prostate
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - ZD4054
Treatment: Drugs - Placebo
Experimental: ZD4054 - ZD4054 10 mg oral tablet once daily
Placebo Comparator: Placebo - Matching Placebo, oral tablets once daily
Treatment: Drugs: ZD4054
ZD4054 10 mg oral tablet once daily
Treatment: Drugs: Placebo
Matching placebo oral tablet once daily
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Overall Survival
Query!
Assessment method [1]
0
0
Median time (in months) from randomisation until death using the Kaplan-Meier method
Query!
Timepoint [1]
0
0
From date of randomization until date of death, assessed up to 32 months
Query!
Secondary outcome [1]
0
0
Progression Free Survival
Query!
Assessment method [1]
0
0
Median time (in months) from randomisation until clinical progression of disease, where progression is defined, using RECIST, as a measurable increase in the smallest dimension of any target or non-target lesion, or the appearance of new lesions, since baseline, using the Kaplan-Meier method
Query!
Timepoint [1]
0
0
From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 31 months
Query!
Secondary outcome [2]
0
0
Time to Use of Opiates
Query!
Assessment method [2]
0
0
Median time (in months) from randomisation until use of opiates for disease-related symptoms for a duration =1 week using the Kaplan-Meier method
Query!
Timepoint [2]
0
0
From date of randomization until use of opiates for disease-related symptoms for a duration =1 week, assessed up to 31 months
Query!
Secondary outcome [3]
0
0
Incidence of Skeletal Related Events
Query!
Assessment method [3]
0
0
Median time (in months) from randomisation until occurrence of a skeletal related event, where skeletal related event is defined as the first occurrence of a pathological fracture, a vertebral compression fracture not related to trauma, prophylactic surgery or radiation for impending fracture or spinal cord compression, or a spinal cord compression, using the Kaplan-Meier method.
Query!
Timepoint [3]
0
0
From date of randomization until occurrence of a skeletal related event, assessed up to 31 months
Query!
Secondary outcome [4]
0
0
Bone Metastases Formation
Query!
Assessment method [4]
0
0
Median time (in months) from randomisation to appearance of =4 new bone lesions using the Kaplan-Meier method
Query!
Timepoint [4]
0
0
Patients were assessed every 12 weeks
Query!
Secondary outcome [5]
0
0
Health Related Quality of Life
Query!
Assessment method [5]
0
0
Median time (in months) from randomisation until deterioration of Health related Quality of Life using the Kaplan-Meier method, where deterioration is defined as a change from baseline of less than or equal to -6 points in Total FACT-P score maintained for 2 consecutive visits.
Query!
Timepoint [5]
0
0
Patients were assessed at every visit
Query!
Secondary outcome [6]
0
0
Time to Prostate-specific Antigen (PSA) Progression
Query!
Assessment method [6]
0
0
Median time (in months) from randomisation to first PSA value >50% higher than baseline of at least 5ng/ml seen in at least 2 consecutive PSA values at least 2 weeks apart using the Kaplan-Meier method.
Query!
Timepoint [6]
0
0
Patients were assessed every 12 weeks
Query!
Secondary outcome [7]
0
0
Time to Pain Progression
Query!
Assessment method [7]
0
0
Median time (in months) from randomisation to first assessment of an increased pain event, where increased pain event is defined as the first of a patient requiring opiate medication for duration of =1 week for pain due to prostate cancer metastasis, pain due to metastasis that has an increase in the worst pain item of the Brief Pain Inventory (BPI) from baseline to a minimum score of 5 with no decrease in analgesic use, or pain due to metastasis requiring radionuclide therapy, radiation therapy or surgery.
Query!
Timepoint [7]
0
0
Patients were assessed every 12 weeks
Query!
Secondary outcome [8]
0
0
Time to Initiation of Chemotherapy
Query!
Assessment method [8]
0
0
Median time (in months) from randomisation to first administration of any chemotherapy using the Kaplan-Meier method
Query!
Timepoint [8]
0
0
Patients were assessed every 12 weeks
Query!
Secondary outcome [9]
0
0
Pharmacokinetic Characteristics of ZD4054
Query!
Assessment method [9]
0
0
Query!
Timepoint [9]
0
0
PK samples were performed at randomisation, Week 4, Week 8 and Week 12
Query!
Eligibility
Key inclusion criteria
Patients who answer TRUE to the following criteria may be eligible to participate in this
trial.
1. Confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate) that has
spread to the bone (bone metastases)
2. Increasing Prostate Specific Antigen (PSA) over a one month period
3. No pain, or mild pain from prostate cancer
4. Currently receiving treatment with surgical or medical castration
Query!
Minimum age
18
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Males
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
Patients who answer TRUE to the following may NOT eligible to participate in this trial.
1. Currently using opiates based pain killers)
2. Previous treatment with chemotherapy (paclitaxel, docetaxel, and mitoxantrone)
3. Suffering from heart failure or had a myocardial infarction within last 6 months
4. A history of epilepsy or seizures
Query!
Study design
Purpose of the study
Treatment
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
1/11/2007
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
1/08/2011
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
896
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,WA
Query!
Recruitment hospital [1]
0
0
Research Site - Hornsby
Query!
Recruitment hospital [2]
0
0
Research Site - St Leonards
Query!
Recruitment hospital [3]
0
0
Research Site - Redcliffe
Query!
Recruitment hospital [4]
0
0
Research Site - Ashford
Query!
Recruitment hospital [5]
0
0
Research Site - Subiaco
Query!
Recruitment postcode(s) [1]
0
0
- Hornsby
Query!
Recruitment postcode(s) [2]
0
0
- St Leonards
Query!
Recruitment postcode(s) [3]
0
0
- Redcliffe
Query!
Recruitment postcode(s) [4]
0
0
- Ashford
Query!
Recruitment postcode(s) [5]
0
0
- Subiaco
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Arizona
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
California
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
Connecticut
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
District of Columbia
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Florida
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Iowa
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Ohio
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Pennsylvania
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Tennessee
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Utah
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Vermont
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Virginia
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Washington
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
West Virginia
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Wisconsin
Query!
Country [16]
0
0
Argentina
Query!
State/province [16]
0
0
Buenos Aires Province
Query!
Country [17]
0
0
Argentina
Query!
State/province [17]
0
0
Santa Fe Province
Query!
Country [18]
0
0
Austria
Query!
State/province [18]
0
0
Graz
Query!
Country [19]
0
0
Austria
Query!
State/province [19]
0
0
Wels
Query!
Country [20]
0
0
Belgium
Query!
State/province [20]
0
0
Brussels
Query!
Country [21]
0
0
Belgium
Query!
State/province [21]
0
0
Gent
Query!
Country [22]
0
0
Belgium
Query!
State/province [22]
0
0
Kortrijk
Query!
Country [23]
0
0
Belgium
Query!
State/province [23]
0
0
Leuven
Query!
Country [24]
0
0
Brazil
Query!
State/province [24]
0
0
Ceara
Query!
Country [25]
0
0
Brazil
Query!
State/province [25]
0
0
Goias
Query!
Country [26]
0
0
Brazil
Query!
State/province [26]
0
0
Minas Gerais
Query!
Country [27]
0
0
Brazil
Query!
State/province [27]
0
0
Parana
Query!
Country [28]
0
0
Brazil
Query!
State/province [28]
0
0
Rio Grande do Sul
Query!
Country [29]
0
0
Brazil
Query!
State/province [29]
0
0
Sao Paulo
Query!
Country [30]
0
0
Canada
Query!
State/province [30]
0
0
Alberta
Query!
Country [31]
0
0
Canada
Query!
State/province [31]
0
0
British Columbia
Query!
Country [32]
0
0
Canada
Query!
State/province [32]
0
0
Nova Scotia
Query!
Country [33]
0
0
Canada
Query!
State/province [33]
0
0
Ontario
Query!
Country [34]
0
0
Canada
Query!
State/province [34]
0
0
Quebec
Query!
Country [35]
0
0
China
Query!
State/province [35]
0
0
Beijing
Query!
Country [36]
0
0
China
Query!
State/province [36]
0
0
Hubei
Query!
Country [37]
0
0
China
Query!
State/province [37]
0
0
Jiangsu
Query!
Country [38]
0
0
China
Query!
State/province [38]
0
0
Shanghai
Query!
Country [39]
0
0
China
Query!
State/province [39]
0
0
Shanxi
Query!
Country [40]
0
0
Czech Republic
Query!
State/province [40]
0
0
Prague
Query!
Country [41]
0
0
Czech Republic
Query!
State/province [41]
0
0
Brno
Query!
Country [42]
0
0
Czech Republic
Query!
State/province [42]
0
0
Olomouc
Query!
Country [43]
0
0
Czech Republic
Query!
State/province [43]
0
0
Usti nad Labem
Query!
Country [44]
0
0
Denmark
Query!
State/province [44]
0
0
Aalborg
Query!
Country [45]
0
0
Denmark
Query!
State/province [45]
0
0
Aarhus
Query!
Country [46]
0
0
Denmark
Query!
State/province [46]
0
0
Herlev
Query!
Country [47]
0
0
Denmark
Query!
State/province [47]
0
0
Kobenhavn
Query!
Country [48]
0
0
Finland
Query!
State/province [48]
0
0
Joensuu
Query!
Country [49]
0
0
Finland
Query!
State/province [49]
0
0
Kajaanintie
Query!
Country [50]
0
0
Finland
Query!
State/province [50]
0
0
Tampere
Query!
Country [51]
0
0
France
Query!
State/province [51]
0
0
Montpellier
Query!
Country [52]
0
0
France
Query!
State/province [52]
0
0
Paris
Query!
Country [53]
0
0
France
Query!
State/province [53]
0
0
Poitiers Cedex
Query!
Country [54]
0
0
France
Query!
State/province [54]
0
0
Suresnes
Query!
Country [55]
0
0
France
Query!
State/province [55]
0
0
Toulouse
Query!
Country [56]
0
0
France
Query!
State/province [56]
0
0
Villejuif
Query!
Country [57]
0
0
Germany
Query!
State/province [57]
0
0
Muenchen
Query!
Country [58]
0
0
Germany
Query!
State/province [58]
0
0
Teck
Query!
Country [59]
0
0
Germany
Query!
State/province [59]
0
0
Augsburg
Query!
Country [60]
0
0
Germany
Query!
State/province [60]
0
0
Bad Gegeberg
Query!
Country [61]
0
0
Germany
Query!
State/province [61]
0
0
Berlin
Query!
Country [62]
0
0
Germany
Query!
State/province [62]
0
0
Emmendingen
Query!
Country [63]
0
0
Germany
Query!
State/province [63]
0
0
Leipzig
Query!
Country [64]
0
0
Germany
Query!
State/province [64]
0
0
Luebeck
Query!
Country [65]
0
0
Germany
Query!
State/province [65]
0
0
Mannheim
Query!
Country [66]
0
0
Germany
Query!
State/province [66]
0
0
Reutlingen
Query!
Country [67]
0
0
Hong Kong
Query!
State/province [67]
0
0
Hong Kong
Query!
Country [68]
0
0
Hong Kong
Query!
State/province [68]
0
0
Shatin
Query!
Country [69]
0
0
Hong Kong
Query!
State/province [69]
0
0
Tuen Mun
Query!
Country [70]
0
0
Hungary
Query!
State/province [70]
0
0
Budapest
Query!
Country [71]
0
0
Hungary
Query!
State/province [71]
0
0
Debrecen
Query!
Country [72]
0
0
Hungary
Query!
State/province [72]
0
0
Miskolc
Query!
Country [73]
0
0
Hungary
Query!
State/province [73]
0
0
Nyiregyhaza
Query!
Country [74]
0
0
Hungary
Query!
State/province [74]
0
0
Szeged
Query!
Country [75]
0
0
India
Query!
State/province [75]
0
0
Delhi
Query!
Country [76]
0
0
India
Query!
State/province [76]
0
0
Kerala
Query!
Country [77]
0
0
India
Query!
State/province [77]
0
0
Madhya Pradesh
Query!
Country [78]
0
0
India
Query!
State/province [78]
0
0
Maharashtra
Query!
Country [79]
0
0
India
Query!
State/province [79]
0
0
Punjab
Query!
Country [80]
0
0
India
Query!
State/province [80]
0
0
Rajasthan
Query!
Country [81]
0
0
India
Query!
State/province [81]
0
0
West Bengal
Query!
Country [82]
0
0
India
Query!
State/province [82]
0
0
Gujarat
Query!
Country [83]
0
0
India
Query!
State/province [83]
0
0
New Delhi
Query!
Country [84]
0
0
Italy
Query!
State/province [84]
0
0
Milan
Query!
Country [85]
0
0
Italy
Query!
State/province [85]
0
0
Rome
Query!
Country [86]
0
0
Japan
Query!
State/province [86]
0
0
Chiba
Query!
Country [87]
0
0
Japan
Query!
State/province [87]
0
0
Ehime
Query!
Country [88]
0
0
Japan
Query!
State/province [88]
0
0
Fukuoka
Query!
Country [89]
0
0
Japan
Query!
State/province [89]
0
0
Gunma
Query!
Country [90]
0
0
Japan
Query!
State/province [90]
0
0
Hiroshima
Query!
Country [91]
0
0
Japan
Query!
State/province [91]
0
0
Hokkaido
Query!
Country [92]
0
0
Japan
Query!
State/province [92]
0
0
Hyogo
Query!
Country [93]
0
0
Japan
Query!
State/province [93]
0
0
Ibaraki
Query!
Country [94]
0
0
Japan
Query!
State/province [94]
0
0
Kagawa
Query!
Country [95]
0
0
Japan
Query!
State/province [95]
0
0
Kanagawa
Query!
Country [96]
0
0
Japan
Query!
State/province [96]
0
0
Kyoto
Query!
Country [97]
0
0
Japan
Query!
State/province [97]
0
0
Miyagi
Query!
Country [98]
0
0
Japan
Query!
State/province [98]
0
0
Oita
Query!
Country [99]
0
0
Japan
Query!
State/province [99]
0
0
Osaka
Query!
Country [100]
0
0
Japan
Query!
State/province [100]
0
0
Saitama
Query!
Country [101]
0
0
Japan
Query!
State/province [101]
0
0
Shizuoka
Query!
Country [102]
0
0
Japan
Query!
State/province [102]
0
0
Tokyo
Query!
Country [103]
0
0
Japan
Query!
State/province [103]
0
0
Nagasaki
Query!
Country [104]
0
0
Korea, Republic of
Query!
State/province [104]
0
0
Chungbuk
Query!
Country [105]
0
0
Korea, Republic of
Query!
State/province [105]
0
0
Gyeonggi-do
Query!
Country [106]
0
0
Korea, Republic of
Query!
State/province [106]
0
0
Pusan
Query!
Country [107]
0
0
Korea, Republic of
Query!
State/province [107]
0
0
Seoul
Query!
Country [108]
0
0
Mexico
Query!
State/province [108]
0
0
Estado de Mexico
Query!
Country [109]
0
0
Mexico
Query!
State/province [109]
0
0
Distrito Federal Ciudad
Query!
Country [110]
0
0
Mexico
Query!
State/province [110]
0
0
Mexico City
Query!
Country [111]
0
0
Netherlands
Query!
State/province [111]
0
0
Amsterdam
Query!
Country [112]
0
0
Netherlands
Query!
State/province [112]
0
0
Eindhoven
Query!
Country [113]
0
0
Netherlands
Query!
State/province [113]
0
0
Groningen
Query!
Country [114]
0
0
Netherlands
Query!
State/province [114]
0
0
Nijmegen
Query!
Country [115]
0
0
Poland
Query!
State/province [115]
0
0
Bialystok
Query!
Country [116]
0
0
Poland
Query!
State/province [116]
0
0
Koscierzyna
Query!
Country [117]
0
0
Poland
Query!
State/province [117]
0
0
Krakow
Query!
Country [118]
0
0
Poland
Query!
State/province [118]
0
0
Rzeszow
Query!
Country [119]
0
0
Poland
Query!
State/province [119]
0
0
Warszawa
Query!
Country [120]
0
0
Poland
Query!
State/province [120]
0
0
Wroclaw
Query!
Country [121]
0
0
Portugal
Query!
State/province [121]
0
0
Coimbra
Query!
Country [122]
0
0
Portugal
Query!
State/province [122]
0
0
Lisboa
Query!
Country [123]
0
0
Portugal
Query!
State/province [123]
0
0
Porto
Query!
Country [124]
0
0
Russian Federation
Query!
State/province [124]
0
0
Belgorodskaya region
Query!
Country [125]
0
0
Russian Federation
Query!
State/province [125]
0
0
Barnaul
Query!
Country [126]
0
0
Russian Federation
Query!
State/province [126]
0
0
Izhevsk
Query!
Country [127]
0
0
Russian Federation
Query!
State/province [127]
0
0
Kursk
Query!
Country [128]
0
0
Russian Federation
Query!
State/province [128]
0
0
Moscow
Query!
Country [129]
0
0
Russian Federation
Query!
State/province [129]
0
0
Sochi
Query!
Country [130]
0
0
Russian Federation
Query!
State/province [130]
0
0
St. Petersgurg
Query!
Country [131]
0
0
Russian Federation
Query!
State/province [131]
0
0
Voronezh
Query!
Country [132]
0
0
Serbia
Query!
State/province [132]
0
0
Belgrade
Query!
Country [133]
0
0
Serbia
Query!
State/province [133]
0
0
Nis
Query!
Country [134]
0
0
Serbia
Query!
State/province [134]
0
0
Novi Sad
Query!
Country [135]
0
0
Singapore
Query!
State/province [135]
0
0
Singapore
Query!
Country [136]
0
0
South Africa
Query!
State/province [136]
0
0
Cape Town
Query!
Country [137]
0
0
South Africa
Query!
State/province [137]
0
0
Bloemfontein
Query!
Country [138]
0
0
South Africa
Query!
State/province [138]
0
0
Pietermaritzburg
Query!
Country [139]
0
0
South Africa
Query!
State/province [139]
0
0
Port Elizabeth
Query!
Country [140]
0
0
Sweden
Query!
State/province [140]
0
0
Goteborg
Query!
Country [141]
0
0
Sweden
Query!
State/province [141]
0
0
Gothenburg
Query!
Country [142]
0
0
Sweden
Query!
State/province [142]
0
0
Stockholm
Query!
Country [143]
0
0
Switzerland
Query!
State/province [143]
0
0
Basel
Query!
Country [144]
0
0
Switzerland
Query!
State/province [144]
0
0
Bern
Query!
Country [145]
0
0
Switzerland
Query!
State/province [145]
0
0
Locarno
Query!
Country [146]
0
0
Switzerland
Query!
State/province [146]
0
0
Sursee
Query!
Country [147]
0
0
Taiwan
Query!
State/province [147]
0
0
Kaohsiung
Query!
Country [148]
0
0
Taiwan
Query!
State/province [148]
0
0
Taipei
Query!
Country [149]
0
0
Taiwan
Query!
State/province [149]
0
0
Taoyuan
Query!
Country [150]
0
0
United Kingdom
Query!
State/province [150]
0
0
Berkshire
Query!
Country [151]
0
0
United Kingdom
Query!
State/province [151]
0
0
Cambridgeshire
Query!
Country [152]
0
0
United Kingdom
Query!
State/province [152]
0
0
Kent
Query!
Country [153]
0
0
United Kingdom
Query!
State/province [153]
0
0
Yorkshire
Query!
Country [154]
0
0
United Kingdom
Query!
State/province [154]
0
0
London
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Query!
Name
AstraZeneca
Query!
Address
Query!
Country
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
Enthuse M1 is a large phase III clinical trial studying the safety and efficacy of ZD4054
(Zibotentan) in patients with hormone resistant prostate cancer and bone metastases.
- This clinical trial will test if the Endothelin A Receptor Antagonist ZD4054
(Zibotentan) can improve survival compared with placebo.
- ZD4054(Zibotentan) is a new type of agent, which is thought to slow tumour growth and
spread by blocking Endothelin A receptor activity. This trial will look at the effects
of ZD4054 (Zibotentan) in hormone resistant prostate cancer patients with bone
metastases.
- All patients participating in this clinical trial will receive existing standard
prostate cancer treatments in addition to trial therapy.
- Half the patients will receive ZD4054 (Zibotentan), and half the patients will receive
placebo in addition to standard prostate cancer therapy. By participating in this trial
there is a 50% chance that patients will receive an agent that may slow the progression
of the tumour.
- No patients will be deprived of standard prostate cancer therapy.
Query!
Trial website
https://clinicaltrials.gov/ct2/show/NCT00554229
Query!
Trial related presentations / publications
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Martin Gleave, MD, FRCSC, FACS
Query!
Address
0
0
The Prostate Centre at Vancouver General Hospital
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT00554229
Download to PDF