Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT00571649
Registration number
NCT00571649
Ethics application status
Date submitted
11/12/2007
Date registered
12/12/2007
Date last updated
15/09/2016
Titles & IDs
Public title
Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients
Query!
Scientific title
Multicenter, Randomized, Parallel-group Efficacy and Safety Study for the Prevention of Venous Thromboembolism in Hospitalized Medically Ill Patients Comparing Rivaroxaban With Enoxaparin. The MAGELLAN Study
Query!
Secondary ID [1]
0
0
2007-004614-14
Query!
Secondary ID [2]
0
0
12839
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
MAGELLAN
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Venous Thromboembolism
0
0
Query!
Condition category
Condition code
Cardiovascular
0
0
0
0
Query!
Diseases of the vasculature and circulation including the lymphatic system
Query!
Blood
0
0
0
0
Query!
Clotting disorders
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban (Xarelto, BAY59-7939)
Treatment: Drugs - Enoxaparin
Treatment: Drugs - Rivaroxaban placebo
Treatment: Drugs - Enoxaparin placebo
Experimental: Rivaroxaban (Xarelto, BAY59-7939) - Participants received 10 mg oral rivaroxaban tablet once daily (OD) for 35 +/- 4 days, plus subcutaneous enoxaparin-matched placebo solution OD for 10 +/- 4 days
Active comparator: Enoxaparin - Participants received oral rivaroxaban-matched placebo tablet OD for 35 +/- 4 days, plus 40 mg subcutaneous enoxaparin solution OD for 10 +/- 4 days
Treatment: Drugs: Rivaroxaban (Xarelto, BAY59-7939)
Oral rivaroxaban 10 mg once daily administered for 35 +/- 4 days
Treatment: Drugs: Enoxaparin
Subcutaneous enoxaparin 40 mg once daily (OD) administered for 10 +/- 4 days
Treatment: Drugs: Rivaroxaban placebo
Oral rivaroxaban-matched placebo tablet OD for 35 +/- 4 days
Treatment: Drugs: Enoxaparin placebo
Subcutaneous enoxaparin-matched placebo solution OD for 10 +/- 4 days
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Percentage of Participants With Composite Endpoint of Venous Thromboembolism [VTE] (Any Deep Vein Thrombosis [DVT], Non Fatal Pulmonary Embolism [PE]) and VTE-related Death up to Day 35 + 6 Days
Query!
Assessment method [1]
0
0
A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.
Query!
Timepoint [1]
0
0
Up to Day 35 + 6 days
Query!
Primary outcome [2]
0
0
Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 10 + 5 Days
Query!
Assessment method [2]
0
0
A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.
Query!
Timepoint [2]
0
0
Up to Day 10 + 5 days
Query!
Secondary outcome [1]
0
0
Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and All-cause Mortality up to Day 35 + 6 Days
Query!
Assessment method [1]
0
0
A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and death (VTE-related and not VTE-related).
Query!
Timepoint [1]
0
0
Up to Day 35 + 6 days
Query!
Secondary outcome [2]
0
0
Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 10 + 5 Days Per mITT Population
Query!
Assessment method [2]
0
0
A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.
Query!
Timepoint [2]
0
0
Up to Day 10 + 5 days
Query!
Secondary outcome [3]
0
0
Percentage of Participants With VTE Combined With All-cause Mortality up to Day 10 + 5 Days
Query!
Assessment method [3]
0
0
A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and death (VTE-related and not VTE-related).
Query!
Timepoint [3]
0
0
Up to Day 10 + 5 days
Query!
Secondary outcome [4]
0
0
Percentage of Participants With Symptomatic VTE, Including and Excluding VTE-related Death up to Days 10, 35, and 90
Query!
Assessment method [4]
0
0
Symptomatic VTE (non-fatal PE and DVT in lower extremity), including and excluding VTE-related death (PE and PE cannot be excluded) up to Days 10, 35, and 90
Query!
Timepoint [4]
0
0
At Day 10 + 5 days, at Day 35 + 6 days, and at Day 90 + 7 days
Query!
Secondary outcome [5]
0
0
Percentage of Participants With Net Clinical Benefit (Any DVT, Non-fatal PE, VTE-related Death, Plus Major and Clinically Relevant Non-major Bleeding Events) up to Day 35 + 6 Days
Query!
Assessment method [5]
0
0
Net clinical benefit is a composite of the primary efficacy endpoint (asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death) plus major and clinically relevant non-major bleeding events.
Query!
Timepoint [5]
0
0
Up to Day 35 + 6 days
Query!
Secondary outcome [6]
0
0
Percentage of Participants With Net Clinical Benefit (Any DVT, Non-fatal PE, VTE-related Death, Plus Major and Clinically Relevant Non-major Bleeding Events) up to Day 10 + 5 Days
Query!
Assessment method [6]
0
0
Net clinical benefit is a composite of the primary efficacy endpoint (asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death) plus major and clinically relevant non-major bleeding events
Query!
Timepoint [6]
0
0
Up to Day 10 + 5 days
Query!
Secondary outcome [7]
0
0
Percentage of Participants With Major Vascular Events up to Days 10, 35, and 90
Query!
Assessment method [7]
0
0
Major vascular events included cardiovascular death, acute myocardial infarction (MI), or acute ischemic stroke. Participants may have had a vascular event in more than one category.
Query!
Timepoint [7]
0
0
At Day 10 + 5 days, at Day 35 + 6 days, and at Day 90 + 7 days
Query!
Secondary outcome [8]
0
0
Percentage of Participants With Each Component of the Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 35 + 6 Days
Query!
Assessment method [8]
0
0
The components of the composite endpoint include asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.
Query!
Timepoint [8]
0
0
Up to Day 35 + 6 days
Query!
Secondary outcome [9]
0
0
Percentage of Participants With Each Component of the Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 10 + 5 Days
Query!
Assessment method [9]
0
0
The components of the composite endpoint include asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.
Query!
Timepoint [9]
0
0
Up to Day 10 + 5 days
Query!
Secondary outcome [10]
0
0
Percentage of Participants With All-cause Mortality up to Day 90 + 7 Days
Query!
Assessment method [10]
0
0
All deaths, including VTE-related deaths, cardiovascular deaths, and other deaths.
Query!
Timepoint [10]
0
0
Up to Day 90 + 7 days
Query!
Secondary outcome [11]
0
0
Percentage of Participants With the Composite of Treatment Emergent Major Bleeding Events and Non-major Clinically Relevant Bleeding Events up to 2 Days After Last Intake of Any Study Medication (Day 35 + 6 Days)
Query!
Assessment method [11]
0
0
Major bleeding events were defined as events leading to \>=2 g/dL fall in hemoglobin; or transfusion of \>= 2 units of packed RBCs (Red blood cells) or whole blood; or leading to death. Non-major bleeding events were defined as overt bleeding not meeting the criteria of major bleeding
Query!
Timepoint [11]
0
0
Up to Day 35 + 6 days
Query!
Secondary outcome [12]
0
0
Percentage of Participants With the Composite of Treatment Emergent Major Bleeding Events and Non-major Clinically Relevant Bleeding Events up to 2 Days After Last Application of a Study Medication Syringe (Day 10 + 5 Days)
Query!
Assessment method [12]
0
0
Major bleeding events were defined as events leading to \>=2 g/dL fall in hemoglobin or transfusion of \>=2 units of packed RBCs or whole blood or leading to death. Non-major bleeding events were defined as overt bleeding not meeting the criteria of major bleeding.
Query!
Timepoint [12]
0
0
Up to Day 10 + 5 days
Query!
Eligibility
Key inclusion criteria
* Male and female patients aged 40 years or more
* Patients at risk of venous thromboembolic events being hospitalized for acute medical conditions as follows:
* Heart failure, New York Heart Association (NYHA) class III or IV
* Active cancer
* Acute ischemic stroke
* Acute infectious and inflammatory diseases, including acute rheumatic diseases
* Acute respiratory insufficiency
* Additional risk factor for VTE, including reduced mobility
Query!
Minimum age
40
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Conditions that contraindicate the use of antithrombotic therapy with the Low Molecular-Weight Heparin (LMWH) enoxaparin
* Conditions that may increase the risk of bleeding, including intracranial hemorrhage
* Required drugs or procedures which may interfere with the study treatment
* Concomitant conditions or diseases which may increase the risk of study subjects or interfere with the study outcome
* General conditions in which subjects are not suitable to participate in the study
Query!
Study design
Purpose of the study
Prevention
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
1/12/2007
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
1/11/2010
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
8101
Query!
Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,TAS,VIC,WA
Query!
Recruitment hospital [1]
0
0
- Garran
Query!
Recruitment hospital [2]
0
0
- Kogarah
Query!
Recruitment hospital [3]
0
0
- Lismore
Query!
Recruitment hospital [4]
0
0
- Sydney
Query!
Recruitment hospital [5]
0
0
- Auchenflower
Query!
Recruitment hospital [6]
0
0
- Brisbane
Query!
Recruitment hospital [7]
0
0
- Redcliffe
Query!
Recruitment hospital [8]
0
0
- Southport
Query!
Recruitment hospital [9]
0
0
- Woollongabba
Query!
Recruitment hospital [10]
0
0
- Adelaide
Query!
Recruitment hospital [11]
0
0
- Launceston
Query!
Recruitment hospital [12]
0
0
- Box Hill
Query!
Recruitment hospital [13]
0
0
- Clayton
Query!
Recruitment hospital [14]
0
0
- Melbourne
Query!
Recruitment hospital [15]
0
0
- Perth
Query!
Recruitment postcode(s) [1]
0
0
2605 - Garran
Query!
Recruitment postcode(s) [2]
0
0
2217 - Kogarah
Query!
Recruitment postcode(s) [3]
0
0
2480 - Lismore
Query!
Recruitment postcode(s) [4]
0
0
2229 - Sydney
Query!
Recruitment postcode(s) [5]
0
0
4066 - Auchenflower
Query!
Recruitment postcode(s) [6]
0
0
4066 - Brisbane
Query!
Recruitment postcode(s) [7]
0
0
4101 - Brisbane
Query!
Recruitment postcode(s) [8]
0
0
4020 - Redcliffe
Query!
Recruitment postcode(s) [9]
0
0
4215 - Southport
Query!
Recruitment postcode(s) [10]
0
0
4102 - Woollongabba
Query!
Recruitment postcode(s) [11]
0
0
5042 - Adelaide
Query!
Recruitment postcode(s) [12]
0
0
7250 - Launceston
Query!
Recruitment postcode(s) [13]
0
0
3128 - Box Hill
Query!
Recruitment postcode(s) [14]
0
0
3168 - Clayton
Query!
Recruitment postcode(s) [15]
0
0
3135 - Melbourne
Query!
Recruitment postcode(s) [16]
0
0
3144 - Melbourne
Query!
Recruitment postcode(s) [17]
0
0
6000 - Perth
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arkansas
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
California
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Colorado
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Connecticut
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Delaware
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
District of Columbia
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Florida
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Georgia
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Idaho
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Illinois
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Indiana
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Iowa
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Kansas
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Louisiana
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Maine
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Maryland
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Massachusetts
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Michigan
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Minnesota
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Missouri
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Montana
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Nebraska
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
New Jersey
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
New York
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
North Carolina
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
North Dakota
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
Ohio
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
Pennsylvania
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
South Carolina
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
Tennessee
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
Texas
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
Utah
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
Virginia
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
Washington
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
West Virginia
Query!
Country [37]
0
0
Argentina
Query!
State/province [37]
0
0
Buenos Aires
Query!
Country [38]
0
0
Argentina
Query!
State/province [38]
0
0
Ciudad Auton. de Buenos Aires
Query!
Country [39]
0
0
Argentina
Query!
State/province [39]
0
0
Vicente López
Query!
Country [40]
0
0
Austria
Query!
State/province [40]
0
0
Burgenland
Query!
Country [41]
0
0
Austria
Query!
State/province [41]
0
0
Kärnten
Query!
Country [42]
0
0
Austria
Query!
State/province [42]
0
0
Oberösterreich
Query!
Country [43]
0
0
Austria
Query!
State/province [43]
0
0
Steiermark
Query!
Country [44]
0
0
Austria
Query!
State/province [44]
0
0
Tirol
Query!
Country [45]
0
0
Austria
Query!
State/province [45]
0
0
Innsbruck
Query!
Country [46]
0
0
Austria
Query!
State/province [46]
0
0
Linz
Query!
Country [47]
0
0
Austria
Query!
State/province [47]
0
0
Mürzzuschlag
Query!
Country [48]
0
0
Austria
Query!
State/province [48]
0
0
St. Pölten
Query!
Country [49]
0
0
Austria
Query!
State/province [49]
0
0
Wien
Query!
Country [50]
0
0
Belgium
Query!
State/province [50]
0
0
Aalst
Query!
Country [51]
0
0
Belgium
Query!
State/province [51]
0
0
Brugge
Query!
Country [52]
0
0
Belgium
Query!
State/province [52]
0
0
Bruxelles - Brussel
Query!
Country [53]
0
0
Belgium
Query!
State/province [53]
0
0
Dendermonde
Query!
Country [54]
0
0
Belgium
Query!
State/province [54]
0
0
Hasselt
Query!
Country [55]
0
0
Belgium
Query!
State/province [55]
0
0
HUY
Query!
Country [56]
0
0
Belgium
Query!
State/province [56]
0
0
Ieper
Query!
Country [57]
0
0
Belgium
Query!
State/province [57]
0
0
Leuven
Query!
Country [58]
0
0
Belgium
Query!
State/province [58]
0
0
Malmedy
Query!
Country [59]
0
0
Belgium
Query!
State/province [59]
0
0
MOL
Query!
Country [60]
0
0
Belgium
Query!
State/province [60]
0
0
Montigny S/sambre
Query!
Country [61]
0
0
Belgium
Query!
State/province [61]
0
0
Mortsel
Query!
Country [62]
0
0
Belgium
Query!
State/province [62]
0
0
Roeselare
Query!
Country [63]
0
0
Belgium
Query!
State/province [63]
0
0
Sint-niklaas
Query!
Country [64]
0
0
Belgium
Query!
State/province [64]
0
0
Tubize
Query!
Country [65]
0
0
Belgium
Query!
State/province [65]
0
0
Turnhout
Query!
Country [66]
0
0
Brazil
Query!
State/province [66]
0
0
Parana
Query!
Country [67]
0
0
Brazil
Query!
State/province [67]
0
0
Rio Grande do Sul
Query!
Country [68]
0
0
Brazil
Query!
State/province [68]
0
0
Sao Paulo
Query!
Country [69]
0
0
Bulgaria
Query!
State/province [69]
0
0
Pleven
Query!
Country [70]
0
0
Bulgaria
Query!
State/province [70]
0
0
Ruse
Query!
Country [71]
0
0
Bulgaria
Query!
State/province [71]
0
0
Sofia
Query!
Country [72]
0
0
Bulgaria
Query!
State/province [72]
0
0
Stara Zagora
Query!
Country [73]
0
0
Bulgaria
Query!
State/province [73]
0
0
Varna
Query!
Country [74]
0
0
Bulgaria
Query!
State/province [74]
0
0
Veliko Tarnovo
Query!
Country [75]
0
0
Canada
Query!
State/province [75]
0
0
Alberta
Query!
Country [76]
0
0
Canada
Query!
State/province [76]
0
0
British Columbia
Query!
Country [77]
0
0
Canada
Query!
State/province [77]
0
0
New Brunswick
Query!
Country [78]
0
0
Canada
Query!
State/province [78]
0
0
Ontario
Query!
Country [79]
0
0
Canada
Query!
State/province [79]
0
0
Quebec
Query!
Country [80]
0
0
Chile
Query!
State/province [80]
0
0
Santiago
Query!
Country [81]
0
0
Chile
Query!
State/province [81]
0
0
Viña del Mar
Query!
Country [82]
0
0
China
Query!
State/province [82]
0
0
Guangdong
Query!
Country [83]
0
0
China
Query!
State/province [83]
0
0
Hunan
Query!
Country [84]
0
0
China
Query!
State/province [84]
0
0
Jiangsu
Query!
Country [85]
0
0
China
Query!
State/province [85]
0
0
Jilin
Query!
Country [86]
0
0
China
Query!
State/province [86]
0
0
Liaoning
Query!
Country [87]
0
0
China
Query!
State/province [87]
0
0
Shaanxi
Query!
Country [88]
0
0
China
Query!
State/province [88]
0
0
Sichuan
Query!
Country [89]
0
0
China
Query!
State/province [89]
0
0
Beijing
Query!
Country [90]
0
0
China
Query!
State/province [90]
0
0
Chongqing
Query!
Country [91]
0
0
China
Query!
State/province [91]
0
0
Shanghai
Query!
Country [92]
0
0
Colombia
Query!
State/province [92]
0
0
Antioquia
Query!
Country [93]
0
0
Colombia
Query!
State/province [93]
0
0
Distrito Capital de Bogotá
Query!
Country [94]
0
0
Colombia
Query!
State/province [94]
0
0
Valle del Cauca
Query!
Country [95]
0
0
Colombia
Query!
State/province [95]
0
0
Bogota
Query!
Country [96]
0
0
Colombia
Query!
State/province [96]
0
0
Bogotá
Query!
Country [97]
0
0
Colombia
Query!
State/province [97]
0
0
Cali
Query!
Country [98]
0
0
Colombia
Query!
State/province [98]
0
0
Medellín
Query!
Country [99]
0
0
Croatia
Query!
State/province [99]
0
0
Osijek
Query!
Country [100]
0
0
Croatia
Query!
State/province [100]
0
0
Rijeka
Query!
Country [101]
0
0
Croatia
Query!
State/province [101]
0
0
Zadar
Query!
Country [102]
0
0
Croatia
Query!
State/province [102]
0
0
Zagreb
Query!
Country [103]
0
0
Czech Republic
Query!
State/province [103]
0
0
Brno
Query!
Country [104]
0
0
Czech Republic
Query!
State/province [104]
0
0
Kutna Hora
Query!
Country [105]
0
0
Czech Republic
Query!
State/province [105]
0
0
Nove Mesto na Morave
Query!
Country [106]
0
0
Czech Republic
Query!
State/province [106]
0
0
Olomouc
Query!
Country [107]
0
0
Czech Republic
Query!
State/province [107]
0
0
Plzen
Query!
Country [108]
0
0
Czech Republic
Query!
State/province [108]
0
0
Praha 2
Query!
Country [109]
0
0
Czech Republic
Query!
State/province [109]
0
0
Ricany
Query!
Country [110]
0
0
Czech Republic
Query!
State/province [110]
0
0
Znojmo
Query!
Country [111]
0
0
Denmark
Query!
State/province [111]
0
0
Esbjerg
Query!
Country [112]
0
0
Denmark
Query!
State/province [112]
0
0
Frederiksberg C
Query!
Country [113]
0
0
Denmark
Query!
State/province [113]
0
0
Kolding
Query!
Country [114]
0
0
Denmark
Query!
State/province [114]
0
0
København NV
Query!
Country [115]
0
0
Denmark
Query!
State/province [115]
0
0
København S
Query!
Country [116]
0
0
Denmark
Query!
State/province [116]
0
0
Roskilde
Query!
Country [117]
0
0
Estonia
Query!
State/province [117]
0
0
Tallinn
Query!
Country [118]
0
0
Estonia
Query!
State/province [118]
0
0
Tartu
Query!
Country [119]
0
0
Finland
Query!
State/province [119]
0
0
Helsinki
Query!
Country [120]
0
0
Finland
Query!
State/province [120]
0
0
Hämeenlinna
Query!
Country [121]
0
0
Finland
Query!
State/province [121]
0
0
Jyväskylä
Query!
Country [122]
0
0
Finland
Query!
State/province [122]
0
0
Lahti
Query!
Country [123]
0
0
Finland
Query!
State/province [123]
0
0
Lappeenranta
Query!
Country [124]
0
0
Finland
Query!
State/province [124]
0
0
Raisio
Query!
Country [125]
0
0
Finland
Query!
State/province [125]
0
0
Turku
Query!
Country [126]
0
0
France
Query!
State/province [126]
0
0
Arras
Query!
Country [127]
0
0
France
Query!
State/province [127]
0
0
Besancon
Query!
Country [128]
0
0
France
Query!
State/province [128]
0
0
Brest Cedex
Query!
Country [129]
0
0
France
Query!
State/province [129]
0
0
Castelnau Le Lez
Query!
Country [130]
0
0
France
Query!
State/province [130]
0
0
Clermont Ferrand
Query!
Country [131]
0
0
France
Query!
State/province [131]
0
0
Colombes Cedex
Query!
Country [132]
0
0
France
Query!
State/province [132]
0
0
Dijon
Query!
Country [133]
0
0
France
Query!
State/province [133]
0
0
Lille
Query!
Country [134]
0
0
France
Query!
State/province [134]
0
0
Limoges
Query!
Country [135]
0
0
France
Query!
State/province [135]
0
0
Lomme
Query!
Country [136]
0
0
France
Query!
State/province [136]
0
0
Lyon
Query!
Country [137]
0
0
France
Query!
State/province [137]
0
0
Montpellier Cedex
Query!
Country [138]
0
0
France
Query!
State/province [138]
0
0
Nice
Query!
Country [139]
0
0
France
Query!
State/province [139]
0
0
Nimes
Query!
Country [140]
0
0
France
Query!
State/province [140]
0
0
Paris
Query!
Country [141]
0
0
France
Query!
State/province [141]
0
0
Pierre Benite
Query!
Country [142]
0
0
France
Query!
State/province [142]
0
0
Reims
Query!
Country [143]
0
0
France
Query!
State/province [143]
0
0
Roubaix
Query!
Country [144]
0
0
France
Query!
State/province [144]
0
0
Saint Herblain Cedex
Query!
Country [145]
0
0
France
Query!
State/province [145]
0
0
Saint-etienne
Query!
Country [146]
0
0
France
Query!
State/province [146]
0
0
Strasbourg Cedex
Query!
Country [147]
0
0
France
Query!
State/province [147]
0
0
Toulouse
Query!
Country [148]
0
0
France
Query!
State/province [148]
0
0
TOURCOING cedex
Query!
Country [149]
0
0
France
Query!
State/province [149]
0
0
Vandoeuvre Les Nancy
Query!
Country [150]
0
0
Germany
Query!
State/province [150]
0
0
Baden-Württemberg
Query!
Country [151]
0
0
Germany
Query!
State/province [151]
0
0
Bayern
Query!
Country [152]
0
0
Germany
Query!
State/province [152]
0
0
Brandenburg
Query!
Country [153]
0
0
Germany
Query!
State/province [153]
0
0
Nordrhein-Westfalen
Query!
Country [154]
0
0
Germany
Query!
State/province [154]
0
0
Rheinland-Pfalz
Query!
Country [155]
0
0
Germany
Query!
State/province [155]
0
0
Sachsen-Anhalt
Query!
Country [156]
0
0
Germany
Query!
State/province [156]
0
0
Sachsen
Query!
Country [157]
0
0
Germany
Query!
State/province [157]
0
0
Berlin
Query!
Country [158]
0
0
Germany
Query!
State/province [158]
0
0
Bremen
Query!
Country [159]
0
0
Greece
Query!
State/province [159]
0
0
Attica
Query!
Country [160]
0
0
Greece
Query!
State/province [160]
0
0
Abelokipi - Athens
Query!
Country [161]
0
0
Greece
Query!
State/province [161]
0
0
Athens
Query!
Country [162]
0
0
Greece
Query!
State/province [162]
0
0
Nea Ionia
Query!
Country [163]
0
0
Greece
Query!
State/province [163]
0
0
Piraeus
Query!
Country [164]
0
0
Greece
Query!
State/province [164]
0
0
Rio / Patras
Query!
Country [165]
0
0
Hong Kong
Query!
State/province [165]
0
0
N.t.
Query!
Country [166]
0
0
Hong Kong
Query!
State/province [166]
0
0
Shatin
Query!
Country [167]
0
0
Hungary
Query!
State/province [167]
0
0
Baja
Query!
Country [168]
0
0
Hungary
Query!
State/province [168]
0
0
Balassagyarmat
Query!
Country [169]
0
0
Hungary
Query!
State/province [169]
0
0
Budapest
Query!
Country [170]
0
0
Hungary
Query!
State/province [170]
0
0
Debrecen
Query!
Country [171]
0
0
Hungary
Query!
State/province [171]
0
0
Gyor
Query!
Country [172]
0
0
Hungary
Query!
State/province [172]
0
0
Hodmezovasarhely
Query!
Country [173]
0
0
Hungary
Query!
State/province [173]
0
0
Kecskemet
Query!
Country [174]
0
0
Hungary
Query!
State/province [174]
0
0
Szekesfehervar
Query!
Country [175]
0
0
Hungary
Query!
State/province [175]
0
0
Tatabanya
Query!
Country [176]
0
0
Hungary
Query!
State/province [176]
0
0
Zalaegerszeg-Pozva
Query!
Country [177]
0
0
India
Query!
State/province [177]
0
0
Gujar?t
Query!
Country [178]
0
0
India
Query!
State/province [178]
0
0
Karn?taka
Query!
Country [179]
0
0
India
Query!
State/province [179]
0
0
Kerala
Query!
Country [180]
0
0
India
Query!
State/province [180]
0
0
Maharashtra
Query!
Country [181]
0
0
India
Query!
State/province [181]
0
0
Punjab
Query!
Country [182]
0
0
India
Query!
State/province [182]
0
0
Tamil N?du
Query!
Country [183]
0
0
India
Query!
State/province [183]
0
0
West Bengal
Query!
Country [184]
0
0
India
Query!
State/province [184]
0
0
Hyderabad
Query!
Country [185]
0
0
India
Query!
State/province [185]
0
0
Mumbai
Query!
Country [186]
0
0
India
Query!
State/province [186]
0
0
Noida
Query!
Country [187]
0
0
Indonesia
Query!
State/province [187]
0
0
Jakarta
Query!
Country [188]
0
0
Indonesia
Query!
State/province [188]
0
0
Surabaya
Query!
Country [189]
0
0
Israel
Query!
State/province [189]
0
0
Afula
Query!
Country [190]
0
0
Israel
Query!
State/province [190]
0
0
Ashkelon
Query!
Country [191]
0
0
Israel
Query!
State/province [191]
0
0
Haifa
Query!
Country [192]
0
0
Israel
Query!
State/province [192]
0
0
Holon
Query!
Country [193]
0
0
Israel
Query!
State/province [193]
0
0
Kfar Saba
Query!
Country [194]
0
0
Israel
Query!
State/province [194]
0
0
Rehovot
Query!
Country [195]
0
0
Israel
Query!
State/province [195]
0
0
Tel Aviv
Query!
Country [196]
0
0
Israel
Query!
State/province [196]
0
0
Zefat
Query!
Country [197]
0
0
Italy
Query!
State/province [197]
0
0
Bari
Query!
Country [198]
0
0
Italy
Query!
State/province [198]
0
0
Campania
Query!
Country [199]
0
0
Italy
Query!
State/province [199]
0
0
Emilia-Romagna
Query!
Country [200]
0
0
Italy
Query!
State/province [200]
0
0
Lazio
Query!
Country [201]
0
0
Italy
Query!
State/province [201]
0
0
Liguria
Query!
Country [202]
0
0
Italy
Query!
State/province [202]
0
0
Lombardia
Query!
Country [203]
0
0
Italy
Query!
State/province [203]
0
0
Molise
Query!
Country [204]
0
0
Italy
Query!
State/province [204]
0
0
Parma
Query!
Country [205]
0
0
Italy
Query!
State/province [205]
0
0
Sicilia
Query!
Country [206]
0
0
Italy
Query!
State/province [206]
0
0
Trentino-Alto Adige
Query!
Country [207]
0
0
Italy
Query!
State/province [207]
0
0
Umbria
Query!
Country [208]
0
0
Italy
Query!
State/province [208]
0
0
Verbano-Cusio-Ossola
Query!
Country [209]
0
0
Italy
Query!
State/province [209]
0
0
Bergamo
Query!
Country [210]
0
0
Italy
Query!
State/province [210]
0
0
Latina
Query!
Country [211]
0
0
Italy
Query!
State/province [211]
0
0
Reggio Calabria
Query!
Country [212]
0
0
Italy
Query!
State/province [212]
0
0
Vicenza
Query!
Country [213]
0
0
Japan
Query!
State/province [213]
0
0
Aichi
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Ehime
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Fukuoka
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Gunma
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Hiroshima
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Hokkaido
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Hyogo
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Ishikawa
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Iwate
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Kanagawa
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Kochi
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Mie
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Niigata
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Okinawa
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Osaka
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Shiga
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Shizuoka
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Tokyo
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Yamaguchi
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Fukui
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Ibaraki
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Kumamoto
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Kyoto
Query!
Country [236]
0
0
Korea, Republic of
Query!
State/province [236]
0
0
Korea
Query!
Country [237]
0
0
Korea, Republic of
Query!
State/province [237]
0
0
Seoul Teugbyeolsi
Query!
Country [238]
0
0
Korea, Republic of
Query!
State/province [238]
0
0
Gyeonggi-do
Query!
Country [239]
0
0
Korea, Republic of
Query!
State/province [239]
0
0
Jeollanam-do
Query!
Country [240]
0
0
Korea, Republic of
Query!
State/province [240]
0
0
Seoul
Query!
Country [241]
0
0
Latvia
Query!
State/province [241]
0
0
Daugavpils
Query!
Country [242]
0
0
Latvia
Query!
State/province [242]
0
0
Liepaja
Query!
Country [243]
0
0
Latvia
Query!
State/province [243]
0
0
Riga
Query!
Country [244]
0
0
Latvia
Query!
State/province [244]
0
0
Valmiera
Query!
Country [245]
0
0
Latvia
Query!
State/province [245]
0
0
Ventspils
Query!
Country [246]
0
0
Lithuania
Query!
State/province [246]
0
0
Kaunas
Query!
Country [247]
0
0
Lithuania
Query!
State/province [247]
0
0
Klaipeda
Query!
Country [248]
0
0
Lithuania
Query!
State/province [248]
0
0
Siauliai
Query!
Country [249]
0
0
Lithuania
Query!
State/province [249]
0
0
Utena
Query!
Country [250]
0
0
Lithuania
Query!
State/province [250]
0
0
Vilnius
Query!
Country [251]
0
0
Luxembourg
Query!
State/province [251]
0
0
Kirchberg
Query!
Country [252]
0
0
Luxembourg
Query!
State/province [252]
0
0
Luxembourg
Query!
Country [253]
0
0
Luxembourg
Query!
State/province [253]
0
0
Niederkorn
Query!
Country [254]
0
0
Malaysia
Query!
State/province [254]
0
0
Kuala Lumpur
Query!
Country [255]
0
0
Malaysia
Query!
State/province [255]
0
0
Negeri Sembilan,
Query!
Country [256]
0
0
Malaysia
Query!
State/province [256]
0
0
Sarawak
Query!
Country [257]
0
0
Mexico
Query!
State/province [257]
0
0
Chiapas
Query!
Country [258]
0
0
Mexico
Query!
State/province [258]
0
0
Coahuila
Query!
Country [259]
0
0
Mexico
Query!
State/province [259]
0
0
Distrito Federal
Query!
Country [260]
0
0
Mexico
Query!
State/province [260]
0
0
Jalisco
Query!
Country [261]
0
0
Mexico
Query!
State/province [261]
0
0
Michoacán
Query!
Country [262]
0
0
Mexico
Query!
State/province [262]
0
0
México
Query!
Country [263]
0
0
Mexico
Query!
State/province [263]
0
0
Nuevo Leon
Query!
Country [264]
0
0
Mexico
Query!
State/province [264]
0
0
Sonora
Query!
Country [265]
0
0
Mexico
Query!
State/province [265]
0
0
Yucatán
Query!
Country [266]
0
0
Mexico
Query!
State/province [266]
0
0
Aguascalientes
Query!
Country [267]
0
0
Mexico
Query!
State/province [267]
0
0
Chihuahua
Query!
Country [268]
0
0
Mexico
Query!
State/province [268]
0
0
Puebla
Query!
Country [269]
0
0
Mexico
Query!
State/province [269]
0
0
Zacatecas
Query!
Country [270]
0
0
Netherlands
Query!
State/province [270]
0
0
Amersfoort
Query!
Country [271]
0
0
Netherlands
Query!
State/province [271]
0
0
Amsterdam
Query!
Country [272]
0
0
Netherlands
Query!
State/province [272]
0
0
Enschede
Query!
Country [273]
0
0
Netherlands
Query!
State/province [273]
0
0
Heerlen
Query!
Country [274]
0
0
Netherlands
Query!
State/province [274]
0
0
Maastricht
Query!
Country [275]
0
0
Netherlands
Query!
State/province [275]
0
0
Nieuwegein
Query!
Country [276]
0
0
Netherlands
Query!
State/province [276]
0
0
Rotterdam
Query!
Country [277]
0
0
Netherlands
Query!
State/province [277]
0
0
Sittard
Query!
Country [278]
0
0
Netherlands
Query!
State/province [278]
0
0
Utrecht
Query!
Country [279]
0
0
New Zealand
Query!
State/province [279]
0
0
Auckland
Query!
Country [280]
0
0
New Zealand
Query!
State/province [280]
0
0
Christchurch
Query!
Country [281]
0
0
Norway
Query!
State/province [281]
0
0
Fredrikstad
Query!
Country [282]
0
0
Norway
Query!
State/province [282]
0
0
Gjøvik
Query!
Country [283]
0
0
Norway
Query!
State/province [283]
0
0
Hamar
Query!
Country [284]
0
0
Norway
Query!
State/province [284]
0
0
Oslo
Query!
Country [285]
0
0
Pakistan
Query!
State/province [285]
0
0
Karachi
Query!
Country [286]
0
0
Pakistan
Query!
State/province [286]
0
0
Lahore
Query!
Country [287]
0
0
Peru
Query!
State/province [287]
0
0
Callao
Query!
Country [288]
0
0
Peru
Query!
State/province [288]
0
0
Lima Cercado
Query!
Country [289]
0
0
Peru
Query!
State/province [289]
0
0
Lima
Query!
Country [290]
0
0
Poland
Query!
State/province [290]
0
0
Bialystok
Query!
Country [291]
0
0
Poland
Query!
State/province [291]
0
0
Bydgoszcz
Query!
Country [292]
0
0
Poland
Query!
State/province [292]
0
0
Krakow
Query!
Country [293]
0
0
Poland
Query!
State/province [293]
0
0
Lublin
Query!
Country [294]
0
0
Poland
Query!
State/province [294]
0
0
Olsztyn
Query!
Country [295]
0
0
Poland
Query!
State/province [295]
0
0
Piotrkow Trybunalski
Query!
Country [296]
0
0
Poland
Query!
State/province [296]
0
0
Siedlce
Query!
Country [297]
0
0
Poland
Query!
State/province [297]
0
0
Starogard Gdanski
Query!
Country [298]
0
0
Poland
Query!
State/province [298]
0
0
Szczecin
Query!
Country [299]
0
0
Poland
Query!
State/province [299]
0
0
Tarnów
Query!
Country [300]
0
0
Poland
Query!
State/province [300]
0
0
Warszawa
Query!
Country [301]
0
0
Poland
Query!
State/province [301]
0
0
Wloclawek
Query!
Country [302]
0
0
Portugal
Query!
State/province [302]
0
0
Coimbra
Query!
Country [303]
0
0
Portugal
Query!
State/province [303]
0
0
Amadora
Query!
Country [304]
0
0
Portugal
Query!
State/province [304]
0
0
Cascais
Query!
Country [305]
0
0
Portugal
Query!
State/province [305]
0
0
Lisboa
Query!
Country [306]
0
0
Portugal
Query!
State/province [306]
0
0
Matosinhos
Query!
Country [307]
0
0
Portugal
Query!
State/province [307]
0
0
Porto
Query!
Country [308]
0
0
Portugal
Query!
State/province [308]
0
0
Santarém
Query!
Country [309]
0
0
Portugal
Query!
State/province [309]
0
0
Viana do Castelo
Query!
Country [310]
0
0
Romania
Query!
State/province [310]
0
0
Bucharest
Query!
Country [311]
0
0
Romania
Query!
State/province [311]
0
0
Constanta
Query!
Country [312]
0
0
Romania
Query!
State/province [312]
0
0
Suceava
Query!
Country [313]
0
0
Russian Federation
Query!
State/province [313]
0
0
Moscow
Query!
Country [314]
0
0
Russian Federation
Query!
State/province [314]
0
0
Nizhny Novgorod
Query!
Country [315]
0
0
Russian Federation
Query!
State/province [315]
0
0
Yaroslavl
Query!
Country [316]
0
0
Singapore
Query!
State/province [316]
0
0
Singapore
Query!
Country [317]
0
0
Slovakia
Query!
State/province [317]
0
0
Bratislava
Query!
Country [318]
0
0
Slovakia
Query!
State/province [318]
0
0
Lucenec
Query!
Country [319]
0
0
Slovakia
Query!
State/province [319]
0
0
Martin
Query!
Country [320]
0
0
Slovakia
Query!
State/province [320]
0
0
Zilina
Query!
Country [321]
0
0
Slovenia
Query!
State/province [321]
0
0
Golnik
Query!
Country [322]
0
0
Slovenia
Query!
State/province [322]
0
0
Ljubljana
Query!
Country [323]
0
0
Slovenia
Query!
State/province [323]
0
0
Novo mesto
Query!
Country [324]
0
0
South Africa
Query!
State/province [324]
0
0
Freestate
Query!
Country [325]
0
0
South Africa
Query!
State/province [325]
0
0
Gauteng
Query!
Country [326]
0
0
South Africa
Query!
State/province [326]
0
0
Western Cape
Query!
Country [327]
0
0
South Africa
Query!
State/province [327]
0
0
Sandton, Gauteng
Query!
Country [328]
0
0
Spain
Query!
State/province [328]
0
0
Barcelona
Query!
Country [329]
0
0
Spain
Query!
State/province [329]
0
0
Córdoba
Query!
Country [330]
0
0
Spain
Query!
State/province [330]
0
0
Girona
Query!
Country [331]
0
0
Spain
Query!
State/province [331]
0
0
Murcia
Query!
Country [332]
0
0
Spain
Query!
State/province [332]
0
0
Málaga
Query!
Country [333]
0
0
Spain
Query!
State/province [333]
0
0
Pontevedra
Query!
Country [334]
0
0
Spain
Query!
State/province [334]
0
0
Cuenca
Query!
Country [335]
0
0
Spain
Query!
State/province [335]
0
0
Zaragoza
Query!
Country [336]
0
0
Sweden
Query!
State/province [336]
0
0
Borås
Query!
Country [337]
0
0
Sweden
Query!
State/province [337]
0
0
Hässleholm
Query!
Country [338]
0
0
Sweden
Query!
State/province [338]
0
0
Karlshamn
Query!
Country [339]
0
0
Sweden
Query!
State/province [339]
0
0
Kristianstad
Query!
Country [340]
0
0
Sweden
Query!
State/province [340]
0
0
Lund
Query!
Country [341]
0
0
Sweden
Query!
State/province [341]
0
0
Malmö
Query!
Country [342]
0
0
Sweden
Query!
State/province [342]
0
0
Skövde
Query!
Country [343]
0
0
Sweden
Query!
State/province [343]
0
0
Stockholm
Query!
Country [344]
0
0
Sweden
Query!
State/province [344]
0
0
Sundsvall
Query!
Country [345]
0
0
Sweden
Query!
State/province [345]
0
0
Umeå
Query!
Country [346]
0
0
Sweden
Query!
State/province [346]
0
0
Visby
Query!
Country [347]
0
0
Switzerland
Query!
State/province [347]
0
0
Basel-Landschaft
Query!
Country [348]
0
0
Switzerland
Query!
State/province [348]
0
0
Basel-Stadt
Query!
Country [349]
0
0
Switzerland
Query!
State/province [349]
0
0
Bern
Query!
Country [350]
0
0
Switzerland
Query!
State/province [350]
0
0
Baden
Query!
Country [351]
0
0
Switzerland
Query!
State/province [351]
0
0
Genève
Query!
Country [352]
0
0
Switzerland
Query!
State/province [352]
0
0
Luzern
Query!
Country [353]
0
0
Switzerland
Query!
State/province [353]
0
0
Zürich
Query!
Country [354]
0
0
Taiwan
Query!
State/province [354]
0
0
Kaohsiung
Query!
Country [355]
0
0
Taiwan
Query!
State/province [355]
0
0
Tainan
Query!
Country [356]
0
0
Taiwan
Query!
State/province [356]
0
0
Taipei
Query!
Country [357]
0
0
Thailand
Query!
State/province [357]
0
0
Bangkok
Query!
Country [358]
0
0
Thailand
Query!
State/province [358]
0
0
Chiangmai
Query!
Country [359]
0
0
Turkey
Query!
State/province [359]
0
0
Istanbul
Query!
Country [360]
0
0
Turkey
Query!
State/province [360]
0
0
Izmir
Query!
Country [361]
0
0
Ukraine
Query!
State/province [361]
0
0
Donetsk
Query!
Country [362]
0
0
Ukraine
Query!
State/province [362]
0
0
Ivano-Frankivsk
Query!
Country [363]
0
0
Ukraine
Query!
State/province [363]
0
0
Kharkiv
Query!
Country [364]
0
0
Ukraine
Query!
State/province [364]
0
0
Kiev
Query!
Country [365]
0
0
Ukraine
Query!
State/province [365]
0
0
Kyiv
Query!
Country [366]
0
0
Ukraine
Query!
State/province [366]
0
0
Lviv
Query!
Country [367]
0
0
Ukraine
Query!
State/province [367]
0
0
Odessa
Query!
Country [368]
0
0
Ukraine
Query!
State/province [368]
0
0
Simferopol
Query!
Country [369]
0
0
United Kingdom
Query!
State/province [369]
0
0
Cleveland
Query!
Country [370]
0
0
United Kingdom
Query!
State/province [370]
0
0
Dumfries and Galloway
Query!
Country [371]
0
0
United Kingdom
Query!
State/province [371]
0
0
Merseyside
Query!
Country [372]
0
0
United Kingdom
Query!
State/province [372]
0
0
South Yorkshire
Query!
Country [373]
0
0
United Kingdom
Query!
State/province [373]
0
0
Stratchclyde
Query!
Country [374]
0
0
United Kingdom
Query!
State/province [374]
0
0
Tyne and Wear
Query!
Country [375]
0
0
United Kingdom
Query!
State/province [375]
0
0
West Yorkshire
Query!
Country [376]
0
0
United Kingdom
Query!
State/province [376]
0
0
London
Query!
Country [377]
0
0
United Kingdom
Query!
State/province [377]
0
0
Nottingham
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Bayer
Query!
Address
Query!
Country
Query!
Other collaborator category [1]
0
0
Commercial sector/industry
Query!
Name [1]
0
0
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Query!
Address [1]
0
0
Query!
Country [1]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
This study will evaluate if extended therapy with oral rivaroxaban can prevent blood clots in the leg and lung that can occur with patients hospitalized for acute medical illness, and compare these results with those of the standard enoxaparin dose and duration regimen. The safety of rivaroxaban will also be studied.
Query!
Trial website
https://clinicaltrials.gov/study/NCT00571649
Query!
Trial related presentations / publications
Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos A, Tapson V. Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol. J Thromb Thrombolysis. 2011 May;31(4):407-16. doi: 10.1007/s11239-011-0549-x. Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos AC, Tapson V; MAGELLAN Investigators. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med. 2013 Feb 7;368(6):513-23. doi: 10.1056/NEJMoa1111096. Sharma A, Chatterjee S, Lichstein E, Mukherjee D. Extended thromboprophylaxis for medically ill patients with decreased mobility: does it improve outcomes? J Thromb Haemost. 2012 Oct;10(10):2053-60. doi: 10.1111/j.1538-7836.2012.04874.x. Mebazaa A, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Merli G, Schellong SW, Spyropoulos AC, Tapson VF, De Sanctis Y, Cohen AT. Predicting the risk of venous thromboembolism in patients hospitalized with heart failure. Circulation. 2014 Jul 29;130(5):410-8. doi: 10.1161/CIRCULATIONAHA.113.003126. Epub 2014 Jun 26. Cohen AT, Spiro TE, Spyropoulos AC, Desanctis YH, Homering M, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Tapson VF, Burton P; MAGELLAN Study Group. D-dimer as a predictor of venous thromboembolism in acutely ill, hospitalized patients: a subanalysis of the randomized controlled MAGELLAN trial. J Thromb Haemost. 2014 Apr;12(4):479-87. doi: 10.1111/jth.12515. Spyropoulos AC, Raskob GE, Cohen AT, Ageno W, Weitz JI, Spiro TE, Lu W, Lipardi C, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard G, Steg PG, Sugarmann C, Barnathan ES. Association of Bleeding Severity With Mortality in Extended Thromboprophylaxis of Medically Ill Patients in the MAGELLAN and MARINER Trials. Circulation. 2022 May 10;145(19):1471-1479. doi: 10.1161/CIRCULATIONAHA.121.057847. Epub 2022 Apr 7. Raskob GE, Spyropoulos AC, Spiro TE, Lu W, Yuan Z, Levitan B, Suh E, Barnathan ES. Benefit-Risk of Rivaroxaban for Extended Thromboprophylaxis After Hospitalization for Medical Illness: Pooled Analysis From MAGELLAN and MARINER. J Am Heart Assoc. 2021 Nov 16;10(22):e021579. doi: 10.1161/JAHA.121.021579. Epub 2021 Nov 10. Raskob GE, Spyropoulos AC, Cohen AT, Weitz JI, Ageno W, De Sanctis Y, Lu W, Xu J, Albanese J, Sugarmann C, Weber T, Lipardi C, Spiro TE, Barnathan ES. Association Between Asymptomatic Proximal Deep Vein Thrombosis and Mortality in Acutely Ill Medical Patients. J Am Heart Assoc. 2021 Feb;10(5):e019459. doi: 10.1161/JAHA.120.019459. Epub 2021 Feb 15. Jamil A, Jamil U, Singh K, Khan F, Chi G. Extended Thromboprophylaxis With Betrixaban or Rivaroxaban for Acutely Ill Hospitalized Medical Patients: Meta-Analysis of Prespecified Subgroups. Crit Pathw Cardiol. 2021 Mar 1;20(1):16-24. doi: 10.1097/HPC.0000000000000232. Weitz JI, Raskob GE, Spyropoulos AC, Spiro TE, De Sanctis Y, Xu J, Lu W, Suh E, Argenti D, Yang H, Albanese J, Lipardi C, Barnathan ES. Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients with Renal Impairment: Insights from the MAGELLAN and MARINER Trials. Thromb Haemost. 2020 Mar;120(3):515-524. doi: 10.1055/s-0039-1701009. Epub 2020 Jan 23. Chi G, Goldhaber SZ, Kittelson JM, Turpie AGG, Hernandez AF, Hull RD, Gold A, Curnutte JT, Cohen AT, Harrington RA, Gibson CM. Effect of extended-duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis. J Thromb Haemost. 2017 Oct;15(10):1913-1922. doi: 10.1111/jth.13783. Epub 2017 Sep 4. Marszalek J, Mehrsefat S, Chi G. The risk of stroke among acutely ill hospitalized medical patients: lessons from recent trials on extended-duration thromboprophylaxis. Expert Rev Hematol. 2017 Aug;10(8):679-684. doi: 10.1080/17474086.2017.1343662. Epub 2017 Jun 21.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Bayer Study Director
Query!
Address
0
0
Bayer
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
Type
Citations or Other Details
Journal
Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hu...
[
More Details
]
Journal
Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hu...
[
More Details
]
Journal
Sharma A, Chatterjee S, Lichstein E, Mukherjee D. ...
[
More Details
]
Journal
Mebazaa A, Spiro TE, Buller HR, Haskell L, Hu D, H...
[
More Details
]
Journal
Cohen AT, Spiro TE, Spyropoulos AC, Desanctis YH, ...
[
More Details
]
Results are available at
https://clinicaltrials.gov/study/NCT00571649
Download to PDF