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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT03574597
Registration number
NCT03574597
Ethics application status
Date submitted
21/06/2018
Date registered
2/07/2018
Titles & IDs
Public title
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity
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Scientific title
SELECT - Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity
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Secondary ID [1]
0
0
2017-003380-35
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Secondary ID [2]
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0
EX9536-4388
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Universal Trial Number (UTN)
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Trial acronym
SELECT
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Overweight
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0
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Obesity
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0
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Condition category
Condition code
Diet and Nutrition
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0
0
0
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Obesity
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Metabolic and Endocrine
0
0
0
0
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Other metabolic disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Semaglutide
Treatment: Drugs - Placebo (semaglutide)
Experimental: Semaglutide - Participants will receive semaglutide as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.
Placebo comparator: Placebo (semaglutide) - Participants will receive placebo (semaglutide) as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.
Treatment: Drugs: Semaglutide
Semaglutide will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Subjects will start semaglutide treatment at 0.24 mg; dose will gradually be increased every 4 weeks up to 2.4 mg.
Treatment: Drugs: Placebo (semaglutide)
Placebo will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Participants will receive placebo at an equivalent dose to semaglutide.
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Intervention code [1]
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0
Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Participants From Time of Randomization to First Occurrence of a Composite Outcome Measure Consisting of: Cardiovascular (CV) Death, Non-fatal Myocardial Infarction (MI), or Non-fatal Stroke
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Assessment method [1]
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0
Number of participants with first occurrence of composite outcome measure consisted of CV death (undetermined cause of death presumed CV death), non-fatal MI, or non-fatal stroke are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [1]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [1]
0
0
Participants From Time of Randomisation to CV Death
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Assessment method [1]
0
0
Number of participants with CV death are presented. The outcome measure was evalulated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [1]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [2]
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Participants From Time of Randomisation to First Occurrence of a Composite Heart Failure (HF) Outcome Measure Consisting of: HF Hospitalisation, Urgent HF Visit or CV Death
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Assessment method [2]
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Number of participants with first occurrence of a composite HF outcome measure consisted of HF hospitalisation, urgent HF visit or CV death are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [2]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [3]
0
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Participants From Time of Randomisation to All-cause Death
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Assessment method [3]
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Number of participants with all-cause death are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [3]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [4]
0
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Participants From Time of Randomisation to First Occurrence of an Expanded Composite CV Outcome Measure Consisting of: CV Death, Non-fatal MI, Non-fatal Stroke, Coronary Revascularisation or Unstable Angina Pectoris (UAP) Requiring Hospitalisation
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Assessment method [4]
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Number of participants with first occurrence of an expanded composite CV outcome measure consisted of CV death, non-fatal MI, non-fatal stroke, coronary revascularisation or UAP requiring hospitalisation are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [4]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [5]
0
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Participants From Time of Randomisation to First Occurrence of a Composite Outcome Measure Consisting of: All-cause Death, Non-fatal MI, or Non-fatal Stroke
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Assessment method [5]
0
0
Number of participants with first occurrence of a composite outcome measure consisted of all-cause death, non-fatal MI, or non-fatal stroke are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [5]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [6]
0
0
Participants From Time of Randomisation to First Occurrence of Non-fatal MI
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Assessment method [6]
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0
Number of participants with first occurrence of non-fatal MI are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [6]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [7]
0
0
Participants From Time of Randomisation to First Occurrence of Non-fatal Stroke
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Assessment method [7]
0
0
Number of participants with first occurrence of non-fatal stroke are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [7]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [8]
0
0
Participants From Time of Randomisation to First Occurrence of Coronary Revascularisation
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Assessment method [8]
0
0
Number of participants with first occurrence of coronary revascularisation are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [8]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [9]
0
0
Participants From Time of Randomisation to First Occurrence of UAP Requiring Hospitalisation
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Assessment method [9]
0
0
Number of participants with first occurrence of UAP requiring hospitalisation are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [9]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [10]
0
0
Participants From Time of Randomisation to First Occurrence of HF Requiring Hospitalisation or Urgent HF Visit
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Assessment method [10]
0
0
Number of participants with first occurrence of HF requiring hospitalisation or urgent HF visit are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [10]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [11]
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Participants From Time of Randomisation to First Occurrence of Glycosylated Haemoglobin (HbA1c) Greater Than Equals to (=) 48 Millimole Per Mole (mmol/Mol) (6.5 Percentage [%])
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Assessment method [11]
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Number of participants with first occurrence of HbA1c = 48 mmol/mol (6.5%) are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [11]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [12]
0
0
Participants From Time of Randomisation to First Occurrence of a 5-component Composite Nephropathy Outcome Measure
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Assessment method [12]
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0
Number of participants with first occurrence of a 5-component composite nephropathy outcome measure consisted of onset of persistent macroalbuminuria (UACR \> 300 milligram per gram \[mg/g\]), persistent 50% reduction in estimated glomerular filtration rate (eGFR) compared with baseline (randomisation), onset of persistent eGFR \< 15 ml/min/1.73m\^2, initiation of chronic renal replacement therapy (dialysis or transplantation) or renal death. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [12]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [13]
0
0
Participants From Time of Randomisation to HbA1c = 39 mmol/Mol (5.7%) (for Participants With a Screening HbA1c <39 mmol/Mol [5.7%])
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Assessment method [13]
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0
Number of participants with HbA1c = 39 mmol/mol (5.7%) are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [13]
0
0
From randomisation (week 0) up to 240 weeks
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Secondary outcome [14]
0
0
Participants With HbA1c < 39 mmol/Mol (5.7%) (for Participants With a Screening HbA1c = 39 mmol/Mol [5.7%])
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Assessment method [14]
0
0
Number of participants with HbA1c \< 39 mmol/mol (5.7%) are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [14]
0
0
At week 52, week 104
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Secondary outcome [15]
0
0
Change in Systolic Blood Pressure (SBP)
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Assessment method [15]
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0
Change in SBP from randomisation (week 0) to week 104 is presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [15]
0
0
Week 0, week 104
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Secondary outcome [16]
0
0
Change in Diastolic Blood Pressure (DBP)
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Assessment method [16]
0
0
Change in DBP from randomisation (week 0) to week 104 is presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [16]
0
0
Week 0, week 104
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Secondary outcome [17]
0
0
Change in Pulse
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Assessment method [17]
0
0
Change in pulse from randomisation (week 0) to week 104 is presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [17]
0
0
Week 0, week 104
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Secondary outcome [18]
0
0
Change in High Sensitivity C-Reactive Protein (hsCRP) - Ratio to Baseline
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Assessment method [18]
0
0
Change in hsCRP (milligram per liter \[mg/L\]) from randomisation (week 0) to week 104 presented as ratio to baseline (week 0). The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [18]
0
0
Week 0, week 104
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Secondary outcome [19]
0
0
Change in Total Cholesterol - Ratio to Baseline
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Assessment method [19]
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Change in total cholesterol (milligram per deciliter \[mg/dL\]) from randomisation (week 0) to week 104 is presented as ratio to baseline (week 0). The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [19]
0
0
Week 0, week 104
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Secondary outcome [20]
0
0
Change in High Density Lipoprotein (HDL) Cholesterol - Ratio to Baseline
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Assessment method [20]
0
0
Change in HDL (mg/dL) from randomisation (week 0) to week 104 is presented as ratio to baseline (week 0). The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [20]
0
0
Week 0, week 104
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Secondary outcome [21]
0
0
Change in Low Density Lipoprotein (LDL) Cholesterol - Ratio to Baseline
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Assessment method [21]
0
0
Change in LDL (mg/dL) from randomisation (week 0) to week 104 is presented as ratio to baseline (week 0). The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [21]
0
0
Week 0, week 104
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Secondary outcome [22]
0
0
Change in Triglycerides - Ratio to Baseline
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Assessment method [22]
0
0
Change in triglycerides (mg/dL) from randomisation (week 0) to week 104 is presented as ratio to baseline (week 0). The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [22]
0
0
Week 0, week 104
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Secondary outcome [23]
0
0
Change in Body Weight
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Assessment method [23]
0
0
Percentage change in body weight from randomisation (week 0) to week 104 is presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [23]
0
0
Week 0, week 104
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Secondary outcome [24]
0
0
Change in Waist Circumference
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Assessment method [24]
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0
Change is waist circumference from randomisation (week 0) to week 104 is presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [24]
0
0
Week 0, week 104
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Secondary outcome [25]
0
0
Change From Randomisation (Week 0) in Participant Reported Outcome (PRO): EuroQol Five Dimensions Five Level Questionnaire (EQ-5D-5L) Index Score to Week 104
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Assessment method [25]
0
0
EQ-5D-5L is a PRO tool used to estimate impact on participant's health-related quality of life and provides a description of their problems by dimensions (descriptive system). EQ-5D has 5 dimensions: mobility, self-care, usual activities, pain, anxiety/depression, and each dimension has 5 levels: not at all, mild, moderate, severe, extreme. Participant marks most appropriate statement in each dimension, resulting in 1-digit number and digits from 5 dimensions can be combined in 5-digit number describing participant's health state. Index score records an average health status according to dimensions using an algorithm, ranges 0-1 with higher score indicates better health status. Outcome measure was evaluated based on data from in-trial observation period (defined as date of randomisation to one of the dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant \[who were lost to follow-up\], date of death).
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Timepoint [25]
0
0
Week 0, week 104
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Secondary outcome [26]
0
0
Change From Randomisation (Week 0) in PRO: EuroQol Five Dimensions Visual Analogue Scale (EQ-5D-VAS) to Week 104
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Assessment method [26]
0
0
EQ-5D-5L is a PRO tool used to estimate impact on participant's health-related quality of life and provides a description of their problems by dimensions (descriptive system). EQ-5D has 5 dimensions: mobility, self-care, usual activities, pain, anxiety/depression, and each dimension has 5 levels: not at all, mild, moderate, severe, extreme. Participant marks most appropriate statement in each dimension, resulting in 1-digit number and digits from 5 dimensions can be combined in 5-digit number describing participant's health state. VAS component records a participant's overall self-rated health on a range of 0-100 with higher score indicates better self-reported health status. Outcome measure was evaluated based on data from in-trial observation period (defined as date of randomisation to one of the dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant \[who were lost to follow-up\], date of death).
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Timepoint [26]
0
0
Week 0, week 104
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Secondary outcome [27]
0
0
Change in HbA1c - Percentage
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Assessment method [27]
0
0
Change in HbA1c (percentage) from randomisation (week 0) to week 104 is presented. The outcome measure was evaulated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [27]
0
0
Week 0, week 104
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Secondary outcome [28]
0
0
Change in HbA1c - mmol/Mol
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Assessment method [28]
0
0
Change in HbA1c (mmol/mol) from randomisation (week 0) to week 104 is presented. The outcome measure was evaulated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
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Timepoint [28]
0
0
Week 0, week 104
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Eligibility
Key inclusion criteria
* Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial
* Male or female, age greater than or equal to 45 years at the time of signing informed consent
* Body mass index (BMI) greater than or equal to 27 kg/m^2
* Have established cardiovascular (CV) disease as evidenced by at least one of the following: prior myocardial infarction; prior stroke (ischemic or haemorrhagic stroke); or symptomatic peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index (ABI) less than 0.85 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease
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Minimum age
45
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
Cardiovascular-related:
* Any of the following: myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the day of screening
* Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
* Presently classified as being in New York Heart Association (NYHA) Class IV heart failure
Glycaemia-related:
* HbA1c greater than or equal to 48 mmol/mol (6.5 %) as measured by the central laboratory at screening
* History of type 1 or type 2 diabetes (history of gestational diabetes is allowed)
* Treatment with glucose-lowering agents within 90 days before screening
* Treatment with any glucagon-like-peptide-1 receptor agonist (GLP-1 RA) within 90 days before screening
General safety:
* History or presence of chronic pancreatitis
* Presence of acute pancreatitis within the past 180 days prior to the day of screening
* Personal or first degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma
* End stage renal disease or chronic or intermittent haemodialysis or peritoneal dialysis
* Presence or history of malignant neoplasms within the past 5 years prior to the day of screening. Basal and squamous cell skin cancer and any carcinoma in-situ are allowed
* Severe psychiatric disorder which in the investigator's opinion could compromise compliance with the protocol
* Known or suspected hypersensitivity to trial products or related products
* Previous participation in this trial. Participation is defined as randomisation
* Receipt of any investigational medicinal product within 30 days before screening
* Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using a highly effective contraceptive method
* Any disorder, unwillingness or inability, which in the investigator's opinion, might jeopardise the participant's safety or compliance with the protocol
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
24/10/2018
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
29/06/2023
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Sample size
Target
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Accrual to date
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Final
17604
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,VIC,WA
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Recruitment hospital [1]
0
0
The Canberra Hospital_Garran - Garran
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Recruitment hospital [2]
0
0
Gosford Hospital - Gosford
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Recruitment hospital [3]
0
0
Liverpool Hospital - Liverpool
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Recruitment hospital [4]
0
0
Hunter Diabetes Centre - Merewether
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Recruitment hospital [5]
0
0
Advara HeartCare - Milton
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Recruitment hospital [6]
0
0
Core Research Centre - Milton
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Recruitment hospital [7]
0
0
Cholesterol Care Australia - Wollongabba
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Recruitment hospital [8]
0
0
Royal Adelaide Hospital Cardiovascular Clinical Trials - Adelaide
Query!
Recruitment hospital [9]
0
0
Lyell McEwin Hospital - Elizabeth Vale
Query!
Recruitment hospital [10]
0
0
Monash Cardiovascular Research Centre - Clayton
Query!
Recruitment hospital [11]
0
0
Geelong Cardiology Research Unit - Geelong
Query!
Recruitment hospital [12]
0
0
Austin Health, Metabolic Disorders Centre - Heidelberg Heights
Query!
Recruitment hospital [13]
0
0
HeartCare WA (Joondalup) - Joondalup
Query!
Recruitment postcode(s) [1]
0
0
2605 - Garran
Query!
Recruitment postcode(s) [2]
0
0
2250 - Gosford
Query!
Recruitment postcode(s) [3]
0
0
2170 - Liverpool
Query!
Recruitment postcode(s) [4]
0
0
2291 - Merewether
Query!
Recruitment postcode(s) [5]
0
0
4064 - Milton
Query!
Recruitment postcode(s) [6]
0
0
4102 - Wollongabba
Query!
Recruitment postcode(s) [7]
0
0
5000 - Adelaide
Query!
Recruitment postcode(s) [8]
0
0
5112 - Elizabeth Vale
Query!
Recruitment postcode(s) [9]
0
0
3168 - Clayton
Query!
Recruitment postcode(s) [10]
0
0
3220 - Geelong
Query!
Recruitment postcode(s) [11]
0
0
3081 - Heidelberg Heights
Query!
Recruitment postcode(s) [12]
0
0
6027 - Joondalup
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arizona
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
California
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Colorado
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Connecticut
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Florida
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Georgia
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Illinois
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Indiana
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Iowa
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Kansas
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Kentucky
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Louisiana
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Maryland
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Massachusetts
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Michigan
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Mississippi
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Missouri
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Montana
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Nebraska
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Nevada
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
New Hampshire
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
New Jersey
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
New York
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
North Carolina
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
Ohio
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
Oregon
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
Pennsylvania
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
South Carolina
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
Tennessee
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
Texas
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
Utah
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
Vermont
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
Virginia
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
Washington
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
Wisconsin
Query!
Country [37]
0
0
Algeria
Query!
State/province [37]
0
0
Algiers
Query!
Country [38]
0
0
Algeria
Query!
State/province [38]
0
0
Oran
Query!
Country [39]
0
0
Argentina
Query!
State/province [39]
0
0
Buenos Aires, Argentina
Query!
Country [40]
0
0
Argentina
Query!
State/province [40]
0
0
Buenos Aires
Query!
Country [41]
0
0
Argentina
Query!
State/province [41]
0
0
City Of Buenos Aires
Query!
Country [42]
0
0
Argentina
Query!
State/province [42]
0
0
Caba
Query!
Country [43]
0
0
Argentina
Query!
State/province [43]
0
0
Córdoba
Query!
Country [44]
0
0
Argentina
Query!
State/province [44]
0
0
Rosario
Query!
Country [45]
0
0
Austria
Query!
State/province [45]
0
0
Graz
Query!
Country [46]
0
0
Austria
Query!
State/province [46]
0
0
Innsbruck
Query!
Country [47]
0
0
Austria
Query!
State/province [47]
0
0
Salzburg
Query!
Country [48]
0
0
Austria
Query!
State/province [48]
0
0
Wien
Query!
Country [49]
0
0
Belgium
Query!
State/province [49]
0
0
Aalst
Query!
Country [50]
0
0
Belgium
Query!
State/province [50]
0
0
Bonheiden
Query!
Country [51]
0
0
Belgium
Query!
State/province [51]
0
0
Bruxelles
Query!
Country [52]
0
0
Belgium
Query!
State/province [52]
0
0
Genk
Query!
Country [53]
0
0
Belgium
Query!
State/province [53]
0
0
Gent
Query!
Country [54]
0
0
Belgium
Query!
State/province [54]
0
0
Hasselt
Query!
Country [55]
0
0
Brazil
Query!
State/province [55]
0
0
Bahia
Query!
Country [56]
0
0
Brazil
Query!
State/province [56]
0
0
Distrito Federal
Query!
Country [57]
0
0
Brazil
Query!
State/province [57]
0
0
Minas Gerais
Query!
Country [58]
0
0
Brazil
Query!
State/province [58]
0
0
Parana
Query!
Country [59]
0
0
Brazil
Query!
State/province [59]
0
0
Rio Grande Do Sul
Query!
Country [60]
0
0
Brazil
Query!
State/province [60]
0
0
Santa Catarina
Query!
Country [61]
0
0
Brazil
Query!
State/province [61]
0
0
Sao Paulo
Query!
Country [62]
0
0
Brazil
Query!
State/province [62]
0
0
Rio de Janeiro
Query!
Country [63]
0
0
Bulgaria
Query!
State/province [63]
0
0
Dimitrovgrad
Query!
Country [64]
0
0
Bulgaria
Query!
State/province [64]
0
0
Lukovit
Query!
Country [65]
0
0
Bulgaria
Query!
State/province [65]
0
0
Pazardzhik
Query!
Country [66]
0
0
Bulgaria
Query!
State/province [66]
0
0
Pleven
Query!
Country [67]
0
0
Bulgaria
Query!
State/province [67]
0
0
Plovdiv
Query!
Country [68]
0
0
Bulgaria
Query!
State/province [68]
0
0
Razgrad
Query!
Country [69]
0
0
Bulgaria
Query!
State/province [69]
0
0
Sofia
Query!
Country [70]
0
0
Bulgaria
Query!
State/province [70]
0
0
Varna
Query!
Country [71]
0
0
Canada
Query!
State/province [71]
0
0
Alberta
Query!
Country [72]
0
0
Canada
Query!
State/province [72]
0
0
New Brunswick
Query!
Country [73]
0
0
Canada
Query!
State/province [73]
0
0
Ontario
Query!
Country [74]
0
0
Canada
Query!
State/province [74]
0
0
Quebec
Query!
Country [75]
0
0
Colombia
Query!
State/province [75]
0
0
Antioquia
Query!
Country [76]
0
0
Colombia
Query!
State/province [76]
0
0
Atlántico
Query!
Country [77]
0
0
Colombia
Query!
State/province [77]
0
0
Santander
Query!
Country [78]
0
0
Colombia
Query!
State/province [78]
0
0
Barranquilla
Query!
Country [79]
0
0
Colombia
Query!
State/province [79]
0
0
Medellin
Query!
Country [80]
0
0
Croatia
Query!
State/province [80]
0
0
Grad Zagreb
Query!
Country [81]
0
0
Croatia
Query!
State/province [81]
0
0
Krapinsko Zagorska County
Query!
Country [82]
0
0
Croatia
Query!
State/province [82]
0
0
Osijek
Query!
Country [83]
0
0
Croatia
Query!
State/province [83]
0
0
Rijeka
Query!
Country [84]
0
0
Croatia
Query!
State/province [84]
0
0
Zagreb
Query!
Country [85]
0
0
Czechia
Query!
State/province [85]
0
0
Czech Republic
Query!
Country [86]
0
0
Czechia
Query!
State/province [86]
0
0
Broumov
Query!
Country [87]
0
0
Czechia
Query!
State/province [87]
0
0
Chomutov
Query!
Country [88]
0
0
Czechia
Query!
State/province [88]
0
0
Hradec Kralove
Query!
Country [89]
0
0
Czechia
Query!
State/province [89]
0
0
Jihlava
Query!
Country [90]
0
0
Czechia
Query!
State/province [90]
0
0
Liberec
Query!
Country [91]
0
0
Czechia
Query!
State/province [91]
0
0
Policka
Query!
Country [92]
0
0
Czechia
Query!
State/province [92]
0
0
Praha 4
Query!
Country [93]
0
0
Czechia
Query!
State/province [93]
0
0
Praha 8
Query!
Country [94]
0
0
Czechia
Query!
State/province [94]
0
0
Slany
Query!
Country [95]
0
0
Czechia
Query!
State/province [95]
0
0
Svitavy
Query!
Country [96]
0
0
Czechia
Query!
State/province [96]
0
0
Tabor
Query!
Country [97]
0
0
Denmark
Query!
State/province [97]
0
0
Region Hovedstaden
Query!
Country [98]
0
0
Denmark
Query!
State/province [98]
0
0
Aalborg
Query!
Country [99]
0
0
Denmark
Query!
State/province [99]
0
0
Aarhus N
Query!
Country [100]
0
0
Denmark
Query!
State/province [100]
0
0
Herning
Query!
Country [101]
0
0
Denmark
Query!
State/province [101]
0
0
Hvidovre
Query!
Country [102]
0
0
Denmark
Query!
State/province [102]
0
0
Svendborg
Query!
Country [103]
0
0
Finland
Query!
State/province [103]
0
0
Jyväskylä
Query!
Country [104]
0
0
Finland
Query!
State/province [104]
0
0
Kuopio
Query!
Country [105]
0
0
Finland
Query!
State/province [105]
0
0
Lahti
Query!
Country [106]
0
0
Finland
Query!
State/province [106]
0
0
Oulu
Query!
Country [107]
0
0
Finland
Query!
State/province [107]
0
0
Seinäjoki
Query!
Country [108]
0
0
Finland
Query!
State/province [108]
0
0
Tampere
Query!
Country [109]
0
0
Finland
Query!
State/province [109]
0
0
Turku
Query!
Country [110]
0
0
France
Query!
State/province [110]
0
0
Besançon
Query!
Country [111]
0
0
France
Query!
State/province [111]
0
0
Bondy
Query!
Country [112]
0
0
France
Query!
State/province [112]
0
0
Corbeil Essonnes
Query!
Country [113]
0
0
France
Query!
State/province [113]
0
0
DIJON cedex
Query!
Country [114]
0
0
France
Query!
State/province [114]
0
0
La Tronche
Query!
Country [115]
0
0
France
Query!
State/province [115]
0
0
Le Coudray
Query!
Country [116]
0
0
France
Query!
State/province [116]
0
0
Narbonne
Query!
Country [117]
0
0
France
Query!
State/province [117]
0
0
Nice
Query!
Country [118]
0
0
France
Query!
State/province [118]
0
0
Paris Cedex 18
Query!
Country [119]
0
0
France
Query!
State/province [119]
0
0
Paris
Query!
Country [120]
0
0
France
Query!
State/province [120]
0
0
Pessac
Query!
Country [121]
0
0
France
Query!
State/province [121]
0
0
Saint Herblain
Query!
Country [122]
0
0
France
Query!
State/province [122]
0
0
Strasbourg
Query!
Country [123]
0
0
France
Query!
State/province [123]
0
0
Venissieux
Query!
Country [124]
0
0
Germany
Query!
State/province [124]
0
0
Aachen
Query!
Country [125]
0
0
Germany
Query!
State/province [125]
0
0
Bad Homburg
Query!
Country [126]
0
0
Germany
Query!
State/province [126]
0
0
Berlin
Query!
Country [127]
0
0
Germany
Query!
State/province [127]
0
0
Bochum
Query!
Country [128]
0
0
Germany
Query!
State/province [128]
0
0
Dresden
Query!
Country [129]
0
0
Germany
Query!
State/province [129]
0
0
Elsterwerda
Query!
Country [130]
0
0
Germany
Query!
State/province [130]
0
0
Essen
Query!
Country [131]
0
0
Germany
Query!
State/province [131]
0
0
Frankfurt
Query!
Country [132]
0
0
Germany
Query!
State/province [132]
0
0
Friedrichsthal
Query!
Country [133]
0
0
Germany
Query!
State/province [133]
0
0
Hamburg
Query!
Country [134]
0
0
Germany
Query!
State/province [134]
0
0
Hannover
Query!
Country [135]
0
0
Germany
Query!
State/province [135]
0
0
Karlsruhe
Query!
Country [136]
0
0
Germany
Query!
State/province [136]
0
0
Kassel
Query!
Country [137]
0
0
Germany
Query!
State/province [137]
0
0
Leipzig
Query!
Country [138]
0
0
Germany
Query!
State/province [138]
0
0
Ludwigshafen
Query!
Country [139]
0
0
Germany
Query!
State/province [139]
0
0
Lübeck
Query!
Country [140]
0
0
Germany
Query!
State/province [140]
0
0
Oldenburg in Holstein
Query!
Country [141]
0
0
Germany
Query!
State/province [141]
0
0
Pirna
Query!
Country [142]
0
0
Germany
Query!
State/province [142]
0
0
Saint Ingbert-Oberwürzbach
Query!
Country [143]
0
0
Germany
Query!
State/province [143]
0
0
Schkeuditz
Query!
Country [144]
0
0
Germany
Query!
State/province [144]
0
0
Schwerin
Query!
Country [145]
0
0
Germany
Query!
State/province [145]
0
0
Villingen-Schwenningen
Query!
Country [146]
0
0
Germany
Query!
State/province [146]
0
0
Wangen
Query!
Country [147]
0
0
Germany
Query!
State/province [147]
0
0
Wermsdorf
Query!
Country [148]
0
0
Germany
Query!
State/province [148]
0
0
Witten
Query!
Country [149]
0
0
Greece
Query!
State/province [149]
0
0
Attica
Query!
Country [150]
0
0
Greece
Query!
State/province [150]
0
0
Athens
Query!
Country [151]
0
0
Greece
Query!
State/province [151]
0
0
Chios
Query!
Country [152]
0
0
Greece
Query!
State/province [152]
0
0
Ioannina
Query!
Country [153]
0
0
Greece
Query!
State/province [153]
0
0
Lamia
Query!
Country [154]
0
0
Greece
Query!
State/province [154]
0
0
Larissa
Query!
Country [155]
0
0
Greece
Query!
State/province [155]
0
0
Thessaloniki
Query!
Country [156]
0
0
Hungary
Query!
State/province [156]
0
0
Bács-Kiskun Vármegye
Query!
Country [157]
0
0
Hungary
Query!
State/province [157]
0
0
Csongrád-Csanád
Query!
Country [158]
0
0
Hungary
Query!
State/province [158]
0
0
Zala Megye
Query!
Country [159]
0
0
Hungary
Query!
State/province [159]
0
0
Debrecen
Query!
Country [160]
0
0
Hungary
Query!
State/province [160]
0
0
Gyöngyös
Query!
Country [161]
0
0
Hungary
Query!
State/province [161]
0
0
Szombathely
Query!
Country [162]
0
0
India
Query!
State/province [162]
0
0
Andhra Pradesh
Query!
Country [163]
0
0
India
Query!
State/province [163]
0
0
Delhi
Query!
Country [164]
0
0
India
Query!
State/province [164]
0
0
Gujarat
Query!
Country [165]
0
0
India
Query!
State/province [165]
0
0
Haryana
Query!
Country [166]
0
0
India
Query!
State/province [166]
0
0
Karnataka
Query!
Country [167]
0
0
India
Query!
State/province [167]
0
0
Maharashtra
Query!
Country [168]
0
0
India
Query!
State/province [168]
0
0
New Delhi
Query!
Country [169]
0
0
India
Query!
State/province [169]
0
0
Punjab
Query!
Country [170]
0
0
India
Query!
State/province [170]
0
0
Rajasthan
Query!
Country [171]
0
0
India
Query!
State/province [171]
0
0
Tamil Nadu
Query!
Country [172]
0
0
India
Query!
State/province [172]
0
0
Telangana
Query!
Country [173]
0
0
India
Query!
State/province [173]
0
0
Telengana
Query!
Country [174]
0
0
India
Query!
State/province [174]
0
0
Uttar Pradesh
Query!
Country [175]
0
0
India
Query!
State/province [175]
0
0
West Bengal
Query!
Country [176]
0
0
India
Query!
State/province [176]
0
0
Bangalore
Query!
Country [177]
0
0
Ireland
Query!
State/province [177]
0
0
Leinster
Query!
Country [178]
0
0
Ireland
Query!
State/province [178]
0
0
Dublin
Query!
Country [179]
0
0
Ireland
Query!
State/province [179]
0
0
Mallow
Query!
Country [180]
0
0
Israel
Query!
State/province [180]
0
0
Beer Sheva
Query!
Country [181]
0
0
Israel
Query!
State/province [181]
0
0
Haifa
Query!
Country [182]
0
0
Israel
Query!
State/province [182]
0
0
Jerusalem
Query!
Country [183]
0
0
Israel
Query!
State/province [183]
0
0
Kfar Saba
Query!
Country [184]
0
0
Israel
Query!
State/province [184]
0
0
Nahariya
Query!
Country [185]
0
0
Israel
Query!
State/province [185]
0
0
Petah-Tikva
Query!
Country [186]
0
0
Israel
Query!
State/province [186]
0
0
Rehovot
Query!
Country [187]
0
0
Israel
Query!
State/province [187]
0
0
Tel Aviv
Query!
Country [188]
0
0
Israel
Query!
State/province [188]
0
0
Tel Hashomer
Query!
Country [189]
0
0
Israel
Query!
State/province [189]
0
0
Tel-Aviv
Query!
Country [190]
0
0
Italy
Query!
State/province [190]
0
0
LT
Query!
Country [191]
0
0
Italy
Query!
State/province [191]
0
0
MI
Query!
Country [192]
0
0
Italy
Query!
State/province [192]
0
0
RM
Query!
Country [193]
0
0
Italy
Query!
State/province [193]
0
0
Bergamo
Query!
Country [194]
0
0
Italy
Query!
State/province [194]
0
0
Bologna
Query!
Country [195]
0
0
Italy
Query!
State/province [195]
0
0
Catania
Query!
Country [196]
0
0
Italy
Query!
State/province [196]
0
0
Chieti Scalo
Query!
Country [197]
0
0
Italy
Query!
State/province [197]
0
0
Como
Query!
Country [198]
0
0
Italy
Query!
State/province [198]
0
0
Cona - Ferrara
Query!
Country [199]
0
0
Italy
Query!
State/province [199]
0
0
Firenze
Query!
Country [200]
0
0
Italy
Query!
State/province [200]
0
0
Genova
Query!
Country [201]
0
0
Italy
Query!
State/province [201]
0
0
Napoli
Query!
Country [202]
0
0
Italy
Query!
State/province [202]
0
0
Padova
Query!
Country [203]
0
0
Italy
Query!
State/province [203]
0
0
Palermo
Query!
Country [204]
0
0
Italy
Query!
State/province [204]
0
0
Pavia
Query!
Country [205]
0
0
Italy
Query!
State/province [205]
0
0
Pisa
Query!
Country [206]
0
0
Italy
Query!
State/province [206]
0
0
Roma
Query!
Country [207]
0
0
Italy
Query!
State/province [207]
0
0
Rome
Query!
Country [208]
0
0
Italy
Query!
State/province [208]
0
0
Rozzano (MI)
Query!
Country [209]
0
0
Italy
Query!
State/province [209]
0
0
San Donato Milanese (MI)
Query!
Country [210]
0
0
Italy
Query!
State/province [210]
0
0
Savigliano (CN)
Query!
Country [211]
0
0
Italy
Query!
State/province [211]
0
0
Sesto San Giovanni (MI)
Query!
Country [212]
0
0
Italy
Query!
State/province [212]
0
0
Siena
Query!
Country [213]
0
0
Italy
Query!
State/province [213]
0
0
Torino
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Adachi-ku, Tokyo
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Asahikawa, Hokkaido
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Bunkyo-ku, Tokyo
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Chiba
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Chikushino-shi, Fukuoka
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Ehime
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Funabashi-shi, Chiba
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Gifu-city, Gifu
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Hirakata-shi, Osaka
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Hiroshima-shi, Hiroshima
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Kagoshima-shi, Kagoshima
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Kanagawa
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Kasugai-shi, Aichi
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Kawaguchi-shi, Saitama
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Kitakyushu-shi, Fukuoka
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Kochi-shi, Kochi
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Kumamoto-shi, Kumamoto
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Kyoto-shi, Kyoto
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Kyoto-shi,Kyoto
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Kyoto
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Matsuyama-shi, Ehime
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Miyagi
Query!
Country [236]
0
0
Japan
Query!
State/province [236]
0
0
Moriyama-shi, Shiga
Query!
Country [237]
0
0
Japan
Query!
State/province [237]
0
0
Nagoya-shi, Aichi
Query!
Country [238]
0
0
Japan
Query!
State/province [238]
0
0
Naha-shi, Okinawa
Query!
Country [239]
0
0
Japan
Query!
State/province [239]
0
0
Okawa-shi, Fukuoka
Query!
Country [240]
0
0
Japan
Query!
State/province [240]
0
0
Okayama-shi, Okayama
Query!
Country [241]
0
0
Japan
Query!
State/province [241]
0
0
Osaka-city, Osaka
Query!
Country [242]
0
0
Japan
Query!
State/province [242]
0
0
Osaka
Query!
Country [243]
0
0
Japan
Query!
State/province [243]
0
0
Saga-shi, Saga
Query!
Country [244]
0
0
Japan
Query!
State/province [244]
0
0
Sapporo-shi, Hokkaido
Query!
Country [245]
0
0
Japan
Query!
State/province [245]
0
0
Sendai-shi, Miyagi
Query!
Country [246]
0
0
Japan
Query!
State/province [246]
0
0
Shinjuku-ku, Tokyo
Query!
Country [247]
0
0
Japan
Query!
State/province [247]
0
0
Takamatsu-shi, Kagawa
Query!
Country [248]
0
0
Japan
Query!
State/province [248]
0
0
Takasaki-shi, Gunma
Query!
Country [249]
0
0
Japan
Query!
State/province [249]
0
0
Tokorozawa-shi, Saitama
Query!
Country [250]
0
0
Japan
Query!
State/province [250]
0
0
Tokorozawa-shi,Saitama
Query!
Country [251]
0
0
Japan
Query!
State/province [251]
0
0
Tokyo
Query!
Country [252]
0
0
Japan
Query!
State/province [252]
0
0
Wako-city, Saitama
Query!
Country [253]
0
0
Japan
Query!
State/province [253]
0
0
Yanagawa-shi, Fukuoka
Query!
Country [254]
0
0
Japan
Query!
State/province [254]
0
0
Yokosuka-shi, Kanagawa
Query!
Country [255]
0
0
Latvia
Query!
State/province [255]
0
0
Daugavpils
Query!
Country [256]
0
0
Latvia
Query!
State/province [256]
0
0
Liepaja
Query!
Country [257]
0
0
Latvia
Query!
State/province [257]
0
0
Ogre
Query!
Country [258]
0
0
Latvia
Query!
State/province [258]
0
0
Riga
Query!
Country [259]
0
0
Latvia
Query!
State/province [259]
0
0
Ventspils
Query!
Country [260]
0
0
Malaysia
Query!
State/province [260]
0
0
Kelantan
Query!
Country [261]
0
0
Malaysia
Query!
State/province [261]
0
0
Pahang
Query!
Country [262]
0
0
Malaysia
Query!
State/province [262]
0
0
Perak
Query!
Country [263]
0
0
Malaysia
Query!
State/province [263]
0
0
Sarawak
Query!
Country [264]
0
0
Malaysia
Query!
State/province [264]
0
0
Selangor
Query!
Country [265]
0
0
Malaysia
Query!
State/province [265]
0
0
Alor Gajah
Query!
Country [266]
0
0
Malaysia
Query!
State/province [266]
0
0
Alor Setar
Query!
Country [267]
0
0
Malaysia
Query!
State/province [267]
0
0
Kota Samarahan
Query!
Country [268]
0
0
Malaysia
Query!
State/province [268]
0
0
Kuala Lumpur
Query!
Country [269]
0
0
Malaysia
Query!
State/province [269]
0
0
Kuantan
Query!
Country [270]
0
0
Malaysia
Query!
State/province [270]
0
0
Putrajaya
Query!
Country [271]
0
0
Malaysia
Query!
State/province [271]
0
0
Sabah
Query!
Country [272]
0
0
Mexico
Query!
State/province [272]
0
0
Coahuila
Query!
Country [273]
0
0
Mexico
Query!
State/province [273]
0
0
Jalisco
Query!
Country [274]
0
0
Mexico
Query!
State/province [274]
0
0
México, D.F.
Query!
Country [275]
0
0
Mexico
Query!
State/province [275]
0
0
Nuevo León
Query!
Country [276]
0
0
Mexico
Query!
State/province [276]
0
0
San Luis Potosi
Query!
Country [277]
0
0
Mexico
Query!
State/province [277]
0
0
Sinaloa
Query!
Country [278]
0
0
Mexico
Query!
State/province [278]
0
0
Aguascalientes
Query!
Country [279]
0
0
Mexico
Query!
State/province [279]
0
0
Durango
Query!
Country [280]
0
0
Netherlands
Query!
State/province [280]
0
0
Apeldoorn
Query!
Country [281]
0
0
Netherlands
Query!
State/province [281]
0
0
Breda
Query!
Country [282]
0
0
Netherlands
Query!
State/province [282]
0
0
Deventer
Query!
Country [283]
0
0
Netherlands
Query!
State/province [283]
0
0
Groningen
Query!
Country [284]
0
0
Netherlands
Query!
State/province [284]
0
0
Leeuwarden
Query!
Country [285]
0
0
Netherlands
Query!
State/province [285]
0
0
Leiderdorp
Query!
Country [286]
0
0
Netherlands
Query!
State/province [286]
0
0
Roosendaal
Query!
Country [287]
0
0
Netherlands
Query!
State/province [287]
0
0
Rotterdam
Query!
Country [288]
0
0
Netherlands
Query!
State/province [288]
0
0
Sneek
Query!
Country [289]
0
0
Netherlands
Query!
State/province [289]
0
0
Tiel
Query!
Country [290]
0
0
Norway
Query!
State/province [290]
0
0
Bergen
Query!
Country [291]
0
0
Norway
Query!
State/province [291]
0
0
Hamar
Query!
Country [292]
0
0
Norway
Query!
State/province [292]
0
0
Lillehammer
Query!
Country [293]
0
0
Norway
Query!
State/province [293]
0
0
Nordbyhagen
Query!
Country [294]
0
0
Norway
Query!
State/province [294]
0
0
Oslo
Query!
Country [295]
0
0
Norway
Query!
State/province [295]
0
0
Tønsberg
Query!
Country [296]
0
0
Norway
Query!
State/province [296]
0
0
Ålesund
Query!
Country [297]
0
0
Poland
Query!
State/province [297]
0
0
Lodzkie
Query!
Country [298]
0
0
Poland
Query!
State/province [298]
0
0
Lubelskie
Query!
Country [299]
0
0
Poland
Query!
State/province [299]
0
0
Masovian
Query!
Country [300]
0
0
Poland
Query!
State/province [300]
0
0
Podlaskie Voivodeship
Query!
Country [301]
0
0
Poland
Query!
State/province [301]
0
0
Podlaskie
Query!
Country [302]
0
0
Poland
Query!
State/province [302]
0
0
Pomorskie
Query!
Country [303]
0
0
Poland
Query!
State/province [303]
0
0
Wielkopolskie Voivodeship
Query!
Country [304]
0
0
Poland
Query!
State/province [304]
0
0
Gdansk
Query!
Country [305]
0
0
Poland
Query!
State/province [305]
0
0
Krakow
Query!
Country [306]
0
0
Poland
Query!
State/province [306]
0
0
Lodz
Query!
Country [307]
0
0
Poland
Query!
State/province [307]
0
0
Lomza
Query!
Country [308]
0
0
Poland
Query!
State/province [308]
0
0
Lowicz
Query!
Country [309]
0
0
Poland
Query!
State/province [309]
0
0
Poznan
Query!
Country [310]
0
0
Poland
Query!
State/province [310]
0
0
Pulawy
Query!
Country [311]
0
0
Poland
Query!
State/province [311]
0
0
Szczecin
Query!
Country [312]
0
0
Poland
Query!
State/province [312]
0
0
Warszawa
Query!
Country [313]
0
0
Poland
Query!
State/province [313]
0
0
Zamosc
Query!
Country [314]
0
0
Portugal
Query!
State/province [314]
0
0
Almada
Query!
Country [315]
0
0
Portugal
Query!
State/province [315]
0
0
Coimbra
Query!
Country [316]
0
0
Portugal
Query!
State/province [316]
0
0
Lisboa
Query!
Country [317]
0
0
Portugal
Query!
State/province [317]
0
0
Matosinhos
Query!
Country [318]
0
0
Portugal
Query!
State/province [318]
0
0
Porto
Query!
Country [319]
0
0
Puerto Rico
Query!
State/province [319]
0
0
Trujillo Alto
Query!
Country [320]
0
0
Romania
Query!
State/province [320]
0
0
Bihor
Query!
Country [321]
0
0
Romania
Query!
State/province [321]
0
0
Calaras
Query!
Country [322]
0
0
Romania
Query!
State/province [322]
0
0
Cluj
Query!
Country [323]
0
0
Romania
Query!
State/province [323]
0
0
Dolj
Query!
Country [324]
0
0
Romania
Query!
State/province [324]
0
0
Hunedoara
Query!
Country [325]
0
0
Romania
Query!
State/province [325]
0
0
Maramures
Query!
Country [326]
0
0
Romania
Query!
State/province [326]
0
0
Mures
Query!
Country [327]
0
0
Romania
Query!
State/province [327]
0
0
Timis
Query!
Country [328]
0
0
Romania
Query!
State/province [328]
0
0
Bacau
Query!
Country [329]
0
0
Romania
Query!
State/province [329]
0
0
Brasov
Query!
Country [330]
0
0
Romania
Query!
State/province [330]
0
0
Bucharest
Query!
Country [331]
0
0
Romania
Query!
State/province [331]
0
0
Bucuresti
Query!
Country [332]
0
0
Romania
Query!
State/province [332]
0
0
Buzau
Query!
Country [333]
0
0
Romania
Query!
State/province [333]
0
0
Galati
Query!
Country [334]
0
0
Romania
Query!
State/province [334]
0
0
Iasi
Query!
Country [335]
0
0
Romania
Query!
State/province [335]
0
0
Pascani
Query!
Country [336]
0
0
Romania
Query!
State/province [336]
0
0
Ploiesti
Query!
Country [337]
0
0
Romania
Query!
State/province [337]
0
0
Satu Mare
Query!
Country [338]
0
0
Romania
Query!
State/province [338]
0
0
Sibiu
Query!
Country [339]
0
0
Russian Federation
Query!
State/province [339]
0
0
Russia
Query!
Country [340]
0
0
Russian Federation
Query!
State/province [340]
0
0
Arkhangelsk
Query!
Country [341]
0
0
Russian Federation
Query!
State/province [341]
0
0
Barnaul
Query!
Country [342]
0
0
Russian Federation
Query!
State/province [342]
0
0
Belgorod
Query!
Country [343]
0
0
Russian Federation
Query!
State/province [343]
0
0
Ekaterinburg
Query!
Country [344]
0
0
Russian Federation
Query!
State/province [344]
0
0
Ivanovo
Query!
Country [345]
0
0
Russian Federation
Query!
State/province [345]
0
0
Kazan
Query!
Country [346]
0
0
Russian Federation
Query!
State/province [346]
0
0
Kemerovo
Query!
Country [347]
0
0
Russian Federation
Query!
State/province [347]
0
0
Moscow
Query!
Country [348]
0
0
Russian Federation
Query!
State/province [348]
0
0
Novosibirsk
Query!
Country [349]
0
0
Russian Federation
Query!
State/province [349]
0
0
Orenburg
Query!
Country [350]
0
0
Russian Federation
Query!
State/province [350]
0
0
Penza
Query!
Country [351]
0
0
Russian Federation
Query!
State/province [351]
0
0
Rostov-on-Don
Query!
Country [352]
0
0
Russian Federation
Query!
State/province [352]
0
0
Saint Petersburg
Query!
Country [353]
0
0
Russian Federation
Query!
State/province [353]
0
0
Saint-Petersburg, Pushkin
Query!
Country [354]
0
0
Russian Federation
Query!
State/province [354]
0
0
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Novo Nordisk A/S
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Ethics approval
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Summary
Brief summary
The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. The participant's chance of getting semaglutide or placebo is the same. The participant will get the study medicine in a pen. The participants will need to use the pen to inject the study medicine in a skinfold once a week. The study will last for about 2.5 to 5 years. Participants will have up to 25 clinic visits with the study doctor.
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Trial website
https://clinicaltrials.gov/study/NCT03574597
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Trial related presentations / publications
Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, Kushner RF, Marso S, Plutzky J, Brown-Frandsen K, Gronning MOL, Hovingh GK, Holst AG, Ravn H, Lincoff AM. Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design. Am Heart J. 2020 Nov;229:61-69. doi: 10.1016/j.ahj.2020.07.008. Epub 2020 Jul 17. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornoe CW, Ryan DH; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563. Epub 2023 Nov 11. Leite AR, Angelico-Goncalves A, Vasques-Novoa F, Borges-Canha M, Leite-Moreira A, Neves JS, Ferreira JP. Effect of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese adults without diabetes: A meta-analysis of placebo-controlled randomized trials. Diabetes Obes Metab. 2022 Aug;24(8):1676-1680. doi: 10.1111/dom.14707. Epub 2022 May 3. Mares AC, Chatterjee S, Mukherjee D. Semaglutide for weight loss and cardiometabolic risk reduction in overweight/obesity. Curr Opin Cardiol. 2022 Jul 1;37(4):350-355. doi: 10.1097/HCO.0000000000000955. Epub 2022 Feb 16. Kanie T, Mizuno A, Takaoka Y, Suzuki T, Yoneoka D, Nishikawa Y, Tam WWS, Morze J, Rynkiewicz A, Xin Y, Wu O, Providencia R, Kwong JS. Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: a network meta-analysis. Cochrane Database Syst Rev. 2021 Oct 25;10(10):CD013650. doi: 10.1002/14651858.CD013650.pub2.
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Public notes
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Contacts
Principal investigator
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Clinical Transparency (dept.2834)
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Address
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Novo Nordisk A/S
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Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
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What data in particular will be shared?
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
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When will data be available (start and end dates)?
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Available to whom?
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Available for what types of analyses?
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How or where can data be obtained?
IPD available at link: http://novonordisk-trials.com
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What supporting documents are/will be available?
No Supporting Document Provided
Type
Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/97/NCT03574597/Prot_002.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/97/NCT03574597/SAP_003.pdf
Results publications and other study-related documents
Type
Citations or Other Details
Journal
Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emers...
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Journal
Wilding JPH, Batterham RL, Calanna S, Davies M, Va...
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Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfiel...
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Results not provided in
https://clinicaltrials.gov/study/NCT03574597