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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT03786380




Registration number
NCT03786380
Ethics application status
Date submitted
21/12/2018
Date registered
26/12/2018

Titles & IDs
Public title
Diabetic Gastroparesis Study 05
Scientific title
Open-label Extension Study of Relamorelin for the Treatment of Diabetic Gastroparesis
Secondary ID [1] 0 0
2019-000406-30
Secondary ID [2] 0 0
3071-305-020
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Gastroparesis 0 0
Condition category
Condition code
Oral and Gastrointestinal 0 0 0 0
Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
Neurological 0 0 0 0
Other neurological disorders

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Relamorelin 10 µg

Experimental: Relamorelin 10 µg - Relamorelin 10 micrograms (µg) injected subcutaneously twice daily for up to approximately 22 months.


Treatment: Drugs: Relamorelin 10 µg
Relamorelin 10 µg injected subcutaneously twice daily.

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAEs)
Timepoint [1] 0 0
Up to approximately 22 months
Primary outcome [2] 0 0
Number of Participants With Potential Clinically Significant (PCS) Clinical Laboratory Results
Timepoint [2] 0 0
Baseline (Day 1) up to approximately 22 months
Primary outcome [3] 0 0
Number of Participants With Clinically Meaningful Trends for Vital Signs
Timepoint [3] 0 0
Up to approximately 22 months
Primary outcome [4] 0 0
Number of Participants With Clinically Meaningful Trends in Electrocardiogram (ECG) Results
Timepoint [4] 0 0
Up to approximately 22 months

Eligibility
Key inclusion criteria
* Successful completion of either Study RLM-MD-03 or Study RLM-MD-04
* Ability to provide written informed consent (IC) prior to any study procedures and willingness and ability to comply with study procedures
* Demonstration of adequate compliance with the study procedures in Study RLM-MD-03 or RLM-MD-04, in the opinion of the investigator.
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Participant is planning to receive an investigational drug (other than study intervention) or investigational device at any time during Study 3071-305-020
* Participant has an unresolved adverse event (AE) from a lead-in study, ie, a clinically significant finding on physical examination, clinical laboratory test, or 12-lead electrocardiogram (ECG) that, in the investigator's opinion, would limit the participant's ability to participate in or complete the study
* Any other reason that, in the investigator's opinion, would confound proper interpretation of the study or expose a participant to unacceptable risk, including renal, hepatic, or cardiopulmonary disease
* Females who are pregnant, nursing, or planning a pregnancy during the study.

Study design
Purpose of the study
Treatment
Allocation to intervention
NA
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?



Intervention assignment
Single group
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Stopped early
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,VIC
Recruitment hospital [1] 0 0
Nepean Hospital - Kingswood
Recruitment hospital [2] 0 0
Princess Alexandra Hospital - Woolloongabba
Recruitment hospital [3] 0 0
Royal Adelaide Hospital - Central Adelaide Local Health Network Incorporated - Adelaide
Recruitment hospital [4] 0 0
The Alfred Hospital - Melbourne
Recruitment hospital [5] 0 0
Royal Melbourne Hospital - Parkville
Recruitment postcode(s) [1] 0 0
2747 - Kingswood
Recruitment postcode(s) [2] 0 0
4102 - Woolloongabba
Recruitment postcode(s) [3] 0 0
5000 - Adelaide
Recruitment postcode(s) [4] 0 0
3004 - Melbourne
Recruitment postcode(s) [5] 0 0
3050 - Parkville
Recruitment outside Australia
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Alabama
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Venissieux
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Germany
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Baden-Württemberg
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Mecklenburg-Western Pomerania
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Germany
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North Rhine-Westphalia
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Saxony
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Hannover
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Heves
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Zala
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United Kingdom
State/province [231] 0 0
Barnsley
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United Kingdom
State/province [232] 0 0
Blackpool
Country [233] 0 0
United Kingdom
State/province [233] 0 0
Chelmsford
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United Kingdom
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Edinburgh
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United Kingdom
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Leeds
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United Kingdom
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Liverpool
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United Kingdom
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Country [238] 0 0
United Kingdom
State/province [238] 0 0
Manchester
Country [239] 0 0
United Kingdom
State/province [239] 0 0
Newcastle upon Tyne
Country [240] 0 0
United Kingdom
State/province [240] 0 0
Nottingham
Country [241] 0 0
United Kingdom
State/province [241] 0 0
Stockton-on-Tees
Country [242] 0 0
United Kingdom
State/province [242] 0 0
Tooting
Country [243] 0 0
United Kingdom
State/province [243] 0 0
Wolverhampton

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Allergan
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Harvy Schneier
Address 0 0
Allergan
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
No/undecided IPD sharing reason/comment


What supporting documents are/will be available?

Results publications and other study-related documents

No documents have been uploaded by study researchers.