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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT04707469
Registration number
NCT04707469
Ethics application status
Date submitted
12/01/2021
Date registered
13/01/2021
Titles & IDs
Public title
Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
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Scientific title
Efficacy and Safety of Once-daily Oral Semaglutide 25 mg and 50 mg Compared With 14 mg in Subjects With Type 2 Diabetes
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Secondary ID [1]
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U1111-1247-0210
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Secondary ID [2]
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NN9924-4635
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Universal Trial Number (UTN)
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Trial acronym
PIONEER PLUS
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Diabetes Mellitus, Type 2
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Condition category
Condition code
Metabolic and Endocrine
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Diabetes
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Oral semaglutide
Experimental: Oral semaglutide 50 mg - Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12), 25 mg (week 13-16) and 50 mg (week 17-68).
Experimental: Oral semaglutide 25 mg - Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12) and 25 mg (week 13-68).
Active comparator: Oral semaglutide 14 mg - Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8) and 14 mg (week 9-68).
Treatment: Drugs: Oral semaglutide
Participants will receive once daily semaglutide tablets (oral administration) in a dose escalating manner for 68 weeks.
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Change From Baseline in Glycated Haemoglobin (HbA1c) (Week 52)
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Assessment method [1]
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Change from baseline (week 0) in glycosylated haemoglobin (HbA1c) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
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Timepoint [1]
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Baseline (week 0), week 52
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Secondary outcome [1]
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Change From Baseline in Body Weight (Week 52)
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Assessment method [1]
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Change from baseline (week 0) in body weight was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [1]
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Baseline (week 0), week 52
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Secondary outcome [2]
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Change From Baseline in HbA1c (Week 68)
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Assessment method [2]
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Change from baseline (week 0) in HbA1c was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
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Timepoint [2]
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Baseline (week 0), week 68
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Secondary outcome [3]
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Change From Week 12 in HbA1c (Week 52)
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Assessment method [3]
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Change in HbA1c was evaluated from week 12 to week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
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Timepoint [3]
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Week 12, Week 52
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Secondary outcome [4]
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Change From Baseline in Fasting Plasma Glucose (FPG) (Week 52)
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Assessment method [4]
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Change from baseline (week 0) in fasting plasma glucose (FPG) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [4]
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Baseline (week 0), week 52
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Secondary outcome [5]
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Change From Baseline in FPG (Week 68)
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Assessment method [5]
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Change from baseline (week 0) in FPG was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [5]
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Baseline (week 0), week 68
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Secondary outcome [6]
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Percentage of Participants Who Achieved HbA1c Less Than (<) 7.0 (Percent [%]) (Week 52)
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Assessment method [6]
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Percentage of participants who achieved HbA1c \<7.0 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [6]
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At week 52
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Secondary outcome [7]
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Percentage of Participants Who Achieved HbA1c < 7.0 % (Week 68)
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Assessment method [7]
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Percentage of participants who achieved HbA1c \<7.0 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [7]
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At week 68
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Secondary outcome [8]
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Percentage of Participants Who Achieved HbA1c Less Than or Equal to (<=) 6.5 % (Week 52)
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Assessment method [8]
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Percentage of participants who achieved HbA1c \<=6.5 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [8]
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At week 52
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Secondary outcome [9]
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Percentage of Participants Who Achieved HbA1c <= 6.5 % (Week 68)
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Assessment method [9]
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Percentage of participants who achieved HbA1c \<=6.5 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [9]
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At week 68
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Secondary outcome [10]
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Time to Event Analyses of Rescue Medication
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Assessment method [10]
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Time to event analyses of rescue medication was evaluated from baseline (week 0) to week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [10]
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Baseline (week 0), week 68
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Secondary outcome [11]
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Change From Baseline in Body Weight (Week 68)
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Assessment method [11]
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Change from baseline (week 0) in body weight was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [11]
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Baseline (week 0), week 68
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Secondary outcome [12]
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Percentage Change From Baseline in Body Weight (Week 52)
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Assessment method [12]
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Percentage change from baseline (week 0) in body weight was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [12]
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Baseline (week 0), week 52
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Secondary outcome [13]
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Percentage Change From Baseline in Body Weight (Week 68)
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Assessment method [13]
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Percentage change from baseline (week 0) in body weight was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [13]
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Baseline (week 0), week 68
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Secondary outcome [14]
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Percentage Change From Week 12 in Body Weight (Week 52)
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Assessment method [14]
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Percentage change in body weight was evaluated from week 12 to week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [14]
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Week 12, Week 52
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Secondary outcome [15]
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Change From Baseline in Body Mass Index (BMI) (Week 52)
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Assessment method [15]
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Change from baseline (week 0) in body mass index (BMI) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [15]
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Baseline (week 0), week 52
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Secondary outcome [16]
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Change From Baseline in BMI (Week 68)
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Assessment method [16]
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Change from baseline (week 0) in BMI was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [16]
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Baseline (week 0), week 68
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Secondary outcome [17]
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Change From Baseline in Waist Circumference (Week 52)
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Assessment method [17]
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Change from baseline (week 0) in waist circumference was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [17]
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0
Baseline (week 0), week 52
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Secondary outcome [18]
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Change From Baseline in Waist Circumference (Week 68)
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Assessment method [18]
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Change from baseline (week 0) in waist circumference was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [18]
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Baseline (week 0), week 68
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Secondary outcome [19]
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Percentage of Participants Who Achieved Weight Loss Greater Than or Equal to (>=) 5 % (Week 52)
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Assessment method [19]
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Percentage of participants who achieved weight loss \>= 5 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [19]
0
0
At week 52
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Secondary outcome [20]
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Percentage of Participants Who Achieved Weight Loss >= 5 % (Week 68)
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Assessment method [20]
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Percentage of participants who achieved weight loss \>= 5 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [20]
0
0
At week 68
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Secondary outcome [21]
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Percentage of Participants Who Achieved Weight Loss >= 10 % (Week 52)
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Assessment method [21]
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Percentage of participants who achieved weight loss \>= 10 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [21]
0
0
At week 52
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Secondary outcome [22]
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Percentage of Participants Who Achieved Weight Loss >= 10 % (Week 68)
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Assessment method [22]
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Percentage of participants who achieved weight loss \>= 10 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [22]
0
0
At week 68
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Secondary outcome [23]
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Change From Baseline in Total Cholesterol (Week 52)
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Assessment method [23]
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Change from baseline (week 0) in total cholesterol was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [23]
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Baseline, Week 52
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Secondary outcome [24]
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Change From Baseline in Total Cholesterol (Week 68)
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Assessment method [24]
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Change from baseline (week 0) in total cholesterol was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [24]
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Baseline, Week 68
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Secondary outcome [25]
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Change From Baseline in Low Density Lipoproteins (LDL) (Week 52)
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Assessment method [25]
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Change from baseline (week 0) in LDL was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [25]
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Baseline, Week 52
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Secondary outcome [26]
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Change From Baseline in LDL (Week 68)
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Assessment method [26]
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Change from baseline (week 0) in LDL was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [26]
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Baseline, Week 68
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Secondary outcome [27]
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Change From Baseline in High Density Lipoproteins (HDL) (Week 52)
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Assessment method [27]
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Change from baseline (week 0) in HDL was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [27]
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Baseline, Week 52
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Secondary outcome [28]
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Change From Baseline in HDL (Week 68)
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Assessment method [28]
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Change from baseline (week 0) in HDL was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [28]
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Baseline, Week 68
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Secondary outcome [29]
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Change From Baseline in Triglycerides (Week 52)
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Assessment method [29]
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Change from baseline (week 0) in triglycerides was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [29]
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Baseline, Week 52
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Secondary outcome [30]
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Change From Baseline in Triglycerides (Week 68)
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Assessment method [30]
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Change from baseline (week 0) in triglycerides was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
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Timepoint [30]
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Baseline, Week 68
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Secondary outcome [31]
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Number of Adverse Events
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Assessment method [31]
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An adverse event (AE) defined as any unfavourable and unintended sign, including an abnormal laboratory finding, symptom or disease (new or exacerbated) temporally associated with the use of an investigational medicinal products (IMP). Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [31]
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From baseline (week 0) up to week 73
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Secondary outcome [32]
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Number of Clinically Significant Hypoglycaemic Episodes (Level 2) (<3.0 mmol/L (54 Milligram Per Decilitre [mg/dL]) or Severe Hypoglycaemic Episodes (Level 3)
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Assessment method [32]
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Hypoglycaemic episodes were classified according to the American Diabetes Association 2018/ International Hypoglycaemia Study Group 2017, where glycemic criteria for level 2 was \< 3.0 mmol/L (54 mg/dL) and level 3 had no specific glucose threshold. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [32]
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From baseline (week 0) up to week 68
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Secondary outcome [33]
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Change From Baseline in Systolic Blood Pressure (Week 52)
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Assessment method [33]
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Change from baseline (week 0) in systolic blood pressure at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [33]
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0
Baseline (week 0), week 52
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Secondary outcome [34]
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Change From Baseline in Systolic Blood Pressure (Week 68)
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Assessment method [34]
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Change from baseline (week 0) in systolic blood pressure at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [34]
0
0
Baseline (week 0), week 68
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Secondary outcome [35]
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Change From Baseline in Diastolic Blood Pressure (Week 52)
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Assessment method [35]
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Change from baseline (week 0) in diastolic blood pressure at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [35]
0
0
Baseline (week 0), week 52
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Secondary outcome [36]
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Change From Baseline in Diastolic Blood Pressure (Week 68)
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Assessment method [36]
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Change from baseline (week 0) in diastolic blood pressure at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [36]
0
0
Baseline (week 0), week 68
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Secondary outcome [37]
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Change From Baseline in Pulse (Week 52)
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Assessment method [37]
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Change from baseline (week 0) in pulse at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [37]
0
0
Baseline (week 0), week 52
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Secondary outcome [38]
0
0
Change From Baseline in Pulse (Week 68)
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Assessment method [38]
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Change from baseline (week 0) in pulse at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
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Timepoint [38]
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Baseline (week 0), week 68
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Eligibility
Key inclusion criteria
* Male or female, age above or equal to 18 years at the time of signing informed consent.
* Diagnosed with type 2 diabetes mellitus at least 180 days prior to the day of screening.
* HbA1c of 8.0-10.5% (64-91 mmol/mol) (both inclusive).
* BMI equal to or above 25 kg/m^2
* Stable daily dose(s) for 90 days prior to the day of screening of any of the following treatment regimens:
* No more than 3 of the following oral anti-diabetic drugs and at least 1 marked with a *:
* Metformin (equal to or above1500 mg or maximum tolerated or effective dose).
* Sulfonylureas (SU) (equal to or above half of the maximum approved dose according to local label or maximum tolerated or effective dose).
* Sodium/glucose cotransporter 2 (SGLT2) inhibitors (maximum tolerated dose).
* Dipeptidyl peptidase-4 (DPP-4) inhibitors (maximally indicated dose as per local label).
* Subjects, on treatment with stable dose of DPP-4 inhibitors at inclusion, must be willing to discontinue DPP-4 inhibitor treatment at randomisation (with no wash-out).
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Treatment with any medication indicated for the treatment of diabetes or obesity other than stated in the inclusion criteria within the past 90 days prior to the day of screening. However, short term insulin treatment for a maximum of 14 days prior to the day of screening is allowed.
* Renal impairment measured as estimated glomerular filtration rate (eGFR) value of below 30 mL/min/1.73 m^2 according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation as defined by kidney disease improving global outcomes (KDIGO 2012) classification.
* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
15/01/2021
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
8/03/2023
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Sample size
Target
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Accrual to date
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Final
1606
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Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,VIC
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Recruitment hospital [1]
0
0
Liverpool Hospital - Liverpool
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Recruitment hospital [2]
0
0
Royal Brisbane and Women's Hospital - Herston
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Recruitment hospital [3]
0
0
Core Research Centre - Milton
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Recruitment hospital [4]
0
0
South Australian Endocrine Research - Keswick
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Recruitment hospital [5]
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0
Southern Adelaide Diabetes & Endocrine Services - Oaklands Park
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Recruitment hospital [6]
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0
Barwon Health (The Geelong Hospital) - Geelong
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Recruitment postcode(s) [1]
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0
2170 - Liverpool
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Recruitment postcode(s) [2]
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0
4029 - Herston
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Recruitment postcode(s) [3]
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0
4064 - Milton
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Recruitment postcode(s) [4]
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0
5035 - Keswick
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Recruitment postcode(s) [5]
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0
5046 - Oaklands Park
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Recruitment postcode(s) [6]
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0
3220 - Geelong
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Recruitment outside Australia
Country [1]
0
0
United States of America
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State/province [1]
0
0
California
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Country [2]
0
0
United States of America
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State/province [2]
0
0
Colorado
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Country [3]
0
0
United States of America
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State/province [3]
0
0
Connecticut
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Country [4]
0
0
United States of America
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State/province [4]
0
0
Florida
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Country [5]
0
0
United States of America
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State/province [5]
0
0
Georgia
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Country [6]
0
0
United States of America
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State/province [6]
0
0
Hawaii
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Country [7]
0
0
United States of America
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State/province [7]
0
0
Idaho
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Country [8]
0
0
United States of America
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State/province [8]
0
0
Illinois
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Novo Nordisk A/S
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Ethics approval
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Summary
Brief summary
This study compares three doses of once daily semaglutide tablets in people with type 2 diabetes who were previously treated with other oral anti-diabetic medicines. Participants will be initiated on the lowest starting dose of 3 mg and gradually increased until they reach the final trial dose of 14 mg, 25 mg or 50 mg once daily semaglutide tablets. The final three doses will be randomized (i.e., decided by chance). Participants will be administered one tablet per day for 68 weeks. Women cannot take part if they are pregnant, breast-feeding or planning to become pregnant during the study period. Women who can get pregnant will be checked for pregnancy via urine tests. Once daily semaglutide tablets (3 mg, 7 mg and 14 mg) are approved for the treatment of type 2 diabetes in the US, in the EU and in some other countries, under the brand name Rybelsus®.
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Trial website
https://clinicaltrials.gov/study/NCT04707469
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Trial related presentations / publications
Aroda VR, Aberle J, Bardtrum L, Christiansen E, Knop FK, Gabery S, Pedersen SD, Buse JB. Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial. Lancet. 2023 Aug 26;402(10403):693-704. doi: 10.1016/S0140-6736(23)01127-3. Epub 2023 Jun 26.
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Public notes
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Contacts
Principal investigator
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Clinical Transparency (dept. 1452)
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Novo Nordisk A/S
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Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
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What data in particular will be shared?
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
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When will data be available (start and end dates)?
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Available to whom?
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Available for what types of analyses?
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How or where can data be obtained?
IPD available at link: http://novonordisk-trials.com
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What supporting documents are/will be available?
No Supporting Document Provided
Type
Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/69/NCT04707469/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/69/NCT04707469/SAP_001.pdf
Results publications and other study-related documents
Type
Citations or Other Details
Journal
Aroda VR, Aberle J, Bardtrum L, Christiansen E, Kn...
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Results not provided in
https://clinicaltrials.gov/study/NCT04707469