Trial Review

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/ct2/show/NCT00781391




Registration number
NCT00781391
Ethics application status
Date submitted
28/10/2008
Date registered
29/10/2008
Date last updated
5/03/2019

Titles & IDs
Public title
Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation
Scientific title
A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Multi-Center, Multi-National Study for Evaluation of Efficacy and Safety of Edoxaban (DU-176b) Versus Warfarin In Subjects With Atrial Fibrillation - Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation (ENGAGE - AF TIMI - 48)
Secondary ID [1] 0 0
DU176b-C-U301
Universal Trial Number (UTN)
Trial acronym
EngageAFTIMI48
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Stroke 0 0
Atrial Fibrillation 0 0
Embolism 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Other cardiovascular diseases
Cardiovascular 0 0 0 0
Diseases of the vasculature and circulation including the lymphatic system
Blood 0 0 0 0
Clotting disorders

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - warfarin tablets
Treatment: Drugs - Edoxaban tablets (high dose regimen-60mg)
Treatment: Drugs - Edoxaban tablets (low dose regimen-30mg)
Treatment: Drugs - placebo warfarin
Treatment: Drugs - placebo edoxaban

Active Comparator: Warfarin/placebo edoxaban - Warfarin tablets plus placebo Edoxaban tablets

Experimental: high dose edoxaban/placebo warfarin - Edoxaban tablets (60mg) plus warfarin placebo tablets

Experimental: low dose edoxaban/placebo warfarin - Edoxaban tablets (30mg) plus warfarin placebo tablets


Treatment: Drugs: warfarin tablets
Warfarin tablets plus Edoxaban placebo tablets each taken once daily for 24 months

Treatment: Drugs: Edoxaban tablets (high dose regimen-60mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months

Treatment: Drugs: Edoxaban tablets (low dose regimen-30mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months

Treatment: Drugs: placebo warfarin
placebo warfarin

Treatment: Drugs: placebo edoxaban
placebo edoxaban
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke and Systemic Embolic Events (SEE).
Timepoint [1] 0 0
on-treatment period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Primary outcome [2] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke and Systemic Embolic Events (SEE).
Timepoint [2] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Primary outcome [3] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke and Systemic Embolic Events (SEE).
Timepoint [3] 0 0
on-treatment period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Primary outcome [4] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke and Systemic Embolic Events (SEE).
Timepoint [4] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Primary outcome [5] 0 0
Compare Edoxaban to Warfarin for Superiority for Composite of Stroke and Systemic Embolic Events (SEE).
Timepoint [5] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Secondary outcome [1] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke, Systemic Embolic Event (SEE), and Cardiovascular (CV) Mortality
Timepoint [1] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Secondary outcome [2] 0 0
Compare Edoxaban to Warfarin for Major Adverse Cardiac Event (MACE): a Composite of Non-fatal MI, Non-fatal Stroke, Non-fatal SEE, and Death Due to CV Cause or Bleeding
Timepoint [2] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Secondary outcome [3] 0 0
Compare Edoxaban to Warfarin for Composite of Stroke, SEE, and All-cause Mortality
Timepoint [3] 0 0
overall study period 2.5 years of median study drug exposure and 2.8 year of median follow-up
Secondary outcome [4] 0 0
Adjudicated Bleeding Events
Timepoint [4] 0 0
on-treatment period 2.5 years of median study drug exposure and 2.8 year of median follow-up

Eligibility
Key inclusion criteria
- 21 years of age or older; male or female.

- Able to provide written informed consent.

- History of documented AF within the prior 12 months

- A moderate to high risk of stroke, as defined by CHADS2 index score of at least 2
Minimum age
21 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Transient atrial fibrillation secondary to other reversible disorders

- Subjects with moderate or severe mitral stenosis, unresected atrial myxoma, or a
mechanical heart valve

- Subjects with any contraindication for anticoagulant agents;

- Subjects with conditions associated with high risk of bleeding or have known or
suspected hereditary or acquired bleeding disorders

- Females of childbearing potential including the following:

- Females with a history of tubal-ligation

- Females less than 2 years post-menopausal

Study design
Purpose of the study
Prevention
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
1/11/2008
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
1/05/2013
Sample size
Target
Accrual to date
Final
21105
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,VIC
Recruitment hospital [1] 0 0
- Broken Hill
Recruitment hospital [2] 0 0
- East Gosford
Recruitment hospital [3] 0 0
- Carina Heights
Recruitment hospital [4] 0 0
- Milton
Recruitment hospital [5] 0 0
- Adelaide
Recruitment hospital [6] 0 0
- Frankston
Recruitment hospital [7] 0 0
- Ashford
Recruitment hospital [8] 0 0
- Camperdown
Recruitment hospital [9] 0 0
- Elizabeth Vale
Recruitment hospital [10] 0 0
- Joondalup
Recruitment hospital [11] 0 0
- Melbourne
Recruitment hospital [12] 0 0
- Parkville
Recruitment hospital [13] 0 0
- Perth
Recruitment postcode(s) [1] 0 0
- Broken Hill
Recruitment postcode(s) [2] 0 0
- East Gosford
Recruitment postcode(s) [3] 0 0
- Carina Heights
Recruitment postcode(s) [4] 0 0
- Milton
Recruitment postcode(s) [5] 0 0
- Adelaide
Recruitment postcode(s) [6] 0 0
- Frankston
Recruitment postcode(s) [7] 0 0
- Ashford
Recruitment postcode(s) [8] 0 0
- Camperdown
Recruitment postcode(s) [9] 0 0
- Elizabeth Vale
Recruitment postcode(s) [10] 0 0
- Joondalup
Recruitment postcode(s) [11] 0 0
- Melbourne
Recruitment postcode(s) [12] 0 0
- Parkville
Recruitment postcode(s) [13] 0 0
- Perth
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
Connecticut
Country [7] 0 0
United States of America
State/province [7] 0 0
Delaware
Country [8] 0 0
United States of America
State/province [8] 0 0
District of Columbia
Country [9] 0 0
United States of America
State/province [9] 0 0
Florida
Country [10] 0 0
United States of America
State/province [10] 0 0
Georgia
Country [11] 0 0
United States of America
State/province [11] 0 0
Hawaii
Country [12] 0 0
United States of America
State/province [12] 0 0
Idaho
Country [13] 0 0
United States of America
State/province [13] 0 0
Illinois
Country [14] 0 0
United States of America
State/province [14] 0 0
Indiana
Country [15] 0 0
United States of America
State/province [15] 0 0
Iowa
Country [16] 0 0
United States of America
State/province [16] 0 0
Kansas
Country [17] 0 0
United States of America
State/province [17] 0 0
Kentucky
Country [18] 0 0
United States of America
State/province [18] 0 0
Louisiana
Country [19] 0 0
United States of America
State/province [19] 0 0
Maine
Country [20] 0 0
United States of America
State/province [20] 0 0
Maryland
Country [21] 0 0
United States of America
State/province [21] 0 0
Massachusetts
Country [22] 0 0
United States of America
State/province [22] 0 0
Michigan
Country [23] 0 0
United States of America
State/province [23] 0 0
Minnesota
Country [24] 0 0
United States of America
State/province [24] 0 0
Mississippi
Country [25] 0 0
United States of America
State/province [25] 0 0
Missouri
Country [26] 0 0
United States of America
State/province [26] 0 0
Montana
Country [27] 0 0
United States of America
State/province [27] 0 0
Nebraska
Country [28] 0 0
United States of America
State/province [28] 0 0
Nevada
Country [29] 0 0
United States of America
State/province [29] 0 0
New Jersey
Country [30] 0 0
United States of America
State/province [30] 0 0
New Mexico
Country [31] 0 0
United States of America
State/province [31] 0 0
New York
Country [32] 0 0
United States of America
State/province [32] 0 0
North Carolina
Country [33] 0 0
United States of America
State/province [33] 0 0
North Dakota
Country [34] 0 0
United States of America
State/province [34] 0 0
Ohio
Country [35] 0 0
United States of America
State/province [35] 0 0
Oklahoma
Country [36] 0 0
United States of America
State/province [36] 0 0
Oregon
Country [37] 0 0
United States of America
State/province [37] 0 0
Pennsylvania
Country [38] 0 0
United States of America
State/province [38] 0 0
Rhode Island
Country [39] 0 0
United States of America
State/province [39] 0 0
South Carolina
Country [40] 0 0
United States of America
State/province [40] 0 0
South Dakota
Country [41] 0 0
United States of America
State/province [41] 0 0
Tennessee
Country [42] 0 0
United States of America
State/province [42] 0 0
Texas
Country [43] 0 0
United States of America
State/province [43] 0 0
Utah
Country [44] 0 0
United States of America
State/province [44] 0 0
Virginia
Country [45] 0 0
United States of America
State/province [45] 0 0
Washington
Country [46] 0 0
United States of America
State/province [46] 0 0
West Virginia
Country [47] 0 0
United States of America
State/province [47] 0 0
Wisconsin
Country [48] 0 0
Argentina
State/province [48] 0 0
Bahia Blanca
Country [49] 0 0
Argentina
State/province [49] 0 0
Buenos Aires
Country [50] 0 0
Argentina
State/province [50] 0 0
Cordoba
Country [51] 0 0
Argentina
State/province [51] 0 0
Corrientes
Country [52] 0 0
Argentina
State/province [52] 0 0
Formosa
Country [53] 0 0
Argentina
State/province [53] 0 0
Godoy Cruz
Country [54] 0 0
Argentina
State/province [54] 0 0
Jujuy
Country [55] 0 0
Argentina
State/province [55] 0 0
Mar del Plata
Country [56] 0 0
Argentina
State/province [56] 0 0
Mendoza
Country [57] 0 0
Argentina
State/province [57] 0 0
Paraguay
Country [58] 0 0
Argentina
State/province [58] 0 0
Provincia De Chaco
Country [59] 0 0
Argentina
State/province [59] 0 0
Provincia De Rio Negro
Country [60] 0 0
Argentina
State/province [60] 0 0
Provincia De Salta
Country [61] 0 0
Argentina
State/province [61] 0 0
San Luis
Country [62] 0 0
Argentina
State/province [62] 0 0
Santa Fe
Country [63] 0 0
Argentina
State/province [63] 0 0
Sante Fe
Country [64] 0 0
Argentina
State/province [64] 0 0
Tucuman
Country [65] 0 0
Belgium
State/province [65] 0 0
Antwerpen
Country [66] 0 0
Belgium
State/province [66] 0 0
Arlon
Country [67] 0 0
Belgium
State/province [67] 0 0
Brugge
Country [68] 0 0
Belgium
State/province [68] 0 0
Bruxelles
Country [69] 0 0
Belgium
State/province [69] 0 0
Genk
Country [70] 0 0
Belgium
State/province [70] 0 0
Hasselt
Country [71] 0 0
Belgium
State/province [71] 0 0
Leuven
Country [72] 0 0
Belgium
State/province [72] 0 0
Liege
Country [73] 0 0
Belgium
State/province [73] 0 0
Mechelen
Country [74] 0 0
Belgium
State/province [74] 0 0
Merksem
Country [75] 0 0
Belgium
State/province [75] 0 0
Moerkerke
Country [76] 0 0
Belgium
State/province [76] 0 0
Montegnee
Country [77] 0 0
Belgium
State/province [77] 0 0
Mousron
Country [78] 0 0
Belgium
State/province [78] 0 0
Torhout
Country [79] 0 0
Belgium
State/province [79] 0 0
Veurne
Country [80] 0 0
Belgium
State/province [80] 0 0
Wetteren
Country [81] 0 0
Brazil
State/province [81] 0 0
Belo Horizonte
Country [82] 0 0
Brazil
State/province [82] 0 0
Blumenau
Country [83] 0 0
Brazil
State/province [83] 0 0
Brasilia
Country [84] 0 0
Brazil
State/province [84] 0 0
Campina Grande do Sul
Country [85] 0 0
Brazil
State/province [85] 0 0
Campinas
Country [86] 0 0
Brazil
State/province [86] 0 0
Caxias do Sul
Country [87] 0 0
Brazil
State/province [87] 0 0
Curitiba
Country [88] 0 0
Brazil
State/province [88] 0 0
Goiania
Country [89] 0 0
Brazil
State/province [89] 0 0
Lajeados
Country [90] 0 0
Brazil
State/province [90] 0 0
Maceio
Country [91] 0 0
Brazil
State/province [91] 0 0
Marilia
Country [92] 0 0
Brazil
State/province [92] 0 0
Passo Fundo
Country [93] 0 0
Brazil
State/province [93] 0 0
Porto Alegre
Country [94] 0 0
Brazil
State/province [94] 0 0
Recife
Country [95] 0 0
Brazil
State/province [95] 0 0
Ribeirao Preto
Country [96] 0 0
Brazil
State/province [96] 0 0
Rio de Janeiro
Country [97] 0 0
Brazil
State/province [97] 0 0
Salvador
Country [98] 0 0
Brazil
State/province [98] 0 0
Santo Andre
Country [99] 0 0
Brazil
State/province [99] 0 0
Sao Jose
Country [100] 0 0
Brazil
State/province [100] 0 0
Sao Paulo
Country [101] 0 0
Brazil
State/province [101] 0 0
Uberlandia
Country [102] 0 0
Bulgaria
State/province [102] 0 0
Burgas
Country [103] 0 0
Bulgaria
State/province [103] 0 0
Dimitrovgrad
Country [104] 0 0
Bulgaria
State/province [104] 0 0
Haskovo
Country [105] 0 0
Bulgaria
State/province [105] 0 0
Pleven
Country [106] 0 0
Bulgaria
State/province [106] 0 0
Plovdiv
Country [107] 0 0
Bulgaria
State/province [107] 0 0
Ruse
Country [108] 0 0
Bulgaria
State/province [108] 0 0
Sofia
Country [109] 0 0
Bulgaria
State/province [109] 0 0
Varna
Country [110] 0 0
Canada
State/province [110] 0 0
Alberta
Country [111] 0 0
Canada
State/province [111] 0 0
British Columbia
Country [112] 0 0
Canada
State/province [112] 0 0
New Brunswick
Country [113] 0 0
Canada
State/province [113] 0 0
Nova Scotia
Country [114] 0 0
Canada
State/province [114] 0 0
Ontario
Country [115] 0 0
Canada
State/province [115] 0 0
Quebec
Country [116] 0 0
Canada
State/province [116] 0 0
Saskatchewan
Country [117] 0 0
Canada
State/province [117] 0 0
Mount Pearl
Country [118] 0 0
Canada
State/province [118] 0 0
St. John's
Country [119] 0 0
Chile
State/province [119] 0 0
Iquique
Country [120] 0 0
Chile
State/province [120] 0 0
La Serena
Country [121] 0 0
Chile
State/province [121] 0 0
Osorno
Country [122] 0 0
Chile
State/province [122] 0 0
Puerto Montt
Country [123] 0 0
Chile
State/province [123] 0 0
Rancagua
Country [124] 0 0
Chile
State/province [124] 0 0
Santiago
Country [125] 0 0
Chile
State/province [125] 0 0
Talcahuano
Country [126] 0 0
Chile
State/province [126] 0 0
Temuco
Country [127] 0 0
Chile
State/province [127] 0 0
Victoria
Country [128] 0 0
Chile
State/province [128] 0 0
Vina del Mar
Country [129] 0 0
China
State/province [129] 0 0
Baotou
Country [130] 0 0
China
State/province [130] 0 0
Beijing
Country [131] 0 0
China
State/province [131] 0 0
Changchun
Country [132] 0 0
China
State/province [132] 0 0
Changsha
Country [133] 0 0
China
State/province [133] 0 0
Chendu City
Country [134] 0 0
China
State/province [134] 0 0
Chongqing
Country [135] 0 0
China
State/province [135] 0 0
Guangxi
Country [136] 0 0
China
State/province [136] 0 0
Guangzhou
Country [137] 0 0
China
State/province [137] 0 0
Hainan Province
Country [138] 0 0
China
State/province [138] 0 0
Hangzhou
Country [139] 0 0
China
State/province [139] 0 0
Harbin
Country [140] 0 0
China
State/province [140] 0 0
Jinzhou
Country [141] 0 0
China
State/province [141] 0 0
Lanzhou
Country [142] 0 0
China
State/province [142] 0 0
Liaoning Province
Country [143] 0 0
China
State/province [143] 0 0
Nanchang
Country [144] 0 0
China
State/province [144] 0 0
Shaanxi Province
Country [145] 0 0
China
State/province [145] 0 0
Shanghai
Country [146] 0 0
China
State/province [146] 0 0
Shenyang
Country [147] 0 0
China
State/province [147] 0 0
Shijiazhuang City
Country [148] 0 0
China
State/province [148] 0 0
Tianjin
Country [149] 0 0
China
State/province [149] 0 0
Wenzhou
Country [150] 0 0
China
State/province [150] 0 0
Wuhan
Country [151] 0 0
Colombia
State/province [151] 0 0
Antioquia
Country [152] 0 0
Colombia
State/province [152] 0 0
Armenia
Country [153] 0 0
Colombia
State/province [153] 0 0
Barranquilla
Country [154] 0 0
Colombia
State/province [154] 0 0
Bogota
Country [155] 0 0
Colombia
State/province [155] 0 0
Bucaramanga
Country [156] 0 0
Colombia
State/province [156] 0 0
Cartagena
Country [157] 0 0
Colombia
State/province [157] 0 0
Envigado
Country [158] 0 0
Colombia
State/province [158] 0 0
Manizales
Country [159] 0 0
Colombia
State/province [159] 0 0
Medellin
Country [160] 0 0
Croatia
State/province [160] 0 0
Dubrovnik
Country [161] 0 0
Croatia
State/province [161] 0 0
Karlovac
Country [162] 0 0
Croatia
State/province [162] 0 0
Koprivnica
Country [163] 0 0
Croatia
State/province [163] 0 0
Krapinski Toplice
Country [164] 0 0
Croatia
State/province [164] 0 0
Osijek
Country [165] 0 0
Croatia
State/province [165] 0 0
Rijeka
Country [166] 0 0
Croatia
State/province [166] 0 0
Slavonski Brod
Country [167] 0 0
Croatia
State/province [167] 0 0
Split
Country [168] 0 0
Croatia
State/province [168] 0 0
Varazdin
Country [169] 0 0
Croatia
State/province [169] 0 0
Zadar
Country [170] 0 0
Croatia
State/province [170] 0 0
Zagreb
Country [171] 0 0
Czechia
State/province [171] 0 0
Benatky nad Jizerou
Country [172] 0 0
Czechia
State/province [172] 0 0
Benesov
Country [173] 0 0
Czechia
State/province [173] 0 0
Bilovec
Country [174] 0 0
Czechia
State/province [174] 0 0
Brno-Lesna
Country [175] 0 0
Czechia
State/province [175] 0 0
Brno
Country [176] 0 0
Czechia
State/province [176] 0 0
Cesky Krumlov
Country [177] 0 0
Czechia
State/province [177] 0 0
Chrudim
Country [178] 0 0
Czechia
State/province [178] 0 0
Havlickux Brod
Country [179] 0 0
Czechia
State/province [179] 0 0
Hradec Kralove
Country [180] 0 0
Czechia
State/province [180] 0 0
Hranice
Country [181] 0 0
Czechia
State/province [181] 0 0
Jindrichuv Hradec
Country [182] 0 0
Czechia
State/province [182] 0 0
Kolin
Country [183] 0 0
Czechia
State/province [183] 0 0
Kromeriz
Country [184] 0 0
Czechia
State/province [184] 0 0
Marianske Lazne
Country [185] 0 0
Czechia
State/province [185] 0 0
Mlada Boleslav
Country [186] 0 0
Czechia
State/province [186] 0 0
Nachod
Country [187] 0 0
Czechia
State/province [187] 0 0
Ostrava-Trebovice
Country [188] 0 0
Czechia
State/province [188] 0 0
Ostrava
Country [189] 0 0
Czechia
State/province [189] 0 0
Pardubice
Country [190] 0 0
Czechia
State/province [190] 0 0
Plzen
Country [191] 0 0
Czechia
State/province [191] 0 0
Praha
Country [192] 0 0
Czechia
State/province [192] 0 0
Pribram
Country [193] 0 0
Czechia
State/province [193] 0 0
Revnice
Country [194] 0 0
Czechia
State/province [194] 0 0
Semily
Country [195] 0 0
Czechia
State/province [195] 0 0
Slany
Country [196] 0 0
Czechia
State/province [196] 0 0
Teplice
Country [197] 0 0
Czechia
State/province [197] 0 0
Trutnov
Country [198] 0 0
Czechia
State/province [198] 0 0
Usti nad Labem
Country [199] 0 0
Denmark
State/province [199] 0 0
Aarhus N
Country [200] 0 0
Denmark
State/province [200] 0 0
Esbjerg
Country [201] 0 0
Denmark
State/province [201] 0 0
Frederiksberg
Country [202] 0 0
Denmark
State/province [202] 0 0
Glostrup
Country [203] 0 0
Denmark
State/province [203] 0 0
Hellerup
Country [204] 0 0
Denmark
State/province [204] 0 0
Holbaek
Country [205] 0 0
Denmark
State/province [205] 0 0
Horsens
Country [206] 0 0
Denmark
State/province [206] 0 0
Kobenhaven
Country [207] 0 0
Denmark
State/province [207] 0 0
Kobenhavn
Country [208] 0 0
Estonia
State/province [208] 0 0
Harjumaa
Country [209] 0 0
Estonia
State/province [209] 0 0
Tartu
Country [210] 0 0
Estonia
State/province [210] 0 0
Parnu
Country [211] 0 0
Estonia
State/province [211] 0 0
Tallinn
Country [212] 0 0
Estonia
State/province [212] 0 0
Tallin
Country [213] 0 0
Finland
State/province [213] 0 0
Jyvaskyla
Country [214] 0 0
Finland
State/province [214] 0 0
Kuopio
Country [215] 0 0
Finland
State/province [215] 0 0
Lappeenranta
Country [216] 0 0
Finland
State/province [216] 0 0
Oulu
Country [217] 0 0
Finland
State/province [217] 0 0
Seinajoki
Country [218] 0 0
Finland
State/province [218] 0 0
Tampere
Country [219] 0 0
France
State/province [219] 0 0
Abbeville
Country [220] 0 0
France
State/province [220] 0 0
Amiens Cedex
Country [221] 0 0
France
State/province [221] 0 0
Brest
Country [222] 0 0
France
State/province [222] 0 0
Cambrai
Country [223] 0 0
France
State/province [223] 0 0
Clamart
Country [224] 0 0
France
State/province [224] 0 0
La Roche sur Yon
Country [225] 0 0
France
State/province [225] 0 0
Lille
Country [226] 0 0
France
State/province [226] 0 0
Lyon Cedex
Country [227] 0 0
France
State/province [227] 0 0
Massy
Country [228] 0 0
France
State/province [228] 0 0
Nantes
Country [229] 0 0
France
State/province [229] 0 0
Paris
Country [230] 0 0
France
State/province [230] 0 0
Pau
Country [231] 0 0
France
State/province [231] 0 0
Pessac
Country [232] 0 0
France
State/province [232] 0 0
Poitiers
Country [233] 0 0
France
State/province [233] 0 0
Tours Cedex
Country [234] 0 0
France
State/province [234] 0 0
Valenciennes
Country [235] 0 0
Germany
State/province [235] 0 0
Altenburg
Country [236] 0 0
Germany
State/province [236] 0 0
Aschaffenburg
Country [237] 0 0
Germany
State/province [237] 0 0
Augsburg
Country [238] 0 0
Germany
State/province [238] 0 0
Bad Nauheim
Country [239] 0 0
Germany
State/province [239] 0 0
Berlin
Country [240] 0 0
Germany
State/province [240] 0 0
Bochum
Country [241] 0 0
Germany
State/province [241] 0 0
Cloppenburg
Country [242] 0 0
Germany
State/province [242] 0 0
Dortmund
Country [243] 0 0
Germany
State/province [243] 0 0
Dresden
Country [244] 0 0
Germany
State/province [244] 0 0
Essen
Country [245] 0 0
Germany
State/province [245] 0 0
Frankfurt
Country [246] 0 0
Germany
State/province [246] 0 0
Giengen
Country [247] 0 0
Germany
State/province [247] 0 0
Goerlitz
Country [248] 0 0
Germany
State/province [248] 0 0
Grossheirath
Country [249] 0 0
Germany
State/province [249] 0 0
Hamburg
Country [250] 0 0
Germany
State/province [250] 0 0
Heidelberg
Country [251] 0 0
Germany
State/province [251] 0 0
Heilbronn
Country [252] 0 0
Germany
State/province [252] 0 0
Homburg
Country [253] 0 0
Germany
State/province [253] 0 0
Ingelheim
Country [254] 0 0
Germany
State/province [254] 0 0
Kallstadt
Country [255] 0 0
Germany
State/province [255] 0 0
Kassel
Country [256] 0 0
Germany
State/province [256] 0 0
Kiel-Kronshagen
Country [257] 0 0
Germany
State/province [257] 0 0
Koeln
Country [258] 0 0
Germany
State/province [258] 0 0
Leipzig
Country [259] 0 0
Germany
State/province [259] 0 0
Ludwigshafen
Country [260] 0 0
Germany
State/province [260] 0 0
Luebeck
Country [261] 0 0
Germany
State/province [261] 0 0
Magdeburg
Country [262] 0 0
Germany
State/province [262] 0 0
Mainz
Country [263] 0 0
Germany
State/province [263] 0 0
Mannheim
Country [264] 0 0
Germany
State/province [264] 0 0
Markkleeberg
Country [265] 0 0
Germany
State/province [265] 0 0
Muenchen
Country [266] 0 0
Germany
State/province [266] 0 0
Nienburg
Country [267] 0 0
Germany
State/province [267] 0 0
Northeinm
Country [268] 0 0
Germany
State/province [268] 0 0
Offenbach-beiber
Country [269] 0 0
Germany
State/province [269] 0 0
Potsdam
Country [270] 0 0
Germany
State/province [270] 0 0
Ruedersdorf
Country [271] 0 0
Germany
State/province [271] 0 0
Siegen
Country [272] 0 0
Germany
State/province [272] 0 0
Stuhr
Country [273] 0 0
Germany
State/province [273] 0 0
Ulm
Country [274] 0 0
Germany
State/province [274] 0 0
Unterschneidheim
Country [275] 0 0
Germany
State/province [275] 0 0
Wardenburg
Country [276] 0 0
Germany
State/province [276] 0 0
Wermsdorf
Country [277] 0 0
Germany
State/province [277] 0 0
Weyhe
Country [278] 0 0
Germany
State/province [278] 0 0
Witten
Country [279] 0 0
Germany
State/province [279] 0 0
Woerishofen
Country [280] 0 0
Germany
State/province [280] 0 0
Wuppertal
Country [281] 0 0
Greece
State/province [281] 0 0
Athens
Country [282] 0 0
Greece
State/province [282] 0 0
Larissa
Country [283] 0 0
Greece
State/province [283] 0 0
Rhodes
Country [284] 0 0
Greece
State/province [284] 0 0
Rio-Patras
Country [285] 0 0
Greece
State/province [285] 0 0
Thessaloniki
Country [286] 0 0
Greece
State/province [286] 0 0
Trikala
Country [287] 0 0
Greece
State/province [287] 0 0
Voula
Country [288] 0 0
Guatemala
State/province [288] 0 0
Ciudad
Country [289] 0 0
Guatemala
State/province [289] 0 0
Clinica
Country [290] 0 0
Guatemala
State/province [290] 0 0
Edificio Multimedica
Country [291] 0 0
Guatemala
State/province [291] 0 0
Nivel
Country [292] 0 0
Guatemala
State/province [292] 0 0
Oficina
Country [293] 0 0
Guatemala
State/province [293] 0 0
Quetzaltenango
Country [294] 0 0
Guatemala
State/province [294] 0 0
Zacapa
Country [295] 0 0
Hungary
State/province [295] 0 0
Ajka
Country [296] 0 0
Hungary
State/province [296] 0 0
Baja
Country [297] 0 0
Hungary
State/province [297] 0 0
Bekescsaba
Country [298] 0 0
Hungary
State/province [298] 0 0
Budapest
Country [299] 0 0
Hungary
State/province [299] 0 0
Debrecen
Country [300] 0 0
Hungary
State/province [300] 0 0
Hodmezovasarhely
Country [301] 0 0
Hungary
State/province [301] 0 0
Kecskemet
Country [302] 0 0
Hungary
State/province [302] 0 0
Keeskemet
Country [303] 0 0
Hungary
State/province [303] 0 0
Kistarcsa
Country [304] 0 0
Hungary
State/province [304] 0 0
Komarom
Country [305] 0 0
Hungary
State/province [305] 0 0
Mako
Country [306] 0 0
Hungary
State/province [306] 0 0
Nagykanizsa
Country [307] 0 0
Hungary
State/province [307] 0 0
Nyiregyhaza
Country [308] 0 0
Hungary
State/province [308] 0 0
Pecs
Country [309] 0 0
Hungary
State/province [309] 0 0
Sopron
Country [310] 0 0
Hungary
State/province [310] 0 0
Szekszard
Country [311] 0 0
Hungary
State/province [311] 0 0
Szombathely
Country [312] 0 0
Hungary
State/province [312] 0 0
Zalaegerszeg
Country [313] 0 0
India
State/province [313] 0 0
AP
Country [314] 0 0
India
State/province [314] 0 0
Kerala
Country [315] 0 0
India
State/province [315] 0 0
Ahmedabad
Country [316] 0 0
India
State/province [316] 0 0
Anddhra Pradesh
Country [317] 0 0
India
State/province [317] 0 0
Andhra Pradesh
Country [318] 0 0
India
State/province [318] 0 0
Aurangabad
Country [319] 0 0
India
State/province [319] 0 0
Bangalore
Country [320] 0 0
India
State/province [320] 0 0
Bikaner
Country [321] 0 0
India
State/province [321] 0 0
Chennai
Country [322] 0 0
India
State/province [322] 0 0
Coimbatore
Country [323] 0 0
India
State/province [323] 0 0
Delhi
Country [324] 0 0
India
State/province [324] 0 0
Gujrat
Country [325] 0 0
India
State/province [325] 0 0
Indore
Country [326] 0 0
India
State/province [326] 0 0
Jaipur
Country [327] 0 0
India
State/province [327] 0 0
Karnataka
Country [328] 0 0
India
State/province [328] 0 0
Kolkata
Country [329] 0 0
India
State/province [329] 0 0
Ludhiana
Country [330] 0 0
India
State/province [330] 0 0
Madhya Pradesh
Country [331] 0 0
India
State/province [331] 0 0
Maharashtra
Country [332] 0 0
India
State/province [332] 0 0
Mangalore
Country [333] 0 0
India
State/province [333] 0 0
Mumbai
Country [334] 0 0
India
State/province [334] 0 0
Nagpur
Country [335] 0 0
India
State/province [335] 0 0
Nashik
Country [336] 0 0
India
State/province [336] 0 0
New Delhi
Country [337] 0 0
India
State/province [337] 0 0
Pune
Country [338] 0 0
India
State/province [338] 0 0
Puni
Country [339] 0 0
India
State/province [339] 0 0
Punjab
Country [340] 0 0
India
State/province [340] 0 0
Rajasthan
Country [341] 0 0
India
State/province [341] 0 0
Ramnagar
Country [342] 0 0
India
State/province [342] 0 0
Shimoga
Country [343] 0 0
India
State/province [343] 0 0
Surat
Country [344] 0 0
India
State/province [344] 0 0
Trivandrum
Country [345] 0 0
India
State/province [345] 0 0
Vadodara
Country [346] 0 0
Israel
State/province [346] 0 0
Afula
Country [347] 0 0
Israel
State/province [347] 0 0
Beer-Sheva
Country [348] 0 0
Israel
State/province [348] 0 0
Dimona
Country [349] 0 0
Israel
State/province [349] 0 0
Givatayim
Country [350] 0 0
Israel
State/province [350] 0 0
Hadera
Country [351] 0 0
Israel
State/province [351] 0 0
Haifa
Country [352] 0 0
Israel
State/province [352] 0 0
Holon
Country [353] 0 0
Israel
State/province [353] 0 0
Jerusalem
Country [354] 0 0
Israel
State/province [354] 0 0
Kfar Saba
Country [355] 0 0
Israel
State/province [355] 0 0
Nahariya
Country [356] 0 0
Israel
State/province [356] 0 0
Nazareth
Country [357] 0 0
Israel
State/province [357] 0 0
Petach Tikva
Country [358] 0 0
Israel
State/province [358] 0 0
Petah-Tikva
Country [359] 0 0
Israel
State/province [359] 0 0
Poriya
Country [360] 0 0
Israel
State/province [360] 0 0
Raanana
Country [361] 0 0
Israel
State/province [361] 0 0
Rehovot
Country [362] 0 0
Israel
State/province [362] 0 0
Tel Aviv
Country [363] 0 0
Israel
State/province [363] 0 0
Tel Hashomer
Country [364] 0 0
Israel
State/province [364] 0 0
Zerifin
Country [365] 0 0
Italy
State/province [365] 0 0
Bologna
Country [366] 0 0
Italy
State/province [366] 0 0
Brescia
Country [367] 0 0
Italy
State/province [367] 0 0
Cantania
Country [368] 0 0
Italy
State/province [368] 0 0
Casarano
Country [369] 0 0
Italy
State/province [369] 0 0
Caserta
Country [370] 0 0
Italy
State/province [370] 0 0
Chieti
Country [371] 0 0
Italy
State/province [371] 0 0
Cremona
Country [372] 0 0
Italy
State/province [372] 0 0
Genova
Country [373] 0 0
Italy
State/province [373] 0 0
Grosseto
Country [374] 0 0
Italy
State/province [374] 0 0
Legnano
Country [375] 0 0
Italy
State/province [375] 0 0
Manerbio
Country [376] 0 0
Italy
State/province [376] 0 0
Milano
Country [377] 0 0
Italy
State/province [377] 0 0
Monserrato
Country [378] 0 0
Italy
State/province [378] 0 0
Napoli
Country [379] 0 0
Italy
State/province [379] 0 0
Novara
Country [380] 0 0
Italy
State/province [380] 0 0
Ostia
Country [381] 0 0
Italy
State/province [381] 0 0
Pavia
Country [382] 0 0
Italy
State/province [382] 0 0
Pisa
Country [383] 0 0
Italy
State/province [383] 0 0
Pozzuoli
Country [384] 0 0
Italy
State/province [384] 0 0
Roma
Country [385] 0 0
Italy
State/province [385] 0 0
Santa Maria Capua Vetere
Country [386] 0 0
Italy
State/province [386] 0 0
Sassari
Country [387] 0 0
Italy
State/province [387] 0 0
Seriate
Country [388] 0 0
Italy
State/province [388] 0 0
Siena
Country [389] 0 0
Italy
State/province [389] 0 0
Trieste
Country [390] 0 0
Italy
State/province [390] 0 0
Venezia Mestre
Country [391] 0 0
Japan
State/province [391] 0 0
Kyoto
Country [392] 0 0
Japan
State/province [392] 0 0
Nagano
Country [393] 0 0
Japan
State/province [393] 0 0
Tokyo
Country [394] 0 0
Japan
State/province [394] 0 0
Aichi
Country [395] 0 0
Japan
State/province [395] 0 0
Aomori
Country [396] 0 0
Japan
State/province [396] 0 0
Chiaki
Country [397] 0 0
Japan
State/province [397] 0 0
Chiba
Country [398] 0 0
Japan
State/province [398] 0 0
Ehime
Country [399] 0 0
Japan
State/province [399] 0 0
Fukuoka
Country [400] 0 0
Japan
State/province [400] 0 0
Fukushima
Country [401] 0 0
Japan
State/province [401] 0 0
Gifu
Country [402] 0 0
Japan
State/province [402] 0 0
Gunma
Country [403] 0 0
Japan
State/province [403] 0 0
Hiroshima
Country [404] 0 0
Japan
State/province [404] 0 0
Hokkai-do
Country [405] 0 0
Japan
State/province [405] 0 0
Hokkaido
Country [406] 0 0
Japan
State/province [406] 0 0
Hyogo
Country [407] 0 0
Japan
State/province [407] 0 0
Ibaraki
Country [408] 0 0
Japan
State/province [408] 0 0
Isesaki-shi
Country [409] 0 0
Japan
State/province [409] 0 0
Ishikawa
Country [410] 0 0
Japan
State/province [410] 0 0
Iwate
Country [411] 0 0
Japan
State/province [411] 0 0
Kagawa
Country [412] 0 0
Japan
State/province [412] 0 0
Kanagawa
Country [413] 0 0
Japan
State/province [413] 0 0
Kumamoto
Country [414] 0 0
Japan
State/province [414] 0 0
Kyota
Country [415] 0 0
Japan
State/province [415] 0 0
Mie
Country [416] 0 0
Japan
State/province [416] 0 0
Miyagi
Country [417] 0 0
Japan
State/province [417] 0 0
Nagaoka-shi
Country [418] 0 0
Japan
State/province [418] 0 0
Nagasaki
Country [419] 0 0
Japan
State/province [419] 0 0
Niigata
Country [420] 0 0
Japan
State/province [420] 0 0
Okayama
Country [421] 0 0
Japan
State/province [421] 0 0
Osaka
Country [422] 0 0
Japan
State/province [422] 0 0
Saitama
Country [423] 0 0
Japan
State/province [423] 0 0
Shimane
Country [424] 0 0
Japan
State/province [424] 0 0
Shizuoka
Country [425] 0 0
Japan
State/province [425] 0 0
Tokushima
Country [426] 0 0
Japan
State/province [426] 0 0
Yamaguchi
Country [427] 0 0
Japan
State/province [427] 0 0
Yokohama-shi
Country [428] 0 0
Korea, Republic of
State/province [428] 0 0
Busan
Country [429] 0 0
Korea, Republic of
State/province [429] 0 0
Daegu
Country [430] 0 0
Korea, Republic of
State/province [430] 0 0
Daejeon
Country [431] 0 0
Korea, Republic of
State/province [431] 0 0
Gangwon-do
Country [432] 0 0
Korea, Republic of
State/province [432] 0 0
Gwangju-si
Country [433] 0 0
Korea, Republic of
State/province [433] 0 0
Gyeonggi-do
Country [434] 0 0
Korea, Republic of
State/province [434] 0 0
Incheon
Country [435] 0 0
Korea, Republic of
State/province [435] 0 0
Pusan
Country [436] 0 0
Korea, Republic of
State/province [436] 0 0
Seoul
Country [437] 0 0
Mexico
State/province [437] 0 0
Jalisco
Country [438] 0 0
Mexico
State/province [438] 0 0
Veracruz
Country [439] 0 0
Mexico
State/province [439] 0 0
Aguascalientes
Country [440] 0 0
Mexico
State/province [440] 0 0
Chihuahua
Country [441] 0 0
Mexico
State/province [441] 0 0
Distrito Federal
Country [442] 0 0
Mexico
State/province [442] 0 0
Durango
Country [443] 0 0
Mexico
State/province [443] 0 0
Monterrey
Country [444] 0 0
Mexico
State/province [444] 0 0
San Luis Potosi
Country [445] 0 0
Mexico
State/province [445] 0 0
Yucatan
Country [446] 0 0
Netherlands
State/province [446] 0 0
Almere
Country [447] 0 0
Netherlands
State/province [447] 0 0
Amstelveen
Country [448] 0 0
Netherlands
State/province [448] 0 0
Amsterdam
Country [449] 0 0
Netherlands
State/province [449] 0 0
Dordrecht
Country [450] 0 0
Netherlands
State/province [450] 0 0
Eindhoven
Country [451] 0 0
Netherlands
State/province [451] 0 0
Ewijk
Country [452] 0 0
Netherlands
State/province [452] 0 0
Leiderdorp
Country [453] 0 0
Netherlands
State/province [453] 0 0
Maastricht
Country [454] 0 0
Netherlands
State/province [454] 0 0
Rotterdam
Country [455] 0 0
Netherlands
State/province [455] 0 0
Venlo
Country [456] 0 0
Netherlands
State/province [456] 0 0
Wildervlank
Country [457] 0 0
New Zealand
State/province [457] 0 0
Wellington
Country [458] 0 0
New Zealand
State/province [458] 0 0
Auckland
Country [459] 0 0
New Zealand
State/province [459] 0 0
Christchurch
Country [460] 0 0
New Zealand
State/province [460] 0 0
Dunedin
Country [461] 0 0
New Zealand
State/province [461] 0 0
Hamilton
Country [462] 0 0
New Zealand
State/province [462] 0 0
Nelson
Country [463] 0 0
New Zealand
State/province [463] 0 0
Tauranga
Country [464] 0 0
Norway
State/province [464] 0 0
Bodo
Country [465] 0 0
Norway
State/province [465] 0 0
Harstad
Country [466] 0 0
Norway
State/province [466] 0 0
Haugesund
Country [467] 0 0
Norway
State/province [467] 0 0
Oslo
Country [468] 0 0
Norway
State/province [468] 0 0
Rud
Country [469] 0 0
Peru
State/province [469] 0 0
Arequipa
Country [470] 0 0
Peru
State/province [470] 0 0
Callao
Country [471] 0 0
Peru
State/province [471] 0 0
Lima
Country [472] 0 0
Philippines
State/province [472] 0 0
Cebu City
Country [473] 0 0
Philippines
State/province [473] 0 0
Cebu
Country [474] 0 0
Philippines
State/province [474] 0 0
Davao City
Country [475] 0 0
Philippines
State/province [475] 0 0
Pasig City
Country [476] 0 0
Philippines
State/province [476] 0 0
Quezon City
Country [477] 0 0
Poland
State/province [477] 0 0
Mazowiecka
Country [478] 0 0
Poland
State/province [478] 0 0
Bydgoszcz
Country [479] 0 0
Poland
State/province [479] 0 0
Chojnice
Country [480] 0 0
Poland
State/province [480] 0 0
Elblag
Country [481] 0 0
Poland
State/province [481] 0 0
Elk
Country [482] 0 0
Poland
State/province [482] 0 0
Gdansk
Country [483] 0 0
Poland
State/province [483] 0 0
Inowroclaw
Country [484] 0 0
Poland
State/province [484] 0 0
Jaroslaw
Country [485] 0 0
Poland
State/province [485] 0 0
Katowice
Country [486] 0 0
Poland
State/province [486] 0 0
Kolobrzeg
Country [487] 0 0
Poland
State/province [487] 0 0
Komenskiego
Country [488] 0 0
Poland
State/province [488] 0 0
Krakow
Country [489] 0 0
Poland
State/province [489] 0 0
Kutno
Country [490] 0 0
Poland
State/province [490] 0 0
Libiaz
Country [491] 0 0
Poland
State/province [491] 0 0
Lodz
Country [492] 0 0
Poland
State/province [492] 0 0
Lubartow
Country [493] 0 0
Poland
State/province [493] 0 0
Lublin
Country [494] 0 0
Poland
State/province [494] 0 0
Plock
Country [495] 0 0
Poland
State/province [495] 0 0
Pomorskie
Country [496] 0 0
Poland
State/province [496] 0 0
Pulawy
Country [497] 0 0
Poland
State/province [497] 0 0
Ruda Slaska
Country [498] 0 0
Poland
State/province [498] 0 0
Rzeszow
Country [499] 0 0
Poland
State/province [499] 0 0
Skierniewice
Country [500] 0 0
Poland
State/province [500] 0 0
Sopot
Country [501] 0 0
Poland
State/province [501] 0 0
Sucharskiego
Country [502] 0 0
Poland
State/province [502] 0 0
Szczecin
Country [503] 0 0
Poland
State/province [503] 0 0
Tarnow
Country [504] 0 0
Poland
State/province [504] 0 0
Torun
Country [505] 0 0
Poland
State/province [505] 0 0
Warszawa
Country [506] 0 0
Poland
State/province [506] 0 0
Warzawa
Country [507] 0 0
Poland
State/province [507] 0 0
Wroclaw
Country [508] 0 0
Portugal
State/province [508] 0 0
Amadora
Country [509] 0 0
Portugal
State/province [509] 0 0
Aveiro
Country [510] 0 0
Portugal
State/province [510] 0 0
Braga
Country [511] 0 0
Portugal
State/province [511] 0 0
Coimbra
Country [512] 0 0
Portugal
State/province [512] 0 0
Leiria
Country [513] 0 0
Portugal
State/province [513] 0 0
Lisboa
Country [514] 0 0
Portugal
State/province [514] 0 0
Lisbon
Country [515] 0 0
Portugal
State/province [515] 0 0
Ponta Delgada
Country [516] 0 0
Portugal
State/province [516] 0 0
Setubal
Country [517] 0 0
Portugal
State/province [517] 0 0
Viseu
Country [518] 0 0
Romania
State/province [518] 0 0
Bacau
Country [519] 0 0
Romania
State/province [519] 0 0
Braila
Country [520] 0 0
Romania
State/province [520] 0 0
Brasov
Country [521] 0 0
Romania
State/province [521] 0 0
Buccuresti
Country [522] 0 0
Romania
State/province [522] 0 0
Bucuresti
Country [523] 0 0
Romania
State/province [523] 0 0
Buzau
Country [524] 0 0
Romania
State/province [524] 0 0
Covasna
Country [525] 0 0
Romania
State/province [525] 0 0
Dambovita
Country [526] 0 0
Romania
State/province [526] 0 0
Iasi
Country [527] 0 0
Romania
State/province [527] 0 0
Judetul Maramures
Country [528] 0 0
Romania
State/province [528] 0 0
Judetul Mures
Country [529] 0 0
Romania
State/province [529] 0 0
Judetul Suceava
Country [530] 0 0
Romania
State/province [530] 0 0
Judetul Vrancea
Country [531] 0 0
Romania
State/province [531] 0 0
Oradea
Country [532] 0 0
Romania
State/province [532] 0 0
Timisoara
Country [533] 0 0
Russian Federation
State/province [533] 0 0
Barnaul
Country [534] 0 0
Russian Federation
State/province [534] 0 0
Chelyabinsk
Country [535] 0 0
Russian Federation
State/province [535] 0 0
Kemerovo
Country [536] 0 0
Russian Federation
State/province [536] 0 0
Krasnoyarsk
Country [537] 0 0
Russian Federation
State/province [537] 0 0
Moscow
Country [538] 0 0
Russian Federation
State/province [538] 0 0
Nizhny Novgorod
Country [539] 0 0
Russian Federation
State/province [539] 0 0
Novosibirsk
Country [540] 0 0
Russian Federation
State/province [540] 0 0
Omsk
Country [541] 0 0
Russian Federation
State/province [541] 0 0
Orenburg
Country [542] 0 0
Russian Federation
State/province [542] 0 0
Perm
Country [543] 0 0
Russian Federation
State/province [543] 0 0
Ryazan
Country [544] 0 0
Russian Federation
State/province [544] 0 0
Saratov
Country [545] 0 0
Russian Federation
State/province [545] 0 0
Smolensk
Country [546] 0 0
Russian Federation
State/province [546] 0 0
St-Petersburg
Country [547] 0 0
Russian Federation
State/province [547] 0 0
St. Petersburg
Country [548] 0 0
Russian Federation
State/province [548] 0 0
Tula
Country [549] 0 0
Russian Federation
State/province [549] 0 0
Tyumen
Country [550] 0 0
Russian Federation
State/province [550] 0 0
Volgograd
Country [551] 0 0
Russian Federation
State/province [551] 0 0
Voronezh
Country [552] 0 0
Russian Federation
State/province [552] 0 0
Yaroslavl
Country [553] 0 0
Serbia
State/province [553] 0 0
Belgrade
Country [554] 0 0
Serbia
State/province [554] 0 0
Niska Banja
Country [555] 0 0
Serbia
State/province [555] 0 0
Nis
Country [556] 0 0
Serbia
State/province [556] 0 0
Sremska Kamenica
Country [557] 0 0
Serbia
State/province [557] 0 0
Zemun
Country [558] 0 0
Serbia
State/province [558] 0 0
Zmaj Jovina
Country [559] 0 0
Slovakia
State/province [559] 0 0
Bardejov
Country [560] 0 0
Slovakia
State/province [560] 0 0
Bratislava
Country [561] 0 0
Slovakia
State/province [561] 0 0
Dolny Kubin
Country [562] 0 0
Slovakia
State/province [562] 0 0
Galanta
Country [563] 0 0
Slovakia
State/province [563] 0 0
Kosice
Country [564] 0 0
Slovakia
State/province [564] 0 0
Levice
Country [565] 0 0
Slovakia
State/province [565] 0 0
Lucenec
Country [566] 0 0
Slovakia
State/province [566] 0 0
Nitra
Country [567] 0 0
Slovakia
State/province [567] 0 0
Nove Zamky
Country [568] 0 0
Slovakia
State/province [568] 0 0
Presov
Country [569] 0 0
Slovakia
State/province [569] 0 0
Rimavska Sobota
Country [570] 0 0
South Africa
State/province [570] 0 0
Alberton
Country [571] 0 0
South Africa
State/province [571] 0 0
Benoni
Country [572] 0 0
South Africa
State/province [572] 0 0
Bloemfontein
Country [573] 0 0
South Africa
State/province [573] 0 0
Cape Town
Country [574] 0 0
South Africa
State/province [574] 0 0
Diepkloof
Country [575] 0 0
South Africa
State/province [575] 0 0
Durban
Country [576] 0 0
South Africa
State/province [576] 0 0
Lyttelton
Country [577] 0 0
South Africa
State/province [577] 0 0
Parktown West
Country [578] 0 0
South Africa
State/province [578] 0 0
Port Elizabeth
Country [579] 0 0
South Africa
State/province [579] 0 0
Potchefstroom
Country [580] 0 0
South Africa
State/province [580] 0 0
Pretoria
Country [581] 0 0
South Africa
State/province [581] 0 0
Somerset West
Country [582] 0 0
South Africa
State/province [582] 0 0
Worcester
Country [583] 0 0
Spain
State/province [583] 0 0
Alcoy
Country [584] 0 0
Spain
State/province [584] 0 0
Almeria
Country [585] 0 0
Spain
State/province [585] 0 0
Barcelona
Country [586] 0 0
Spain
State/province [586] 0 0
Bilbao
Country [587] 0 0
Spain
State/province [587] 0 0
De La Castellana
Country [588] 0 0
Spain
State/province [588] 0 0
Donostia-San Sebastian
Country [589] 0 0
Spain
State/province [589] 0 0
Figueras
Country [590] 0 0
Spain
State/province [590] 0 0
Jaen
Country [591] 0 0
Spain
State/province [591] 0 0
La Coruna
Country [592] 0 0
Spain
State/province [592] 0 0
Lleida
Country [593] 0 0
Spain
State/province [593] 0 0
Madrid
Country [594] 0 0
Spain
State/province [594] 0 0
Murcia
Country [595] 0 0
Spain
State/province [595] 0 0
Santiago De Compostela
Country [596] 0 0
Spain
State/province [596] 0 0
Sevilla
Country [597] 0 0
Spain
State/province [597] 0 0
Vigo
Country [598] 0 0
Spain
State/province [598] 0 0
Vitoria
Country [599] 0 0
Sweden
State/province [599] 0 0
Alingsas
Country [600] 0 0
Sweden
State/province [600] 0 0
Enkoping
Country [601] 0 0
Sweden
State/province [601] 0 0
Goteborg
Country [602] 0 0
Sweden
State/province [602] 0 0
Halmstad
Country [603] 0 0
Sweden
State/province [603] 0 0
Karlshamn
Country [604] 0 0
Sweden
State/province [604] 0 0
Koping
Country [605] 0 0
Sweden
State/province [605] 0 0
Lindesberg
Country [606] 0 0
Sweden
State/province [606] 0 0
Lulea
Country [607] 0 0
Sweden
State/province [607] 0 0
Lund
Country [608] 0 0
Sweden
State/province [608] 0 0
Malmo
Country [609] 0 0
Sweden
State/province [609] 0 0
Molndal
Country [610] 0 0
Sweden
State/province [610] 0 0
Mora
Country [611] 0 0
Sweden
State/province [611] 0 0
Orebro
Country [612] 0 0
Sweden
State/province [612] 0 0
Skene
Country [613] 0 0
Sweden
State/province [613] 0 0
Umea
Country [614] 0 0
Sweden
State/province [614] 0 0
Uppsala
Country [615] 0 0
Sweden
State/province [615] 0 0
Varberg
Country [616] 0 0
Switzerland
State/province [616] 0 0
Lausanne
Country [617] 0 0
Switzerland
State/province [617] 0 0
Lugano
Country [618] 0 0
Taiwan
State/province [618] 0 0
Changhua City
Country [619] 0 0
Taiwan
State/province [619] 0 0
Hualien City
Country [620] 0 0
Taiwan
State/province [620] 0 0
Kaohsiung City
Country [621] 0 0
Taiwan
State/province [621] 0 0
Taichung City
Country [622] 0 0
Taiwan
State/province [622] 0 0
Taipei City
Country [623] 0 0
Taiwan
State/province [623] 0 0
Taipei
Country [624] 0 0
Taiwan
State/province [624] 0 0
Taoyuan County
Country [625] 0 0
Taiwan
State/province [625] 0 0
Yongkang City
Country [626] 0 0
Thailand
State/province [626] 0 0
Bangkok
Country [627] 0 0
Thailand
State/province [627] 0 0
Chang Mai
Country [628] 0 0
Thailand
State/province [628] 0 0
Khon Kaen
Country [629] 0 0
Thailand
State/province [629] 0 0
Nakhon Ratchasima
Country [630] 0 0
Thailand
State/province [630] 0 0
Pathumthani
Country [631] 0 0
Thailand
State/province [631] 0 0
Sai Mai
Country [632] 0 0
Thailand
State/province [632] 0 0
Songkhla
Country [633] 0 0
Turkey
State/province [633] 0 0
Adana
Country [634] 0 0
Turkey
State/province [634] 0 0
Ankara
Country [635] 0 0
Turkey
State/province [635] 0 0
Antalya
Country [636] 0 0
Turkey
State/province [636] 0 0
Aydin
Country [637] 0 0
Turkey
State/province [637] 0 0
Erzurum
Country [638] 0 0
Turkey
State/province [638] 0 0
Eskisehir
Country [639] 0 0
Turkey
State/province [639] 0 0
Isparta
Country [640] 0 0
Turkey
State/province [640] 0 0
Istanbul
Country [641] 0 0
Turkey
State/province [641] 0 0
Izmir
Country [642] 0 0
Turkey
State/province [642] 0 0
Konya
Country [643] 0 0
Turkey
State/province [643] 0 0
Sivas
Country [644] 0 0
Ukraine
State/province [644] 0 0
Cherkasy
Country [645] 0 0
Ukraine
State/province [645] 0 0
Chernigiv
Country [646] 0 0
Ukraine
State/province [646] 0 0
Dnipropetrovsk
Country [647] 0 0
Ukraine
State/province [647] 0 0
Donetsk
Country [648] 0 0
Ukraine
State/province [648] 0 0
Ivano-Frankivsh
Country [649] 0 0
Ukraine
State/province [649] 0 0
Ivano-Frankivsk
Country [650] 0 0
Ukraine
State/province [650] 0 0
Kharkiv
Country [651] 0 0
Ukraine
State/province [651] 0 0
Kherson
Country [652] 0 0
Ukraine
State/province [652] 0 0
Kyiv
Country [653] 0 0
Ukraine
State/province [653] 0 0
Lugansk
Country [654] 0 0
Ukraine
State/province [654] 0 0
Lutsk
Country [655] 0 0
Ukraine
State/province [655] 0 0
Lviv
Country [656] 0 0
Ukraine
State/province [656] 0 0
Mykolayiv
Country [657] 0 0
Ukraine
State/province [657] 0 0
Odesa
Country [658] 0 0
Ukraine
State/province [658] 0 0
Poltava
Country [659] 0 0
Ukraine
State/province [659] 0 0
Uzhgorod
Country [660] 0 0
Ukraine
State/province [660] 0 0
Vinnytsya
Country [661] 0 0
Ukraine
State/province [661] 0 0
Zaporizhzhya
Country [662] 0 0
United Kingdom
State/province [662] 0 0
Birmingham
Country [663] 0 0
United Kingdom
State/province [663] 0 0
Blackpool
Country [664] 0 0
United Kingdom
State/province [664] 0 0
Bournemouth
Country [665] 0 0
United Kingdom
State/province [665] 0 0
Bradford
Country [666] 0 0
United Kingdom
State/province [666] 0 0
Cambridge
Country [667] 0 0
United Kingdom
State/province [667] 0 0
Chesterfield
Country [668] 0 0
United Kingdom
State/province [668] 0 0
Coventry
Country [669] 0 0
United Kingdom
State/province [669] 0 0
Devon
Country [670] 0 0
United Kingdom
State/province [670] 0 0
Dundee
Country [671] 0 0
United Kingdom
State/province [671] 0 0
East Horsley
Country [672] 0 0
United Kingdom
State/province [672] 0 0
East Sussex
Country [673] 0 0
United Kingdom
State/province [673] 0 0
Edinburgh
Country [674] 0 0
United Kingdom
State/province [674] 0 0
Essex
Country [675] 0 0
United Kingdom
State/province [675] 0 0
Glasgow
Country [676] 0 0
United Kingdom
State/province [676] 0 0
Harrow
Country [677] 0 0
United Kingdom
State/province [677] 0 0
Leicester
Country [678] 0 0
United Kingdom
State/province [678] 0 0
Liverpool
Country [679] 0 0
United Kingdom
State/province [679] 0 0
London
Country [680] 0 0
United Kingdom
State/province [680] 0 0
Middlesbrough
Country [681] 0 0
United Kingdom
State/province [681] 0 0
Orpington
Country [682] 0 0
United Kingdom
State/province [682] 0 0
Peterborough
Country [683] 0 0
United Kingdom
State/province [683] 0 0
Portadown
Country [684] 0 0
United Kingdom
State/province [684] 0 0
Sheffield
Country [685] 0 0
United Kingdom
State/province [685] 0 0
Stirling
Country [686] 0 0
United Kingdom
State/province [686] 0 0
Stockport
Country [687] 0 0
United Kingdom
State/province [687] 0 0
Surrey
Country [688] 0 0
United Kingdom
State/province [688] 0 0
Sutton Coldfield
Country [689] 0 0
United Kingdom
State/province [689] 0 0
Swindon
Country [690] 0 0
United Kingdom
State/province [690] 0 0
Warwickshire
Country [691] 0 0
United Kingdom
State/province [691] 0 0
Wolverhampton
Country [692] 0 0
United Kingdom
State/province [692] 0 0
York

Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Name
Daiichi Sankyo
Address
Country
Other collaborator category [1] 0 0
Other
Name [1] 0 0
The TIMI Study Group
Address [1] 0 0
Country [1] 0 0

Ethics approval
Ethics application status

Summary
Brief summary
This study is to demonstrate the safety and efficacy profile, in two different dose regimens
of Edoxaban (DU-176b), (an investigational new drug being tested for the prevention of
stroke/systemic embolic events (SEE)), in individuals with atrial fibrillation. Patients will
be randomized to one of three treatment groups: High Dose Regimen, Low Dose Regimen, &
Warfarin. The expected duration of the study is 24 months.
Trial website
https://clinicaltrials.gov/ct2/show/NCT00781391
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries



Summary Results

For IPD and results data, please see https://clinicaltrials.gov/ct2/show/NCT00781391