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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT00831441
Registration number
NCT00831441
Ethics application status
Date submitted
28/01/2009
Date registered
29/01/2009
Date last updated
27/01/2016
Titles & IDs
Public title
Phase III Acute Coronary Syndrome
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Scientific title
Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects With a Recent Acute Coronary Syndrome
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Secondary ID [1]
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EUDRACT# 2008-008298-77
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Secondary ID [2]
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CV185-068
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Universal Trial Number (UTN)
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Trial acronym
APPRAISE-2
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome
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Condition category
Condition code
Cardiovascular
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Coronary heart disease
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Other
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Research that is not of generic health relevance and not applicable to specific health categories listed above
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Apixaban
Treatment: Drugs - Placebo
Active Comparator: Apixaban -
Placebo Comparator: Placebo -
Treatment: Drugs: Apixaban
Tablets, Oral, 5 mg, twice daily, until study end
Treatment: Drugs: Placebo
Tablets, Oral, 0 mg, twice daily, until study end
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Event Rate of Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
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Assessment method [1]
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Event rate was percent of participants with an event of cardiovascular (CV) death, myocardial infarction (MI), or ischemic stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Study was terminated early and last patient, last visit was in Year 2. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes (eg, cardiogenic shock, heart failure, arrhythmia/sudden death, cardiac rupture, ischemic stroke, pulmonary embolism, venous/arterial thrombotic events) and other sudden deaths for which an alternative cause was not identified. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).
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Timepoint [1]
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Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years
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Primary outcome [2]
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Event Rate of Confirmed Major Bleeding Using Thrombolysis in Myocardial Infarction (TIMI) Criteria During the Treatment Period - Treated Participants
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Assessment method [2]
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TIMI Major Bleed Criteria: Fatal bleeding, intracranial hemorrhage, and clinically overt bleeding with a hemoglobin (Hgb) drop of = 5 grams per deciliter (g/dL), or =15% absolute decrease in hematocrit. To account for transfusions, Hgb measurements were adjusted for transfusions. A transfusion of 1 unit of blood was assumed to result in an increase by 1 g/dL in Hgb or 3% in hematocrit. Event rate was percent of participants with an event of Major Bleed as per TIMI (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Treatment Period=events with onset from first dose to last dose plus 2 days.
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Timepoint [2]
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From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
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Secondary outcome [1]
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Event Rate of Unstable Angina (UA) During the Intended Treatment Period - Randomized Participants
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Assessment method [1]
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Unstable Angina (UA) defined as worsening or recurrent severe or repetitive angina symptoms at rest lasting at least 10 minutes with at least 2 of the following: New and dynamic electrocardiogram (ECG) changes; angina symptoms leading to inpatient hospitalization; angina symptoms leading to an unplanned or urgent cardiac catheterization, with or without revascularization, that showed evidence of hemodynamically and clinically significant stenosis. Event rate was percent of participants with an event of unstable angina (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).
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Timepoint [1]
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Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years
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Secondary outcome [2]
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Event Rate of Stroke During the Intended Treatment Period - Randomized Participants
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Assessment method [2]
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Event rate was percent of participants with an event of stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause (ie, brain tumor). All strokes were classified as hemorrhagic (documentation on imaging (eg computed tomography scan or magnetic resonance imaging) of hemorrhage in the cerebral parenchyma, or a subdural or subarachnoid hemorrhage), non-hemorrhagic/ischemic stroke, ischemic stroke with hemorrhagic conversion, or type unknown. Intended Treatment Period: the period that started on the day of randomization (Day 1) and ended at the efficacy cut-off date (notification of study termination).
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Timepoint [2]
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Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years
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Secondary outcome [3]
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Event Rate of Myocardial Infarction (MI) During the Intended Treatment Period - Randomized Participants
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Assessment method [3]
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MI took into account whether the participant had a recent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Selected key criteria: Elevation of cardiac biomarkers (eg, Creatine Kinase MB fraction (CKMB), Troponin T, Troponin I) above the upper reference limit (URL) plus ischemic symptoms, ECG changes, or imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Death of CV etiology with new ST-segment elevation or left bundle branch block (LBBB) or fresh intracoronary thrombus by angiography or at autopsy occurring before biomarkers could be obtained or before their appearance in the blood; Following a PCI, elevation of cardiac biomarkers more than 3*URL; Following CABG surgery, elevation of cardiac biomarkers more than 5*URL; New, significant (=0.04 s) Q waves in =2 contiguous leads; Pathologic findings of acute MI. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice.
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Timepoint [3]
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Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years
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Secondary outcome [4]
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Event Rate of Stent Thrombosis During the Intended Treatment Period - Randomized Participants
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Assessment method [4]
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Stent thrombosis: Definite stent thrombosis considered to have occurred by either angiographic or pathological confirmation; Probable stent thrombosis considered to have occurred in the following cases: any unexplained death within the first 30 days after stent implantation; irrespective of the time after the procedure, any MI that was related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation of stent thrombosis and in the absence of any other obvious cause; Possible stent thrombosis considered to have occurred with any unexplained death from 30 days after intracoronary stenting until end of study (in Year 2). Event rate was percent of participants with an event of stent thrombosis (number with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice of study termination.
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Timepoint [4]
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Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years
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Secondary outcome [5]
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Event Rate of Composite of Cardiovascular Death, Myocardial Infarction, Unstable Angina, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
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Assessment method [5]
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Event rate was percent of participants with an event of CV death, MI, unstable angina (UA), or ischemic stroke (number of participants with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Each type of event was counted once per participant, but participants could have been counted in multiple categories. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
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Timepoint [5]
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Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years
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Secondary outcome [6]
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Event Rate of Composite of Cardiovascular Death, Fatal Bleed, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants
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Assessment method [6]
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Event rate was percent of participants with an event of CV death, fatal bleed, MI, or stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes; Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause; Fatal bleeding defined as bleeding that Adjudication Committee determined was the primary cause of death or contributed directly to death; MI took into account whether the participant had a recent PCI or CABG surgery. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
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Timepoint [6]
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Randomization (Day 1) to first event (CV death, Fatal Bleed, MI, or stroke), up to March 2011, approximately 2 years
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Secondary outcome [7]
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Event Rate of Composite of All-Cause Death, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants
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Assessment method [7]
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Cause of death was determined by the principal condition that caused the death, not the immediate mode of death.
CV death: included deaths due to CV causes. Non-CV death: included non-CV deaths caused primarily by a malignancy, infection, bleeding, trauma, non-CV system organ failure, or non-CV surgery. Unknown: included deaths that were not attributable to one of the above categories of CV death or to a non-CV cause. MI accounted whether the participant had a recent PCI or CABG surgery. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause. Only events confirmed by the adjudication committee were included in analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
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Timepoint [7]
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Randomization (Day 1) to first event (All Cause Death, MI, or Stroke), up to March 2011, approximately 2 years
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Secondary outcome [8]
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Event Rate of Confirmed Major Bleeding Using International Society on Thrombosis and Hemostasis (ISTH) Criteria During the Treatment Period - Treated Participants
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Assessment method [8]
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ISTH Criteria: Acute clinically overt bleeding defined as new onset, visible bleeding or signs or symptoms suggestive of bleeding confirmed by imaging techniques, which can detect the presence of blood (eg, ultrasound, CT, MRI). Major bleeding: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed red blood cells (RBCs); Bleeding that occurs in at least one of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; thus, a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. Bleeding events were adjudicated by the Adjudication Committee. Event rate was percent of participants with an event (number with event/number randomized) per 100-pt years. Treatment Period=events with onset from first dose to last dose plus 2 days.
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Timepoint [8]
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From first dose to first occurrence of event (ISTH major bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
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Secondary outcome [9]
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Event Rate of Confirmed Major Bleeding or Clinically Relevant Non-Major Bleeding (CRNM) Using ISTH Criteria During the Treatment Period - Treated Participants
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Assessment method [9]
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ISTH Major bleed: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed RBCs; Bleeding that occurs in at least one of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. CRNM: acute clinically overt bleeding that did not satisfy additional criteria required for the bleeding event to be defined as a major bleeding event and meets at least one of the following: Hospital admission for bleeding; Physician guided medical or surgical treatment for bleeding; Change in anti-thrombotic treatment (anticoagulant or antiplatelet) therapy. Bleeding events were adjudicated by the Adjudication Committee. Treatment Period=events with onset from first dose to last dose plus 2 days.
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Timepoint [9]
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From first dose to first occurrence of event (ISTH major or CRNM bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
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Secondary outcome [10]
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Event Rate of All Bleeding Reported by the Investigator During the Treatment Period - Treated Participants
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Assessment method [10]
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Bleeding events were adjudicated by the Adjudication Committee and classified according to Thrombolysis in Myocardial Infarction (TIMI) major, minor, minimal, and International Society on Thrombosis and Hemostasis (ISTH) major and clinically relevant non-major bleeding (CRNM) criteria. The adjudicated results based on TIMI and ISTH classifications, and programmatically identified events (not adjudicated) according to Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) classification were used in the analyses of bleeding endpoints. GUSTO Bleed Criteria included Severe or life-threatening: Intracranial hemorrhage, or bleeding that causes hemodynamic compromise requiring intervention; Moderate: Bleeding that requires a blood transfusion, but does not result in hemodynamic compromise; Mild: Bleeding that does not meet criteria for either severe or moderate bleeding. Treatment Period=events with onset from first dose to last dose plus 2 days.
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Timepoint [10]
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From first dose to first occurrence of event (Bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
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Eligibility
Key inclusion criteria
- Acute coronary syndrome (ACS)
- Clinically stable
- Receiving standard of care for ACS
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
- Severe hypertension
- Active bleeding or high risk for major bleeding
- Hemoglobin < 9 g/dL
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Study design
Purpose of the study
Prevention
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Terminated
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/03/2009
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/03/2011
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Sample size
Target
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Accrual to date
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Final
7484
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,VIC
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Recruitment hospital [1]
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Local Institution - Bruce
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Local Institution - Broken Hill
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Local Institution - Kogarah
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Local Institution - Lismore
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Local Institution - Milton
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Local Institution - Richmond
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Recruitment postcode(s) [1]
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2617 - Bruce
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2880 - Broken Hill
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2217 - Kogarah
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2480 - Lismore
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4870 - Cairns
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4031 - Herston
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Recruitment postcode(s) [7]
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4064 - Milton
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5035 - Ashford
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Recruitment postcode(s) [9]
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5112 - Elizabeth Vale
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5011 - Woodville
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3065 - Fitzroy
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3220 - Geelong
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Recruitment postcode(s) [13]
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3121 - Richmond
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Recruitment outside Australia
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Alabama
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Delaware
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Buenos Aires
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Cordoba
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Corrientes
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Austria
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Feldkirch
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Graz
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Linz
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Oberpullendorf
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Antwerpen
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Belgium
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Brasschaat
Query!
Country [62]
0
0
Belgium
Query!
State/province [62]
0
0
Brugge
Query!
Country [63]
0
0
Belgium
Query!
State/province [63]
0
0
Gent
Query!
Country [64]
0
0
Belgium
Query!
State/province [64]
0
0
Huy
Query!
Country [65]
0
0
Belgium
Query!
State/province [65]
0
0
Ieper
Query!
Country [66]
0
0
Belgium
Query!
State/province [66]
0
0
Mechelen
Query!
Country [67]
0
0
Belgium
Query!
State/province [67]
0
0
Mol
Query!
Country [68]
0
0
Belgium
Query!
State/province [68]
0
0
Yvoir
Query!
Country [69]
0
0
Brazil
Query!
State/province [69]
0
0
Alagoas
Query!
Country [70]
0
0
Brazil
Query!
State/province [70]
0
0
Bahia
Query!
Country [71]
0
0
Brazil
Query!
State/province [71]
0
0
Ceara
Query!
Country [72]
0
0
Brazil
Query!
State/province [72]
0
0
Distrito Federal
Query!
Country [73]
0
0
Brazil
Query!
State/province [73]
0
0
Goias
Query!
Country [74]
0
0
Brazil
Query!
State/province [74]
0
0
Mato Grosso
Query!
Country [75]
0
0
Brazil
Query!
State/province [75]
0
0
Minas Gerais
Query!
Country [76]
0
0
Brazil
Query!
State/province [76]
0
0
Parana
Query!
Country [77]
0
0
Brazil
Query!
State/province [77]
0
0
Para
Query!
Country [78]
0
0
Brazil
Query!
State/province [78]
0
0
Pernambuco
Query!
Country [79]
0
0
Brazil
Query!
State/province [79]
0
0
Rio De Janeiro
Query!
Country [80]
0
0
Brazil
Query!
State/province [80]
0
0
Rio Grande Do Norte
Query!
Country [81]
0
0
Brazil
Query!
State/province [81]
0
0
Rio Grande Do Sul
Query!
Country [82]
0
0
Brazil
Query!
State/province [82]
0
0
Santa Catarina
Query!
Country [83]
0
0
Brazil
Query!
State/province [83]
0
0
Sao Paulo
Query!
Country [84]
0
0
Bulgaria
Query!
State/province [84]
0
0
Burgas
Query!
Country [85]
0
0
Bulgaria
Query!
State/province [85]
0
0
Dimitrovgrad
Query!
Country [86]
0
0
Bulgaria
Query!
State/province [86]
0
0
Pazardzhik
Query!
Country [87]
0
0
Bulgaria
Query!
State/province [87]
0
0
Pleven
Query!
Country [88]
0
0
Bulgaria
Query!
State/province [88]
0
0
Plovdiv
Query!
Country [89]
0
0
Bulgaria
Query!
State/province [89]
0
0
Sofia
Query!
Country [90]
0
0
Bulgaria
Query!
State/province [90]
0
0
Stara Zagora
Query!
Country [91]
0
0
Bulgaria
Query!
State/province [91]
0
0
Varna
Query!
Country [92]
0
0
Canada
Query!
State/province [92]
0
0
Alberta
Query!
Country [93]
0
0
Canada
Query!
State/province [93]
0
0
British Columbia
Query!
Country [94]
0
0
Canada
Query!
State/province [94]
0
0
Manitoba
Query!
Country [95]
0
0
Canada
Query!
State/province [95]
0
0
Newfoundland and Labrador
Query!
Country [96]
0
0
Canada
Query!
State/province [96]
0
0
Nova Scotia
Query!
Country [97]
0
0
Canada
Query!
State/province [97]
0
0
Ontario
Query!
Country [98]
0
0
Canada
Query!
State/province [98]
0
0
Quebec
Query!
Country [99]
0
0
Chile
Query!
State/province [99]
0
0
Araucania
Query!
Country [100]
0
0
Chile
Query!
State/province [100]
0
0
Biobio
Query!
Country [101]
0
0
Chile
Query!
State/province [101]
0
0
Los Lagos
Query!
Country [102]
0
0
Chile
Query!
State/province [102]
0
0
Magallanes Antartica
Query!
Country [103]
0
0
Chile
Query!
State/province [103]
0
0
Metropolitana
Query!
Country [104]
0
0
Chile
Query!
State/province [104]
0
0
Valparaiso
Query!
Country [105]
0
0
Chile
Query!
State/province [105]
0
0
Puerto Montt
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Beijing
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Chongqing
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Gansu
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Guangdong
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Guangxi
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Hebei
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Heilongjiang
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Hubei
Query!
Country [114]
0
0
China
Query!
State/province [114]
0
0
Hunan
Query!
Country [115]
0
0
China
Query!
State/province [115]
0
0
Jiangsu
Query!
Country [116]
0
0
China
Query!
State/province [116]
0
0
Jiangxi
Query!
Country [117]
0
0
China
Query!
State/province [117]
0
0
Jilin
Query!
Country [118]
0
0
China
Query!
State/province [118]
0
0
Liaoning
Query!
Country [119]
0
0
China
Query!
State/province [119]
0
0
Shandong
Query!
Country [120]
0
0
China
Query!
State/province [120]
0
0
Shanghai
Query!
Country [121]
0
0
China
Query!
State/province [121]
0
0
Sichuan
Query!
Country [122]
0
0
China
Query!
State/province [122]
0
0
Yunnan
Query!
Country [123]
0
0
China
Query!
State/province [123]
0
0
Zhejiang
Query!
Country [124]
0
0
China
Query!
State/province [124]
0
0
Xian
Query!
Country [125]
0
0
Colombia
Query!
State/province [125]
0
0
Bolivar
Query!
Country [126]
0
0
Colombia
Query!
State/province [126]
0
0
Cundinamaral
Query!
Country [127]
0
0
Colombia
Query!
State/province [127]
0
0
Valle
Query!
Country [128]
0
0
Colombia
Query!
State/province [128]
0
0
Barranquilla
Query!
Country [129]
0
0
Colombia
Query!
State/province [129]
0
0
Bogota
Query!
Country [130]
0
0
Colombia
Query!
State/province [130]
0
0
Floridablanca
Query!
Country [131]
0
0
Colombia
Query!
State/province [131]
0
0
Manizales
Query!
Country [132]
0
0
Colombia
Query!
State/province [132]
0
0
Medelin
Query!
Country [133]
0
0
Colombia
Query!
State/province [133]
0
0
Medellin
Query!
Country [134]
0
0
Czech Republic
Query!
State/province [134]
0
0
Brno
Query!
Country [135]
0
0
Czech Republic
Query!
State/province [135]
0
0
Hradec Kralove
Query!
Country [136]
0
0
Czech Republic
Query!
State/province [136]
0
0
Liberec
Query!
Country [137]
0
0
Czech Republic
Query!
State/province [137]
0
0
Novy Jicin
Query!
Country [138]
0
0
Czech Republic
Query!
State/province [138]
0
0
Olomouc
Query!
Country [139]
0
0
Czech Republic
Query!
State/province [139]
0
0
Ostrava
Query!
Country [140]
0
0
Czech Republic
Query!
State/province [140]
0
0
Praha 10
Query!
Country [141]
0
0
Czech Republic
Query!
State/province [141]
0
0
Rakovnik
Query!
Country [142]
0
0
Czech Republic
Query!
State/province [142]
0
0
Usti Nad Orlici
Query!
Country [143]
0
0
Denmark
Query!
State/province [143]
0
0
Arhus C
Query!
Country [144]
0
0
Denmark
Query!
State/province [144]
0
0
Copenhagen
Query!
Country [145]
0
0
Denmark
Query!
State/province [145]
0
0
Esbjerg
Query!
Country [146]
0
0
Denmark
Query!
State/province [146]
0
0
Haderslev
Query!
Country [147]
0
0
Denmark
Query!
State/province [147]
0
0
Hellerup
Query!
Country [148]
0
0
Denmark
Query!
State/province [148]
0
0
Hillerod
Query!
Country [149]
0
0
Denmark
Query!
State/province [149]
0
0
Hvidovre
Query!
Country [150]
0
0
Denmark
Query!
State/province [150]
0
0
Naestved
Query!
Country [151]
0
0
Denmark
Query!
State/province [151]
0
0
Silkeborg
Query!
Country [152]
0
0
Denmark
Query!
State/province [152]
0
0
Slagelse
Query!
Country [153]
0
0
Finland
Query!
State/province [153]
0
0
Espoo
Query!
Country [154]
0
0
Finland
Query!
State/province [154]
0
0
Helsinki
Query!
Country [155]
0
0
Finland
Query!
State/province [155]
0
0
Rovaniemi
Query!
Country [156]
0
0
Finland
Query!
State/province [156]
0
0
Tampere
Query!
Country [157]
0
0
France
Query!
State/province [157]
0
0
Albi Cedex 09
Query!
Country [158]
0
0
France
Query!
State/province [158]
0
0
Amiens Cedex 1
Query!
Country [159]
0
0
France
Query!
State/province [159]
0
0
Avignon
Query!
Country [160]
0
0
France
Query!
State/province [160]
0
0
Cholet
Query!
Country [161]
0
0
France
Query!
State/province [161]
0
0
Lagny Sur Marne
Query!
Country [162]
0
0
France
Query!
State/province [162]
0
0
Langres Cedex
Query!
Country [163]
0
0
France
Query!
State/province [163]
0
0
Montpellier
Query!
Country [164]
0
0
France
Query!
State/province [164]
0
0
Paris Cedex 13
Query!
Country [165]
0
0
France
Query!
State/province [165]
0
0
Pau Universite Cedex
Query!
Country [166]
0
0
France
Query!
State/province [166]
0
0
Strasbourg Cedex
Query!
Country [167]
0
0
France
Query!
State/province [167]
0
0
Toulouse Cedex 03
Query!
Country [168]
0
0
Germany
Query!
State/province [168]
0
0
Bad Berka
Query!
Country [169]
0
0
Germany
Query!
State/province [169]
0
0
Bad Nauheim
Query!
Country [170]
0
0
Germany
Query!
State/province [170]
0
0
Berlin
Query!
Country [171]
0
0
Germany
Query!
State/province [171]
0
0
Bernau
Query!
Country [172]
0
0
Germany
Query!
State/province [172]
0
0
Bonn
Query!
Country [173]
0
0
Germany
Query!
State/province [173]
0
0
Chemnitz
Query!
Country [174]
0
0
Germany
Query!
State/province [174]
0
0
Coswig
Query!
Country [175]
0
0
Germany
Query!
State/province [175]
0
0
Cottbus
Query!
Country [176]
0
0
Germany
Query!
State/province [176]
0
0
Dachau
Query!
Country [177]
0
0
Germany
Query!
State/province [177]
0
0
Essen
Query!
Country [178]
0
0
Germany
Query!
State/province [178]
0
0
Flensburg
Query!
Country [179]
0
0
Germany
Query!
State/province [179]
0
0
Halle/Saale
Query!
Country [180]
0
0
Germany
Query!
State/province [180]
0
0
Hamburg
Query!
Country [181]
0
0
Germany
Query!
State/province [181]
0
0
Hoyerswerda
Query!
Country [182]
0
0
Germany
Query!
State/province [182]
0
0
Jena
Query!
Country [183]
0
0
Germany
Query!
State/province [183]
0
0
Leverkusen
Query!
Country [184]
0
0
Germany
Query!
State/province [184]
0
0
Limburg
Query!
Country [185]
0
0
Germany
Query!
State/province [185]
0
0
Luebeck
Query!
Country [186]
0
0
Germany
Query!
State/province [186]
0
0
Mainz
Query!
Country [187]
0
0
Germany
Query!
State/province [187]
0
0
Muenster
Query!
Country [188]
0
0
Germany
Query!
State/province [188]
0
0
Neuss
Query!
Country [189]
0
0
Germany
Query!
State/province [189]
0
0
Paderborn
Query!
Country [190]
0
0
Germany
Query!
State/province [190]
0
0
Pirna
Query!
Country [191]
0
0
Germany
Query!
State/province [191]
0
0
Regensburg
Query!
Country [192]
0
0
Germany
Query!
State/province [192]
0
0
Rostock
Query!
Country [193]
0
0
Germany
Query!
State/province [193]
0
0
Wesel
Query!
Country [194]
0
0
Hungary
Query!
State/province [194]
0
0
Baja
Query!
Country [195]
0
0
Hungary
Query!
State/province [195]
0
0
Balatonfured
Query!
Country [196]
0
0
Hungary
Query!
State/province [196]
0
0
Budapest
Query!
Country [197]
0
0
Hungary
Query!
State/province [197]
0
0
Budpest
Query!
Country [198]
0
0
Hungary
Query!
State/province [198]
0
0
Cegled
Query!
Country [199]
0
0
Hungary
Query!
State/province [199]
0
0
Debrecen
Query!
Country [200]
0
0
Hungary
Query!
State/province [200]
0
0
Dunaujvaros
Query!
Country [201]
0
0
Hungary
Query!
State/province [201]
0
0
Hodmezovasarhely
Query!
Country [202]
0
0
Hungary
Query!
State/province [202]
0
0
Kecskemet
Query!
Country [203]
0
0
Hungary
Query!
State/province [203]
0
0
Miskolc
Query!
Country [204]
0
0
Hungary
Query!
State/province [204]
0
0
Szekesfehervar
Query!
Country [205]
0
0
Hungary
Query!
State/province [205]
0
0
Szekszard
Query!
Country [206]
0
0
Hungary
Query!
State/province [206]
0
0
Szentes
Query!
Country [207]
0
0
Hungary
Query!
State/province [207]
0
0
Szombathely
Query!
Country [208]
0
0
Hungary
Query!
State/province [208]
0
0
Zalaegerszeg
Query!
Country [209]
0
0
India
Query!
State/province [209]
0
0
Andhra Pradesh
Query!
Country [210]
0
0
India
Query!
State/province [210]
0
0
Gujarat
Query!
Country [211]
0
0
India
Query!
State/province [211]
0
0
Haryana
Query!
Country [212]
0
0
India
Query!
State/province [212]
0
0
Karnataka
Query!
Country [213]
0
0
India
Query!
State/province [213]
0
0
Madhya Pradesh
Query!
Country [214]
0
0
India
Query!
State/province [214]
0
0
Maharashtra
Query!
Country [215]
0
0
India
Query!
State/province [215]
0
0
Maharastra
Query!
Country [216]
0
0
India
Query!
State/province [216]
0
0
Punjab
Query!
Country [217]
0
0
India
Query!
State/province [217]
0
0
Rajasthan
Query!
Country [218]
0
0
India
Query!
State/province [218]
0
0
Tamil Nadu
Query!
Country [219]
0
0
India
Query!
State/province [219]
0
0
Tamilnadu
Query!
Country [220]
0
0
India
Query!
State/province [220]
0
0
Uttar Pradesh
Query!
Country [221]
0
0
India
Query!
State/province [221]
0
0
Bangalore, Karnataka
Query!
Country [222]
0
0
India
Query!
State/province [222]
0
0
Bikaner
Query!
Country [223]
0
0
India
Query!
State/province [223]
0
0
Mangalore
Query!
Country [224]
0
0
India
Query!
State/province [224]
0
0
New Delhi
Query!
Country [225]
0
0
India
Query!
State/province [225]
0
0
Pune
Query!
Country [226]
0
0
Israel
Query!
State/province [226]
0
0
Afula
Query!
Country [227]
0
0
Israel
Query!
State/province [227]
0
0
Ashkelon
Query!
Country [228]
0
0
Israel
Query!
State/province [228]
0
0
Hadera
Query!
Country [229]
0
0
Israel
Query!
State/province [229]
0
0
Haifa
Query!
Country [230]
0
0
Israel
Query!
State/province [230]
0
0
Jerusalem
Query!
Country [231]
0
0
Israel
Query!
State/province [231]
0
0
Kfar-Saba
Query!
Country [232]
0
0
Israel
Query!
State/province [232]
0
0
Nahariya
Query!
Country [233]
0
0
Israel
Query!
State/province [233]
0
0
Nazareth
Query!
Country [234]
0
0
Israel
Query!
State/province [234]
0
0
Petach Tikva
Query!
Country [235]
0
0
Israel
Query!
State/province [235]
0
0
Rehovot
Query!
Country [236]
0
0
Israel
Query!
State/province [236]
0
0
Safed
Query!
Country [237]
0
0
Israel
Query!
State/province [237]
0
0
Tel Aviv
Query!
Country [238]
0
0
Israel
Query!
State/province [238]
0
0
Tiberias
Query!
Country [239]
0
0
Italy
Query!
State/province [239]
0
0
Ascoli Piceno
Query!
Country [240]
0
0
Italy
Query!
State/province [240]
0
0
Bergamo
Query!
Country [241]
0
0
Italy
Query!
State/province [241]
0
0
Chieti
Query!
Country [242]
0
0
Italy
Query!
State/province [242]
0
0
Foggia
Query!
Country [243]
0
0
Italy
Query!
State/province [243]
0
0
Gravedona (Co)
Query!
Country [244]
0
0
Italy
Query!
State/province [244]
0
0
Grosseto
Query!
Country [245]
0
0
Italy
Query!
State/province [245]
0
0
Massa
Query!
Country [246]
0
0
Italy
Query!
State/province [246]
0
0
Milano
Query!
Country [247]
0
0
Italy
Query!
State/province [247]
0
0
Milan
Query!
Country [248]
0
0
Italy
Query!
State/province [248]
0
0
Naples
Query!
Country [249]
0
0
Italy
Query!
State/province [249]
0
0
Novara
Query!
Country [250]
0
0
Italy
Query!
State/province [250]
0
0
Pavia
Query!
Country [251]
0
0
Italy
Query!
State/province [251]
0
0
Perugia
Query!
Country [252]
0
0
Italy
Query!
State/province [252]
0
0
Roma
Query!
Country [253]
0
0
Italy
Query!
State/province [253]
0
0
San Daniele Del Friuli (Udine)
Query!
Country [254]
0
0
Italy
Query!
State/province [254]
0
0
Saronno (Va)
Query!
Country [255]
0
0
Italy
Query!
State/province [255]
0
0
Verona
Query!
Country [256]
0
0
Japan
Query!
State/province [256]
0
0
Aichi
Query!
Country [257]
0
0
Japan
Query!
State/province [257]
0
0
Chiba
Query!
Country [258]
0
0
Japan
Query!
State/province [258]
0
0
Fukuoka
Query!
Country [259]
0
0
Japan
Query!
State/province [259]
0
0
Gifu
Query!
Country [260]
0
0
Japan
Query!
State/province [260]
0
0
Hiroshima
Query!
Country [261]
0
0
Japan
Query!
State/province [261]
0
0
Hokkaido
Query!
Country [262]
0
0
Japan
Query!
State/province [262]
0
0
Ibaraki
Query!
Country [263]
0
0
Japan
Query!
State/province [263]
0
0
Ishikawa
Query!
Country [264]
0
0
Japan
Query!
State/province [264]
0
0
Kagoshima
Query!
Country [265]
0
0
Japan
Query!
State/province [265]
0
0
Kanagawa
Query!
Country [266]
0
0
Japan
Query!
State/province [266]
0
0
Nagano
Query!
Country [267]
0
0
Japan
Query!
State/province [267]
0
0
Oita
Query!
Country [268]
0
0
Japan
Query!
State/province [268]
0
0
Osaka
Query!
Country [269]
0
0
Japan
Query!
State/province [269]
0
0
Saga
Query!
Country [270]
0
0
Japan
Query!
State/province [270]
0
0
Saitama
Query!
Country [271]
0
0
Japan
Query!
State/province [271]
0
0
Tokushima
Query!
Country [272]
0
0
Japan
Query!
State/province [272]
0
0
Tokyo
Query!
Country [273]
0
0
Japan
Query!
State/province [273]
0
0
Yamaguchi
Query!
Country [274]
0
0
Japan
Query!
State/province [274]
0
0
Kochi
Query!
Country [275]
0
0
Japan
Query!
State/province [275]
0
0
Kumamoto
Query!
Country [276]
0
0
Japan
Query!
State/province [276]
0
0
Kyoto
Query!
Country [277]
0
0
Korea, Republic of
Query!
State/province [277]
0
0
Gangwon-Do
Query!
Country [278]
0
0
Korea, Republic of
Query!
State/province [278]
0
0
Gyeongangnam-Do
Query!
Country [279]
0
0
Korea, Republic of
Query!
State/province [279]
0
0
Gyeonggi-Do
Query!
Country [280]
0
0
Korea, Republic of
Query!
State/province [280]
0
0
Gyeongsangam-Do
Query!
Country [281]
0
0
Korea, Republic of
Query!
State/province [281]
0
0
Daegu
Query!
Country [282]
0
0
Korea, Republic of
Query!
State/province [282]
0
0
Goyang
Query!
Country [283]
0
0
Korea, Republic of
Query!
State/province [283]
0
0
Gwangju
Query!
Country [284]
0
0
Korea, Republic of
Query!
State/province [284]
0
0
Incheon
Query!
Country [285]
0
0
Korea, Republic of
Query!
State/province [285]
0
0
Jeonbuk
Query!
Country [286]
0
0
Korea, Republic of
Query!
State/province [286]
0
0
Pusan
Query!
Country [287]
0
0
Korea, Republic of
Query!
State/province [287]
0
0
Seoul
Query!
Country [288]
0
0
Korea, Republic of
Query!
State/province [288]
0
0
Suwon
Query!
Country [289]
0
0
Mexico
Query!
State/province [289]
0
0
Baja Californa Sur
Query!
Country [290]
0
0
Mexico
Query!
State/province [290]
0
0
Baja California
Query!
Country [291]
0
0
Mexico
Query!
State/province [291]
0
0
Coahuila
Query!
Country [292]
0
0
Mexico
Query!
State/province [292]
0
0
Estado De Mexico
Query!
Country [293]
0
0
Mexico
Query!
State/province [293]
0
0
Guerrero
Query!
Country [294]
0
0
Mexico
Query!
State/province [294]
0
0
Hidalgo
Query!
Country [295]
0
0
Mexico
Query!
State/province [295]
0
0
Jalisco
Query!
Country [296]
0
0
Mexico
Query!
State/province [296]
0
0
Nuevo Leon
Query!
Country [297]
0
0
Mexico
Query!
State/province [297]
0
0
Sinaloa
Query!
Country [298]
0
0
Mexico
Query!
State/province [298]
0
0
Veracruz
Query!
Country [299]
0
0
Mexico
Query!
State/province [299]
0
0
Aguascalientes
Query!
Country [300]
0
0
Mexico
Query!
State/province [300]
0
0
Chihuahua
Query!
Country [301]
0
0
Mexico
Query!
State/province [301]
0
0
Durango
Query!
Country [302]
0
0
Mexico
Query!
State/province [302]
0
0
Queretaro
Query!
Country [303]
0
0
Mexico
Query!
State/province [303]
0
0
San Luis Potosi
Query!
Country [304]
0
0
Netherlands
Query!
State/province [304]
0
0
Alkmaar
Query!
Country [305]
0
0
Netherlands
Query!
State/province [305]
0
0
Almere
Query!
Country [306]
0
0
Netherlands
Query!
State/province [306]
0
0
Amsterdam
Query!
Country [307]
0
0
Netherlands
Query!
State/province [307]
0
0
Beverwijk
Query!
Country [308]
0
0
Netherlands
Query!
State/province [308]
0
0
Boxmeer
Query!
Country [309]
0
0
Netherlands
Query!
State/province [309]
0
0
Den Haag
Query!
Country [310]
0
0
Netherlands
Query!
State/province [310]
0
0
Dirksland
Query!
Country [311]
0
0
Netherlands
Query!
State/province [311]
0
0
Ede
Query!
Country [312]
0
0
Netherlands
Query!
State/province [312]
0
0
Goes
Query!
Country [313]
0
0
Netherlands
Query!
State/province [313]
0
0
Gouda
Query!
Country [314]
0
0
Netherlands
Query!
State/province [314]
0
0
Heerlen
Query!
Country [315]
0
0
Netherlands
Query!
State/province [315]
0
0
Hilversum
Query!
Country [316]
0
0
Netherlands
Query!
State/province [316]
0
0
Maastrict
Query!
Country [317]
0
0
Netherlands
Query!
State/province [317]
0
0
Meppel
Query!
Country [318]
0
0
Netherlands
Query!
State/province [318]
0
0
Purmerend
Query!
Country [319]
0
0
Netherlands
Query!
State/province [319]
0
0
Sneek
Query!
Country [320]
0
0
Netherlands
Query!
State/province [320]
0
0
Veldhoven
Query!
Country [321]
0
0
Netherlands
Query!
State/province [321]
0
0
Weert
Query!
Country [322]
0
0
Netherlands
Query!
State/province [322]
0
0
Zwolle
Query!
Country [323]
0
0
New Zealand
Query!
State/province [323]
0
0
Auckland
Query!
Country [324]
0
0
New Zealand
Query!
State/province [324]
0
0
Christchurch
Query!
Country [325]
0
0
New Zealand
Query!
State/province [325]
0
0
Hastings
Query!
Country [326]
0
0
New Zealand
Query!
State/province [326]
0
0
Nelson
Query!
Country [327]
0
0
New Zealand
Query!
State/province [327]
0
0
Palmerston North
Query!
Country [328]
0
0
Norway
Query!
State/province [328]
0
0
Bergen
Query!
Country [329]
0
0
Norway
Query!
State/province [329]
0
0
Bodo
Query!
Country [330]
0
0
Norway
Query!
State/province [330]
0
0
Drammen
Query!
Country [331]
0
0
Norway
Query!
State/province [331]
0
0
Hamar
Query!
Country [332]
0
0
Norway
Query!
State/province [332]
0
0
Kongsvinger
Query!
Country [333]
0
0
Norway
Query!
State/province [333]
0
0
Kristiansund
Query!
Country [334]
0
0
Norway
Query!
State/province [334]
0
0
Lillehammer
Query!
Country [335]
0
0
Norway
Query!
State/province [335]
0
0
Oslo
Query!
Country [336]
0
0
Norway
Query!
State/province [336]
0
0
Stavanger
Query!
Country [337]
0
0
Norway
Query!
State/province [337]
0
0
Tynset
Query!
Country [338]
0
0
Peru
Query!
State/province [338]
0
0
Callao
Query!
Country [339]
0
0
Peru
Query!
State/province [339]
0
0
Lambayeque
Query!
Country [340]
0
0
Peru
Query!
State/province [340]
0
0
Cusco
Query!
Country [341]
0
0
Peru
Query!
State/province [341]
0
0
Ica
Query!
Country [342]
0
0
Peru
Query!
State/province [342]
0
0
Lima
Query!
Country [343]
0
0
Poland
Query!
State/province [343]
0
0
Mazowiekie
Query!
Country [344]
0
0
Poland
Query!
State/province [344]
0
0
Bialystok
Query!
Country [345]
0
0
Poland
Query!
State/province [345]
0
0
Bydgoszcz
Query!
Country [346]
0
0
Poland
Query!
State/province [346]
0
0
Bytom
Query!
Country [347]
0
0
Poland
Query!
State/province [347]
0
0
Czestochowa
Query!
Country [348]
0
0
Poland
Query!
State/province [348]
0
0
Elblag
Query!
Country [349]
0
0
Poland
Query!
State/province [349]
0
0
Gdynia
Query!
Country [350]
0
0
Poland
Query!
State/province [350]
0
0
Grodzisk Mazowiecki
Query!
Country [351]
0
0
Poland
Query!
State/province [351]
0
0
Inowroclaw
Query!
Country [352]
0
0
Poland
Query!
State/province [352]
0
0
Kielce
Query!
Country [353]
0
0
Poland
Query!
State/province [353]
0
0
Koscierzyna
Query!
Country [354]
0
0
Poland
Query!
State/province [354]
0
0
Krakow
Query!
Country [355]
0
0
Poland
Query!
State/province [355]
0
0
Lodz
Query!
Country [356]
0
0
Poland
Query!
State/province [356]
0
0
Lublin
Query!
Country [357]
0
0
Poland
Query!
State/province [357]
0
0
Opole
Query!
Country [358]
0
0
Poland
Query!
State/province [358]
0
0
Ostrowiec Swietokrzyski
Query!
Country [359]
0
0
Poland
Query!
State/province [359]
0
0
Plock
Query!
Country [360]
0
0
Poland
Query!
State/province [360]
0
0
Poznan
Query!
Country [361]
0
0
Poland
Query!
State/province [361]
0
0
Radom
Query!
Country [362]
0
0
Poland
Query!
State/province [362]
0
0
Rzeszow
Query!
Country [363]
0
0
Poland
Query!
State/province [363]
0
0
Slupsk
Query!
Country [364]
0
0
Poland
Query!
State/province [364]
0
0
Szczecin
Query!
Country [365]
0
0
Poland
Query!
State/province [365]
0
0
Tarnow
Query!
Country [366]
0
0
Poland
Query!
State/province [366]
0
0
Torun
Query!
Country [367]
0
0
Poland
Query!
State/province [367]
0
0
Warsaw
Query!
Country [368]
0
0
Poland
Query!
State/province [368]
0
0
Warszawa
Query!
Country [369]
0
0
Poland
Query!
State/province [369]
0
0
Wloclawek
Query!
Country [370]
0
0
Poland
Query!
State/province [370]
0
0
Zabrze
Query!
Country [371]
0
0
Poland
Query!
State/province [371]
0
0
Zielona Gora
Query!
Country [372]
0
0
Puerto Rico
Query!
State/province [372]
0
0
Cidra
Query!
Country [373]
0
0
Puerto Rico
Query!
State/province [373]
0
0
San Juan
Query!
Country [374]
0
0
Romania
Query!
State/province [374]
0
0
Arad
Query!
Country [375]
0
0
Romania
Query!
State/province [375]
0
0
Baia Mare
Query!
Country [376]
0
0
Romania
Query!
State/province [376]
0
0
Braila
Query!
Country [377]
0
0
Romania
Query!
State/province [377]
0
0
Bucharest
Query!
Country [378]
0
0
Romania
Query!
State/province [378]
0
0
Craiova
Query!
Country [379]
0
0
Romania
Query!
State/province [379]
0
0
Oradea
Query!
Country [380]
0
0
Romania
Query!
State/province [380]
0
0
Pitesti
Query!
Country [381]
0
0
Romania
Query!
State/province [381]
0
0
Sibiu
Query!
Country [382]
0
0
Romania
Query!
State/province [382]
0
0
Targu Mures
Query!
Country [383]
0
0
Romania
Query!
State/province [383]
0
0
Timisoara
Query!
Country [384]
0
0
Russian Federation
Query!
State/province [384]
0
0
Barnaul
Query!
Country [385]
0
0
Russian Federation
Query!
State/province [385]
0
0
Chelyabinsk
Query!
Country [386]
0
0
Russian Federation
Query!
State/province [386]
0
0
Ekaterinburg
Query!
Country [387]
0
0
Russian Federation
Query!
State/province [387]
0
0
Kaluga
Query!
Country [388]
0
0
Russian Federation
Query!
State/province [388]
0
0
Kazan
Query!
Country [389]
0
0
Russian Federation
Query!
State/province [389]
0
0
Kemerovo
Query!
Country [390]
0
0
Russian Federation
Query!
State/province [390]
0
0
Krasnoyarsk
Query!
Country [391]
0
0
Russian Federation
Query!
State/province [391]
0
0
Moscow Reg. Zhekeznodorozhniy
Query!
Country [392]
0
0
Russian Federation
Query!
State/province [392]
0
0
Moscow
Query!
Country [393]
0
0
Russian Federation
Query!
State/province [393]
0
0
Nizhni Novgorod
Query!
Country [394]
0
0
Russian Federation
Query!
State/province [394]
0
0
Nizhny Novgorod
Query!
Country [395]
0
0
Russian Federation
Query!
State/province [395]
0
0
Novosibirsk
Query!
Country [396]
0
0
Russian Federation
Query!
State/province [396]
0
0
Odintsovo
Query!
Country [397]
0
0
Russian Federation
Query!
State/province [397]
0
0
Penza
Query!
Country [398]
0
0
Russian Federation
Query!
State/province [398]
0
0
Perm
Query!
Country [399]
0
0
Russian Federation
Query!
State/province [399]
0
0
Rostov-On-Don
Query!
Country [400]
0
0
Russian Federation
Query!
State/province [400]
0
0
Ryazan
Query!
Country [401]
0
0
Russian Federation
Query!
State/province [401]
0
0
Saint Petersburg
Query!
Country [402]
0
0
Russian Federation
Query!
State/province [402]
0
0
Saint-Petersburg
Query!
Country [403]
0
0
Russian Federation
Query!
State/province [403]
0
0
Saratov
Query!
Country [404]
0
0
Russian Federation
Query!
State/province [404]
0
0
St. Petersburg
Query!
Country [405]
0
0
Russian Federation
Query!
State/province [405]
0
0
Tomsk
Query!
Country [406]
0
0
Russian Federation
Query!
State/province [406]
0
0
Tver
Query!
Country [407]
0
0
Russian Federation
Query!
State/province [407]
0
0
Tyumen
Query!
Country [408]
0
0
Russian Federation
Query!
State/province [408]
0
0
Vasilievsky Island
Query!
Country [409]
0
0
Russian Federation
Query!
State/province [409]
0
0
Voronezh
Query!
Country [410]
0
0
Russian Federation
Query!
State/province [410]
0
0
Yaroslavl
Query!
Country [411]
0
0
Russian Federation
Query!
State/province [411]
0
0
Zhukovskiy
Query!
Country [412]
0
0
Singapore
Query!
State/province [412]
0
0
Singapore
Query!
Country [413]
0
0
Slovakia
Query!
State/province [413]
0
0
Banska Bystrica
Query!
Country [414]
0
0
Slovakia
Query!
State/province [414]
0
0
Bratislava
Query!
Country [415]
0
0
Slovakia
Query!
State/province [415]
0
0
Kosice
Query!
Country [416]
0
0
Slovakia
Query!
State/province [416]
0
0
Kralovsky Chlmec
Query!
Country [417]
0
0
Slovakia
Query!
State/province [417]
0
0
Liptovsky Hradok
Query!
Country [418]
0
0
Slovakia
Query!
State/province [418]
0
0
Lucenec
Query!
Country [419]
0
0
Slovakia
Query!
State/province [419]
0
0
Martin
Query!
Country [420]
0
0
Slovakia
Query!
State/province [420]
0
0
Nitra
Query!
Country [421]
0
0
South Africa
Query!
State/province [421]
0
0
Eastern Cape
Query!
Country [422]
0
0
South Africa
Query!
State/province [422]
0
0
Free State
Query!
Country [423]
0
0
South Africa
Query!
State/province [423]
0
0
Gauteng
Query!
Country [424]
0
0
South Africa
Query!
State/province [424]
0
0
Kwa Zulu Natal
Query!
Country [425]
0
0
South Africa
Query!
State/province [425]
0
0
Western Cape
Query!
Country [426]
0
0
South Africa
Query!
State/province [426]
0
0
Johannesburg
Query!
Country [427]
0
0
Spain
Query!
State/province [427]
0
0
Alicante
Query!
Country [428]
0
0
Spain
Query!
State/province [428]
0
0
Asturas
Query!
Country [429]
0
0
Spain
Query!
State/province [429]
0
0
Gerona
Query!
Country [430]
0
0
Spain
Query!
State/province [430]
0
0
Madrid
Query!
Country [431]
0
0
Spain
Query!
State/province [431]
0
0
Almeria
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Country [432]
0
0
Spain
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State/province [432]
0
0
Barcelona
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Country [433]
0
0
Spain
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State/province [433]
0
0
Caceres
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Country [434]
0
0
Spain
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State/province [434]
0
0
El Ejido
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Country [435]
0
0
Spain
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State/province [435]
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0
Granada
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Country [436]
0
0
Spain
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State/province [436]
0
0
Lleida
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Country [437]
0
0
Spain
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State/province [437]
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0
Lugo
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Country [438]
0
0
Spain
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State/province [438]
0
0
Malaga
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Country [439]
0
0
Spain
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State/province [439]
0
0
Santiago De Compostela
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Country [440]
0
0
Spain
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State/province [440]
0
0
Sevilla
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Country [441]
0
0
Spain
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State/province [441]
0
0
Tarragona
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Country [442]
0
0
Spain
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State/province [442]
0
0
Torrevieja
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Country [443]
0
0
Spain
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State/province [443]
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0
Valencia
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Country [444]
0
0
Spain
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State/province [444]
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0
Valladolid
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Country [445]
0
0
Spain
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State/province [445]
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0
Zaragoza
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Country [446]
0
0
Sweden
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State/province [446]
0
0
Eskilstuna
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Country [447]
0
0
Sweden
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State/province [447]
0
0
Halmstad
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Country [448]
0
0
Sweden
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State/province [448]
0
0
Helsingborg
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Country [449]
0
0
Sweden
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State/province [449]
0
0
Karlskoga
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Country [450]
0
0
Sweden
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State/province [450]
0
0
Karlstad
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Country [451]
0
0
Sweden
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State/province [451]
0
0
Koping
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Country [452]
0
0
Sweden
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State/province [452]
0
0
Lidkoping
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Country [453]
0
0
Sweden
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State/province [453]
0
0
Molndal
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Country [454]
0
0
Sweden
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State/province [454]
0
0
Skovde
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Country [455]
0
0
Sweden
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State/province [455]
0
0
Stockholm
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Country [456]
0
0
Sweden
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State/province [456]
0
0
Uppsala
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Country [457]
0
0
Sweden
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State/province [457]
0
0
Vaxjo
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Country [458]
0
0
Switzerland
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State/province [458]
0
0
Ticino
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Country [459]
0
0
Switzerland
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State/province [459]
0
0
Geneve
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Country [460]
0
0
Switzerland
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State/province [460]
0
0
St Gallen
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Country [461]
0
0
Switzerland
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State/province [461]
0
0
Zurich
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Country [462]
0
0
Turkey
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State/province [462]
0
0
Ankara
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Country [463]
0
0
Turkey
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State/province [463]
0
0
Haseki
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Country [464]
0
0
Turkey
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State/province [464]
0
0
Izmir
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Country [465]
0
0
Turkey
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State/province [465]
0
0
Diyarbakir
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Country [466]
0
0
Turkey
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State/province [466]
0
0
Isparta
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Country [467]
0
0
Turkey
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State/province [467]
0
0
Kirikkale
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Country [468]
0
0
Turkey
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State/province [468]
0
0
Konya
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Country [469]
0
0
Ukraine
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State/province [469]
0
0
Chernivtsy
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Country [470]
0
0
Ukraine
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State/province [470]
0
0
Dnipropetrovsk
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Country [471]
0
0
Ukraine
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State/province [471]
0
0
Donetsk
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Country [472]
0
0
Ukraine
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State/province [472]
0
0
Ivano-Frankivsk
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Country [473]
0
0
Ukraine
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State/province [473]
0
0
Kharkiv
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Country [474]
0
0
Ukraine
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State/province [474]
0
0
Kyiv
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Country [475]
0
0
Ukraine
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State/province [475]
0
0
Lugansk
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Country [476]
0
0
Ukraine
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State/province [476]
0
0
Lutsk
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Country [477]
0
0
Ukraine
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State/province [477]
0
0
Lviv
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Country [478]
0
0
Ukraine
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State/province [478]
0
0
Mykolayiv
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Country [479]
0
0
Ukraine
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State/province [479]
0
0
Odessa
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Country [480]
0
0
Ukraine
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State/province [480]
0
0
Simferopol
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Country [481]
0
0
Ukraine
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State/province [481]
0
0
Vinnitsa
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Country [482]
0
0
Ukraine
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State/province [482]
0
0
Zhaporizhzhya
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Country [483]
0
0
United Kingdom
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State/province [483]
0
0
Antrim
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Country [484]
0
0
United Kingdom
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State/province [484]
0
0
Armagh
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Country [485]
0
0
United Kingdom
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State/province [485]
0
0
Ayrshire
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Country [486]
0
0
United Kingdom
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State/province [486]
0
0
Cambridgeshire
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Country [487]
0
0
United Kingdom
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State/province [487]
0
0
Derbyshire
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Country [488]
0
0
United Kingdom
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State/province [488]
0
0
Dumfriesshire
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Country [489]
0
0
United Kingdom
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State/province [489]
0
0
East Yorkshire
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Country [490]
0
0
United Kingdom
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State/province [490]
0
0
Essex
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Country [491]
0
0
United Kingdom
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State/province [491]
0
0
Kent
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Country [492]
0
0
United Kingdom
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State/province [492]
0
0
Lancashire
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Country [493]
0
0
United Kingdom
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State/province [493]
0
0
Lincolnshire
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Country [494]
0
0
United Kingdom
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State/province [494]
0
0
Middlesex
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Country [495]
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0
United Kingdom
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State/province [495]
0
0
Nottinghamshire
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Country [496]
0
0
United Kingdom
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State/province [496]
0
0
South Yorkshire
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Country [497]
0
0
United Kingdom
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State/province [497]
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0
Tyne And Wear
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Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
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Name
Bristol-Myers Squibb
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Address
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Country
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Other collaborator category [1]
0
0
Commercial sector/Industry
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Name [1]
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0
Pfizer
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Address [1]
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0
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0
0
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Other collaborator category [2]
0
0
Other
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Name [2]
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0
Duke Clinical Research Institute
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Address [2]
0
0
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Country [2]
0
0
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Ethics approval
Ethics application status
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Summary
Brief summary
The purpose of this study is to determine if apixaban is superior to placebo for preventing
cardiovascular death, non-fatal myocardial infarction, or ischemic stroke in subjects with a
recent acute coronary syndrome
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Trial website
https://clinicaltrials.gov/ct2/show/NCT00831441
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
Name
0
0
Bristol-Myers Squibb
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Address
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0
Bristol-Myers Squibb
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Contact person for scientific queries
Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT00831441
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