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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT01193075
Registration number
NCT01193075
Ethics application status
Date submitted
9/08/2010
Date registered
1/09/2010
Date last updated
13/05/2024
Titles & IDs
Public title
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
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Scientific title
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Type (CMT1B), 2A (CMT2A), 4A (CMT4A), 4C (CMT4C), and Others
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Secondary ID [1]
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1U54NS065712-01
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Secondary ID [2]
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INC-6601
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Universal Trial Number (UTN)
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Trial acronym
INC-6601
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Charcot Marie Tooth Disease
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Condition category
Condition code
Oral and Gastrointestinal
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Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
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Human Genetics and Inherited Disorders
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Other human genetics and inherited disorders
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Musculoskeletal
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Other muscular and skeletal disorders
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Neurological
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Other neurological disorders
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Intervention/exposure
Study type
Observational
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Patient registry
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Target follow-up duration
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Target follow-up type
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Description of intervention(s) / exposure
CMT1B - Families/patients with genetically confirmed CMT1B
CMT2A - Families/patients with genetically confirmed CMT2A
CMT4A - Families/patients with genetically confirmed CMT4A
CMT4C - Families/patients with genetically confirmed CMT4C
All other CMT - Families/patients with all other forms of CMT or CMT that has not yet been genetically identified
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Charcot Marie Tooth Neuropathy Score (CMTNS)
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Assessment method [1]
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Charcot Marie Tooth Neuropathy Score (CMTNS) is a composite measure of disability based on a person's symptoms, signs, and electrophysiology. It is based on a 36 point scale, with 9 items each worth up to 4 points. A higher score signifies increased disability.
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Timepoint [1]
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1 year
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Primary outcome [2]
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Minimal dataset
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Assessment method [2]
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This includes diagnosis, family history, developmental history, walking ability, hand function, strength, sensation, and neurophysiology.
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Timepoint [2]
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1 year
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Eligibility
Key inclusion criteria
All patients must be seen in-person at a participating center for the initial visit.
Inclusion Criteria - patients with CMT (all subtypes)
1. Patient has documented, pathogenic or likely pathogenic CMT-causing variant(s)
OR
2. Patient has a first- or second-degree family member (parent, child, sibling,
half-sibling, aunt, uncle, grandparent, or grandchild) with a documented pathogenic or
likely pathogenic CMT-causing variant AND a clear link between that family member and
the affected patient AND a phenotype consistent with the diagnosis
i. A clear link is necessary for a second-degree relative. For example, if a
grandparent is affected and has a pathogenic or likely pathogenic variant, and the
parent does not have any signs, symptoms, or electrophysiology consistent with the
diagnosis, there is no clear link unless the parent has also been found to have the
pathogenic or likely pathogenic variant such as in cases with reduced penetrance
ii. In cases where clear links are not available, genetic testing is required for the
patient or the family member who is not clearly affected.
3. Patients who have a variant of uncertain significance, as determined by the laboratory
performing the testing may still be included if one of the following circumstances
applies:
i. Variant is categorized as pathogenic or likely pathogenic per the ACMG variant
interpretation guidelines. [80, 81]
ii. Variant has been found in multiple affected people in a family and has not been
found in unaffected family members. (Note - both affected and unaffected family
members must be tested in this situation to be included).
iii. The principal investigator and the site investigator agree that the variant(s) is
(are) most likely pathogenic.
4. Patients whose clinical presentation is suggestive of CMT, but CMT type and variant
are unknown will be characterized by the following categories:
1. Nerve conduction velocities: demyelinating, axonal, intermediate
2. Inheritance: dominant, recessive, X-linked, or unknown
5. Patient or patient's legally authorized representative has understood and signed an
IRB approved consent form for the study. Teenagers (age 13 - 17 years) and cognitively
impaired adults who are able to read and write must sign an assent form (depending on
local ethics committee requirements).
Inclusion Criteria - Controls
1. Person does not have a peripheral neuropathy, as determined by the investigator.
2. Person has understood and signed an IRB approved consent form for the study. Teenagers
(age 13-17 years) must sign an assent form (depending on local ethics committee
requirements).
EXCLUSION CRITERIA
1. Patient has a variant of uncertain significance that cannot be further classified
following methods listed in the Inclusion Criteria.
2. Patient does not wish to be a part of the study or has not signed an informed consent
form.
3. Patient is deemed inappropriate by the Site PI.
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Minimum age
No limit
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
Yes
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Key exclusion criteria
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Study design
Purpose
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Duration
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Selection
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Timing
Prospective
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Statistical methods / analysis
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Recruitment
Recruitment status
Recruiting
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/04/2010
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
1/12/2026
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Actual
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Sample size
Target
5000
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Accrual to date
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Final
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Recruitment in Australia
Recruitment state(s)
NSW
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Recruitment hospital [1]
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University of Westmead - Sydney
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Recruitment postcode(s) [1]
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2145 - Sydney
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Recruitment outside Australia
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United States of America
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State/province [1]
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California
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United States of America
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Colorado
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United States of America
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Connecticut
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United States of America
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District of Columbia
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United States of America
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Florida
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United States of America
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Iowa
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United States of America
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Maryland
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United States of America
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Massachusetts
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United States of America
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Michigan
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United States of America
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Minnesota
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United States of America
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New York
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Country [12]
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United States of America
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Pennsylvania
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Country [13]
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United States of America
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Tennessee
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Country [14]
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United States of America
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Washington
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Canada
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Ontario
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Italy
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Milan
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United Kingdom
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State/province [17]
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England
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Funding & Sponsors
Primary sponsor type
Other
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Name
Michael Shy
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Address
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Other collaborator category [1]
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Other
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Name [1]
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Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
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Address [1]
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Other collaborator category [2]
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Other
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Name [2]
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Johns Hopkins University
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Address [2]
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Other collaborator category [3]
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Government body
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Name [3]
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National Institute of Neurological Disorders and Stroke (NINDS)
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Address [3]
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Other collaborator category [4]
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Other
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Name [4]
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King's College Hospital NHS Trust
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Address [4]
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Other collaborator category [5]
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Other
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Name [5]
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Nemours Children's Hospital
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Other collaborator category [6]
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Other
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Stanford University
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Other
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University of Pennsylvania
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Other collaborator category [8]
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Other
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University of Rochester
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Other collaborator category [9]
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Other
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Name [9]
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Children's Hospital of Philadelphia
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Other collaborator category [10]
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Other
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Name [10]
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Sydney Children's Hospitals Network
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Address [10]
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Other collaborator category [11]
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Other
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Name [11]
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Rare Diseases Clinical Research Network
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Other collaborator category [12]
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Other
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Name [12]
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Muscular Dystrophy Association
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Address [12]
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Government body
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Name [13]
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National Institutes of Health (NIH)
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Other collaborator category [14]
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Other
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Name [14]
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Charcot-Marie-Tooth Association
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Address [14]
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Other collaborator category [15]
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Other
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Name [15]
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Massachusetts General Hospital
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Other collaborator category [16]
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Other
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Cedars-Sinai Medical Center
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Other collaborator category [17]
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Other
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University of Miami
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Other collaborator category [18]
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Other
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University of Minnesota
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Other collaborator category [19]
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Other
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Connecticut Children's Medical Center
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Other collaborator category [20]
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Other
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University of Colorado, Denver
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Other collaborator category [21]
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Other
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The National Hospital for Neurology and Neurosurgery
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Other collaborator category [22]
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Other
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Name [22]
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Dubowitz Neuromuscular Centre
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Ethics approval
Ethics application status
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Summary
Brief summary
This is an observational longitudinal study to determine the natural history and
genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease
(CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C (CMT4C).
The investigators will also be determine the capability of the newly developed CMT Pediatric
Scale (CMT Peds scale) and the Minimal Dataset to measure impairment and perform longitudinal
measurements in patients with multiple forms of CMT over a five year window
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Trial website
https://clinicaltrials.gov/ct2/show/NCT01193075
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
Name
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Michael E Shy, MD
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Address
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University of Iowa
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Phone
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Fax
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Email
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Contact person for public queries
Name
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Nicole M Kressin, MSN, RN
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Address
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Country
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Phone
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319-384-6362
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Fax
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Email
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[email protected]
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Contact person for scientific queries
Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT01193075
Download to PDF