Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01318941
Registration number
NCT01318941
Ethics application status
Date submitted
17/03/2011
Date registered
21/03/2011
Date last updated
23/05/2016
Titles & IDs
Public title
Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting
Query!
Scientific title
LUMINOUS: Study to Observe the Effectiveness and Safety of Ranibizumab Through Individualized Patient Treatment and Associated Outcomes
Query!
Secondary ID [1]
0
0
CRFB002A2406
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
LUMINOUS
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
0
0
Query!
Wet Age Related Macular Degeneration
0
0
Query!
Diabetic Macular Edema
0
0
Query!
Retinal Vein Occlusion
0
0
Query!
Condition category
Condition code
Eye
0
0
0
0
Query!
Diseases / disorders of the eye
Query!
Neurological
0
0
0
0
Query!
Other neurological disorders
Query!
Cardiovascular
0
0
0
0
Query!
Diseases of the vasculature and circulation including the lymphatic system
Query!
Intervention/exposure
Study type
Observational
Query!
Patient registry
Query!
Target follow-up duration
Query!
Target follow-up type
Query!
Description of intervention(s) / exposure
Ranibizumab -
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Mean Visual Acuity (VA) and mean change in VA
Query!
Assessment method [1]
0
0
Query!
Timepoint [1]
0
0
3,6, and 12 months from the baseline visit, and annually thereafter
Query!
Primary outcome [2]
0
0
Incidence rate, relationship and severity of treatment emergent ocular and non-ocular adverse events
Query!
Assessment method [2]
0
0
Query!
Timepoint [2]
0
0
Defined time periods during study duration from FPFV until 30 days after LPLV
Query!
Primary outcome [3]
0
0
Mean visual acuity at quarterly intervals for the primary treated eye set
Query!
Assessment method [3]
0
0
Query!
Timepoint [3]
0
0
Quarterly intervals from baseline visit during study duration (5 years)
Query!
Secondary outcome [1]
0
0
Incidence rate of Adverse Events (AEs) and Serious Adverse Events (SAEs)
Query!
Assessment method [1]
0
0
Query!
Timepoint [1]
0
0
From the time the patient signed the informed consent until 30 days after study discontinuation
Query!
Secondary outcome [2]
0
0
Number of ranibizumab injections administered per patient, per eye, and per person-year
Query!
Assessment method [2]
0
0
Query!
Timepoint [2]
0
0
annually
Query!
Secondary outcome [3]
0
0
"National Eye Institute Visual Functioning Questionnaire-25" change from baseline
Query!
Assessment method [3]
0
0
Query!
Timepoint [3]
0
0
annually
Query!
Secondary outcome [4]
0
0
Overall number of ranibizumab injections, number of visits, time interval between injections, duration of treatment, number of re-treatment, and reasons for treatment termination
Query!
Assessment method [4]
0
0
Query!
Timepoint [4]
0
0
Over time during study duration (5 years)
Query!
Secondary outcome [5]
0
0
Change from baseline in National Eye Institute Visual Function Questionnaire 25 composite and sub-scale scores
Query!
Assessment method [5]
0
0
Query!
Timepoint [5]
0
0
Over time during study duration (5 years)
Query!
Eligibility
Key inclusion criteria
* Adult patients, within age limits as defined by local regulations and local product label, who have previously been treated with, who are currently being treated with or initiating treatment with ranibizumab for any approved indication included in the local product label
* Willing and able to provide informed written consent personally or by legal proxy
Query!
Minimum age
No limit
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Simultaneous participation in a study that includes administration of any investigational drug or procedure
* Systemic or ocular treatment with any VEGF inhibitor other than ranibizumab in the 90 days prior to enrollment
* Other protocol-defined inclusion/exclusion criteria may apply
Query!
Study design
Purpose
Query!
Duration
Query!
Selection
Query!
Timing
Prospective
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
1/03/2011
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
1/04/2016
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
30490
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,TAS,VIC
Query!
Recruitment hospital [1]
0
0
Novartis Investigative Site - Chatswood
Query!
Recruitment hospital [2]
0
0
Novartis Investigative Site - Forster
Query!
Recruitment hospital [3]
0
0
Novartis Investigative Site - Kogarah
Query!
Recruitment hospital [4]
0
0
Novartis Investigative Site - Liverpool
Query!
Recruitment hospital [5]
0
0
Novartis Investigative Site - North Ryde
Query!
Recruitment hospital [6]
0
0
Novartis Investigative Site - Parramatta
Query!
Recruitment hospital [7]
0
0
Novartis Investigative Site - Strathfield
Query!
Recruitment hospital [8]
0
0
Novartis Investigative Site - Sydney
Query!
Recruitment hospital [9]
0
0
Novartis Investigative Site - Westmead
Query!
Recruitment hospital [10]
0
0
Novartis Investigative Site - Brisbane
Query!
Recruitment hospital [11]
0
0
Novartis Investigative Site - South Brisbane
Query!
Recruitment hospital [12]
0
0
Novartis Investigative Site - Southport
Query!
Recruitment hospital [13]
0
0
Novartis Investigative Site - Adelaide
Query!
Recruitment hospital [14]
0
0
Novartis Investigative Site - North Adelaide
Query!
Recruitment hospital [15]
0
0
Novartis Investigative Site - Hobart
Query!
Recruitment hospital [16]
0
0
Novartis Investigative Site - South Launceston
Query!
Recruitment hospital [17]
0
0
Novartis Investigative Site - East Melbourne
Query!
Recruitment hospital [18]
0
0
Novartis Investigative Site - Geelong
Query!
Recruitment hospital [19]
0
0
Novartis Investigative Site - Glen Waverley
Query!
Recruitment hospital [20]
0
0
Novartis Investigative Site - Oakleigh
Query!
Recruitment postcode(s) [1]
0
0
2067 - Chatswood
Query!
Recruitment postcode(s) [2]
0
0
2428 - Forster
Query!
Recruitment postcode(s) [3]
0
0
2217 - Kogarah
Query!
Recruitment postcode(s) [4]
0
0
2170 - Liverpool
Query!
Recruitment postcode(s) [5]
0
0
2109 - North Ryde
Query!
Recruitment postcode(s) [6]
0
0
2150 - Parramatta
Query!
Recruitment postcode(s) [7]
0
0
2135 - Strathfield
Query!
Recruitment postcode(s) [8]
0
0
2000 - Sydney
Query!
Recruitment postcode(s) [9]
0
0
Australia - Sydney
Query!
Recruitment postcode(s) [10]
0
0
2145 - Westmead
Query!
Recruitment postcode(s) [11]
0
0
4000 - Brisbane
Query!
Recruitment postcode(s) [12]
0
0
4101 - South Brisbane
Query!
Recruitment postcode(s) [13]
0
0
4125 - Southport
Query!
Recruitment postcode(s) [14]
0
0
5000 - Adelaide
Query!
Recruitment postcode(s) [15]
0
0
5006 - North Adelaide
Query!
Recruitment postcode(s) [16]
0
0
7000 - Hobart
Query!
Recruitment postcode(s) [17]
0
0
7249 - South Launceston
Query!
Recruitment postcode(s) [18]
0
0
3002 - East Melbourne
Query!
Recruitment postcode(s) [19]
0
0
3220 - Geelong
Query!
Recruitment postcode(s) [20]
0
0
VIC 3150 - Glen Waverley
Query!
Recruitment postcode(s) [21]
0
0
3166 - Oakleigh
Query!
Recruitment outside Australia
Country [1]
0
0
Argentina
Query!
State/province [1]
0
0
Buenos Aires
Query!
Country [2]
0
0
Argentina
Query!
State/province [2]
0
0
Santa Fe
Query!
Country [3]
0
0
Argentina
Query!
State/province [3]
0
0
Caballito
Query!
Country [4]
0
0
Argentina
Query!
State/province [4]
0
0
Ciudad de Buenos Aires,
Query!
Country [5]
0
0
Argentina
Query!
State/province [5]
0
0
Concepción del Uruguay
Query!
Country [6]
0
0
Argentina
Query!
State/province [6]
0
0
Córdoba
Query!
Country [7]
0
0
Argentina
Query!
State/province [7]
0
0
Guaymallén, Mendoza
Query!
Country [8]
0
0
Argentina
Query!
State/province [8]
0
0
La Plata
Query!
Country [9]
0
0
Argentina
Query!
State/province [9]
0
0
Rosario
Query!
Country [10]
0
0
Argentina
Query!
State/province [10]
0
0
San Martin, Buenos Aires
Query!
Country [11]
0
0
Austria
Query!
State/province [11]
0
0
Linz
Query!
Country [12]
0
0
Austria
Query!
State/province [12]
0
0
Vienna
Query!
Country [13]
0
0
Belgium
Query!
State/province [13]
0
0
Aalst
Query!
Country [14]
0
0
Belgium
Query!
State/province [14]
0
0
Aarschot
Query!
Country [15]
0
0
Belgium
Query!
State/province [15]
0
0
Bonheiden
Query!
Country [16]
0
0
Belgium
Query!
State/province [16]
0
0
Bruxelles
Query!
Country [17]
0
0
Belgium
Query!
State/province [17]
0
0
Dinant
Query!
Country [18]
0
0
Belgium
Query!
State/province [18]
0
0
Edegem
Query!
Country [19]
0
0
Belgium
Query!
State/province [19]
0
0
Gent
Query!
Country [20]
0
0
Belgium
Query!
State/province [20]
0
0
Hasselt
Query!
Country [21]
0
0
Belgium
Query!
State/province [21]
0
0
Leuven
Query!
Country [22]
0
0
Belgium
Query!
State/province [22]
0
0
Mouscron
Query!
Country [23]
0
0
Belgium
Query!
State/province [23]
0
0
Namur
Query!
Country [24]
0
0
Belgium
Query!
State/province [24]
0
0
Nivelles
Query!
Country [25]
0
0
Belgium
Query!
State/province [25]
0
0
Reet
Query!
Country [26]
0
0
Belgium
Query!
State/province [26]
0
0
Yvoir
Query!
Country [27]
0
0
Belgium
Query!
State/province [27]
0
0
Zottegem
Query!
Country [28]
0
0
Brazil
Query!
State/province [28]
0
0
GO
Query!
Country [29]
0
0
Brazil
Query!
State/province [29]
0
0
MG
Query!
Country [30]
0
0
Brazil
Query!
State/province [30]
0
0
RJ
Query!
Country [31]
0
0
Brazil
Query!
State/province [31]
0
0
RS
Query!
Country [32]
0
0
Brazil
Query!
State/province [32]
0
0
SP
Query!
Country [33]
0
0
Canada
Query!
State/province [33]
0
0
Alberta
Query!
Country [34]
0
0
Canada
Query!
State/province [34]
0
0
British Columbia
Query!
Country [35]
0
0
Canada
Query!
State/province [35]
0
0
New Brunswick
Query!
Country [36]
0
0
Canada
Query!
State/province [36]
0
0
Nova Scotia
Query!
Country [37]
0
0
Canada
Query!
State/province [37]
0
0
Ontario
Query!
Country [38]
0
0
Canada
Query!
State/province [38]
0
0
Quebec
Query!
Country [39]
0
0
Canada
Query!
State/province [39]
0
0
Barrie
Query!
Country [40]
0
0
Canada
Query!
State/province [40]
0
0
Drummondville
Query!
Country [41]
0
0
Canada
Query!
State/province [41]
0
0
Hamilton
Query!
Country [42]
0
0
Chile
Query!
State/province [42]
0
0
Calama
Query!
Country [43]
0
0
China
Query!
State/province [43]
0
0
Beijing
Query!
Country [44]
0
0
China
Query!
State/province [44]
0
0
Guangdong
Query!
Country [45]
0
0
China
Query!
State/province [45]
0
0
Guizhou
Query!
Country [46]
0
0
China
Query!
State/province [46]
0
0
Hubei
Query!
Country [47]
0
0
China
Query!
State/province [47]
0
0
Shandong
Query!
Country [48]
0
0
China
Query!
State/province [48]
0
0
Tianjin
Query!
Country [49]
0
0
China
Query!
State/province [49]
0
0
Yunnan
Query!
Country [50]
0
0
China
Query!
State/province [50]
0
0
Changchun City
Query!
Country [51]
0
0
China
Query!
State/province [51]
0
0
Chongqing
Query!
Country [52]
0
0
China
Query!
State/province [52]
0
0
Fujian
Query!
Country [53]
0
0
China
Query!
State/province [53]
0
0
Shanghai
Query!
Country [54]
0
0
China
Query!
State/province [54]
0
0
Wulumuqi City
Query!
Country [55]
0
0
Colombia
Query!
State/province [55]
0
0
Atlantico
Query!
Country [56]
0
0
Colombia
Query!
State/province [56]
0
0
Quindío
Query!
Country [57]
0
0
Colombia
Query!
State/province [57]
0
0
Bogota
Query!
Country [58]
0
0
Colombia
Query!
State/province [58]
0
0
Bogotá
Query!
Country [59]
0
0
Colombia
Query!
State/province [59]
0
0
Cali
Query!
Country [60]
0
0
Colombia
Query!
State/province [60]
0
0
Yopal
Query!
Country [61]
0
0
Costa Rica
Query!
State/province [61]
0
0
San Jose
Query!
Country [62]
0
0
Czech Republic
Query!
State/province [62]
0
0
Brno - Bohunice
Query!
Country [63]
0
0
Czech Republic
Query!
State/province [63]
0
0
Hradec Kralove
Query!
Country [64]
0
0
Czech Republic
Query!
State/province [64]
0
0
Olomouc
Query!
Country [65]
0
0
Czech Republic
Query!
State/province [65]
0
0
Ostrava-Poruba
Query!
Country [66]
0
0
Czech Republic
Query!
State/province [66]
0
0
Plzen
Query!
Country [67]
0
0
Czech Republic
Query!
State/province [67]
0
0
Praha 10
Query!
Country [68]
0
0
Czech Republic
Query!
State/province [68]
0
0
Praha
Query!
Country [69]
0
0
Czech Republic
Query!
State/province [69]
0
0
Ustri nad Labem
Query!
Country [70]
0
0
Dominican Republic
Query!
State/province [70]
0
0
Republica Dominicana
Query!
Country [71]
0
0
Ecuador
Query!
State/province [71]
0
0
Guayaquil
Query!
Country [72]
0
0
Egypt
Query!
State/province [72]
0
0
Cairo
Query!
Country [73]
0
0
Egypt
Query!
State/province [73]
0
0
Giza
Query!
Country [74]
0
0
France
Query!
State/province [74]
0
0
Bordeaux
Query!
Country [75]
0
0
France
Query!
State/province [75]
0
0
Creteil
Query!
Country [76]
0
0
France
Query!
State/province [76]
0
0
Dijon
Query!
Country [77]
0
0
France
Query!
State/province [77]
0
0
Lyon CEDEX 04
Query!
Country [78]
0
0
France
Query!
State/province [78]
0
0
Melun
Query!
Country [79]
0
0
France
Query!
State/province [79]
0
0
Montargis
Query!
Country [80]
0
0
France
Query!
State/province [80]
0
0
Montauban
Query!
Country [81]
0
0
France
Query!
State/province [81]
0
0
Nantes Cedex 1
Query!
Country [82]
0
0
France
Query!
State/province [82]
0
0
Nice
Query!
Country [83]
0
0
France
Query!
State/province [83]
0
0
Paris cedex 10
Query!
Country [84]
0
0
France
Query!
State/province [84]
0
0
Paris Cedex 19
Query!
Country [85]
0
0
France
Query!
State/province [85]
0
0
Paris
Query!
Country [86]
0
0
France
Query!
State/province [86]
0
0
Poitiers
Query!
Country [87]
0
0
France
Query!
State/province [87]
0
0
Reims
Query!
Country [88]
0
0
France
Query!
State/province [88]
0
0
Toulouse Cedex 9
Query!
Country [89]
0
0
France
Query!
State/province [89]
0
0
Vannes
Query!
Country [90]
0
0
Germany
Query!
State/province [90]
0
0
Augsburg
Query!
Country [91]
0
0
Germany
Query!
State/province [91]
0
0
Berlin
Query!
Country [92]
0
0
Germany
Query!
State/province [92]
0
0
Bonn
Query!
Country [93]
0
0
Germany
Query!
State/province [93]
0
0
Dannenberg
Query!
Country [94]
0
0
Germany
Query!
State/province [94]
0
0
Hamburg
Query!
Country [95]
0
0
Germany
Query!
State/province [95]
0
0
Ingolstadt
Query!
Country [96]
0
0
Germany
Query!
State/province [96]
0
0
Koeln
Query!
Country [97]
0
0
Germany
Query!
State/province [97]
0
0
Luedenscheid
Query!
Country [98]
0
0
Germany
Query!
State/province [98]
0
0
Muenster
Query!
Country [99]
0
0
Germany
Query!
State/province [99]
0
0
Neu-Ulm
Query!
Country [100]
0
0
Germany
Query!
State/province [100]
0
0
Osnabrück
Query!
Country [101]
0
0
Germany
Query!
State/province [101]
0
0
Regensburg
Query!
Country [102]
0
0
Germany
Query!
State/province [102]
0
0
Rothenburg
Query!
Country [103]
0
0
Germany
Query!
State/province [103]
0
0
Schriesheim
Query!
Country [104]
0
0
Germany
Query!
State/province [104]
0
0
Tuebingen
Query!
Country [105]
0
0
Germany
Query!
State/province [105]
0
0
Tönisvorst
Query!
Country [106]
0
0
Greece
Query!
State/province [106]
0
0
GR
Query!
Country [107]
0
0
Greece
Query!
State/province [107]
0
0
Alexandroupolis
Query!
Country [108]
0
0
Greece
Query!
State/province [108]
0
0
Athens
Query!
Country [109]
0
0
Greece
Query!
State/province [109]
0
0
Lamia, Phthiotis
Query!
Country [110]
0
0
Guatemala
Query!
State/province [110]
0
0
Guatemala City
Query!
Country [111]
0
0
Hong Kong
Query!
State/province [111]
0
0
Kowloon
Query!
Country [112]
0
0
Hungary
Query!
State/province [112]
0
0
Budapest
Query!
Country [113]
0
0
Hungary
Query!
State/province [113]
0
0
Debrecen
Query!
Country [114]
0
0
Hungary
Query!
State/province [114]
0
0
Pecs
Query!
Country [115]
0
0
Hungary
Query!
State/province [115]
0
0
Szeged
Query!
Country [116]
0
0
India
Query!
State/province [116]
0
0
Bhudaneswar
Query!
Country [117]
0
0
India
Query!
State/province [117]
0
0
Tamil Nadu
Query!
Country [118]
0
0
India
Query!
State/province [118]
0
0
Telangana
Query!
Country [119]
0
0
India
Query!
State/province [119]
0
0
Ahmedabad
Query!
Country [120]
0
0
India
Query!
State/province [120]
0
0
New Delhi
Query!
Country [121]
0
0
Ireland
Query!
State/province [121]
0
0
Dublin 7
Query!
Country [122]
0
0
Ireland
Query!
State/province [122]
0
0
Dublin
Query!
Country [123]
0
0
Ireland
Query!
State/province [123]
0
0
Waterford
Query!
Country [124]
0
0
Israel
Query!
State/province [124]
0
0
Haifa
Query!
Country [125]
0
0
Israel
Query!
State/province [125]
0
0
Petach Tikva
Query!
Country [126]
0
0
Israel
Query!
State/province [126]
0
0
Tel Aviv
Query!
Country [127]
0
0
Italy
Query!
State/province [127]
0
0
BA
Query!
Country [128]
0
0
Italy
Query!
State/province [128]
0
0
CA
Query!
Country [129]
0
0
Italy
Query!
State/province [129]
0
0
GE
Query!
Country [130]
0
0
Italy
Query!
State/province [130]
0
0
Alessandria
Query!
Country [131]
0
0
Italy
Query!
State/province [131]
0
0
Belluno
Query!
Country [132]
0
0
Italy
Query!
State/province [132]
0
0
Brescia
Query!
Country [133]
0
0
Italy
Query!
State/province [133]
0
0
Pisa
Query!
Country [134]
0
0
Italy
Query!
State/province [134]
0
0
Reggio Calabria
Query!
Country [135]
0
0
Italy
Query!
State/province [135]
0
0
Roma
Query!
Country [136]
0
0
Japan
Query!
State/province [136]
0
0
Aichi
Query!
Country [137]
0
0
Japan
Query!
State/province [137]
0
0
Chiba
Query!
Country [138]
0
0
Japan
Query!
State/province [138]
0
0
Ehime
Query!
Country [139]
0
0
Japan
Query!
State/province [139]
0
0
Fukui
Query!
Country [140]
0
0
Japan
Query!
State/province [140]
0
0
Fukuoka
Query!
Country [141]
0
0
Japan
Query!
State/province [141]
0
0
Fukushima
Query!
Country [142]
0
0
Japan
Query!
State/province [142]
0
0
Gunma
Query!
Country [143]
0
0
Japan
Query!
State/province [143]
0
0
Hiroshima
Query!
Country [144]
0
0
Japan
Query!
State/province [144]
0
0
Hokkaido
Query!
Country [145]
0
0
Japan
Query!
State/province [145]
0
0
Hokkido
Query!
Country [146]
0
0
Japan
Query!
State/province [146]
0
0
Hyogo
Query!
Country [147]
0
0
Japan
Query!
State/province [147]
0
0
Ibaraki
Query!
Country [148]
0
0
Japan
Query!
State/province [148]
0
0
Ishikawa
Query!
Country [149]
0
0
Japan
Query!
State/province [149]
0
0
Kagawa
Query!
Country [150]
0
0
Japan
Query!
State/province [150]
0
0
Kanagawa
Query!
Country [151]
0
0
Japan
Query!
State/province [151]
0
0
Kangawa
Query!
Country [152]
0
0
Japan
Query!
State/province [152]
0
0
Kyoto
Query!
Country [153]
0
0
Japan
Query!
State/province [153]
0
0
Mie
Query!
Country [154]
0
0
Japan
Query!
State/province [154]
0
0
Miyagi
Query!
Country [155]
0
0
Japan
Query!
State/province [155]
0
0
Miyazakiken
Query!
Country [156]
0
0
Japan
Query!
State/province [156]
0
0
Miyazaki
Query!
Country [157]
0
0
Japan
Query!
State/province [157]
0
0
Nagano
Query!
Country [158]
0
0
Japan
Query!
State/province [158]
0
0
Nagasaki
Query!
Country [159]
0
0
Japan
Query!
State/province [159]
0
0
Nara
Query!
Country [160]
0
0
Japan
Query!
State/province [160]
0
0
Osaka
Query!
Country [161]
0
0
Japan
Query!
State/province [161]
0
0
Saitama
Query!
Country [162]
0
0
Japan
Query!
State/province [162]
0
0
Shizuoka
Query!
Country [163]
0
0
Japan
Query!
State/province [163]
0
0
Tochigi
Query!
Country [164]
0
0
Japan
Query!
State/province [164]
0
0
Tokushima
Query!
Country [165]
0
0
Japan
Query!
State/province [165]
0
0
Tokyo
Query!
Country [166]
0
0
Japan
Query!
State/province [166]
0
0
Toyama
Query!
Country [167]
0
0
Japan
Query!
State/province [167]
0
0
Yamanashi
Query!
Country [168]
0
0
Japan
Query!
State/province [168]
0
0
Akita
Query!
Country [169]
0
0
Japan
Query!
State/province [169]
0
0
Aomori
Query!
Country [170]
0
0
Japan
Query!
State/province [170]
0
0
Chiyoda-ku
Query!
Country [171]
0
0
Japan
Query!
State/province [171]
0
0
Gifu
Query!
Country [172]
0
0
Japan
Query!
State/province [172]
0
0
Hamamatsu-shi
Query!
Country [173]
0
0
Japan
Query!
State/province [173]
0
0
Kagoshima
Query!
Country [174]
0
0
Japan
Query!
State/province [174]
0
0
Kakogawa-shi
Query!
Country [175]
0
0
Japan
Query!
State/province [175]
0
0
Kawasaki-shi
Query!
Country [176]
0
0
Japan
Query!
State/province [176]
0
0
Kitami-shi
Query!
Country [177]
0
0
Japan
Query!
State/province [177]
0
0
Koriyama-shi
Query!
Country [178]
0
0
Japan
Query!
State/province [178]
0
0
Kouchi
Query!
Country [179]
0
0
Japan
Query!
State/province [179]
0
0
Kyoto-shi
Query!
Country [180]
0
0
Japan
Query!
State/province [180]
0
0
Nagasaki-shi
Query!
Country [181]
0
0
Japan
Query!
State/province [181]
0
0
Nantan-shi
Query!
Country [182]
0
0
Japan
Query!
State/province [182]
0
0
Otsu-shi
Query!
Country [183]
0
0
Japan
Query!
State/province [183]
0
0
Saitama-ken
Query!
Country [184]
0
0
Japan
Query!
State/province [184]
0
0
Sanjo-shi
Query!
Country [185]
0
0
Japan
Query!
State/province [185]
0
0
Shizuoka-shi
Query!
Country [186]
0
0
Japan
Query!
State/province [186]
0
0
Shunan-shi
Query!
Country [187]
0
0
Japan
Query!
State/province [187]
0
0
Toyohashi-shi
Query!
Country [188]
0
0
Japan
Query!
State/province [188]
0
0
Wakayama
Query!
Country [189]
0
0
Japan
Query!
State/province [189]
0
0
Yamagata
Query!
Country [190]
0
0
Korea, Republic of
Query!
State/province [190]
0
0
Gyeonggi-do
Query!
Country [191]
0
0
Korea, Republic of
Query!
State/province [191]
0
0
Gyeonggi
Query!
Country [192]
0
0
Korea, Republic of
Query!
State/province [192]
0
0
Korea
Query!
Country [193]
0
0
Korea, Republic of
Query!
State/province [193]
0
0
Busan
Query!
Country [194]
0
0
Korea, Republic of
Query!
State/province [194]
0
0
Daegu
Query!
Country [195]
0
0
Korea, Republic of
Query!
State/province [195]
0
0
Pusan
Query!
Country [196]
0
0
Korea, Republic of
Query!
State/province [196]
0
0
Seoul
Query!
Country [197]
0
0
Korea, Republic of
Query!
State/province [197]
0
0
Taegu
Query!
Country [198]
0
0
Malaysia
Query!
State/province [198]
0
0
Selangor
Query!
Country [199]
0
0
Malaysia
Query!
State/province [199]
0
0
Kuala Lumpur
Query!
Country [200]
0
0
Mexico
Query!
State/province [200]
0
0
CP
Query!
Country [201]
0
0
Mexico
Query!
State/province [201]
0
0
Distrito Federal
Query!
Country [202]
0
0
Mexico
Query!
State/province [202]
0
0
Nuevo León
Query!
Country [203]
0
0
Mexico
Query!
State/province [203]
0
0
Yucatán
Query!
Country [204]
0
0
Netherlands
Query!
State/province [204]
0
0
Almere
Query!
Country [205]
0
0
Netherlands
Query!
State/province [205]
0
0
Amsterdam
Query!
Country [206]
0
0
Netherlands
Query!
State/province [206]
0
0
Tilburg
Query!
Country [207]
0
0
Panama
Query!
State/province [207]
0
0
Panamá
Query!
Country [208]
0
0
Peru
Query!
State/province [208]
0
0
Lima
Query!
Country [209]
0
0
Poland
Query!
State/province [209]
0
0
Bydgoszcz
Query!
Country [210]
0
0
Poland
Query!
State/province [210]
0
0
Chojnice
Query!
Country [211]
0
0
Poland
Query!
State/province [211]
0
0
Chorzow
Query!
Country [212]
0
0
Poland
Query!
State/province [212]
0
0
Gdansk
Query!
Country [213]
0
0
Poland
Query!
State/province [213]
0
0
Gda¿sk
Query!
Country [214]
0
0
Poland
Query!
State/province [214]
0
0
Kalisz
Query!
Country [215]
0
0
Poland
Query!
State/province [215]
0
0
Kielce
Query!
Country [216]
0
0
Poland
Query!
State/province [216]
0
0
Krakow
Query!
Country [217]
0
0
Poland
Query!
State/province [217]
0
0
Lodz
Query!
Country [218]
0
0
Poland
Query!
State/province [218]
0
0
Olsztyn
Query!
Country [219]
0
0
Poland
Query!
State/province [219]
0
0
Poznan
Query!
Country [220]
0
0
Poland
Query!
State/province [220]
0
0
Walbrzych
Query!
Country [221]
0
0
Poland
Query!
State/province [221]
0
0
Warszawa
Query!
Country [222]
0
0
Poland
Query!
State/province [222]
0
0
Wolomin
Query!
Country [223]
0
0
Portugal
Query!
State/province [223]
0
0
Aveiro
Query!
Country [224]
0
0
Portugal
Query!
State/province [224]
0
0
Coimbra
Query!
Country [225]
0
0
Portugal
Query!
State/province [225]
0
0
Leiria
Query!
Country [226]
0
0
Portugal
Query!
State/province [226]
0
0
Lisboa
Query!
Country [227]
0
0
Portugal
Query!
State/province [227]
0
0
Matosinhos
Query!
Country [228]
0
0
Portugal
Query!
State/province [228]
0
0
Santa Maria Da Feira
Query!
Country [229]
0
0
Russian Federation
Query!
State/province [229]
0
0
Cheboksary
Query!
Country [230]
0
0
Russian Federation
Query!
State/province [230]
0
0
Chelyabinsk
Query!
Country [231]
0
0
Russian Federation
Query!
State/province [231]
0
0
Chita
Query!
Country [232]
0
0
Russian Federation
Query!
State/province [232]
0
0
Irkutsk
Query!
Country [233]
0
0
Russian Federation
Query!
State/province [233]
0
0
Kazan
Query!
Country [234]
0
0
Russian Federation
Query!
State/province [234]
0
0
Khabarovsk
Query!
Country [235]
0
0
Russian Federation
Query!
State/province [235]
0
0
Krasnodar
Query!
Country [236]
0
0
Russian Federation
Query!
State/province [236]
0
0
Moscow
Query!
Country [237]
0
0
Russian Federation
Query!
State/province [237]
0
0
Novosibirsk
Query!
Country [238]
0
0
Russian Federation
Query!
State/province [238]
0
0
Penza
Query!
Country [239]
0
0
Russian Federation
Query!
State/province [239]
0
0
Saint Petersburg
Query!
Country [240]
0
0
Russian Federation
Query!
State/province [240]
0
0
Samara
Query!
Country [241]
0
0
Russian Federation
Query!
State/province [241]
0
0
Saratov
Query!
Country [242]
0
0
Russian Federation
Query!
State/province [242]
0
0
Surgut
Query!
Country [243]
0
0
Russian Federation
Query!
State/province [243]
0
0
Tambov
Query!
Country [244]
0
0
Russian Federation
Query!
State/province [244]
0
0
Tyumen
Query!
Country [245]
0
0
Russian Federation
Query!
State/province [245]
0
0
Ufa
Query!
Country [246]
0
0
Russian Federation
Query!
State/province [246]
0
0
Yakutsk
Query!
Country [247]
0
0
Saudi Arabia
Query!
State/province [247]
0
0
Riyadh
Query!
Country [248]
0
0
Singapore
Query!
State/province [248]
0
0
Singapore
Query!
Country [249]
0
0
Slovakia
Query!
State/province [249]
0
0
Slovak Republic
Query!
Country [250]
0
0
Slovakia
Query!
State/province [250]
0
0
Bratislava
Query!
Country [251]
0
0
Slovakia
Query!
State/province [251]
0
0
Ljubljana
Query!
Country [252]
0
0
Slovakia
Query!
State/province [252]
0
0
Nove Zamky
Query!
Country [253]
0
0
Slovakia
Query!
State/province [253]
0
0
Poprad
Query!
Country [254]
0
0
Slovakia
Query!
State/province [254]
0
0
Ruzomberok
Query!
Country [255]
0
0
Slovakia
Query!
State/province [255]
0
0
Trencin
Query!
Country [256]
0
0
Slovakia
Query!
State/province [256]
0
0
Zilina
Query!
Country [257]
0
0
Slovakia
Query!
State/province [257]
0
0
Zvolen
Query!
Country [258]
0
0
Slovenia
Query!
State/province [258]
0
0
Celje
Query!
Country [259]
0
0
Slovenia
Query!
State/province [259]
0
0
Ljubljana
Query!
Country [260]
0
0
Slovenia
Query!
State/province [260]
0
0
Maribor
Query!
Country [261]
0
0
Slovenia
Query!
State/province [261]
0
0
Novo Mesto
Query!
Country [262]
0
0
Spain
Query!
State/province [262]
0
0
Andalucia
Query!
Country [263]
0
0
Spain
Query!
State/province [263]
0
0
Castilla y Leon
Query!
Country [264]
0
0
Spain
Query!
State/province [264]
0
0
Catalunya
Query!
Country [265]
0
0
Spain
Query!
State/province [265]
0
0
Cataluña
Query!
Country [266]
0
0
Spain
Query!
State/province [266]
0
0
Comunidad Valenciana
Query!
Country [267]
0
0
Spain
Query!
State/province [267]
0
0
Galicia
Query!
Country [268]
0
0
Spain
Query!
State/province [268]
0
0
Hospital La Rioja provincia
Query!
Country [269]
0
0
Spain
Query!
State/province [269]
0
0
Barcelona
Query!
Country [270]
0
0
Spain
Query!
State/province [270]
0
0
Burgos
Query!
Country [271]
0
0
Spain
Query!
State/province [271]
0
0
Granollers
Query!
Country [272]
0
0
Spain
Query!
State/province [272]
0
0
Madrid
Query!
Country [273]
0
0
Spain
Query!
State/province [273]
0
0
Murcia
Query!
Country [274]
0
0
Spain
Query!
State/province [274]
0
0
Zaragoza
Query!
Country [275]
0
0
Turkey
Query!
State/province [275]
0
0
Altindag / Ankara
Query!
Country [276]
0
0
Turkey
Query!
State/province [276]
0
0
Ankara
Query!
Country [277]
0
0
Turkey
Query!
State/province [277]
0
0
Mecidiyekoy/Istanbul
Query!
Country [278]
0
0
Ukraine
Query!
State/province [278]
0
0
Dnipropetrovsk
Query!
Country [279]
0
0
Ukraine
Query!
State/province [279]
0
0
Kyev
Query!
Country [280]
0
0
Ukraine
Query!
State/province [280]
0
0
Lugansk
Query!
Country [281]
0
0
Ukraine
Query!
State/province [281]
0
0
Odesa
Query!
Country [282]
0
0
United Kingdom
Query!
State/province [282]
0
0
Cornwall
Query!
Country [283]
0
0
United Kingdom
Query!
State/province [283]
0
0
County Durham
Query!
Country [284]
0
0
United Kingdom
Query!
State/province [284]
0
0
Devon,
Query!
Country [285]
0
0
United Kingdom
Query!
State/province [285]
0
0
England
Query!
Country [286]
0
0
United Kingdom
Query!
State/province [286]
0
0
Essex
Query!
Country [287]
0
0
United Kingdom
Query!
State/province [287]
0
0
Gloucestershire
Query!
Country [288]
0
0
United Kingdom
Query!
State/province [288]
0
0
Lancashire
Query!
Country [289]
0
0
United Kingdom
Query!
State/province [289]
0
0
London
Query!
Country [290]
0
0
United Kingdom
Query!
State/province [290]
0
0
Oxfordshire
Query!
Country [291]
0
0
United Kingdom
Query!
State/province [291]
0
0
South Yorkshire
Query!
Country [292]
0
0
United Kingdom
Query!
State/province [292]
0
0
Staffordshire
Query!
Country [293]
0
0
United Kingdom
Query!
State/province [293]
0
0
Surrey
Query!
Country [294]
0
0
United Kingdom
Query!
State/province [294]
0
0
UK
Query!
Country [295]
0
0
United Kingdom
Query!
State/province [295]
0
0
West Yorkshire
Query!
Country [296]
0
0
United Kingdom
Query!
State/province [296]
0
0
Bedford
Query!
Country [297]
0
0
United Kingdom
Query!
State/province [297]
0
0
Birmingham
Query!
Country [298]
0
0
United Kingdom
Query!
State/province [298]
0
0
Bristol
Query!
Country [299]
0
0
United Kingdom
Query!
State/province [299]
0
0
Cardiff
Query!
Country [300]
0
0
United Kingdom
Query!
State/province [300]
0
0
Cheshire
Query!
Country [301]
0
0
United Kingdom
Query!
State/province [301]
0
0
Colchester
Query!
Country [302]
0
0
United Kingdom
Query!
State/province [302]
0
0
Inverness
Query!
Country [303]
0
0
United Kingdom
Query!
State/province [303]
0
0
Kent
Query!
Country [304]
0
0
United Kingdom
Query!
State/province [304]
0
0
Leeds
Query!
Country [305]
0
0
United Kingdom
Query!
State/province [305]
0
0
Liverpool
Query!
Country [306]
0
0
United Kingdom
Query!
State/province [306]
0
0
Maidstone
Query!
Country [307]
0
0
United Kingdom
Query!
State/province [307]
0
0
Manchester
Query!
Country [308]
0
0
United Kingdom
Query!
State/province [308]
0
0
Merseyside
Query!
Country [309]
0
0
United Kingdom
Query!
State/province [309]
0
0
Middlesborough
Query!
Country [310]
0
0
United Kingdom
Query!
State/province [310]
0
0
Newport
Query!
Country [311]
0
0
United Kingdom
Query!
State/province [311]
0
0
Portsmouth
Query!
Country [312]
0
0
United Kingdom
Query!
State/province [312]
0
0
Southend
Query!
Country [313]
0
0
United Kingdom
Query!
State/province [313]
0
0
Sunderland
Query!
Country [314]
0
0
United Kingdom
Query!
State/province [314]
0
0
Uxbridge
Query!
Country [315]
0
0
United Kingdom
Query!
State/province [315]
0
0
Wolverhampton
Query!
Country [316]
0
0
United Kingdom
Query!
State/province [316]
0
0
York
Query!
Country [317]
0
0
Venezuela
Query!
State/province [317]
0
0
Isla Margarita
Query!
Country [318]
0
0
Venezuela
Query!
State/province [318]
0
0
Caracas, Piso 6, Ofic. 607
Query!
Country [319]
0
0
Venezuela
Query!
State/province [319]
0
0
Caracas
Query!
Country [320]
0
0
Venezuela
Query!
State/province [320]
0
0
Santa Paula
Query!
Country [321]
0
0
Venezuela
Query!
State/province [321]
0
0
Torre Venezuela, Piso 1
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Novartis Pharmaceuticals
Query!
Address
Query!
Country
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
This study will describe the long-term safety and effectiveness, treatment patterns,and patient reported quality of life associated with ranibizumab treatment in routine clinical practice for all approved indication included in the local product label.
Query!
Trial website
https://clinicaltrials.gov/study/NCT01318941
Query!
Trial related presentations / publications
Holz FG, Minnella AM, Tuli R, Yoganathan P, Parikh S, Hamilton R; LUMINOUS study group. Ranibizumab treatment patterns in prior ranibizumab-treated neovascular age-related macular degeneration patients: Real-world outcomes from the LUMINOUS study. PLoS One. 2020 Dec 30;15(12):e0244183. doi: 10.1371/journal.pone.0244183. eCollection 2020. Leys AM, Ramboer E, Favreau M, Denhaerynck K, MacDonald K, Abraham I, Brie H. Long-Term Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Belgian Subanalysis from the Global Real-World LUMINOUSTM Study. Clin Ophthalmol. 2020 Jun 2;14:1473-1481. doi: 10.2147/OPTH.S242547. eCollection 2020. Pearce I, Clemens A, Brent MH, Lu L, Gallego-Pinazo R, Minnella AM, Creuzot-Garcher C, Spital G, Sakamoto T, Dunger-Baldauf C, McAllister IL; all the LUMINOUS study investigators. Real-world outcomes with ranibizumab in branch retinal vein occlusion: The prospective, global, LUMINOUS study. PLoS One. 2020 Jun 18;15(6):e0234739. doi: 10.1371/journal.pone.0234739. eCollection 2020. Mitchell P, Sheidow TG, Farah ME, Mahmood S, Minnella AM, Eter N, Eldem B, Al-Dhibi H, Macfadden W, Parikh S, Dunger-Baldauf C, Mahgoub MM, Schmidt-Erfurth U; LUMINOUS study investigators. Effectiveness and safety of ranibizumab 0.5 mg in treatment-naive patients with diabetic macular edema: Results from the real-world global LUMINOUS study. PLoS One. 2020 Jun 3;15(6):e0233595. doi: 10.1371/journal.pone.0233595. eCollection 2020. Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Mones J, Richard G, Bandello F; European Society of Retina Specialists. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol. 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Novartis Pharmaceuticals
Query!
Address
0
0
Novartis Pharmaceuticals
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results not provided in
https://clinicaltrials.gov/study/NCT01318941
Download to PDF