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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT01730040
Registration number
NCT01730040
Ethics application status
Date submitted
9/11/2012
Date registered
21/11/2012
Date last updated
31/08/2015
Titles & IDs
Public title
Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)
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Scientific title
A Randomized, Double-Blind Study of the Efficacy and Safety of Alirocumab Added on to Atorvastatin Versus Ezetimibe Added on to Atorvastatin Versus Atorvastatin Dose Increase Versus Switch to Rosuvastatin in Patients Who Are Not Controlled on Atorvastatin
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Secondary ID [1]
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0
R727-CL-1110
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Universal Trial Number (UTN)
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Trial acronym
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Hypercholesterolemia
0
0
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Condition category
Condition code
Metabolic and Endocrine
0
0
0
0
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Other metabolic disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Alirocumab
Treatment: Drugs - Atorvastatin
Treatment: Drugs - Ezetimibe
Treatment: Drugs - Rosuvastatin
Treatment: Drugs - Placebo
Active Comparator: Atorvastatin 40 mg - Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received atorvastatin 40 mg over-encapsulated tablets orally once daily (QD), placebo for alirocumab SC injection every two weeks (Q2W), and placebo for ezetimibe over-encapsulated tablets orally QD added to stable Lipid-Modifying Therapy (LMT) for 24 weeks.
Active Comparator: Ezetimibe 10 mg + Atorvastatin 20 mg - Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received ezetimibe 10 mg over-encapsulated tablets orally QD, atorvastatin 20 mg over-encapsulated tablets orally QD, and placebo for alirocumab SC injection Q2W added to stable LMT for 24 weeks.
Experimental: Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg - Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received Alirocumab 75 mg SC injection Q2W, atorvastatin 20 mg over-encapsulated tablets orally QD, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks. Alirocumab dose up-titrated to 150 mg Q2W from Week 12 when LDL-C levels =70 mg/dL (1.81 mmol/L) or =100 mg/dL (2.59 mmol/L) at Week 8, based on baseline disease characteristic and medical history.
Active Comparator: Atorvastatin 80 mg - Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received Atorvastatin 80 mg over-encapsulated tablets orally QD, placebo for alirocumab SC injection Q2W, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
Active Comparator: Rosuvastatin 40 mg - Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received rosuvastatin 40 mg over-encapsulated tablets orally QD, placebo for alirocumab SC injection Q2W, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
Active Comparator: Ezetimibe 10 mg + Atorvastatin 40 mg - Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received ezetimibe 10 mg over-encapsulated tablets orally QD, atorvastatin 40 mg over-encapsulated tablets orally QD, and placebo for alirocumab SC injection Q2W added to stable LMT for 24 weeks.
Experimental: Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg - Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received alirocumab 75 mg SC injection Q2W, atorvastatin 40 mg over-encapsulated tablets orally QD, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks. Alirocumab dose up-titrated to 150 mg Q2W from Week 12 when LDL-C levels =70 mg/dL (1.81 mmol/L) or =100 mg/dL (2.59 mmol/L) at Week 8, based on baseline disease characteristic and medical history.
Treatment: Drugs: Alirocumab
Alirocumab administered as a SC injection of 1 mL into the abdomen, thigh, or outer area of the upper arm.
Treatment: Drugs: Atorvastatin
Atorvastatin over-encapsulated tablets orally.
Treatment: Drugs: Ezetimibe
Ezetimibe over-encapsulated tablet orally.
Treatment: Drugs: Rosuvastatin
Rosuvastatin over-encapsulated tablets orally.
Treatment: Drugs: Placebo
Placebo for alirocumab and ezetimibe.
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Percent Change From Baseline in Calculated LDL-C at Week 24 - Intent-to-treat (ITT) Analysis
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Assessment method [1]
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Calculated LDL-C values were obtained from Friedewald formula. Adjusted Least-squares (LS) means and standard errors at Week 24 were obtained from a mixed-effect model with repeated measures (MMRM) to account for missing data. All available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment were used in the model (ITT analysis).
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Timepoint [1]
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From Baseline to Week 24
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Secondary outcome [1]
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Percent Change From Baseline in Calculated LDL-C at Week 24 - On-Treatment Analysis
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Assessment method [1]
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Calculated LDL-C values were obtained from Friedewald formula. Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first) (on-treatment analysis).
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Timepoint [1]
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From Baseline to Week 24
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Secondary outcome [2]
0
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Percent Change From Baseline in Calculated LDL-C at Week 12 - ITT Analysis
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Assessment method [2]
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Calculated LDL-C values were obtained from Friedewald formula. Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment (ITT analysis).
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Timepoint [2]
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0
From Baseline to Week 24
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Secondary outcome [3]
0
0
Percent Change From Baseline in Calculated LDL-C at Week 12 - On-Treatment Analysis
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Assessment method [3]
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Calculated LDL-C values were obtained from Friedewald formula. Adjusted LS means and standard errors at Week 12 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first) (on-treatment analysis).
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Timepoint [3]
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0
From Baseline to Week 24
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Secondary outcome [4]
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0
Percent Change From Baseline in Apolipoprotein (Apo) B at Week 24 - ITT Analysis
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Assessment method [4]
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0
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [4]
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0
From Baseline to Week 24
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Secondary outcome [5]
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0
Percent Change From Baseline in Apo B at Week 24 - On-Treatment Analysis
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Assessment method [5]
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Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (ie. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first).
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Timepoint [5]
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From Baseline to Week 24
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Secondary outcome [6]
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Percent Change From Baseline in Non-High-density Lipoprotein Cholesterol (Non-HDL-C) at Week 24 - ITT Analysis
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Assessment method [6]
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Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [6]
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From Baseline to Week 24
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Secondary outcome [7]
0
0
Percent Change From Baseline in Non-HDL-C at Week 24 - On-Treatment Analysis
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Assessment method [7]
0
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Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first).
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Timepoint [7]
0
0
From Baseline to Week 24
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Secondary outcome [8]
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0
Percent Change From Baseline in Total Cholesterol (Total-C) at Week 24 - ITT Analysis
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Assessment method [8]
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0
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [8]
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0
From Baseline to Week 24
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Secondary outcome [9]
0
0
Percent Change From Baseline in Apo B at Week 12 - ITT Analysis
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Assessment method [9]
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0
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [9]
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0
From Baseline to Week 24
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Secondary outcome [10]
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0
Percent Change From Baseline in Non-HDL-C at Week 12 - ITT Analysis
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Assessment method [10]
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0
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [10]
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0
From Baseline to Week 24
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Secondary outcome [11]
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0
Percent Change From Baseline in Total-C at Week 12 - ITT Analysis
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Assessment method [11]
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Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [11]
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From Baseline to Week 24
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Secondary outcome [12]
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Percentage of Very High CV Risk Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) or High CV Risk Participants Reaching Calculated LDL-C <100 mg/dL (2.59 mmol/L) at Week 24 - ITT Analysis
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Assessment method [12]
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Adjusted percentages at Week 24 were obtained from a multiple imputation approach model for handling of missing data. All available post-baseline data from Week 4 to week 24 regardless of status on- or off-treatment were included in the imputation model (ITT analysis).
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Timepoint [12]
0
0
Up to Week 24
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Secondary outcome [13]
0
0
Percentage of Very High CV Risk Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) or High CV Risk Participants Reaching Calculated LDL-C <100 mg/dL (2.59 mmol/L) at Week 24 - On-Treatment Analysis
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Assessment method [13]
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Adjusted percentages at Week 24 were obtained from a multiple imputation approach model including available post-baseline on-treatment data from Week 4 to Week 24 i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first (on-treatment analysis).
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Timepoint [13]
0
0
Up to Week 24
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Secondary outcome [14]
0
0
Percentage of Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) at Week 24 - ITT Analysis
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Assessment method [14]
0
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Adjusted percentages at Week 24 were obtained from a multiple imputation approach model for handling of missing data. All available post-baseline data from Week 4 to week 24 regardless of status on- or off-treatment were included in the imputation model (ITT analysis).
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Timepoint [14]
0
0
Up to Week 24
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Secondary outcome [15]
0
0
Percentage of Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) at Week 24 - On-Treatment Analysis
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Assessment method [15]
0
0
Adjusted percentages at Week 24 were obtained from a multiple imputation approach model including available post-baseline on-treatment data from Week 4 to Week 24 i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first (on-treatment analysis).
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Timepoint [15]
0
0
Up to Week 24
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Secondary outcome [16]
0
0
Percent Change From Baseline in Lipoprotein(a) at Week 24 - ITT Analysis
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Assessment method [16]
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0
Adjusted means and standard errors at Week 24 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [16]
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0
From Baseline to Week 24
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Secondary outcome [17]
0
0
Percent Change From Baseline in HDL-C at Week 24 - ITT Analysis
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Assessment method [17]
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Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [17]
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From Baseline to Week 24
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Secondary outcome [18]
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Percent Change From Baseline in Fasting Triglycerides at Week 24 - ITT Analysis
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Assessment method [18]
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Adjusted means and standard errors at Week 24 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [18]
0
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From Baseline to Week 24
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Secondary outcome [19]
0
0
Percent Change From Baseline in Apo A-1 at Week 24 - ITT Analysis
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Assessment method [19]
0
0
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [19]
0
0
From Baseline to Week 24
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Secondary outcome [20]
0
0
Percent Change From Baseline in Lipoprotein(a) at Week 12 - ITT Analysis
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Assessment method [20]
0
0
Adjusted means and standard errors at Week 12 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [20]
0
0
From Baseline to Week 24
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Secondary outcome [21]
0
0
Percent Change From Baseline in HDL-C at Week 12 - ITT Analysis
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Assessment method [21]
0
0
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [21]
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0
From Baseline to Week 24
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Secondary outcome [22]
0
0
Percent Change From Baseline in Fasting Triglycerides at Week 12 - ITT Analysis
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Assessment method [22]
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0
Adjusted means and standard errors at Week 12 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [22]
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From Baseline to Week 24
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Secondary outcome [23]
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0
Percent Change From Baseline in Apo A-1 at Week 12 - ITT Analysis
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Assessment method [23]
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Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
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Timepoint [23]
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From Baseline to Week 24
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Eligibility
Key inclusion criteria
1. Patients with screening (visit 1) LDL-C greater than or equal to 70 mg/dL with
documented CVD, not adequately controlled with a daily dose of atorvastatin. OR
2. Patients with screening (visit 1) LDL-C greater than or equal to 100 mg/dL at high
risk for CVD who are not adequately controlled with a daily dose of atorvastatin.
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
1. LDL-C greater than 250 mg/dL
2. LDL-C less than 70 mg/dL at the screening visit in patients with history of documented
CVD
3. LDL-C less than 100 mg/dL at the screening visit in patients without history of
documented CHD or non-CHD CVD, but with other risk factors
4. TG greater than 400 mg/dL
5. Homozygous FH (clinically or previous genotyping)
6. Currently taking a statin that is not atorvastatin
7. Currently taking Ezetimibe (EZE)
8. Not on a stable dose of allowable lipid modifying treatments (LMT)
(The inclusion/ exclusion criteria provided above is not intended to contain all
considerations relevant to a patient's potential participation in this clinical trial).
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/10/2012
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/05/2014
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Sample size
Target
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Accrual to date
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Final
355
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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- Herston QLD
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Recruitment hospital [2]
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- New Lambton Heights
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Recruitment hospital [3]
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- Perth
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Recruitment hospital [4]
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- Sherwood
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Recruitment hospital [5]
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- Woolloongabba
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Recruitment postcode(s) [1]
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- Herston QLD
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Recruitment postcode(s) [2]
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- New Lambton Heights
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Recruitment postcode(s) [3]
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- Perth
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Recruitment postcode(s) [4]
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- Sherwood
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Recruitment postcode(s) [5]
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- Woolloongabba
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Recruitment outside Australia
Country [1]
0
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United States of America
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State/province [1]
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Alabama
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0
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United States of America
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State/province [2]
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Arizona
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0
0
United States of America
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California
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Country [4]
0
0
United States of America
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State/province [4]
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0
Connecticut
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Country [5]
0
0
United States of America
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State/province [5]
0
0
Florida
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Country [6]
0
0
United States of America
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State/province [6]
0
0
Idaho
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Country [7]
0
0
United States of America
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State/province [7]
0
0
Illinois
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Country [8]
0
0
United States of America
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State/province [8]
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0
Indiana
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Country [9]
0
0
United States of America
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State/province [9]
0
0
Kansas
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0
0
United States of America
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State/province [10]
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0
Kentucky
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0
0
United States of America
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State/province [11]
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Maine
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Country [12]
0
0
United States of America
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State/province [12]
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Maryland
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0
0
United States of America
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Minnesota
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0
0
United States of America
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Mississippi
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0
0
United States of America
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State/province [15]
0
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Missouri
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Country [16]
0
0
United States of America
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State/province [16]
0
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Montana
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Country [17]
0
0
United States of America
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State/province [17]
0
0
Nevada
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0
0
United States of America
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State/province [18]
0
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New York
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0
0
United States of America
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North Carolina
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United States of America
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Ohio
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0
0
United States of America
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Oklahoma
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0
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United States of America
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Rhode Island
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0
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United States of America
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South Carolina
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0
0
United States of America
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Tennessee
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United States of America
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Texas
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United States of America
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Utah
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United States of America
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Washington
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Canada
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Ontario
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0
0
Canada
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0
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Quebec
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0
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France
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Dijon
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France
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Lille
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France
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State/province [32]
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Venissieux
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0
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Germany
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Bad Oeynhausen
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Germany
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Berlin
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Germany
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Koeln
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Germany
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Munich
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Germany
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Regensburg
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Germany
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Ulm
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Italy
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Chiete
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0
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Italy
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Genova
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0
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Italy
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Napoli
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0
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Italy
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Palermo
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0
0
Italy
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State/province [43]
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Roma (2 locations)
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0
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Mexico
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State/province [44]
0
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Distrito Federal
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0
0
Mexico
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0
Guadalajara, Jalisco
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0
0
Mexico
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0
Guadalajara
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0
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Mexico
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Monterrey Nuevo Leon
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0
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Mexico
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0
Tijuana Baja California
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0
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Mexico
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State/province [49]
0
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Zapopan Jalisco
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0
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Spain
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Barcelona (3 locations)
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Spain
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0
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Madrid
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Country [52]
0
0
Spain
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State/province [52]
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0
Sant Joan Despi
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Country [53]
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United Kingdom
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State/province [53]
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Carmarthen
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Country [54]
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0
United Kingdom
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State/province [54]
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Chester
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Country [55]
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0
United Kingdom
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State/province [55]
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0
Peterborough
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Country [56]
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0
United Kingdom
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State/province [56]
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0
Salford
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Country [57]
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0
United Kingdom
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State/province [57]
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0
Stevenage
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Country [58]
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0
United Kingdom
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State/province [58]
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West Bromwich, West Midlands
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Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
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Name
Regeneron Pharmaceuticals
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Address
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Country
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Other collaborator category [1]
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0
Commercial sector/Industry
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Name [1]
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Sanofi
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Address [1]
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0
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Country [1]
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0
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Ethics approval
Ethics application status
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Summary
Brief summary
This is a randomized, double-blind, active-comparator, parallel-group study in patients at
high cardiovascular risk with nonfamilial hypercholesterolemia or heterozygous familial
hypercholesterolemia (heFH).
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Trial website
https://clinicaltrials.gov/ct2/show/NCT01730040
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
Name
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Clinical Trial Management
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Address
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Regeneron Pharmaceuticals
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Country
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0
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Phone
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0
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Fax
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0
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Email
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Contact person for public queries
Name
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Address
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0
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Country
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0
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Phone
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0
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Fax
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0
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Email
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0
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Contact person for scientific queries
Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT01730040
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