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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/ct2/show/NCT01764633
Registration number
NCT01764633
Ethics application status
Date submitted
8/01/2013
Date registered
9/01/2013
Date last updated
28/05/2024
Titles & IDs
Public title
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
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Scientific title
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease
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Secondary ID [1]
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2014/01/004324
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Secondary ID [2]
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20110118
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Universal Trial Number (UTN)
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Trial acronym
FOURIER
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Dyslipidemia
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Condition category
Condition code
Cardiovascular
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Other cardiovascular diseases
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Blood
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Other blood disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Other interventions - Evolocumab
Treatment: Drugs - Placebo
Placebo Comparator: Placebo - Participants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference.
Experimental: Evolocumab - Participants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference.
Other interventions: Evolocumab
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Treatment: Drugs: Placebo
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
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Intervention code [1]
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Other interventions
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Intervention code [2]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Time to Cardiovascular Death, Myocardial Infarction, Hospitalization for Unstable Angina, Stroke, or Coronary Revascularization
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Assessment method [1]
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All deaths and potential endpoint events were adjudicated by an independent external Clinical Events Committee (CEC) led by the Thrombolysis in Myocardial Infarction (TIMI) Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction".
Time to cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [1]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [1]
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Time to Cardiovascular Death, Myocardial Infarction, or Stroke
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Assessment method [1]
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Time to cardiovascular death, myocardial infarction, or stroke was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [1]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [2]
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Time to Cardiovascular Death
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Assessment method [2]
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction".
Cardiovascular death includes death resulting from an acute myocardial infarction (MI), sudden cardiac death, death due to heart failure (HF), death due to stroke, death due to cardiovascular (CV) procedures, death due to CV hemorrhage, and death due to other CV causes.
Time to cardiovascular death was defined as the time from randomization to the date of cardiovascular death and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on the last confirmed survival status date.
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Timepoint [2]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [3]
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Time to All Cause Death
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Assessment method [3]
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Time to all-cause death was defined as the time from randomization to the date of death and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on the last confirmed survival status date.
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Timepoint [3]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [4]
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Time to First Myocardial Infarction
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Assessment method [4]
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction".
The diagnosis of myocardial infarction required the combination of:
Evidence of myocardial necrosis (either changes in cardiac biomarkers or post-mortem pathological findings); and
Supporting information derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery Imaging.
Time to first myocardial infarction was defined as the time from randomization to the date of the first MI and was analyzed using Kaplan-Meier survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [4]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [5]
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Time to First Stroke
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Assessment method [5]
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction".
Stroke was defined as an acute episode of focal or global neurological dysfunction caused by brain, spinal cord, or retinal vascular injury as a result of hemorrhage or infarction.
Time to first stroke was defined as the time from randomization to the date of the stroke and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [5]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [6]
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Time to First Coronary Revascularization
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Assessment method [6]
0
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction".
Time to first coronary revascularization was defined as the time from randomization to the date of the coronary revascularization and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [6]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [7]
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Time to Cardiovascular Death or First Hospitalization for Worsening Heart Failure
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Assessment method [7]
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All events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions.
HF hospitalization was defined as an event that met all of the following criteria:
Admitted to hospital with a primary diagnosis of HF
In hospital for at least 24 hours
Documented new or worsening symptoms due to HF, including at least 1 of the following:
Dyspnea
Decreased exercise tolerance
Fatigue
Other symptoms of worsened end-organ perfusion or volume overload
Evidence of new or worsening HF consisting of at least 2 physical exam findings or 1 physical exam finding and at least 1 laboratory criterion
Received new or increased treatment for HF. Time to CV death or first hospitalization for worsening HF was defined as the time from randomization to the first occurrence of any component of the endpoint analyzed using KM survival analysis. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [7]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Secondary outcome [8]
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Time to First Ischemic Fatal or Non-Fatal Stroke or Transient Ischemic Attack
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Assessment method [8]
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All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions.
Ischemic stroke was defined as an acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of central nervous system tissue. Transient ischemic attack (TIA) was defined as a transient episode of focal neurological dysfunction caused by brain, spinal cord, or retinal ischemia, without acute infarction.
Time to first ischemic fatal or non-fatal stroke or TIA was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using KM analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.
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Timepoint [8]
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Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
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Eligibility
Key inclusion criteria
- Male or female = 40 to = 85 years of age
- History of clinically evident cardiovascular disease at high risk for a recurrent
event
- Fasting low-density lipoprotein cholesterol (LDL-C) = 70 mg/dL (= 1.8 mmol/L) ) or
non-high-density lipoprotein cholesterol (non-HDL-C) = 100 mg/dL (> 2.6 mmol/L)
- Fasting triglycerides = 400 mg/dL (4.5 mmol/L)
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Minimum age
40
Years
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Maximum age
85
Years
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
- New York Heart Association (NYHA) class III or IV, or last known left ventricular
ejection fraction < 30%
- Uncontrolled hypertension
- Uncontrolled or recurrent ventricular tachycardia
- Untreated hyperthyroidism or hypothyroidism
- Homozygous familial hypercholesterolemia
- LDL or plasma apheresis
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
8/02/2013
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
11/11/2016
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Sample size
Target
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Accrual to date
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Final
27564
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,TAS,VIC,WA
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Recruitment hospital [1]
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Research Site - Woden
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Research Site - Nedlands
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Recruitment postcode(s) [1]
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2605 - Woden
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Recruitment postcode(s) [2]
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2050 - Camperdown
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2139 - Concord
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2217 - Kogarah
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Recruitment postcode(s) [5]
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2170 - Liverpool
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Recruitment postcode(s) [6]
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4102 - Woolloongabba
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Recruitment postcode(s) [7]
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4066 - Auchenflower
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Recruitment postcode(s) [8]
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4029 - Herston
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Recruitment postcode(s) [9]
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5000 - Adelaide
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Recruitment postcode(s) [10]
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5035 - Ashford
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Recruitment postcode(s) [11]
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5036 - Ashford
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Recruitment postcode(s) [12]
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5063 - Fullarton
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5011 - Woodville South
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Recruitment postcode(s) [14]
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7000 - Hobart
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Recruitment postcode(s) [15]
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3128 - Box Hill
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Recruitment postcode(s) [16]
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3076 - Epping
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3011 - Footscray
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3220 - Geelong
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3084 - Heidelberg
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Recruitment postcode(s) [20]
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6009 - Nedlands
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Recruitment outside Australia
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Belgium
Query!
State/province [73]
0
0
Turnhout
Query!
Country [74]
0
0
Brazil
Query!
State/province [74]
0
0
Ceará
Query!
Country [75]
0
0
Brazil
Query!
State/province [75]
0
0
Distrito Federal
Query!
Country [76]
0
0
Brazil
Query!
State/province [76]
0
0
Espírito Santo
Query!
Country [77]
0
0
Brazil
Query!
State/province [77]
0
0
Goiás
Query!
Country [78]
0
0
Brazil
Query!
State/province [78]
0
0
Minas Gerais
Query!
Country [79]
0
0
Brazil
Query!
State/province [79]
0
0
Paraná
Query!
Country [80]
0
0
Brazil
Query!
State/province [80]
0
0
Rio Grande Do Sul
Query!
Country [81]
0
0
Brazil
Query!
State/province [81]
0
0
São Paulo
Query!
Country [82]
0
0
Brazil
Query!
State/province [82]
0
0
Rio De Janeiro
Query!
Country [83]
0
0
Bulgaria
Query!
State/province [83]
0
0
Haskovo
Query!
Country [84]
0
0
Bulgaria
Query!
State/province [84]
0
0
Kazanlak
Query!
Country [85]
0
0
Bulgaria
Query!
State/province [85]
0
0
Pazardzhik
Query!
Country [86]
0
0
Bulgaria
Query!
State/province [86]
0
0
Pleven
Query!
Country [87]
0
0
Bulgaria
Query!
State/province [87]
0
0
Plovdiv
Query!
Country [88]
0
0
Bulgaria
Query!
State/province [88]
0
0
Sofia
Query!
Country [89]
0
0
Bulgaria
Query!
State/province [89]
0
0
Varna
Query!
Country [90]
0
0
Canada
Query!
State/province [90]
0
0
Alberta
Query!
Country [91]
0
0
Canada
Query!
State/province [91]
0
0
British Columbia
Query!
Country [92]
0
0
Canada
Query!
State/province [92]
0
0
Newfoundland and Labrador
Query!
Country [93]
0
0
Canada
Query!
State/province [93]
0
0
Nova Scotia
Query!
Country [94]
0
0
Canada
Query!
State/province [94]
0
0
Ontario
Query!
Country [95]
0
0
Canada
Query!
State/province [95]
0
0
Quebec
Query!
Country [96]
0
0
Canada
Query!
State/province [96]
0
0
Saskatchewan
Query!
Country [97]
0
0
Chile
Query!
State/province [97]
0
0
Cautín
Query!
Country [98]
0
0
Chile
Query!
State/province [98]
0
0
Osorno
Query!
Country [99]
0
0
Chile
Query!
State/province [99]
0
0
Santiago
Query!
Country [100]
0
0
China
Query!
State/province [100]
0
0
Beijing
Query!
Country [101]
0
0
China
Query!
State/province [101]
0
0
Guangdong
Query!
Country [102]
0
0
China
Query!
State/province [102]
0
0
Heilongjiang
Query!
Country [103]
0
0
China
Query!
State/province [103]
0
0
Henan
Query!
Country [104]
0
0
China
Query!
State/province [104]
0
0
Hubei
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Hunan
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Inner Mongolia
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Jiangsu
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Jilin
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Liaoning
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Ningxia
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Shandong
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Shanxi
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Tianjin
Query!
Country [114]
0
0
China
Query!
State/province [114]
0
0
Xinjiang
Query!
Country [115]
0
0
China
Query!
State/province [115]
0
0
Zhejiang
Query!
Country [116]
0
0
Colombia
Query!
State/province [116]
0
0
Antioquia
Query!
Country [117]
0
0
Colombia
Query!
State/province [117]
0
0
Atlántico
Query!
Country [118]
0
0
Colombia
Query!
State/province [118]
0
0
Bolívar
Query!
Country [119]
0
0
Colombia
Query!
State/province [119]
0
0
Caldas
Query!
Country [120]
0
0
Colombia
Query!
State/province [120]
0
0
Cundinamarca
Query!
Country [121]
0
0
Colombia
Query!
State/province [121]
0
0
Quindío
Query!
Country [122]
0
0
Colombia
Query!
State/province [122]
0
0
Santander
Query!
Country [123]
0
0
Colombia
Query!
State/province [123]
0
0
Valle Del Cauca
Query!
Country [124]
0
0
Czechia
Query!
State/province [124]
0
0
Benatky nad Jizerou
Query!
Country [125]
0
0
Czechia
Query!
State/province [125]
0
0
Benesov
Query!
Country [126]
0
0
Czechia
Query!
State/province [126]
0
0
Beroun
Query!
Country [127]
0
0
Czechia
Query!
State/province [127]
0
0
Bilovec
Query!
Country [128]
0
0
Czechia
Query!
State/province [128]
0
0
Brandys nad Labem
Query!
Country [129]
0
0
Czechia
Query!
State/province [129]
0
0
Brno
Query!
Country [130]
0
0
Czechia
Query!
State/province [130]
0
0
Ceske Budejovice
Query!
Country [131]
0
0
Czechia
Query!
State/province [131]
0
0
Cesky Krumlov
Query!
Country [132]
0
0
Czechia
Query!
State/province [132]
0
0
Chomutov
Query!
Country [133]
0
0
Czechia
Query!
State/province [133]
0
0
Havlickuv Brod
Query!
Country [134]
0
0
Czechia
Query!
State/province [134]
0
0
Hodonin
Query!
Country [135]
0
0
Czechia
Query!
State/province [135]
0
0
Hradec Kralove
Query!
Country [136]
0
0
Czechia
Query!
State/province [136]
0
0
Hranice na Morave
Query!
Country [137]
0
0
Czechia
Query!
State/province [137]
0
0
Jihlava
Query!
Country [138]
0
0
Czechia
Query!
State/province [138]
0
0
Kladno
Query!
Country [139]
0
0
Czechia
Query!
State/province [139]
0
0
Klatovy IV
Query!
Country [140]
0
0
Czechia
Query!
State/province [140]
0
0
Kutna Hora
Query!
Country [141]
0
0
Czechia
Query!
State/province [141]
0
0
Liberec
Query!
Country [142]
0
0
Czechia
Query!
State/province [142]
0
0
Litomerice
Query!
Country [143]
0
0
Czechia
Query!
State/province [143]
0
0
Litomysl
Query!
Country [144]
0
0
Czechia
Query!
State/province [144]
0
0
Milevsko
Query!
Country [145]
0
0
Czechia
Query!
State/province [145]
0
0
Mlada Boleslav
Query!
Country [146]
0
0
Czechia
Query!
State/province [146]
0
0
Mohelnice
Query!
Country [147]
0
0
Czechia
Query!
State/province [147]
0
0
Moravske Budejovice
Query!
Country [148]
0
0
Czechia
Query!
State/province [148]
0
0
Nymburk
Query!
Country [149]
0
0
Czechia
Query!
State/province [149]
0
0
Olomouc
Query!
Country [150]
0
0
Czechia
Query!
State/province [150]
0
0
Ostrava - Zabreh
Query!
Country [151]
0
0
Czechia
Query!
State/province [151]
0
0
Ostrava-Poruba
Query!
Country [152]
0
0
Czechia
Query!
State/province [152]
0
0
Ostrava
Query!
Country [153]
0
0
Czechia
Query!
State/province [153]
0
0
Pardubice
Query!
Country [154]
0
0
Czechia
Query!
State/province [154]
0
0
Plzen
Query!
Country [155]
0
0
Czechia
Query!
State/province [155]
0
0
Policka
Query!
Country [156]
0
0
Czechia
Query!
State/province [156]
0
0
Prachatice
Query!
Country [157]
0
0
Czechia
Query!
State/province [157]
0
0
Praha 10
Query!
Country [158]
0
0
Czechia
Query!
State/province [158]
0
0
Praha 2
Query!
Country [159]
0
0
Czechia
Query!
State/province [159]
0
0
Praha 3
Query!
Country [160]
0
0
Czechia
Query!
State/province [160]
0
0
Praha 4
Query!
Country [161]
0
0
Czechia
Query!
State/province [161]
0
0
Praha 5 - Smichov
Query!
Country [162]
0
0
Czechia
Query!
State/province [162]
0
0
Praha 5
Query!
Country [163]
0
0
Czechia
Query!
State/province [163]
0
0
Prerov
Query!
Country [164]
0
0
Czechia
Query!
State/province [164]
0
0
Pribram VIII
Query!
Country [165]
0
0
Czechia
Query!
State/province [165]
0
0
Svitavy
Query!
Country [166]
0
0
Czechia
Query!
State/province [166]
0
0
Teplice
Query!
Country [167]
0
0
Czechia
Query!
State/province [167]
0
0
Uherske Hradiste
Query!
Country [168]
0
0
Czechia
Query!
State/province [168]
0
0
Znojmo
Query!
Country [169]
0
0
Denmark
Query!
State/province [169]
0
0
Aalborg
Query!
Country [170]
0
0
Denmark
Query!
State/province [170]
0
0
Aarhus N
Query!
Country [171]
0
0
Denmark
Query!
State/province [171]
0
0
Ballerup
Query!
Country [172]
0
0
Denmark
Query!
State/province [172]
0
0
Esbjerg
Query!
Country [173]
0
0
Denmark
Query!
State/province [173]
0
0
Glostrup
Query!
Country [174]
0
0
Denmark
Query!
State/province [174]
0
0
Hvidovre
Query!
Country [175]
0
0
Denmark
Query!
State/province [175]
0
0
København S
Query!
Country [176]
0
0
Denmark
Query!
State/province [176]
0
0
København
Query!
Country [177]
0
0
Denmark
Query!
State/province [177]
0
0
Køge
Query!
Country [178]
0
0
Denmark
Query!
State/province [178]
0
0
Odense
Query!
Country [179]
0
0
Denmark
Query!
State/province [179]
0
0
Roskilde
Query!
Country [180]
0
0
Denmark
Query!
State/province [180]
0
0
Svendborg
Query!
Country [181]
0
0
Denmark
Query!
State/province [181]
0
0
Vejle
Query!
Country [182]
0
0
Denmark
Query!
State/province [182]
0
0
Viborg
Query!
Country [183]
0
0
Estonia
Query!
State/province [183]
0
0
Harjumaa
Query!
Country [184]
0
0
Estonia
Query!
State/province [184]
0
0
Paide
Query!
Country [185]
0
0
Estonia
Query!
State/province [185]
0
0
Tallinn
Query!
Country [186]
0
0
Finland
Query!
State/province [186]
0
0
Helsinki
Query!
Country [187]
0
0
Finland
Query!
State/province [187]
0
0
Hämeenlinna
Query!
Country [188]
0
0
Finland
Query!
State/province [188]
0
0
Jyväskylä
Query!
Country [189]
0
0
Finland
Query!
State/province [189]
0
0
Kokkola
Query!
Country [190]
0
0
Finland
Query!
State/province [190]
0
0
Kuopio
Query!
Country [191]
0
0
Finland
Query!
State/province [191]
0
0
Oulo
Query!
Country [192]
0
0
Finland
Query!
State/province [192]
0
0
Oulu
Query!
Country [193]
0
0
Finland
Query!
State/province [193]
0
0
Tampere
Query!
Country [194]
0
0
Finland
Query!
State/province [194]
0
0
Turku
Query!
Country [195]
0
0
France
Query!
State/province [195]
0
0
Besançon Cedex
Query!
Country [196]
0
0
France
Query!
State/province [196]
0
0
Brest Cedex 2
Query!
Country [197]
0
0
France
Query!
State/province [197]
0
0
Chambray les Tours
Query!
Country [198]
0
0
France
Query!
State/province [198]
0
0
Clermont Ferrand
Query!
Country [199]
0
0
France
Query!
State/province [199]
0
0
Créteil
Query!
Country [200]
0
0
France
Query!
State/province [200]
0
0
Dijon cedex
Query!
Country [201]
0
0
France
Query!
State/province [201]
0
0
Le Coudray
Query!
Country [202]
0
0
France
Query!
State/province [202]
0
0
Lille Cedex
Query!
Country [203]
0
0
France
Query!
State/province [203]
0
0
Lyon
Query!
Country [204]
0
0
France
Query!
State/province [204]
0
0
Marseille Cedex 08
Query!
Country [205]
0
0
France
Query!
State/province [205]
0
0
Metz cedex 03
Query!
Country [206]
0
0
France
Query!
State/province [206]
0
0
Montpellier cedex 05
Query!
Country [207]
0
0
France
Query!
State/province [207]
0
0
Montpellier cedex 5
Query!
Country [208]
0
0
France
Query!
State/province [208]
0
0
Nantes Cedex 1
Query!
Country [209]
0
0
France
Query!
State/province [209]
0
0
Nantes Cedex 2
Query!
Country [210]
0
0
France
Query!
State/province [210]
0
0
Nice
Query!
Country [211]
0
0
France
Query!
State/province [211]
0
0
Nimes
Query!
Country [212]
0
0
France
Query!
State/province [212]
0
0
Orleans
Query!
Country [213]
0
0
France
Query!
State/province [213]
0
0
Paris
Query!
Country [214]
0
0
France
Query!
State/province [214]
0
0
Pau
Query!
Country [215]
0
0
France
Query!
State/province [215]
0
0
Perpignan Cedex
Query!
Country [216]
0
0
France
Query!
State/province [216]
0
0
Pessac Cedex
Query!
Country [217]
0
0
France
Query!
State/province [217]
0
0
Poitiers
Query!
Country [218]
0
0
France
Query!
State/province [218]
0
0
Reims cedex
Query!
Country [219]
0
0
France
Query!
State/province [219]
0
0
Rennes
Query!
Country [220]
0
0
France
Query!
State/province [220]
0
0
Saint Priest en Jarez
Query!
Country [221]
0
0
France
Query!
State/province [221]
0
0
Strasbourg
Query!
Country [222]
0
0
France
Query!
State/province [222]
0
0
Toulouse Cedex 9
Query!
Country [223]
0
0
France
Query!
State/province [223]
0
0
Vandoeuvre les Nancy
Query!
Country [224]
0
0
France
Query!
State/province [224]
0
0
Vesoul
Query!
Country [225]
0
0
Germany
Query!
State/province [225]
0
0
Bad Krozingen
Query!
Country [226]
0
0
Germany
Query!
State/province [226]
0
0
Berlin
Query!
Country [227]
0
0
Germany
Query!
State/province [227]
0
0
Bochum
Query!
Country [228]
0
0
Germany
Query!
State/province [228]
0
0
Demmin
Query!
Country [229]
0
0
Germany
Query!
State/province [229]
0
0
Dortmund
Query!
Country [230]
0
0
Germany
Query!
State/province [230]
0
0
Dresden
Query!
Country [231]
0
0
Germany
Query!
State/province [231]
0
0
Düsseldorf
Query!
Country [232]
0
0
Germany
Query!
State/province [232]
0
0
Frankfurt am Main
Query!
Country [233]
0
0
Germany
Query!
State/province [233]
0
0
Giessen
Query!
Country [234]
0
0
Germany
Query!
State/province [234]
0
0
Hamburg
Query!
Country [235]
0
0
Germany
Query!
State/province [235]
0
0
Hannover
Query!
Country [236]
0
0
Germany
Query!
State/province [236]
0
0
Heidelberg
Query!
Country [237]
0
0
Germany
Query!
State/province [237]
0
0
Ingelheim
Query!
Country [238]
0
0
Germany
Query!
State/province [238]
0
0
Kassel
Query!
Country [239]
0
0
Germany
Query!
State/province [239]
0
0
Köln
Query!
Country [240]
0
0
Germany
Query!
State/province [240]
0
0
Lahr
Query!
Country [241]
0
0
Germany
Query!
State/province [241]
0
0
Leipzig
Query!
Country [242]
0
0
Germany
Query!
State/province [242]
0
0
Limburg
Query!
Country [243]
0
0
Germany
Query!
State/province [243]
0
0
Magdeburg
Query!
Country [244]
0
0
Germany
Query!
State/province [244]
0
0
Mainz
Query!
Country [245]
0
0
Germany
Query!
State/province [245]
0
0
Mannheim
Query!
Country [246]
0
0
Germany
Query!
State/province [246]
0
0
Marburg
Query!
Country [247]
0
0
Germany
Query!
State/province [247]
0
0
München
Query!
Country [248]
0
0
Germany
Query!
State/province [248]
0
0
Regensburg
Query!
Country [249]
0
0
Germany
Query!
State/province [249]
0
0
Stuttgart
Query!
Country [250]
0
0
Germany
Query!
State/province [250]
0
0
Ulm
Query!
Country [251]
0
0
Germany
Query!
State/province [251]
0
0
Witten
Query!
Country [252]
0
0
Germany
Query!
State/province [252]
0
0
Wuppertal
Query!
Country [253]
0
0
Greece
Query!
State/province [253]
0
0
Alexandroupoli
Query!
Country [254]
0
0
Greece
Query!
State/province [254]
0
0
Athens
Query!
Country [255]
0
0
Greece
Query!
State/province [255]
0
0
Chalkida
Query!
Country [256]
0
0
Greece
Query!
State/province [256]
0
0
Heraklion
Query!
Country [257]
0
0
Greece
Query!
State/province [257]
0
0
Ioannina
Query!
Country [258]
0
0
Greece
Query!
State/province [258]
0
0
Larissa
Query!
Country [259]
0
0
Greece
Query!
State/province [259]
0
0
Nikaia, Piraeus
Query!
Country [260]
0
0
Greece
Query!
State/province [260]
0
0
Piraeus
Query!
Country [261]
0
0
Greece
Query!
State/province [261]
0
0
Rhodes
Query!
Country [262]
0
0
Greece
Query!
State/province [262]
0
0
Thessaloniki
Query!
Country [263]
0
0
Hong Kong
Query!
State/province [263]
0
0
Hong Kong
Query!
Country [264]
0
0
Hong Kong
Query!
State/province [264]
0
0
New Territories
Query!
Country [265]
0
0
Hungary
Query!
State/province [265]
0
0
Balatonfured
Query!
Country [266]
0
0
Hungary
Query!
State/province [266]
0
0
Bekescsaba
Query!
Country [267]
0
0
Hungary
Query!
State/province [267]
0
0
Berettyoujfalu
Query!
Country [268]
0
0
Hungary
Query!
State/province [268]
0
0
Budapest
Query!
Country [269]
0
0
Hungary
Query!
State/province [269]
0
0
Cegled
Query!
Country [270]
0
0
Hungary
Query!
State/province [270]
0
0
Debrecen
Query!
Country [271]
0
0
Hungary
Query!
State/province [271]
0
0
Gyongyos
Query!
Country [272]
0
0
Hungary
Query!
State/province [272]
0
0
Gyula
Query!
Country [273]
0
0
Hungary
Query!
State/province [273]
0
0
Kaposvar
Query!
Country [274]
0
0
Hungary
Query!
State/province [274]
0
0
Kecskemet
Query!
Country [275]
0
0
Hungary
Query!
State/province [275]
0
0
Komarom
Query!
Country [276]
0
0
Hungary
Query!
State/province [276]
0
0
Miskolc
Query!
Country [277]
0
0
Hungary
Query!
State/province [277]
0
0
Nyiregyhaza
Query!
Country [278]
0
0
Hungary
Query!
State/province [278]
0
0
Pecs
Query!
Country [279]
0
0
Hungary
Query!
State/province [279]
0
0
Szeged
Query!
Country [280]
0
0
Hungary
Query!
State/province [280]
0
0
Szekszard
Query!
Country [281]
0
0
Hungary
Query!
State/province [281]
0
0
Szolnok
Query!
Country [282]
0
0
Hungary
Query!
State/province [282]
0
0
Zalaegerszeg
Query!
Country [283]
0
0
Iceland
Query!
State/province [283]
0
0
Kopavogur
Query!
Country [284]
0
0
Iceland
Query!
State/province [284]
0
0
Reykjavik
Query!
Country [285]
0
0
India
Query!
State/province [285]
0
0
Andhra Pradesh
Query!
Country [286]
0
0
India
Query!
State/province [286]
0
0
Delhi
Query!
Country [287]
0
0
India
Query!
State/province [287]
0
0
Gujarat
Query!
Country [288]
0
0
India
Query!
State/province [288]
0
0
Haryana
Query!
Country [289]
0
0
India
Query!
State/province [289]
0
0
Karnataka
Query!
Country [290]
0
0
India
Query!
State/province [290]
0
0
Maharashtra
Query!
Country [291]
0
0
India
Query!
State/province [291]
0
0
Uttar Pradesh
Query!
Country [292]
0
0
India
Query!
State/province [292]
0
0
West Bengal
Query!
Country [293]
0
0
Ireland
Query!
State/province [293]
0
0
Ballinasloe
Query!
Country [294]
0
0
Ireland
Query!
State/province [294]
0
0
Dublin
Query!
Country [295]
0
0
Ireland
Query!
State/province [295]
0
0
Galway
Query!
Country [296]
0
0
Israel
Query!
State/province [296]
0
0
Hadera
Query!
Country [297]
0
0
Israel
Query!
State/province [297]
0
0
Haifa
Query!
Country [298]
0
0
Israel
Query!
State/province [298]
0
0
Herzliya-on-sea
Query!
Country [299]
0
0
Israel
Query!
State/province [299]
0
0
Holon
Query!
Country [300]
0
0
Israel
Query!
State/province [300]
0
0
Jerusalem
Query!
Country [301]
0
0
Israel
Query!
State/province [301]
0
0
Nahariya
Query!
Country [302]
0
0
Israel
Query!
State/province [302]
0
0
Netanya
Query!
Country [303]
0
0
Israel
Query!
State/province [303]
0
0
Rehovot
Query!
Country [304]
0
0
Israel
Query!
State/province [304]
0
0
Tel Aviv
Query!
Country [305]
0
0
Israel
Query!
State/province [305]
0
0
Tel Hashomer
Query!
Country [306]
0
0
Italy
Query!
State/province [306]
0
0
Ascoli Piceno
Query!
Country [307]
0
0
Italy
Query!
State/province [307]
0
0
Bergamo
Query!
Country [308]
0
0
Italy
Query!
State/province [308]
0
0
Bologna
Query!
Country [309]
0
0
Italy
Query!
State/province [309]
0
0
Chieti
Query!
Country [310]
0
0
Italy
Query!
State/province [310]
0
0
Colleferro RM
Query!
Country [311]
0
0
Italy
Query!
State/province [311]
0
0
Cortona AR
Query!
Country [312]
0
0
Italy
Query!
State/province [312]
0
0
Firenze
Query!
Country [313]
0
0
Italy
Query!
State/province [313]
0
0
L' Aquila
Query!
Country [314]
0
0
Italy
Query!
State/province [314]
0
0
Milano
Query!
Country [315]
0
0
Italy
Query!
State/province [315]
0
0
Napoli
Query!
Country [316]
0
0
Italy
Query!
State/province [316]
0
0
Palermo
Query!
Country [317]
0
0
Italy
Query!
State/province [317]
0
0
Parma
Query!
Country [318]
0
0
Italy
Query!
State/province [318]
0
0
Pavia
Query!
Country [319]
0
0
Italy
Query!
State/province [319]
0
0
Perugia
Query!
Country [320]
0
0
Italy
Query!
State/province [320]
0
0
Pisa
Query!
Country [321]
0
0
Italy
Query!
State/province [321]
0
0
Roma
Query!
Country [322]
0
0
Italy
Query!
State/province [322]
0
0
Sanremo (IM)
Query!
Country [323]
0
0
Italy
Query!
State/province [323]
0
0
Siena
Query!
Country [324]
0
0
Japan
Query!
State/province [324]
0
0
Aichi
Query!
Country [325]
0
0
Japan
Query!
State/province [325]
0
0
Chiba
Query!
Country [326]
0
0
Japan
Query!
State/province [326]
0
0
Ehime
Query!
Country [327]
0
0
Japan
Query!
State/province [327]
0
0
Fukuoka
Query!
Country [328]
0
0
Japan
Query!
State/province [328]
0
0
Fukushima
Query!
Country [329]
0
0
Japan
Query!
State/province [329]
0
0
Hiroshima
Query!
Country [330]
0
0
Japan
Query!
State/province [330]
0
0
Hokkaido
Query!
Country [331]
0
0
Japan
Query!
State/province [331]
0
0
Hyogo
Query!
Country [332]
0
0
Japan
Query!
State/province [332]
0
0
Ibaraki
Query!
Country [333]
0
0
Japan
Query!
State/province [333]
0
0
Ishikawa
Query!
Country [334]
0
0
Japan
Query!
State/province [334]
0
0
Kagawa
Query!
Country [335]
0
0
Japan
Query!
State/province [335]
0
0
Kanagawa
Query!
Country [336]
0
0
Japan
Query!
State/province [336]
0
0
Kumamoto
Query!
Country [337]
0
0
Japan
Query!
State/province [337]
0
0
Kyoto
Query!
Country [338]
0
0
Japan
Query!
State/province [338]
0
0
Miyagi
Query!
Country [339]
0
0
Japan
Query!
State/province [339]
0
0
Nagasaki
Query!
Country [340]
0
0
Japan
Query!
State/province [340]
0
0
Oita
Query!
Country [341]
0
0
Japan
Query!
State/province [341]
0
0
Okayama
Query!
Country [342]
0
0
Japan
Query!
State/province [342]
0
0
Okinawa
Query!
Country [343]
0
0
Japan
Query!
State/province [343]
0
0
Osaka
Query!
Country [344]
0
0
Japan
Query!
State/province [344]
0
0
Saga
Query!
Country [345]
0
0
Japan
Query!
State/province [345]
0
0
Saitama
Query!
Country [346]
0
0
Japan
Query!
State/province [346]
0
0
Shiga
Query!
Country [347]
0
0
Japan
Query!
State/province [347]
0
0
Shimane
Query!
Country [348]
0
0
Japan
Query!
State/province [348]
0
0
Shizuoka
Query!
Country [349]
0
0
Japan
Query!
State/province [349]
0
0
Tokushima
Query!
Country [350]
0
0
Japan
Query!
State/province [350]
0
0
Tokyo
Query!
Country [351]
0
0
Japan
Query!
State/province [351]
0
0
Yamanashi
Query!
Country [352]
0
0
Korea, Republic of
Query!
State/province [352]
0
0
Busan, Seo-gu
Query!
Country [353]
0
0
Korea, Republic of
Query!
State/province [353]
0
0
Daejeon
Query!
Country [354]
0
0
Korea, Republic of
Query!
State/province [354]
0
0
Goyang-si, Gyeonggi-do
Query!
Country [355]
0
0
Korea, Republic of
Query!
State/province [355]
0
0
Gwangju
Query!
Country [356]
0
0
Korea, Republic of
Query!
State/province [356]
0
0
Seongnam-si
Query!
Country [357]
0
0
Korea, Republic of
Query!
State/province [357]
0
0
Seoul
Query!
Country [358]
0
0
Korea, Republic of
Query!
State/province [358]
0
0
Suwon-si
Query!
Country [359]
0
0
Latvia
Query!
State/province [359]
0
0
Daugavpils
Query!
Country [360]
0
0
Latvia
Query!
State/province [360]
0
0
Kuldiga
Query!
Country [361]
0
0
Latvia
Query!
State/province [361]
0
0
Liepaja
Query!
Country [362]
0
0
Latvia
Query!
State/province [362]
0
0
Ogre
Query!
Country [363]
0
0
Latvia
Query!
State/province [363]
0
0
Riga
Query!
Country [364]
0
0
Lithuania
Query!
State/province [364]
0
0
Kaunas
Query!
Country [365]
0
0
Lithuania
Query!
State/province [365]
0
0
Klaipeda
Query!
Country [366]
0
0
Lithuania
Query!
State/province [366]
0
0
Vilnius
Query!
Country [367]
0
0
Malaysia
Query!
State/province [367]
0
0
Johor
Query!
Country [368]
0
0
Malaysia
Query!
State/province [368]
0
0
Perak
Query!
Country [369]
0
0
Malaysia
Query!
State/province [369]
0
0
Sabah
Query!
Country [370]
0
0
Malaysia
Query!
State/province [370]
0
0
Wilayah Persekutuan
Query!
Country [371]
0
0
Malaysia
Query!
State/province [371]
0
0
Georgetown
Query!
Country [372]
0
0
Malaysia
Query!
State/province [372]
0
0
Kuala Lumpur
Query!
Country [373]
0
0
Malaysia
Query!
State/province [373]
0
0
Melaka
Query!
Country [374]
0
0
Malaysia
Query!
State/province [374]
0
0
Penang
Query!
Country [375]
0
0
Mexico
Query!
State/province [375]
0
0
Coahuila
Query!
Country [376]
0
0
Mexico
Query!
State/province [376]
0
0
Distrito Federal
Query!
Country [377]
0
0
Mexico
Query!
State/province [377]
0
0
Guanajuato
Query!
Country [378]
0
0
Mexico
Query!
State/province [378]
0
0
Jalisco
Query!
Country [379]
0
0
Mexico
Query!
State/province [379]
0
0
Nuevo León
Query!
Country [380]
0
0
Mexico
Query!
State/province [380]
0
0
Querétaro
Query!
Country [381]
0
0
Mexico
Query!
State/province [381]
0
0
San Luis Potosí
Query!
Country [382]
0
0
Mexico
Query!
State/province [382]
0
0
Sinaloa
Query!
Country [383]
0
0
Mexico
Query!
State/province [383]
0
0
Tamaulipas
Query!
Country [384]
0
0
Mexico
Query!
State/province [384]
0
0
Veracruz
Query!
Country [385]
0
0
Mexico
Query!
State/province [385]
0
0
Aguascalientes
Query!
Country [386]
0
0
Mexico
Query!
State/province [386]
0
0
Chihuahua
Query!
Country [387]
0
0
Netherlands
Query!
State/province [387]
0
0
Alkmaar
Query!
Country [388]
0
0
Netherlands
Query!
State/province [388]
0
0
Almelo
Query!
Country [389]
0
0
Netherlands
Query!
State/province [389]
0
0
Amstelveen
Query!
Country [390]
0
0
Netherlands
Query!
State/province [390]
0
0
Amsterdam
Query!
Country [391]
0
0
Netherlands
Query!
State/province [391]
0
0
Arnhem
Query!
Country [392]
0
0
Netherlands
Query!
State/province [392]
0
0
Beverwijk
Query!
Country [393]
0
0
Netherlands
Query!
State/province [393]
0
0
Den Helder
Query!
Country [394]
0
0
Netherlands
Query!
State/province [394]
0
0
Deventer
Query!
Country [395]
0
0
Netherlands
Query!
State/province [395]
0
0
Doetinchem
Query!
Country [396]
0
0
Netherlands
Query!
State/province [396]
0
0
Ede
Query!
Country [397]
0
0
Netherlands
Query!
State/province [397]
0
0
Eindhoven
Query!
Country [398]
0
0
Netherlands
Query!
State/province [398]
0
0
Goes
Query!
Country [399]
0
0
Netherlands
Query!
State/province [399]
0
0
Gorinchem
Query!
Country [400]
0
0
Netherlands
Query!
State/province [400]
0
0
Gouda
Query!
Country [401]
0
0
Netherlands
Query!
State/province [401]
0
0
Harderwijk
Query!
Country [402]
0
0
Netherlands
Query!
State/province [402]
0
0
Helmond
Query!
Country [403]
0
0
Netherlands
Query!
State/province [403]
0
0
Hoogeveen
Query!
Country [404]
0
0
Netherlands
Query!
State/province [404]
0
0
Hoorn
Query!
Country [405]
0
0
Netherlands
Query!
State/province [405]
0
0
Leiden
Query!
Country [406]
0
0
Netherlands
Query!
State/province [406]
0
0
Nieuwegein
Query!
Country [407]
0
0
Netherlands
Query!
State/province [407]
0
0
Nijmegen
Query!
Country [408]
0
0
Netherlands
Query!
State/province [408]
0
0
Purmerend
Query!
Country [409]
0
0
Netherlands
Query!
State/province [409]
0
0
Rotterdam
Query!
Country [410]
0
0
Netherlands
Query!
State/province [410]
0
0
Sneek
Query!
Country [411]
0
0
Netherlands
Query!
State/province [411]
0
0
Tiel
Query!
Country [412]
0
0
Netherlands
Query!
State/province [412]
0
0
Tilburg
Query!
Country [413]
0
0
Netherlands
Query!
State/province [413]
0
0
Uden
Query!
Country [414]
0
0
Netherlands
Query!
State/province [414]
0
0
Veldhoven
Query!
Country [415]
0
0
Netherlands
Query!
State/province [415]
0
0
Venlo
Query!
Country [416]
0
0
New Zealand
Query!
State/province [416]
0
0
Christchurch
Query!
Country [417]
0
0
New Zealand
Query!
State/province [417]
0
0
Papatoetoe, Auckland
Query!
Country [418]
0
0
New Zealand
Query!
State/province [418]
0
0
Tauranga
Query!
Country [419]
0
0
Norway
Query!
State/province [419]
0
0
Bekkestua
Query!
Country [420]
0
0
Norway
Query!
State/province [420]
0
0
Bodø
Query!
Country [421]
0
0
Norway
Query!
State/province [421]
0
0
Hamar
Query!
Country [422]
0
0
Norway
Query!
State/province [422]
0
0
Lierskogen
Query!
Country [423]
0
0
Norway
Query!
State/province [423]
0
0
Oslo
Query!
Country [424]
0
0
Norway
Query!
State/province [424]
0
0
Skedsmokorset
Query!
Country [425]
0
0
Norway
Query!
State/province [425]
0
0
Skien
Query!
Country [426]
0
0
Norway
Query!
State/province [426]
0
0
Stavanger
Query!
Country [427]
0
0
Norway
Query!
State/province [427]
0
0
Ålesund
Query!
Country [428]
0
0
Philippines
Query!
State/province [428]
0
0
Davao
Query!
Country [429]
0
0
Philippines
Query!
State/province [429]
0
0
Angeles
Query!
Country [430]
0
0
Philippines
Query!
State/province [430]
0
0
Baguio City
Query!
Country [431]
0
0
Philippines
Query!
State/province [431]
0
0
Dasmariñas Cavite
Query!
Country [432]
0
0
Philippines
Query!
State/province [432]
0
0
Iloilo
Query!
Country [433]
0
0
Philippines
Query!
State/province [433]
0
0
Makati City
Query!
Country [434]
0
0
Philippines
Query!
State/province [434]
0
0
Manila
Query!
Country [435]
0
0
Philippines
Query!
State/province [435]
0
0
Marikiina
Query!
Country [436]
0
0
Philippines
Query!
State/province [436]
0
0
Quezon City
Query!
Country [437]
0
0
Poland
Query!
State/province [437]
0
0
Bielsko-Biala
Query!
Country [438]
0
0
Poland
Query!
State/province [438]
0
0
Bydgoszcz
Query!
Country [439]
0
0
Poland
Query!
State/province [439]
0
0
Gdansk
Query!
Country [440]
0
0
Poland
Query!
State/province [440]
0
0
Gdynia
Query!
Country [441]
0
0
Poland
Query!
State/province [441]
0
0
Gizycko
Query!
Country [442]
0
0
Poland
Query!
State/province [442]
0
0
Jelenia Gora
Query!
Country [443]
0
0
Poland
Query!
State/province [443]
0
0
Katowice
Query!
Country [444]
0
0
Poland
Query!
State/province [444]
0
0
Kielce
Query!
Country [445]
0
0
Poland
Query!
State/province [445]
0
0
Krakow
Query!
Country [446]
0
0
Poland
Query!
State/province [446]
0
0
Lodz
Query!
Country [447]
0
0
Poland
Query!
State/province [447]
0
0
Lublin
Query!
Country [448]
0
0
Poland
Query!
State/province [448]
0
0
Nowa Sol
Query!
Country [449]
0
0
Poland
Query!
State/province [449]
0
0
Nysa
Query!
Country [450]
0
0
Poland
Query!
State/province [450]
0
0
Olsztyn
Query!
Country [451]
0
0
Poland
Query!
State/province [451]
0
0
Plock
Query!
Country [452]
0
0
Poland
Query!
State/province [452]
0
0
Poznan
Query!
Country [453]
0
0
Poland
Query!
State/province [453]
0
0
Pszczyna
Query!
Country [454]
0
0
Poland
Query!
State/province [454]
0
0
Pulawy
Query!
Country [455]
0
0
Poland
Query!
State/province [455]
0
0
Ruda Slaska
Query!
Country [456]
0
0
Poland
Query!
State/province [456]
0
0
Skierniewice
Query!
Country [457]
0
0
Poland
Query!
State/province [457]
0
0
Starogard Gdanski
Query!
Country [458]
0
0
Poland
Query!
State/province [458]
0
0
Staszow
Query!
Country [459]
0
0
Poland
Query!
State/province [459]
0
0
Swidnik
Query!
Country [460]
0
0
Poland
Query!
State/province [460]
0
0
Tarnow
Query!
Country [461]
0
0
Poland
Query!
State/province [461]
0
0
Torun
Query!
Country [462]
0
0
Poland
Query!
State/province [462]
0
0
Warszawa
Query!
Country [463]
0
0
Poland
Query!
State/province [463]
0
0
Wloclawek
Query!
Country [464]
0
0
Poland
Query!
State/province [464]
0
0
Wroclaw
Query!
Country [465]
0
0
Poland
Query!
State/province [465]
0
0
Zamosc
Query!
Country [466]
0
0
Portugal
Query!
State/province [466]
0
0
Almada
Query!
Country [467]
0
0
Portugal
Query!
State/province [467]
0
0
Amadora
Query!
Country [468]
0
0
Portugal
Query!
State/province [468]
0
0
Carnaxide
Query!
Country [469]
0
0
Portugal
Query!
State/province [469]
0
0
Coimbra
Query!
Country [470]
0
0
Portugal
Query!
State/province [470]
0
0
Covilha
Query!
Country [471]
0
0
Portugal
Query!
State/province [471]
0
0
Lisboa
Query!
Country [472]
0
0
Portugal
Query!
State/province [472]
0
0
Porto
Query!
Country [473]
0
0
Portugal
Query!
State/province [473]
0
0
Setubal
Query!
Country [474]
0
0
Romania
Query!
State/province [474]
0
0
Bucharest
Query!
Country [475]
0
0
Romania
Query!
State/province [475]
0
0
Bucuresti
Query!
Country [476]
0
0
Romania
Query!
State/province [476]
0
0
Cluj-Napoca
Query!
Country [477]
0
0
Romania
Query!
State/province [477]
0
0
Craiova
Query!
Country [478]
0
0
Romania
Query!
State/province [478]
0
0
Iasi
Query!
Country [479]
0
0
Romania
Query!
State/province [479]
0
0
Oradea
Query!
Country [480]
0
0
Romania
Query!
State/province [480]
0
0
Timisoara
Query!
Country [481]
0
0
Russian Federation
Query!
State/province [481]
0
0
Barnaul
Query!
Country [482]
0
0
Russian Federation
Query!
State/province [482]
0
0
Ekaterinburg
Query!
Country [483]
0
0
Russian Federation
Query!
State/province [483]
0
0
Ivanovo
Query!
Country [484]
0
0
Russian Federation
Query!
State/province [484]
0
0
Izhevsk
Query!
Country [485]
0
0
Russian Federation
Query!
State/province [485]
0
0
Kemerovo
Query!
Country [486]
0
0
Russian Federation
Query!
State/province [486]
0
0
Kirov
Query!
Country [487]
0
0
Russian Federation
Query!
State/province [487]
0
0
Moscow
Query!
Country [488]
0
0
Russian Federation
Query!
State/province [488]
0
0
Nizhniy Novgorod
Query!
Country [489]
0
0
Russian Federation
Query!
State/province [489]
0
0
Novosibirsk
Query!
Country [490]
0
0
Russian Federation
Query!
State/province [490]
0
0
Omsk
Query!
Country [491]
0
0
Russian Federation
Query!
State/province [491]
0
0
Pushkin
Query!
Country [492]
0
0
Russian Federation
Query!
State/province [492]
0
0
Saint Petersburg
Query!
Country [493]
0
0
Russian Federation
Query!
State/province [493]
0
0
Saint-Petersburg
Query!
Country [494]
0
0
Russian Federation
Query!
State/province [494]
0
0
Saratov
Query!
Country [495]
0
0
Russian Federation
Query!
State/province [495]
0
0
St. Petersburg
Query!
Country [496]
0
0
Russian Federation
Query!
State/province [496]
0
0
Tomsk
Query!
Country [497]
0
0
Russian Federation
Query!
State/province [497]
0
0
Tyumen
Query!
Country [498]
0
0
Singapore
Query!
State/province [498]
0
0
Singapore
Query!
Country [499]
0
0
Slovakia
Query!
State/province [499]
0
0
Banovce nad Bebravou
Query!
Country [500]
0
0
Slovakia
Query!
State/province [500]
0
0
Bardejov
Query!
Country [501]
0
0
Slovakia
Query!
State/province [501]
0
0
Bratislava
Query!
Country [502]
0
0
Slovakia
Query!
State/province [502]
0
0
Brezno
Query!
Country [503]
0
0
Slovakia
Query!
State/province [503]
0
0
Dolny Kubin
Query!
Country [504]
0
0
Slovakia
Query!
State/province [504]
0
0
Kosice
Query!
Country [505]
0
0
Slovakia
Query!
State/province [505]
0
0
Lucenec
Query!
Country [506]
0
0
Slovakia
Query!
State/province [506]
0
0
Martin
Query!
Country [507]
0
0
Slovakia
Query!
State/province [507]
0
0
Moldava nad Bodvou
Query!
Country [508]
0
0
Slovakia
Query!
State/province [508]
0
0
Nitra
Query!
Country [509]
0
0
Slovakia
Query!
State/province [509]
0
0
Nove Zamky
Query!
Country [510]
0
0
Slovakia
Query!
State/province [510]
0
0
Presov
Query!
Country [511]
0
0
Slovakia
Query!
State/province [511]
0
0
Rimavska Sobota
Query!
Country [512]
0
0
Slovakia
Query!
State/province [512]
0
0
Roznava
Query!
Country [513]
0
0
Slovakia
Query!
State/province [513]
0
0
Snina
Query!
Country [514]
0
0
Slovakia
Query!
State/province [514]
0
0
Svidnik
Query!
Country [515]
0
0
Slovakia
Query!
State/province [515]
0
0
Trencin
Query!
Country [516]
0
0
Slovakia
Query!
State/province [516]
0
0
Trnava
Query!
Country [517]
0
0
South Africa
Query!
State/province [517]
0
0
Eastern Cape
Query!
Country [518]
0
0
South Africa
Query!
State/province [518]
0
0
Free State
Query!
Country [519]
0
0
South Africa
Query!
State/province [519]
0
0
Gauteng
Query!
Country [520]
0
0
South Africa
Query!
State/province [520]
0
0
KwaZulu-Natal
Query!
Country [521]
0
0
South Africa
Query!
State/province [521]
0
0
Western Cape
Query!
Country [522]
0
0
South Africa
Query!
State/province [522]
0
0
Cape Town
Query!
Country [523]
0
0
South Africa
Query!
State/province [523]
0
0
Kempton Park
Query!
Country [524]
0
0
Spain
Query!
State/province [524]
0
0
Andalucía
Query!
Country [525]
0
0
Spain
Query!
State/province [525]
0
0
Aragón
Query!
Country [526]
0
0
Spain
Query!
State/province [526]
0
0
Cataluña
Query!
Country [527]
0
0
Spain
Query!
State/province [527]
0
0
Comunidad Valenciana
Query!
Country [528]
0
0
Spain
Query!
State/province [528]
0
0
Galicia
Query!
Country [529]
0
0
Spain
Query!
State/province [529]
0
0
Murcia
Query!
Country [530]
0
0
Spain
Query!
State/province [530]
0
0
País Vasco
Query!
Country [531]
0
0
Spain
Query!
State/province [531]
0
0
Madrid
Query!
Country [532]
0
0
Sweden
Query!
State/province [532]
0
0
Bollnäs
Query!
Country [533]
0
0
Sweden
Query!
State/province [533]
0
0
Eksjö
Query!
Country [534]
0
0
Sweden
Query!
State/province [534]
0
0
Eskilstuna
Query!
Country [535]
0
0
Sweden
Query!
State/province [535]
0
0
Falun
Query!
Country [536]
0
0
Sweden
Query!
State/province [536]
0
0
Helsingborg
Query!
Country [537]
0
0
Sweden
Query!
State/province [537]
0
0
Jönköping
Query!
Country [538]
0
0
Sweden
Query!
State/province [538]
0
0
Linköping
Query!
Country [539]
0
0
Sweden
Query!
State/province [539]
0
0
Luleå
Query!
Country [540]
0
0
Sweden
Query!
State/province [540]
0
0
Lund
Query!
Country [541]
0
0
Sweden
Query!
State/province [541]
0
0
Stockholm
Query!
Country [542]
0
0
Sweden
Query!
State/province [542]
0
0
Uddevalla
Query!
Country [543]
0
0
Sweden
Query!
State/province [543]
0
0
Umeå
Query!
Country [544]
0
0
Sweden
Query!
State/province [544]
0
0
Västerås
Query!
Country [545]
0
0
Sweden
Query!
State/province [545]
0
0
Örebro
Query!
Country [546]
0
0
Sweden
Query!
State/province [546]
0
0
Östersund
Query!
Country [547]
0
0
Switzerland
Query!
State/province [547]
0
0
Baden
Query!
Country [548]
0
0
Switzerland
Query!
State/province [548]
0
0
Basel
Query!
Country [549]
0
0
Switzerland
Query!
State/province [549]
0
0
Bern
Query!
Country [550]
0
0
Switzerland
Query!
State/province [550]
0
0
Geneva 14
Query!
Country [551]
0
0
Switzerland
Query!
State/province [551]
0
0
Lausanne
Query!
Country [552]
0
0
Switzerland
Query!
State/province [552]
0
0
Lugano
Query!
Country [553]
0
0
Switzerland
Query!
State/province [553]
0
0
Sion
Query!
Country [554]
0
0
Switzerland
Query!
State/province [554]
0
0
Winterthur
Query!
Country [555]
0
0
Switzerland
Query!
State/province [555]
0
0
Zurich
Query!
Country [556]
0
0
Taiwan
Query!
State/province [556]
0
0
Taipei
Query!
Country [557]
0
0
Taiwan
Query!
State/province [557]
0
0
Changhua
Query!
Country [558]
0
0
Taiwan
Query!
State/province [558]
0
0
Kaohsiung
Query!
Country [559]
0
0
Taiwan
Query!
State/province [559]
0
0
Taichung City
Query!
Country [560]
0
0
Taiwan
Query!
State/province [560]
0
0
Tainan
Query!
Country [561]
0
0
Taiwan
Query!
State/province [561]
0
0
Taoyuan
Query!
Country [562]
0
0
Turkey
Query!
State/province [562]
0
0
Adana
Query!
Country [563]
0
0
Turkey
Query!
State/province [563]
0
0
Ankara
Query!
Country [564]
0
0
Turkey
Query!
State/province [564]
0
0
Istanbul
Query!
Country [565]
0
0
Turkey
Query!
State/province [565]
0
0
Izmir
Query!
Country [566]
0
0
Turkey
Query!
State/province [566]
0
0
Kocaeli
Query!
Country [567]
0
0
Turkey
Query!
State/province [567]
0
0
Konya
Query!
Country [568]
0
0
Turkey
Query!
State/province [568]
0
0
Sivas
Query!
Country [569]
0
0
Ukraine
Query!
State/province [569]
0
0
Cherkasy
Query!
Country [570]
0
0
Ukraine
Query!
State/province [570]
0
0
Ivano-Frankivsk
Query!
Country [571]
0
0
Ukraine
Query!
State/province [571]
0
0
Kharkiv
Query!
Country [572]
0
0
Ukraine
Query!
State/province [572]
0
0
Kyiv
Query!
Country [573]
0
0
Ukraine
Query!
State/province [573]
0
0
Lugansk
Query!
Country [574]
0
0
Ukraine
Query!
State/province [574]
0
0
Uzhgorod
Query!
Country [575]
0
0
Ukraine
Query!
State/province [575]
0
0
Vinnytsia
Query!
Country [576]
0
0
Ukraine
Query!
State/province [576]
0
0
Zaporizhzhia
Query!
Country [577]
0
0
Ukraine
Query!
State/province [577]
0
0
Zaporizhzhya
Query!
Country [578]
0
0
United Kingdom
Query!
State/province [578]
0
0
Aberdeen
Query!
Country [579]
0
0
United Kingdom
Query!
State/province [579]
0
0
Addlestone
Query!
Country [580]
0
0
United Kingdom
Query!
State/province [580]
0
0
Arnsley
Query!
Country [581]
0
0
United Kingdom
Query!
State/province [581]
0
0
Basildon
Query!
Country [582]
0
0
United Kingdom
Query!
State/province [582]
0
0
Belfast
Query!
Country [583]
0
0
United Kingdom
Query!
State/province [583]
0
0
Birmingham
Query!
Country [584]
0
0
United Kingdom
Query!
State/province [584]
0
0
Blackpool
Query!
Country [585]
0
0
United Kingdom
Query!
State/province [585]
0
0
Bournemouth
Query!
Country [586]
0
0
United Kingdom
Query!
State/province [586]
0
0
Bury St Edmunds
Query!
Country [587]
0
0
United Kingdom
Query!
State/province [587]
0
0
Canterbury
Query!
Country [588]
0
0
United Kingdom
Query!
State/province [588]
0
0
Cardiff
Query!
Country [589]
0
0
United Kingdom
Query!
State/province [589]
0
0
Chesterfield
Query!
Country [590]
0
0
United Kingdom
Query!
State/province [590]
0
0
Chippenham
Query!
Country [591]
0
0
United Kingdom
Query!
State/province [591]
0
0
Chorley
Query!
Country [592]
0
0
United Kingdom
Query!
State/province [592]
0
0
Colchester
Query!
Country [593]
0
0
United Kingdom
Query!
State/province [593]
0
0
Cottingham
Query!
Country [594]
0
0
United Kingdom
Query!
State/province [594]
0
0
Coventry
Query!
Country [595]
0
0
United Kingdom
Query!
State/province [595]
0
0
Dundee
Query!
Country [596]
0
0
United Kingdom
Query!
State/province [596]
0
0
Edinburgh
Query!
Country [597]
0
0
United Kingdom
Query!
State/province [597]
0
0
Glasgow
Query!
Country [598]
0
0
United Kingdom
Query!
State/province [598]
0
0
Harrow
Query!
Country [599]
0
0
United Kingdom
Query!
State/province [599]
0
0
Haxey, Doncaster
Query!
Country [600]
0
0
United Kingdom
Query!
State/province [600]
0
0
Hayle
Query!
Country [601]
0
0
United Kingdom
Query!
State/province [601]
0
0
Hexham
Query!
Country [602]
0
0
United Kingdom
Query!
State/province [602]
0
0
Hitchin
Query!
Country [603]
0
0
United Kingdom
Query!
State/province [603]
0
0
Inverness
Query!
Country [604]
0
0
United Kingdom
Query!
State/province [604]
0
0
Leamington Spa
Query!
Country [605]
0
0
United Kingdom
Query!
State/province [605]
0
0
Leeds
Query!
Country [606]
0
0
United Kingdom
Query!
State/province [606]
0
0
Leicester
Query!
Country [607]
0
0
United Kingdom
Query!
State/province [607]
0
0
Liverpool
Query!
Country [608]
0
0
United Kingdom
Query!
State/province [608]
0
0
London
Query!
Country [609]
0
0
United Kingdom
Query!
State/province [609]
0
0
Luton
Query!
Country [610]
0
0
United Kingdom
Query!
State/province [610]
0
0
Manchester
Query!
Country [611]
0
0
United Kingdom
Query!
State/province [611]
0
0
Middlesbrough
Query!
Country [612]
0
0
United Kingdom
Query!
State/province [612]
0
0
Newport
Query!
Country [613]
0
0
United Kingdom
Query!
State/province [613]
0
0
Northampton
Query!
Country [614]
0
0
United Kingdom
Query!
State/province [614]
0
0
Nottingham
Query!
Country [615]
0
0
United Kingdom
Query!
State/province [615]
0
0
Nuneaton
Query!
Country [616]
0
0
United Kingdom
Query!
State/province [616]
0
0
Penzance
Query!
Country [617]
0
0
United Kingdom
Query!
State/province [617]
0
0
Plymouth
Query!
Country [618]
0
0
United Kingdom
Query!
State/province [618]
0
0
Portsmouth
Query!
Country [619]
0
0
United Kingdom
Query!
State/province [619]
0
0
Reading
Query!
Country [620]
0
0
United Kingdom
Query!
State/province [620]
0
0
Rotherham
Query!
Country [621]
0
0
United Kingdom
Query!
State/province [621]
0
0
Rugby
Query!
Country [622]
0
0
United Kingdom
Query!
State/province [622]
0
0
Sandbach
Query!
Country [623]
0
0
United Kingdom
Query!
State/province [623]
0
0
Sheffield
Query!
Country [624]
0
0
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St Austell
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St. Leonards-on-Sea
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Stevenage
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Stoke-on-Trent
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Swansea
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Telford
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Torquay
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Welwyn Garden City
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West Bromwich
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Whitby
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Wiltshire
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Wirral
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Wolverhampton
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Worcester
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York
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Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
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Name
Amgen
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Summary
Brief summary
The primary objective was to evaluate the effect of treatment with evolocumab, compared with
placebo, on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization
for unstable angina, or coronary revascularization, whichever occurs first, in patients with
clinically evident cardiovascular disease.
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Trial website
https://clinicaltrials.gov/ct2/show/NCT01764633
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Trial related presentations / publications
Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, Sever PS, Pedersen TR; FOURIER Steering Committee and Investigators. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017 May 4;376(18):1713-1722. doi: 10.1056/NEJMoa1615664. Epub 2017 Mar 17.
Fonarow GC, Keech AC, Pedersen TR, Giugliano RP, Sever PS, Lindgren P, van Hout B, Villa G, Qian Y, Somaratne R, Sabatine MS. Cost-effectiveness of Evolocumab Therapy for Reducing Cardiovascular Events in Patients With Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2017 Oct 1;2(10):1069-1078. doi: 10.1001/jamacardio.2017.2762. Erratum In: JAMA Cardiol. 2017 Oct 1;2(10):1170.
Fonarow GC, van Hout B, Villa G, Arellano J, Lindgren P. Updated Cost-effectiveness Analysis of Evolocumab in Patients With Very High-risk Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2019 Jul 1;4(7):691-695. doi: 10.1001/jamacardio.2019.1647.
Schludi B, Giugliano RP, Sabatine MS, Raal FJ, Teramoto T, Koren MJ, Stein EA, Wang H, Monsalvo ML. Time-averaged low-density lipoprotein cholesterol lowering with evolocumab: Pooled analysis of phase 2 trials. J Clin Lipidol. 2022 Jul-Aug;16(4):538-543. doi: 10.1016/j.jacl.2022.05.069. Epub 2022 Jun 6.
Berg DD, Moura FA, Bellavia A, Scirica BM, Wiviott SD, Bhatt DL, Raz I, Bohula EA, Giugliano RP, Park JG, Feinberg MW, Braunwald E, Morrow DA, Sabatine MS. Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol. 2023 Jun 27;81(25):2391-2402. doi: 10.1016/j.jacc.2023.04.031.
Clinical Benefit of Evolocumab Treatment Among Patients With Atherosclerotic Cardiovascular Disease: Exploration Based on the Chinese Subgroup of FOURIER Study, ZHANG Lihua1 , LI Weimin2 , YAO Zhuhua3 , CHEN Jiyan4 , DONG Jun5 , LI Jing1 (Chinese Circulation Journal, 2023, 38: 704.)
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Public notes
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Contacts
Principal investigator
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MD
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Amgen
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Summary Results
For IPD and results data, please see
https://clinicaltrials.gov/ct2/show/NCT01764633
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