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Trial registered on ANZCTR
Registration number
ACTRN12624000617561p
Ethics application status
Submitted, not yet approved
Date submitted
11/04/2024
Date registered
13/05/2024
Date last updated
13/05/2024
Date data sharing statement initially provided
13/05/2024
Type of registration
Prospectively registered
Titles & IDs
Public title
Comparing Isometric and Dynamic Resistance Training: Impact on Muscle Performance and Body Composition
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Scientific title
Effectiveness of Isometric versus Dynamic Resistance Training on Muscle Performance and Body Composition in Healthy adults
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Secondary ID [1]
311944
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Nill
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Universal Trial Number (UTN)
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Trial acronym
ISO_RT
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Muscular Strength
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Muscle Mass
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Condition category
Condition code
Physical Medicine / Rehabilitation
330216
330216
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0
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Physiotherapy
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Musculoskeletal
330217
330217
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0
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Normal musculoskeletal and cartilage development and function
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Isometric Resistance Training Group:
Materials: Keiser pneumatic resistance machines (Keiser Sports Health Equipment, Inc., Fresno, CA 93706, USA).
Procedures: Participants will engage in multi-joint isometric resistance training exercises targeting the chest (i.e., chest press) and leg muscles (i.e., leg press).
Delivery: Conducted in a group setting at a designated fitness facility under the supervision of researchers.
Frequency and Duration: There will be three sessions per week for a total of 12 weeks. Each session will include three sets of 6 repetitions each for the chest press and leg press exercises. Each session lasts approximately 60 minutes.
Specifics: Isometric contractions will be performed at 80% of the participant's maximal voluntary contraction (MVC). Each participant's MVC will be determined before the beginning of the trial, reassessed midway through the study, and the training load adjusted accordingly. Each set will be executed at a different angle within the normal lifting range of motion (i.e., lower third, middle third, and upper third).
Adherence/Fidelity:
Adherence will be monitored through attendance records for each session. Fidelity will be ensured through standardized protocols and regular training sessions for the intervention providers.
Location:
The study will be conducted at the Susan Wakil Health Building level 5, the University of Sydney (Camperdown).
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Intervention code [1]
328401
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Treatment: Other
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Comparator / control treatment
Traditional Resistance Training Group:
Materials: Same as above.
Procedures: Participants will engage in multi-joint dynamic resistance training exercises targeting the chest (i.e., chest press) and leg (i.e., leg press) muscles.
Delivery: Conducted in a group setting at the same designated fitness facility under the supervision of researchers.
Frequency and Duration: There will be three sessions per week for a total of 12 weeks. Each session will include three sets of 6 repetitions each for the chest press and leg press exercises. Each session lasts approximately 60 minutes.
Specifics: Isotonic contractions will be performed at 80% of the participant's one-repetition maximum (1RM), with the full range of motion (ROM).
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Control group
Active
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Outcomes
Primary outcome [1]
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Chest Dynamic strength (1RM)
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Assessment method [1]
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The chest 1RM test will be used to assess the dynamic strength of the chest (Keiser Sports Health Equipment, Inc., Fresno, CA 93706, USA). Beginning with a warm-up, participants will perform unweighted repetitions to establish a full range of motion. During the test phase, a set load will be incrementally added, and participants will execute single repetitions, with success evaluated based on the full range of motion and good form. Perceived exertion, both self-reported by participants and objectively assessed by the researcher, will be recorded. Rest intervals of 30 seconds between repetitions will be implemented, extending to 1 minute once perceived exertion approaches maximum. The test will conclude when participants fail with the same load twice, with the maximum load successfully lifted recorded. Safety measures include careful equipment positioning and assistance during mounting and dismounting to minimize injury risk.
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Timepoint [1]
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Baseline and 8 weeks after intervention commencement
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Primary outcome [2]
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Chest Isometric strength (MVC)
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Assessment method [2]
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The Chest muscles MVC will be assessed using the chest press at three different angles. Initially, the full ROM will be determined, followed by determining the three different angles for MVC testing, which includes 1/3 (just prior to the lockout), 2/3 (mid-way point), and 3/3 (end of the eccentric phase). The MVC test will be executed using Keiser A420 pneumatic resistance training equipment (Keiser Sports Health Equipment, Inc., Fresno, CA 93706, USA). A custom-made adjustable strap will secure the movable component of the Keiser Machine. The strap will be equipped with a gauge that digitalizes the mechanical force exerted during the MVC. The customizable nature of the strap will allow for swift adjustments in length, facilitating the secure placement of the Keiser Machine's arms at desired angles. During the MVC test, participants will execute three single repetitions at each predetermined angle separated by a 1–2-minute rest interval. Each MVC will be sustained for 3 seconds, and the highest force exerted across the three repetitions will be defined as the MVC at the respective joint angle. Throughout the MVC testing, participants will receive clear instructions on how to exert maximal force. Verbal encouragement will be consistently administered to motivate participants, ensuring the achievement of peak force levels.
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Timepoint [2]
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Baseline and 8 weeks after intervention commencement
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Primary outcome [3]
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Leg isometric strength (MVC)
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Assessment method [3]
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The leg muscles MVC will be assessed using the chest press at three different angles. Initially, The full ROM will be determined, followed by determining the three different angles for MVC testing, which includes 1/3 (just prior to the lockout), 2/3 (mid-way point), and 3/3 (end of the eccentric phase). The MVC test will be executed using Keiser A420 pneumatic resistance training equipment (Keiser Sports Health Equipment, Inc., Fresno, CA 93706, USA). A custom-made adjustable strap will secure the movable component of the Keiser Machine. The strap will be equipped with a gauge that digitalizes the mechanical force exerted during the MVC. The customizable nature of the strap will allow for swift adjustments in length, facilitating the secure placement of the Keiser Machine's arms at desired angles. During the MVC test, participants will execute three single repetitions at each predetermined angle separated by a 1–2-minute rest interval. Each MVC will be sustained for 3 seconds, and the highest force exerted across the three repetitions will be defined as the MVC at the respective joint angle. Throughout the MVC testing, participants will receive clear instructions on how to exert maximal force. Verbal encouragement will be consistently administered to motivate participants, ensuring the achievement of peak force levels.
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Timepoint [3]
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Baseline and 8 weeks after intervention commencement
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Secondary outcome [1]
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Chest Muscle Endurance
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Assessment method [1]
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Chest Muscle ENdurance will be assessed using Keiser pneumatic resistance training equipment. A standardized load (60% of previously determined 1RM) will be used. The Keiser Machine display is set to "Position Mode" for a range of motion assessment, and participants will be instructed to perform as many consecutive repetitions as possible with good form. Repetitions will be executed at a cadence of approximately 3 seconds concentric/3 seconds eccentric. The test will conclude when a lift deviates by more than 4 degrees or mm from the full range of motion. Recorded metrics will include the total number of complete repetitions, total work, velocity, and power during the first and last repetitions.
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Timepoint [1]
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Baseline and 8 weeks after intervention commencement
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Secondary outcome [2]
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Leg Muscle Endurance
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Assessment method [2]
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Legs Muscle nedurance will be assessed using Keiser pneumatic resistance training equipment. A standardised load (60% of previously determined 1RM) will be used. The Keiser Machine display is set to "Position Mode" for range of motion assessment, and participants will be instructed to perform as many consecutive repetitions as possible with good form. Repetitions will be executed at a cadence of approximately 3 seconds concentric/3 seconds eccentric. The test will conclude when a lift deviates by more than 4 degrees or mm from the full range of motion. Recorded metrics will include the total number of complete repetitions, total work, velocity, and power during the first and last repetitions.
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Timepoint [2]
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Baseline and follow-up ( 8 weeks after intervention commencement)
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Eligibility
Key inclusion criteria
1) male, 2) aged 18-45 years; 3) not engaged in structured resistance training, and 4) be apparently healthy.
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Minimum age
18
Years
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Maximum age
45
Years
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Sex
Males
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Can healthy volunteers participate?
Yes
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Key exclusion criteria
1) unstable medical conditions that would preclude exercising; 2) current musculoskeletal injuries, conditions, or limitations (e.g., muscle strain/pain and joint instability) of the upper or lower body; 3) current lower back pain; and 4) inguinal, femoral, or umbilical hernia.
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Study design
Purpose of the study
Educational / counselling / training
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
central randomisation by phone/fax/computer
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Simple randomisation using a randomisation table created by computer software (i.e. computerised sequence generation)
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Masking / blinding
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Who is / are masked / blinded?
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Intervention assignment
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Other design features
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Phase
Not Applicable
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Not yet recruiting
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Date of first participant enrolment
Anticipated
21/09/2024
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Actual
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Date of last participant enrolment
Anticipated
31/12/2024
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Actual
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Date of last data collection
Anticipated
30/04/2025
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Actual
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Sample size
Target
20
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Accrual to date
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Final
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Recruitment in Australia
Recruitment state(s)
NSW
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Funding & Sponsors
Funding source category [1]
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University
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Name [1]
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The University of Sydney
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Address [1]
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Country [1]
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Australia
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Primary sponsor type
University
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Name
University of Sydney
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Address
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Country
Australia
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Secondary sponsor category [1]
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None
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Name [1]
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Address [1]
318472
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Country [1]
318472
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Ethics approval
Ethics application status
Submitted, not yet approved
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Ethics committee name [1]
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The University of Sydney Human Research Ethics Committee
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Ethics committee address [1]
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https://www.sydney.edu.au/research/research-integrity-and-ethics.html
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Ethics committee country [1]
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Australia
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Date submitted for ethics approval [1]
315101
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03/05/2024
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Approval date [1]
315101
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Ethics approval number [1]
315101
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Summary
Brief summary
This study aims to evaluate the effects of multi-joint isometric resistance training at various joint angles on several aspects of muscular fitness, including strength (both isometric and dynamic), power, muscle endurance, muscle hypertrophy (both whole body and region-specific), and fatigue recovery. These outcomes will be compared to those of traditional resistance training (i.e., dynamic/isotonic), with careful attention to ensuring equal volume and intensity between the groups. The study will adopt a randomised controlled trial design, with eligible participants randomly assigned to either an isometric resistance training group or a traditional resistance training group. Participants will engage in 3 sets of 6 repetitions each for the chest press and leg press exercises. In the traditional resistance training group, sets will involve isotonic contractions (ISOT) with the full range of motion (ROM) at 80% of their one-repetition maximum (1RM). Conversely, the isometric resistance training group will perform isometric contractions (ISOM) at 80% of their maximal voluntary contraction (MVC), with each set executed at a different angle within the normal lifting range of motion (i.e., lower third, middle third, and upper third). It is anticipated that this research will provide insights into the longitudinal effects of isometric resistance training on muscle performance.
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Trial website
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
Name
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Dr Daniel Hackett
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Address
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Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
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Country
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Australia
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Phone
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+61 2 9351 9294
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Fax
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Email
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[email protected]
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Contact person for public queries
Name
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Morteza Ghayomzadeh
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Address
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Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
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Country
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Australia
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Phone
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+61 2 9351 9294
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Fax
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Email
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[email protected]
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Contact person for scientific queries
Name
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Morteza Ghayomzadeh
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Address
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Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
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Country
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Australia
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Phone
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+61 2 9351 9294
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Fax
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Email
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[email protected]
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Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
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No/undecided IPD sharing reason/comment
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What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
Documents added manually
No documents have been uploaded by study researchers.
Documents added automatically
No additional documents have been identified.
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