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Trial registered on ANZCTR
Registration number
ACTRN12624001131549
Ethics application status
Approved
Date submitted
26/08/2024
Date registered
19/09/2024
Date last updated
19/09/2024
Date data sharing statement initially provided
19/09/2024
Type of registration
Retrospectively registered
Titles & IDs
Public title
Effect of acute curcumin supplementation on recovery from a match-play simulation in team-sport athletes.
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Scientific title
Effect of acute curcumin supplementation on recovery from a match-play simulation in team-sport athletes.
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Secondary ID [1]
312806
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Nil
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Universal Trial Number (UTN)
U1111-1312-3735
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Trial acronym
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Muscle damage
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Recovery
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Condition category
Condition code
Physical Medicine / Rehabilitation
331425
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0
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Other physical medicine / rehabilitation
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Alternative and Complementary Medicine
331426
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0
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Other alternative and complementary medicine
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
This study examines the effects of acute curcumin supplementation in team sport athletes, using a randomised, cross-over, repeated-measure, placebo-controlled, double blind design. Participants will consume two capsules daily of either curcumin (Curcumin Gold with LipiSperse technology vy Natures Help, each containing 396 mg of curcumin) or a placebo for five consecutive days. After completing the supplement phase, participants will undergo a seven-day washout period before starting the second round of supplementation.
Prior to supplementation, participants will undergo a baseline testing session (approximately 90 minutes) that includes a series of field tests (countermovement jump, repeated sprints, Yo-Yo fitness test). Once baseline testing is complete, participants will be randomly assigned to begin their first supplementation.
The supplementation timeline and requirements for curcumin and placebo will be identical. Participants will start taking their assigned supplement two days before a match-play simulation (approximately 120 minutes including warm-up). The match-play simulation is a circuit designed to elicit physiological changes similar to team sport matches. The circuit will incorporate repeated sprints, agility, deceleration and walking. Post match-play simulation, the participants will continue to take the supplement for a further two days. Afterward, they will return to perform the same battery off tests conducted during the baseline sessions.
All sessions will be run and supervised by an exercise scientist. Adherence to the intervention will be assessed by the return of the pill boxes. Each participant will be provided a pill box with the correct amount of supplementation required for the duration of the testing.
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Intervention code [1]
329348
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Treatment: Other
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Comparator / control treatment
Participants received an oblique capsule containing either curcumin or the placebo. The placebo capsule contained 48.5g of glucose (Glucodin Pure Glucose Energy, Glucodin).
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Control group
Placebo
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Outcomes
Primary outcome [1]
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Recovery
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Assessment method [1]
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Adapted RESTQ-Sport (Kallus & Kellmann, 2016)
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Timepoint [1]
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Baseline, immediately post, 24 hours & 48 hours post match play simulation for each condition.
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Secondary outcome [1]
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Creatine Kinase
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Assessment method [1]
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Blood sample collection
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Timepoint [1]
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Baseline, 24 & 48 hours post match play simulation simulation for each condition.
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Secondary outcome [2]
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Countermovement Jump Performance
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Assessment method [2]
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Countermovement Jump Height through GymAware equipment. The best of 3 jumps will be recorded.
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Timepoint [2]
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Baseline, 48 hours post match play simulation for each condition.
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Secondary outcome [3]
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Repeated sprint ability
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Assessment method [3]
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Repeated sprint ability test (6x20m sprints with 20 second rest between each sprint). The sprints times will be recorded with timing gates.
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Timepoint [3]
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Baseline and 48 hours post match-play simulation for each condition.
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Secondary outcome [4]
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Endurance performance
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Assessment method [4]
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Yo-Yo Level 1 test
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Timepoint [4]
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Baseline and 48 hours post match-play simulation for each condition.
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Eligibility
Key inclusion criteria
The inclusion criteria is:
- team sport athletes from soccer, Australian Rules football, field hockey and rugby.
- training a minimum twice a week and recently been competing in a team sport environment.
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Minimum age
18
Years
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Maximum age
35
Years
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Sex
Both males and females
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Can healthy volunteers participate?
Yes
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Key exclusion criteria
Participants are excluded if they:
- have been regularly consuming nonsteroidal anti-inflammatory drugs (NSAIDs).
- Have any current inflamed injuries or past injuries that may limit performance.
- Are currently (or in the last three months) taking any supplementation containing curcumin or any other anti-inflammatory/antioxidant ingredients.
- Currently have or have had liver problems or any other health conditions that may impact exercise.
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Participants will not know the order of supplement consumption. Allocation of the order will be completed by the chief investigator, capsule boxes will be handed over to the researcher labelled either block 1 or block 2. All supplements will be within oblique capsules. The researcher will not know what supplements are in which container.
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
A simple randomisation (coin toss) will be used to decide which condition the participant will complete first,
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Crossover
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Other design features
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Phase
Not Applicable
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Type of endpoint/s
Efficacy
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Statistical methods / analysis
A sample size of 18 has a 90% power to detect a standardised mean difference of 0.41 based on previous research considering countermovement jump as the primary outcome post-supplementation (Foskett et al., 2009). Therefore we will recruit 20 participants to account for any missing data and dropouts whilst still achieving power.
A two-way repeated-measures analysis of variance (ANOVA) will be used to assess the difference in exercise performance, recovery, and blood measures. Data will be expressed as means + standard deviation (SD), unless stated otherwise, with statistical significance set at p < 0.05. In addition, Cohen's d effect size (ES) will be calculated to assess the magnitude of any differences. Classification of ES: >0.8 large, 0.5-0.79 moderate, and < 0.49 small effect (Cohen, 1988). Data anaylsis will be performed using R.
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Recruitment
Recruitment status
Recruiting
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Date of first participant enrolment
Anticipated
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Actual
15/07/2024
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Date of last participant enrolment
Anticipated
31/03/2025
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Actual
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Date of last data collection
Anticipated
28/04/2025
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Actual
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Sample size
Target
20
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Accrual to date
4
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Final
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Recruitment in Australia
Recruitment state(s)
VIC
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Funding & Sponsors
Funding source category [1]
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University
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Name [1]
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Curtin University
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Address [1]
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Country [1]
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Australia
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Primary sponsor type
University
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Name
Curtin University
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Address
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Country
Australia
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Secondary sponsor category [1]
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None
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Name [1]
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Address [1]
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Country [1]
319526
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Ethics approval
Ethics application status
Approved
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Ethics committee name [1]
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Curtin University Human Research Ethics Committee
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Ethics committee address [1]
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https://www.curtin.edu.au/students/essentials/higher-degree-by-research/ethics-safety/human/
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Ethics committee country [1]
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Australia
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Date submitted for ethics approval [1]
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08/12/2023
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Approval date [1]
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29/02/2024
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Ethics approval number [1]
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HRE2024-0080
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Summary
Brief summary
The effects of an acute curcumin supplementation on team sport athletes performance and recovery. The study involves team sport athletes, aged 18-35. This is a randiomised, double-blinded, cross-over study where participants will consume either a curcumin supplement or a placebo at a time, without knowing which one they were given. They will be tested on their athletic performance and recovery over five sessions, with a break between the supplements to ensure any effects of the supplements have worn off. The study will measure performance through a battery of field tests and recovery through blood sample collection and questionnaires. The hypothesis of this study an acute dose of curcumin supplementation will reduce the detriment in exercise performance post-fatiguing exercise. Additionally, muscle damage markers and inflammation will be reduced, and the participants’ perceived recovery will be improved.
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Trial website
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Trial related presentations / publications
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Public notes
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Contacts
Principal investigator
Name
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Miss Larissa Walsh
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Address
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Curtin University, GPO Box U1987, Kent Street, Bentley, Western Australia, 6102
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Country
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Australia
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Phone
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+61 417625990
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Fax
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Email
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[email protected]
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Contact person for public queries
Name
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Larissa Walsh
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Address
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Curtin University, GPO Box U1987, Kent Street, Bentley, Western Australia, 6102
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Country
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Australia
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Phone
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+61 417625990
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Fax
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Email
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[email protected]
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Contact person for scientific queries
Name
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Kagan Ducker
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Address
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Curtin University, GPO Box U1987, Kent Street, Bentley, Western Australia, 6102
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Country
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Australia
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Phone
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+61419924263
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Fax
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Email
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[email protected]
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Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
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No/undecided IPD sharing reason/comment
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What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
Documents added manually
No documents have been uploaded by study researchers.
Documents added automatically
No additional documents have been identified.
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