Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01730534
Registration number
NCT01730534
Ethics application status
Date submitted
15/11/2012
Date registered
21/11/2012
Date last updated
26/12/2019
Titles & IDs
Public title
Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events
Query!
Scientific title
Dapagliflozin Effect on Cardiovascular Events A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Dapagliflozin 10 mg Once Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Ischemic Stroke in Patients With Type 2 Diabetes
Query!
Secondary ID [1]
0
0
D1693C00001
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
DECLARE-TIMI58
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Diabetes Mellitus, Non-Insulin-Dependent
0
0
Query!
High Risk for Cardiovascular Event
0
0
Query!
Condition category
Condition code
Metabolic and Endocrine
0
0
0
0
Query!
Diabetes
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - Dapagliflozin 10 mg
Treatment: Drugs - Placebo tablet
Experimental: Dapagliflozin - Dapagliflozin + standard of care therapy for Type 2 Diabetes and for co-morbidities and cardiovascular risk factors
Placebo comparator: Placebo - Placebo + standard of care therapy for Type 2 Diabetes and for co-morbidities and cardiovascular risk factors
Treatment: Drugs: Dapagliflozin 10 mg
Oral dose (od)
Treatment: Drugs: Placebo tablet
Oral dose (od)
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Subjects Included in the Composite Endpoint of CV Death, MI or Ischemic Stroke
Query!
Assessment method [1]
0
0
Safety and co-primary efficacy
Query!
Timepoint [1]
0
0
up to 5.2 years
Query!
Primary outcome [2]
0
0
Subjects Included in the Composite Endpoint of CV Death or Hospitalization Due to Heart Failure.
Query!
Assessment method [2]
0
0
Co-primary efficacy
Query!
Timepoint [2]
0
0
up to 5.2 years
Query!
Secondary outcome [1]
0
0
Subjects Included in the Renal Composite Endpoint: Confirmed Sustained =40% Decrease in eGFR to eGFR <60 ml/Min/1.73m2 and/or ESRD and/or Renal or CV Death.
Query!
Assessment method [1]
0
0
Secondary
Query!
Timepoint [1]
0
0
up to 5.2 years
Query!
Secondary outcome [2]
0
0
Subjects Included in the Endpoint of All-cause Mortality.
Query!
Assessment method [2]
0
0
Secondary
Query!
Timepoint [2]
0
0
up to 5.2 years
Query!
Eligibility
Key inclusion criteria
* Provision of informed consent prior to any study specific procedures
* Female or male aged =40 years
* Diagnosed with Type 2 Diabetes
* High Risk for Cardiovascular events
Query!
Minimum age
40
Years
Query!
Query!
Maximum age
130
Years
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Diagnosis of Type 1 diabetes mellitus History of bladder cancer or history of radiation therapy to the lower abdomen or pelvis at any time
* Chronic cystitis and/or recurrent urinary tract infections
* Pregnant or breast-feeding patients
Query!
Study design
Purpose of the study
Treatment
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
25/04/2013
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
11/09/2018
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
17190
Query!
Recruitment in Australia
Recruitment state(s)
Query!
Recruitment hospital [1]
0
0
Research Site - Adelaide - Oaklands Park
Query!
Recruitment hospital [2]
0
0
Research Site - Ashford
Query!
Recruitment hospital [3]
0
0
Research Site - Box Hill
Query!
Recruitment hospital [4]
0
0
Research Site - Camperdown
Query!
Recruitment hospital [5]
0
0
Research Site - Darlinghurst
Query!
Recruitment hospital [6]
0
0
Research Site - Fullarton
Query!
Recruitment hospital [7]
0
0
Research Site - Garran
Query!
Recruitment hospital [8]
0
0
Research Site - Geelong
Query!
Recruitment hospital [9]
0
0
Research Site - Heidelberg West
Query!
Recruitment hospital [10]
0
0
Research Site - Herston
Query!
Recruitment hospital [11]
0
0
Research Site - Joondalup
Query!
Recruitment hospital [12]
0
0
Research Site - Maroubra
Query!
Recruitment hospital [13]
0
0
Research Site - Melbourne
Query!
Recruitment hospital [14]
0
0
Research Site - Milton
Query!
Recruitment hospital [15]
0
0
Research Site - Murdoch
Query!
Recruitment hospital [16]
0
0
Research Site - Wollongong
Query!
Recruitment postcode(s) [1]
0
0
5046 - Adelaide - Oaklands Park
Query!
Recruitment postcode(s) [2]
0
0
5035 - Ashford
Query!
Recruitment postcode(s) [3]
0
0
3128 - Box Hill
Query!
Recruitment postcode(s) [4]
0
0
2050 - Camperdown
Query!
Recruitment postcode(s) [5]
0
0
2010 - Darlinghurst
Query!
Recruitment postcode(s) [6]
0
0
5063 - Fullarton
Query!
Recruitment postcode(s) [7]
0
0
2605 - Garran
Query!
Recruitment postcode(s) [8]
0
0
3220 - Geelong
Query!
Recruitment postcode(s) [9]
0
0
3081 - Heidelberg West
Query!
Recruitment postcode(s) [10]
0
0
4029 - Herston
Query!
Recruitment postcode(s) [11]
0
0
6027 - Joondalup
Query!
Recruitment postcode(s) [12]
0
0
2035 - Maroubra
Query!
Recruitment postcode(s) [13]
0
0
3004 - Melbourne
Query!
Recruitment postcode(s) [14]
0
0
4064 - Milton
Query!
Recruitment postcode(s) [15]
0
0
6150 - Murdoch
Query!
Recruitment postcode(s) [16]
0
0
2500 - Wollongong
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arizona
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
California
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Colorado
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Connecticut
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Delaware
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
District of Columbia
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Florida
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Georgia
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Hawaii
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Idaho
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Illinois
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Indiana
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Iowa
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Kansas
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Kentucky
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Louisiana
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Maine
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Maryland
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Massachusetts
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Michigan
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Minnesota
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Missouri
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
Montana
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
Nebraska
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
Nevada
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
New Jersey
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
New Mexico
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
New York
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
North Carolina
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
North Dakota
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
Ohio
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
Oklahoma
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
Pennsylvania
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
South Carolina
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
South Dakota
Query!
Country [37]
0
0
United States of America
Query!
State/province [37]
0
0
Tennessee
Query!
Country [38]
0
0
United States of America
Query!
State/province [38]
0
0
Texas
Query!
Country [39]
0
0
United States of America
Query!
State/province [39]
0
0
Utah
Query!
Country [40]
0
0
United States of America
Query!
State/province [40]
0
0
Vermont
Query!
Country [41]
0
0
United States of America
Query!
State/province [41]
0
0
Virginia
Query!
Country [42]
0
0
United States of America
Query!
State/province [42]
0
0
Washington
Query!
Country [43]
0
0
United States of America
Query!
State/province [43]
0
0
Wisconsin
Query!
Country [44]
0
0
Argentina
Query!
State/province [44]
0
0
Buenos Aires
Query!
Country [45]
0
0
Argentina
Query!
State/province [45]
0
0
Caba
Query!
Country [46]
0
0
Argentina
Query!
State/province [46]
0
0
Ciudad Autonoma Buenos Aires
Query!
Country [47]
0
0
Argentina
Query!
State/province [47]
0
0
Ciudad Autonoma de Buenos Aire
Query!
Country [48]
0
0
Argentina
Query!
State/province [48]
0
0
Cordoba
Query!
Country [49]
0
0
Argentina
Query!
State/province [49]
0
0
La Plata
Query!
Country [50]
0
0
Argentina
Query!
State/province [50]
0
0
Lanus
Query!
Country [51]
0
0
Argentina
Query!
State/province [51]
0
0
Mar del Plata
Query!
Country [52]
0
0
Argentina
Query!
State/province [52]
0
0
Ramos Mejía
Query!
Country [53]
0
0
Argentina
Query!
State/province [53]
0
0
Rosario
Query!
Country [54]
0
0
Argentina
Query!
State/province [54]
0
0
San Nicolás
Query!
Country [55]
0
0
Argentina
Query!
State/province [55]
0
0
Santa Fe
Query!
Country [56]
0
0
Belgium
Query!
State/province [56]
0
0
Aalst
Query!
Country [57]
0
0
Belgium
Query!
State/province [57]
0
0
Antwerpen
Query!
Country [58]
0
0
Belgium
Query!
State/province [58]
0
0
Bonheiden
Query!
Country [59]
0
0
Belgium
Query!
State/province [59]
0
0
Brasschaat
Query!
Country [60]
0
0
Belgium
Query!
State/province [60]
0
0
Brugge
Query!
Country [61]
0
0
Belgium
Query!
State/province [61]
0
0
Brussels
Query!
Country [62]
0
0
Belgium
Query!
State/province [62]
0
0
Edegem
Query!
Country [63]
0
0
Belgium
Query!
State/province [63]
0
0
Leuven
Query!
Country [64]
0
0
Belgium
Query!
State/province [64]
0
0
Liege
Query!
Country [65]
0
0
Belgium
Query!
State/province [65]
0
0
Mechelen
Query!
Country [66]
0
0
Belgium
Query!
State/province [66]
0
0
Merksem
Query!
Country [67]
0
0
Belgium
Query!
State/province [67]
0
0
Roeselare
Query!
Country [68]
0
0
Belgium
Query!
State/province [68]
0
0
Tienen
Query!
Country [69]
0
0
Belgium
Query!
State/province [69]
0
0
Turnhout
Query!
Country [70]
0
0
Brazil
Query!
State/province [70]
0
0
Belo Horizonte
Query!
Country [71]
0
0
Brazil
Query!
State/province [71]
0
0
Brasilia
Query!
Country [72]
0
0
Brazil
Query!
State/province [72]
0
0
Campina Grande do Sul
Query!
Country [73]
0
0
Brazil
Query!
State/province [73]
0
0
Campinas
Query!
Country [74]
0
0
Brazil
Query!
State/province [74]
0
0
Marilia
Query!
Country [75]
0
0
Brazil
Query!
State/province [75]
0
0
Porto Alegre
Query!
Country [76]
0
0
Brazil
Query!
State/province [76]
0
0
Sao Jose dos Campos
Query!
Country [77]
0
0
Brazil
Query!
State/province [77]
0
0
Sao Paulo
Query!
Country [78]
0
0
Brazil
Query!
State/province [78]
0
0
São José do Rio Preto
Query!
Country [79]
0
0
Brazil
Query!
State/province [79]
0
0
São Paulo
Query!
Country [80]
0
0
Bulgaria
Query!
State/province [80]
0
0
Blagoevgrad
Query!
Country [81]
0
0
Bulgaria
Query!
State/province [81]
0
0
Botevgrad
Query!
Country [82]
0
0
Bulgaria
Query!
State/province [82]
0
0
Dimitrovgrad
Query!
Country [83]
0
0
Bulgaria
Query!
State/province [83]
0
0
Dupnitsa
Query!
Country [84]
0
0
Bulgaria
Query!
State/province [84]
0
0
Gotse Delchev
Query!
Country [85]
0
0
Bulgaria
Query!
State/province [85]
0
0
Kozloduy
Query!
Country [86]
0
0
Bulgaria
Query!
State/province [86]
0
0
Kyustendil
Query!
Country [87]
0
0
Bulgaria
Query!
State/province [87]
0
0
Lukovit
Query!
Country [88]
0
0
Bulgaria
Query!
State/province [88]
0
0
Petrich
Query!
Country [89]
0
0
Bulgaria
Query!
State/province [89]
0
0
Pleven
Query!
Country [90]
0
0
Bulgaria
Query!
State/province [90]
0
0
Plovdiv
Query!
Country [91]
0
0
Bulgaria
Query!
State/province [91]
0
0
Russe
Query!
Country [92]
0
0
Bulgaria
Query!
State/province [92]
0
0
Sandanski
Query!
Country [93]
0
0
Bulgaria
Query!
State/province [93]
0
0
Sevlievo
Query!
Country [94]
0
0
Bulgaria
Query!
State/province [94]
0
0
Sliven
Query!
Country [95]
0
0
Bulgaria
Query!
State/province [95]
0
0
Smolyan
Query!
Country [96]
0
0
Bulgaria
Query!
State/province [96]
0
0
Sofia
Query!
Country [97]
0
0
Bulgaria
Query!
State/province [97]
0
0
Stara Zagora
Query!
Country [98]
0
0
Bulgaria
Query!
State/province [98]
0
0
Yambol
Query!
Country [99]
0
0
Canada
Query!
State/province [99]
0
0
Alberta
Query!
Country [100]
0
0
Canada
Query!
State/province [100]
0
0
British Columbia
Query!
Country [101]
0
0
Canada
Query!
State/province [101]
0
0
Manitoba
Query!
Country [102]
0
0
Canada
Query!
State/province [102]
0
0
New Brunswick
Query!
Country [103]
0
0
Canada
Query!
State/province [103]
0
0
Newfoundland and Labrador
Query!
Country [104]
0
0
Canada
Query!
State/province [104]
0
0
Nova Scotia
Query!
Country [105]
0
0
Canada
Query!
State/province [105]
0
0
Ontario
Query!
Country [106]
0
0
Canada
Query!
State/province [106]
0
0
Quebec
Query!
Country [107]
0
0
Canada
Query!
State/province [107]
0
0
Saskatchewan
Query!
Country [108]
0
0
Canada
Query!
State/province [108]
0
0
Laval
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Beijing
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Changsha
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Guangzhou
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Hefei
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Jinan
Query!
Country [114]
0
0
China
Query!
State/province [114]
0
0
Nanchang
Query!
Country [115]
0
0
China
Query!
State/province [115]
0
0
Nanjing
Query!
Country [116]
0
0
China
Query!
State/province [116]
0
0
Shanghai
Query!
Country [117]
0
0
China
Query!
State/province [117]
0
0
ShiJiazhuang
Query!
Country [118]
0
0
China
Query!
State/province [118]
0
0
Tianjin
Query!
Country [119]
0
0
Czechia
Query!
State/province [119]
0
0
Beroun
Query!
Country [120]
0
0
Czechia
Query!
State/province [120]
0
0
Brno
Query!
Country [121]
0
0
Czechia
Query!
State/province [121]
0
0
Cheb
Query!
Country [122]
0
0
Czechia
Query!
State/province [122]
0
0
Chomutov
Query!
Country [123]
0
0
Czechia
Query!
State/province [123]
0
0
Chrudim III
Query!
Country [124]
0
0
Czechia
Query!
State/province [124]
0
0
Hodonin
Query!
Country [125]
0
0
Czechia
Query!
State/province [125]
0
0
Horovice
Query!
Country [126]
0
0
Czechia
Query!
State/province [126]
0
0
Hradec Kralove
Query!
Country [127]
0
0
Czechia
Query!
State/province [127]
0
0
Jilove u Prahy
Query!
Country [128]
0
0
Czechia
Query!
State/province [128]
0
0
Kromeriz
Query!
Country [129]
0
0
Czechia
Query!
State/province [129]
0
0
Ostrava - Belsky les
Query!
Country [130]
0
0
Czechia
Query!
State/province [130]
0
0
Ostrava - Dubina
Query!
Country [131]
0
0
Czechia
Query!
State/province [131]
0
0
Ostrava - Kuncice
Query!
Country [132]
0
0
Czechia
Query!
State/province [132]
0
0
Ostrava-Moravska
Query!
Country [133]
0
0
Czechia
Query!
State/province [133]
0
0
Plzen - Severni Predmesti
Query!
Country [134]
0
0
Czechia
Query!
State/province [134]
0
0
Plzen
Query!
Country [135]
0
0
Czechia
Query!
State/province [135]
0
0
Praha 4
Query!
Country [136]
0
0
Czechia
Query!
State/province [136]
0
0
Praha 5
Query!
Country [137]
0
0
Czechia
Query!
State/province [137]
0
0
Praha 6
Query!
Country [138]
0
0
Czechia
Query!
State/province [138]
0
0
Praha
Query!
Country [139]
0
0
Czechia
Query!
State/province [139]
0
0
Prelouc
Query!
Country [140]
0
0
Czechia
Query!
State/province [140]
0
0
Rakovnik
Query!
Country [141]
0
0
Czechia
Query!
State/province [141]
0
0
Slany
Query!
Country [142]
0
0
Czechia
Query!
State/province [142]
0
0
Teplice
Query!
Country [143]
0
0
Czechia
Query!
State/province [143]
0
0
Uherske Hradiste
Query!
Country [144]
0
0
Czechia
Query!
State/province [144]
0
0
Usti nad Labem
Query!
Country [145]
0
0
Czechia
Query!
State/province [145]
0
0
Zlin
Query!
Country [146]
0
0
France
Query!
State/province [146]
0
0
Angers cedex 9
Query!
Country [147]
0
0
France
Query!
State/province [147]
0
0
Corbeil-Essonnes
Query!
Country [148]
0
0
France
Query!
State/province [148]
0
0
Dijon Cedex
Query!
Country [149]
0
0
France
Query!
State/province [149]
0
0
Dijon
Query!
Country [150]
0
0
France
Query!
State/province [150]
0
0
La Rochelle
Query!
Country [151]
0
0
France
Query!
State/province [151]
0
0
Le Creusot
Query!
Country [152]
0
0
France
Query!
State/province [152]
0
0
Nantes Cedex 1
Query!
Country [153]
0
0
France
Query!
State/province [153]
0
0
Nantes Cedex 2
Query!
Country [154]
0
0
France
Query!
State/province [154]
0
0
Pessac
Query!
Country [155]
0
0
France
Query!
State/province [155]
0
0
Poitiers Cedex
Query!
Country [156]
0
0
France
Query!
State/province [156]
0
0
TOULOUSE Cedex 9
Query!
Country [157]
0
0
Germany
Query!
State/province [157]
0
0
Aschaffenburg
Query!
Country [158]
0
0
Germany
Query!
State/province [158]
0
0
Bad Mergentheim
Query!
Country [159]
0
0
Germany
Query!
State/province [159]
0
0
Bad Oeynhausen
Query!
Country [160]
0
0
Germany
Query!
State/province [160]
0
0
Berlin
Query!
Country [161]
0
0
Germany
Query!
State/province [161]
0
0
Dippoldiswalde
Query!
Country [162]
0
0
Germany
Query!
State/province [162]
0
0
Freiburg
Query!
Country [163]
0
0
Germany
Query!
State/province [163]
0
0
Hamburg
Query!
Country [164]
0
0
Germany
Query!
State/province [164]
0
0
Kassel
Query!
Country [165]
0
0
Germany
Query!
State/province [165]
0
0
Köln
Query!
Country [166]
0
0
Germany
Query!
State/province [166]
0
0
Leipzig
Query!
Country [167]
0
0
Germany
Query!
State/province [167]
0
0
München
Query!
Country [168]
0
0
Germany
Query!
State/province [168]
0
0
Villingen-Schwenningen
Query!
Country [169]
0
0
Hong Kong
Query!
State/province [169]
0
0
Causeway Bay
Query!
Country [170]
0
0
Hong Kong
Query!
State/province [170]
0
0
Hongkong
Query!
Country [171]
0
0
Hong Kong
Query!
State/province [171]
0
0
Tai Po
Query!
Country [172]
0
0
Hungary
Query!
State/province [172]
0
0
Balatonfüred
Query!
Country [173]
0
0
Hungary
Query!
State/province [173]
0
0
Ballasagyarmat
Query!
Country [174]
0
0
Hungary
Query!
State/province [174]
0
0
Berettyóújfalu
Query!
Country [175]
0
0
Hungary
Query!
State/province [175]
0
0
Budapest
Query!
Country [176]
0
0
Hungary
Query!
State/province [176]
0
0
Cegléd
Query!
Country [177]
0
0
Hungary
Query!
State/province [177]
0
0
Csongrád
Query!
Country [178]
0
0
Hungary
Query!
State/province [178]
0
0
Debrecen
Query!
Country [179]
0
0
Hungary
Query!
State/province [179]
0
0
Eger
Query!
Country [180]
0
0
Hungary
Query!
State/province [180]
0
0
Esztergom
Query!
Country [181]
0
0
Hungary
Query!
State/province [181]
0
0
Gyor
Query!
Country [182]
0
0
Hungary
Query!
State/province [182]
0
0
Gyöngyös
Query!
Country [183]
0
0
Hungary
Query!
State/province [183]
0
0
Kecskemét
Query!
Country [184]
0
0
Hungary
Query!
State/province [184]
0
0
Kistarcsa
Query!
Country [185]
0
0
Hungary
Query!
State/province [185]
0
0
Komárom
Query!
Country [186]
0
0
Hungary
Query!
State/province [186]
0
0
Mórahalom
Query!
Country [187]
0
0
Hungary
Query!
State/province [187]
0
0
Nyíregyháza
Query!
Country [188]
0
0
Hungary
Query!
State/province [188]
0
0
Polgár
Query!
Country [189]
0
0
Hungary
Query!
State/province [189]
0
0
Sopron
Query!
Country [190]
0
0
Hungary
Query!
State/province [190]
0
0
Szolnok
Query!
Country [191]
0
0
Hungary
Query!
State/province [191]
0
0
Székesfehérvár
Query!
Country [192]
0
0
Hungary
Query!
State/province [192]
0
0
Tát
Query!
Country [193]
0
0
Hungary
Query!
State/province [193]
0
0
Zalaegerszeg
Query!
Country [194]
0
0
Hungary
Query!
State/province [194]
0
0
Ács
Query!
Country [195]
0
0
India
Query!
State/province [195]
0
0
Ahmedabad
Query!
Country [196]
0
0
India
Query!
State/province [196]
0
0
Bangalore
Query!
Country [197]
0
0
India
Query!
State/province [197]
0
0
Pune
Query!
Country [198]
0
0
India
Query!
State/province [198]
0
0
Vellore
Query!
Country [199]
0
0
Israel
Query!
State/province [199]
0
0
Afula
Query!
Country [200]
0
0
Israel
Query!
State/province [200]
0
0
Ashkelon
Query!
Country [201]
0
0
Israel
Query!
State/province [201]
0
0
Beer Sheva
Query!
Country [202]
0
0
Israel
Query!
State/province [202]
0
0
Bnei Barak
Query!
Country [203]
0
0
Israel
Query!
State/province [203]
0
0
Hadera
Query!
Country [204]
0
0
Israel
Query!
State/province [204]
0
0
Haifa
Query!
Country [205]
0
0
Israel
Query!
State/province [205]
0
0
Holon
Query!
Country [206]
0
0
Israel
Query!
State/province [206]
0
0
Jerusalem
Query!
Country [207]
0
0
Israel
Query!
State/province [207]
0
0
Naharia
Query!
Country [208]
0
0
Israel
Query!
State/province [208]
0
0
Petach Tikva
Query!
Country [209]
0
0
Italy
Query!
State/province [209]
0
0
Bergamo
Query!
Country [210]
0
0
Italy
Query!
State/province [210]
0
0
Firenze
Query!
Country [211]
0
0
Italy
Query!
State/province [211]
0
0
Milano
Query!
Country [212]
0
0
Italy
Query!
State/province [212]
0
0
Napoli
Query!
Country [213]
0
0
Italy
Query!
State/province [213]
0
0
Negrar - VR
Query!
Country [214]
0
0
Italy
Query!
State/province [214]
0
0
Padova
Query!
Country [215]
0
0
Italy
Query!
State/province [215]
0
0
Parma
Query!
Country [216]
0
0
Italy
Query!
State/province [216]
0
0
Pavia
Query!
Country [217]
0
0
Italy
Query!
State/province [217]
0
0
Rozzano
Query!
Country [218]
0
0
Italy
Query!
State/province [218]
0
0
S Maria Capua Vetere
Query!
Country [219]
0
0
Italy
Query!
State/province [219]
0
0
Sessa Aurunca
Query!
Country [220]
0
0
Italy
Query!
State/province [220]
0
0
Verona
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Bunkyo-ku
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Daito-shi
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Kasuga-shi
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Kobe-shi
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Kumamoto-shi
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Matsubara-shi
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Saga-shi
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Ube-shi
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Uji-shi
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Yao-shi
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Yokohama-shi
Query!
Country [232]
0
0
Korea, Republic of
Query!
State/province [232]
0
0
Bucheon-si
Query!
Country [233]
0
0
Korea, Republic of
Query!
State/province [233]
0
0
Busan
Query!
Country [234]
0
0
Korea, Republic of
Query!
State/province [234]
0
0
Cheongju-si
Query!
Country [235]
0
0
Korea, Republic of
Query!
State/province [235]
0
0
Daegu
Query!
Country [236]
0
0
Korea, Republic of
Query!
State/province [236]
0
0
Daejeon
Query!
Country [237]
0
0
Korea, Republic of
Query!
State/province [237]
0
0
Goyang-si
Query!
Country [238]
0
0
Korea, Republic of
Query!
State/province [238]
0
0
Gyeonggi-do
Query!
Country [239]
0
0
Korea, Republic of
Query!
State/province [239]
0
0
Jeonju-si, Jeollabuk-do
Query!
Country [240]
0
0
Korea, Republic of
Query!
State/province [240]
0
0
Jung-gu
Query!
Country [241]
0
0
Korea, Republic of
Query!
State/province [241]
0
0
Seongnam-si
Query!
Country [242]
0
0
Korea, Republic of
Query!
State/province [242]
0
0
Seoul
Query!
Country [243]
0
0
Korea, Republic of
Query!
State/province [243]
0
0
Suwon-si
Query!
Country [244]
0
0
Korea, Republic of
Query!
State/province [244]
0
0
Uijeongbu-si
Query!
Country [245]
0
0
Mexico
Query!
State/province [245]
0
0
Acapulco
Query!
Country [246]
0
0
Mexico
Query!
State/province [246]
0
0
Culiacan
Query!
Country [247]
0
0
Mexico
Query!
State/province [247]
0
0
Del. Cuauhtemoc
Query!
Country [248]
0
0
Mexico
Query!
State/province [248]
0
0
Distrito Federal
Query!
Country [249]
0
0
Mexico
Query!
State/province [249]
0
0
Guadalajara
Query!
Country [250]
0
0
Mexico
Query!
State/province [250]
0
0
Meridas
Query!
Country [251]
0
0
Mexico
Query!
State/province [251]
0
0
Mexico
Query!
Country [252]
0
0
Mexico
Query!
State/province [252]
0
0
Monterey
Query!
Country [253]
0
0
Mexico
Query!
State/province [253]
0
0
Monterrey
Query!
Country [254]
0
0
Mexico
Query!
State/province [254]
0
0
Pachuca de Soto
Query!
Country [255]
0
0
Mexico
Query!
State/province [255]
0
0
Queretaro
Query!
Country [256]
0
0
Mexico
Query!
State/province [256]
0
0
San Luis Potosi
Query!
Country [257]
0
0
Mexico
Query!
State/province [257]
0
0
Tijuana
Query!
Country [258]
0
0
Mexico
Query!
State/province [258]
0
0
Veracruz
Query!
Country [259]
0
0
Mexico
Query!
State/province [259]
0
0
Xalapa
Query!
Country [260]
0
0
Mexico
Query!
State/province [260]
0
0
Zapopan, Jalisco
Query!
Country [261]
0
0
Mexico
Query!
State/province [261]
0
0
Zapopan
Query!
Country [262]
0
0
Netherlands
Query!
State/province [262]
0
0
Alkmaar
Query!
Country [263]
0
0
Netherlands
Query!
State/province [263]
0
0
Amsterdam
Query!
Country [264]
0
0
Netherlands
Query!
State/province [264]
0
0
Apeldoorn
Query!
Country [265]
0
0
Netherlands
Query!
State/province [265]
0
0
Arnhem
Query!
Country [266]
0
0
Netherlands
Query!
State/province [266]
0
0
Breda
Query!
Country [267]
0
0
Netherlands
Query!
State/province [267]
0
0
Delft
Query!
Country [268]
0
0
Netherlands
Query!
State/province [268]
0
0
Den Haag
Query!
Country [269]
0
0
Netherlands
Query!
State/province [269]
0
0
EDE
Query!
Country [270]
0
0
Netherlands
Query!
State/province [270]
0
0
Eindhoven
Query!
Country [271]
0
0
Netherlands
Query!
State/province [271]
0
0
Gouda
Query!
Country [272]
0
0
Netherlands
Query!
State/province [272]
0
0
Groningen
Query!
Country [273]
0
0
Netherlands
Query!
State/province [273]
0
0
Haarlem
Query!
Country [274]
0
0
Netherlands
Query!
State/province [274]
0
0
Hardenberg
Query!
Country [275]
0
0
Netherlands
Query!
State/province [275]
0
0
Heerlen
Query!
Country [276]
0
0
Netherlands
Query!
State/province [276]
0
0
Hoogeveen
Query!
Country [277]
0
0
Netherlands
Query!
State/province [277]
0
0
Nijmegen
Query!
Country [278]
0
0
Netherlands
Query!
State/province [278]
0
0
Rotterdam
Query!
Country [279]
0
0
Netherlands
Query!
State/province [279]
0
0
Sliedrecht
Query!
Country [280]
0
0
Netherlands
Query!
State/province [280]
0
0
Sneek
Query!
Country [281]
0
0
Netherlands
Query!
State/province [281]
0
0
Utrecht
Query!
Country [282]
0
0
Netherlands
Query!
State/province [282]
0
0
Venlo
Query!
Country [283]
0
0
Netherlands
Query!
State/province [283]
0
0
Zutphen
Query!
Country [284]
0
0
Philippines
Query!
State/province [284]
0
0
Bacolod
Query!
Country [285]
0
0
Philippines
Query!
State/province [285]
0
0
Cebu City
Query!
Country [286]
0
0
Philippines
Query!
State/province [286]
0
0
Dasmarinas City
Query!
Country [287]
0
0
Philippines
Query!
State/province [287]
0
0
Iloilo City
Query!
Country [288]
0
0
Philippines
Query!
State/province [288]
0
0
Lipa City
Query!
Country [289]
0
0
Philippines
Query!
State/province [289]
0
0
Makati City
Query!
Country [290]
0
0
Philippines
Query!
State/province [290]
0
0
Mandaluyong City
Query!
Country [291]
0
0
Philippines
Query!
State/province [291]
0
0
Manila
Query!
Country [292]
0
0
Philippines
Query!
State/province [292]
0
0
Marikina City
Query!
Country [293]
0
0
Philippines
Query!
State/province [293]
0
0
Pasay City
Query!
Country [294]
0
0
Philippines
Query!
State/province [294]
0
0
Pasig City
Query!
Country [295]
0
0
Philippines
Query!
State/province [295]
0
0
Quezon City
Query!
Country [296]
0
0
Philippines
Query!
State/province [296]
0
0
Tanauan City
Query!
Country [297]
0
0
Poland
Query!
State/province [297]
0
0
Biala Rawska
Query!
Country [298]
0
0
Poland
Query!
State/province [298]
0
0
Bydgoszcz
Query!
Country [299]
0
0
Poland
Query!
State/province [299]
0
0
ChrzanÓw
Query!
Country [300]
0
0
Poland
Query!
State/province [300]
0
0
Gdansk
Query!
Country [301]
0
0
Poland
Query!
State/province [301]
0
0
Gdynia
Query!
Country [302]
0
0
Poland
Query!
State/province [302]
0
0
Gizycko
Query!
Country [303]
0
0
Poland
Query!
State/province [303]
0
0
Katowice
Query!
Country [304]
0
0
Poland
Query!
State/province [304]
0
0
Koluszki
Query!
Country [305]
0
0
Poland
Query!
State/province [305]
0
0
Krakow
Query!
Country [306]
0
0
Poland
Query!
State/province [306]
0
0
Kraków
Query!
Country [307]
0
0
Poland
Query!
State/province [307]
0
0
Legnica
Query!
Country [308]
0
0
Poland
Query!
State/province [308]
0
0
Lublin
Query!
Country [309]
0
0
Poland
Query!
State/province [309]
0
0
Mragowo
Query!
Country [310]
0
0
Poland
Query!
State/province [310]
0
0
Naklo nad Notecia
Query!
Country [311]
0
0
Poland
Query!
State/province [311]
0
0
Poznan
Query!
Country [312]
0
0
Poland
Query!
State/province [312]
0
0
Plock
Query!
Country [313]
0
0
Poland
Query!
State/province [313]
0
0
Ruda Slaska
Query!
Country [314]
0
0
Poland
Query!
State/province [314]
0
0
Skierniewice
Query!
Country [315]
0
0
Poland
Query!
State/province [315]
0
0
Sobótka
Query!
Country [316]
0
0
Poland
Query!
State/province [316]
0
0
Sokólka
Query!
Country [317]
0
0
Poland
Query!
State/province [317]
0
0
Torun
Query!
Country [318]
0
0
Poland
Query!
State/province [318]
0
0
Warszawa
Query!
Country [319]
0
0
Poland
Query!
State/province [319]
0
0
Wierzchoslawice
Query!
Country [320]
0
0
Poland
Query!
State/province [320]
0
0
Wroclaw
Query!
Country [321]
0
0
Poland
Query!
State/province [321]
0
0
Wegrów
Query!
Country [322]
0
0
Poland
Query!
State/province [322]
0
0
Wloclawek
Query!
Country [323]
0
0
Poland
Query!
State/province [323]
0
0
Zabrze
Query!
Country [324]
0
0
Poland
Query!
State/province [324]
0
0
Leczna
Query!
Country [325]
0
0
Romania
Query!
State/province [325]
0
0
Bacau
Query!
Country [326]
0
0
Romania
Query!
State/province [326]
0
0
Bucharest
Query!
Country [327]
0
0
Romania
Query!
State/province [327]
0
0
Bucuresti
Query!
Country [328]
0
0
Romania
Query!
State/province [328]
0
0
Cluj Napoca
Query!
Country [329]
0
0
Romania
Query!
State/province [329]
0
0
Constanta
Query!
Country [330]
0
0
Romania
Query!
State/province [330]
0
0
Galati
Query!
Country [331]
0
0
Romania
Query!
State/province [331]
0
0
Iasi
Query!
Country [332]
0
0
Romania
Query!
State/province [332]
0
0
Ploiesti
Query!
Country [333]
0
0
Romania
Query!
State/province [333]
0
0
Sibiu
Query!
Country [334]
0
0
Romania
Query!
State/province [334]
0
0
Timisoara
Query!
Country [335]
0
0
Romania
Query!
State/province [335]
0
0
Tirgu Mures
Query!
Country [336]
0
0
Romania
Query!
State/province [336]
0
0
Târgu Mures
Query!
Country [337]
0
0
Romania
Query!
State/province [337]
0
0
Zalau
Query!
Country [338]
0
0
Russian Federation
Query!
State/province [338]
0
0
Arkhangelsk
Query!
Country [339]
0
0
Russian Federation
Query!
State/province [339]
0
0
Chelyabinsk
Query!
Country [340]
0
0
Russian Federation
Query!
State/province [340]
0
0
Ivanovo
Query!
Country [341]
0
0
Russian Federation
Query!
State/province [341]
0
0
Izhevsk
Query!
Country [342]
0
0
Russian Federation
Query!
State/province [342]
0
0
Kazan
Query!
Country [343]
0
0
Russian Federation
Query!
State/province [343]
0
0
Moscow
Query!
Country [344]
0
0
Russian Federation
Query!
State/province [344]
0
0
Nizhnii Novgorod
Query!
Country [345]
0
0
Russian Federation
Query!
State/province [345]
0
0
Novosibirsk
Query!
Country [346]
0
0
Russian Federation
Query!
State/province [346]
0
0
Perm
Query!
Country [347]
0
0
Russian Federation
Query!
State/province [347]
0
0
Rostov-on-Don
Query!
Country [348]
0
0
Russian Federation
Query!
State/province [348]
0
0
Saint Petersburg
Query!
Country [349]
0
0
Russian Federation
Query!
State/province [349]
0
0
Saint- Petersburg
Query!
Country [350]
0
0
Russian Federation
Query!
State/province [350]
0
0
Saint-Petersburg
Query!
Country [351]
0
0
Russian Federation
Query!
State/province [351]
0
0
Saratov
Query!
Country [352]
0
0
Russian Federation
Query!
State/province [352]
0
0
Tver
Query!
Country [353]
0
0
Russian Federation
Query!
State/province [353]
0
0
Ufa
Query!
Country [354]
0
0
Russian Federation
Query!
State/province [354]
0
0
Vladikavkaz
Query!
Country [355]
0
0
Russian Federation
Query!
State/province [355]
0
0
Volgograd
Query!
Country [356]
0
0
Russian Federation
Query!
State/province [356]
0
0
Yekaterinburg
Query!
Country [357]
0
0
Slovakia
Query!
State/province [357]
0
0
Banská Bystrica
Query!
Country [358]
0
0
Slovakia
Query!
State/province [358]
0
0
Bratislava
Query!
Country [359]
0
0
Slovakia
Query!
State/province [359]
0
0
Dolný Kubín
Query!
Country [360]
0
0
Slovakia
Query!
State/province [360]
0
0
Kosice
Query!
Country [361]
0
0
Slovakia
Query!
State/province [361]
0
0
Košice
Query!
Country [362]
0
0
Slovakia
Query!
State/province [362]
0
0
Levice
Query!
Country [363]
0
0
Slovakia
Query!
State/province [363]
0
0
Lucenec
Query!
Country [364]
0
0
Slovakia
Query!
State/province [364]
0
0
Nove Zamky
Query!
Country [365]
0
0
Slovakia
Query!
State/province [365]
0
0
Námestovo
Query!
Country [366]
0
0
Slovakia
Query!
State/province [366]
0
0
Pieštany
Query!
Country [367]
0
0
Slovakia
Query!
State/province [367]
0
0
Poprad
Query!
Country [368]
0
0
Slovakia
Query!
State/province [368]
0
0
Povazska Bystrica
Query!
Country [369]
0
0
Slovakia
Query!
State/province [369]
0
0
Prievidza
Query!
Country [370]
0
0
Slovakia
Query!
State/province [370]
0
0
Rimavská Sobota
Query!
Country [371]
0
0
Slovakia
Query!
State/province [371]
0
0
Sabinov
Query!
Country [372]
0
0
Slovakia
Query!
State/province [372]
0
0
Sala
Query!
Country [373]
0
0
Slovakia
Query!
State/province [373]
0
0
Trebišov
Query!
Country [374]
0
0
Slovakia
Query!
State/province [374]
0
0
Trencín
Query!
Country [375]
0
0
Slovakia
Query!
State/province [375]
0
0
Vrutky
Query!
Country [376]
0
0
Slovakia
Query!
State/province [376]
0
0
Žilina
Query!
Country [377]
0
0
South Africa
Query!
State/province [377]
0
0
Alberton
Query!
Country [378]
0
0
South Africa
Query!
State/province [378]
0
0
Benoni
Query!
Country [379]
0
0
South Africa
Query!
State/province [379]
0
0
Cape Town
Query!
Country [380]
0
0
South Africa
Query!
State/province [380]
0
0
Diepkloof, Soweto
Query!
Country [381]
0
0
South Africa
Query!
State/province [381]
0
0
Durban
Query!
Country [382]
0
0
South Africa
Query!
State/province [382]
0
0
Goodwood
Query!
Country [383]
0
0
South Africa
Query!
State/province [383]
0
0
Houghton
Query!
Country [384]
0
0
South Africa
Query!
State/province [384]
0
0
Muckleneuk
Query!
Country [385]
0
0
South Africa
Query!
State/province [385]
0
0
Parktown West
Query!
Country [386]
0
0
South Africa
Query!
State/province [386]
0
0
Parktown
Query!
Country [387]
0
0
South Africa
Query!
State/province [387]
0
0
Phoenix
Query!
Country [388]
0
0
South Africa
Query!
State/province [388]
0
0
Somerset West
Query!
Country [389]
0
0
South Africa
Query!
State/province [389]
0
0
Verulam
Query!
Country [390]
0
0
South Africa
Query!
State/province [390]
0
0
Worcester
Query!
Country [391]
0
0
Spain
Query!
State/province [391]
0
0
Almeria
Query!
Country [392]
0
0
Spain
Query!
State/province [392]
0
0
Barcelona
Query!
Country [393]
0
0
Spain
Query!
State/province [393]
0
0
L'Hospitalet de Llobregat
Query!
Country [394]
0
0
Spain
Query!
State/province [394]
0
0
Madrid
Query!
Country [395]
0
0
Spain
Query!
State/province [395]
0
0
Oviedo
Query!
Country [396]
0
0
Spain
Query!
State/province [396]
0
0
Sant Joan Despi
Query!
Country [397]
0
0
Spain
Query!
State/province [397]
0
0
Santiago de Compostela
Query!
Country [398]
0
0
Spain
Query!
State/province [398]
0
0
Sevilla
Query!
Country [399]
0
0
Sweden
Query!
State/province [399]
0
0
Borås
Query!
Country [400]
0
0
Sweden
Query!
State/province [400]
0
0
Eksjö
Query!
Country [401]
0
0
Sweden
Query!
State/province [401]
0
0
Finspång
Query!
Country [402]
0
0
Sweden
Query!
State/province [402]
0
0
Gothenburg
Query!
Country [403]
0
0
Sweden
Query!
State/province [403]
0
0
Järfälla
Query!
Country [404]
0
0
Sweden
Query!
State/province [404]
0
0
Linköping
Query!
Country [405]
0
0
Sweden
Query!
State/province [405]
0
0
Lund
Query!
Country [406]
0
0
Sweden
Query!
State/province [406]
0
0
Malmo
Query!
Country [407]
0
0
Sweden
Query!
State/province [407]
0
0
Ostersund
Query!
Country [408]
0
0
Sweden
Query!
State/province [408]
0
0
Rättvik
Query!
Country [409]
0
0
Sweden
Query!
State/province [409]
0
0
Stockholm
Query!
Country [410]
0
0
Sweden
Query!
State/province [410]
0
0
Umeå
Query!
Country [411]
0
0
Sweden
Query!
State/province [411]
0
0
Vällingby
Query!
Country [412]
0
0
Taiwan
Query!
State/province [412]
0
0
Changhua
Query!
Country [413]
0
0
Taiwan
Query!
State/province [413]
0
0
Kaohsiung City
Query!
Country [414]
0
0
Taiwan
Query!
State/province [414]
0
0
Kaohsiung
Query!
Country [415]
0
0
Taiwan
Query!
State/province [415]
0
0
Taichung City
Query!
Country [416]
0
0
Taiwan
Query!
State/province [416]
0
0
Taichung
Query!
Country [417]
0
0
Taiwan
Query!
State/province [417]
0
0
Taipei
Query!
Country [418]
0
0
Thailand
Query!
State/province [418]
0
0
Bangkok
Query!
Country [419]
0
0
Thailand
Query!
State/province [419]
0
0
Chiang Mai
Query!
Country [420]
0
0
Thailand
Query!
State/province [420]
0
0
Muang
Query!
Country [421]
0
0
Thailand
Query!
State/province [421]
0
0
Nakhon Ratchasima
Query!
Country [422]
0
0
Thailand
Query!
State/province [422]
0
0
Pathumthani
Query!
Country [423]
0
0
Thailand
Query!
State/province [423]
0
0
Phisanulok
Query!
Country [424]
0
0
Thailand
Query!
State/province [424]
0
0
Rajthevi
Query!
Country [425]
0
0
Thailand
Query!
State/province [425]
0
0
Ratchaburi
Query!
Country [426]
0
0
Thailand
Query!
State/province [426]
0
0
Ratchathewi
Query!
Country [427]
0
0
Turkey
Query!
State/province [427]
0
0
Antalya
Query!
Country [428]
0
0
Turkey
Query!
State/province [428]
0
0
Istanbul
Query!
Country [429]
0
0
Turkey
Query!
State/province [429]
0
0
Izmir
Query!
Country [430]
0
0
Ukraine
Query!
State/province [430]
0
0
Dnepropetrovsk
Query!
Country [431]
0
0
Ukraine
Query!
State/province [431]
0
0
Dnipropetrovsk
Query!
Country [432]
0
0
Ukraine
Query!
State/province [432]
0
0
Donetsk
Query!
Country [433]
0
0
Ukraine
Query!
State/province [433]
0
0
Kharkiv
Query!
Country [434]
0
0
Ukraine
Query!
State/province [434]
0
0
Kharkov
Query!
Country [435]
0
0
Ukraine
Query!
State/province [435]
0
0
Kiev
Query!
Country [436]
0
0
Ukraine
Query!
State/province [436]
0
0
Kyiv
Query!
Country [437]
0
0
Ukraine
Query!
State/province [437]
0
0
Vinnytsia
Query!
Country [438]
0
0
Ukraine
Query!
State/province [438]
0
0
Vynnitsa
Query!
Country [439]
0
0
Ukraine
Query!
State/province [439]
0
0
Zaporizhzhya
Query!
Country [440]
0
0
Ukraine
Query!
State/province [440]
0
0
Zaporozhye
Query!
Country [441]
0
0
United Kingdom
Query!
State/province [441]
0
0
Addlestone
Query!
Country [442]
0
0
United Kingdom
Query!
State/province [442]
0
0
Aylesbury
Query!
Country [443]
0
0
United Kingdom
Query!
State/province [443]
0
0
Bath
Query!
Country [444]
0
0
United Kingdom
Query!
State/province [444]
0
0
Belfast
Query!
Country [445]
0
0
United Kingdom
Query!
State/province [445]
0
0
Blackpool
Query!
Country [446]
0
0
United Kingdom
Query!
State/province [446]
0
0
Canterbury
Query!
Country [447]
0
0
United Kingdom
Query!
State/province [447]
0
0
Corsham
Query!
Country [448]
0
0
United Kingdom
Query!
State/province [448]
0
0
Coventry
Query!
Country [449]
0
0
United Kingdom
Query!
State/province [449]
0
0
Glasgow
Query!
Country [450]
0
0
United Kingdom
Query!
State/province [450]
0
0
Irvine
Query!
Country [451]
0
0
United Kingdom
Query!
State/province [451]
0
0
Leicester
Query!
Country [452]
0
0
United Kingdom
Query!
State/province [452]
0
0
Mortimer Reading
Query!
Country [453]
0
0
United Kingdom
Query!
State/province [453]
0
0
Sheffield
Query!
Country [454]
0
0
United Kingdom
Query!
State/province [454]
0
0
Whitstable
Query!
Country [455]
0
0
Vietnam
Query!
State/province [455]
0
0
Hanoi
Query!
Country [456]
0
0
Vietnam
Query!
State/province [456]
0
0
Ho Chi Minh City
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
AstraZeneca
Query!
Address
Query!
Country
Query!
Other collaborator category [1]
0
0
Commercial sector/industry
Query!
Name [1]
0
0
Bristol-Myers Squibb
Query!
Address [1]
0
0
Query!
Country [1]
0
0
Query!
Other collaborator category [2]
0
0
Other
Query!
Name [2]
0
0
The TIMI Study Group
Query!
Address [2]
0
0
Query!
Country [2]
0
0
Query!
Other collaborator category [3]
0
0
Other
Query!
Name [3]
0
0
Hadassah Medical Organization
Query!
Address [3]
0
0
Query!
Country [3]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
This study is being carried out to determine the effect of dapagliflozin on cardiovacular outcomes when added to current background therapy in patients with type 2 diabetes with either established cardiovacular disease or cardiovascular risk factors.
Query!
Trial website
https://clinicaltrials.gov/study/NCT01730534
Query!
Trial related presentations / publications
Mosenzon O, Raz I, Wiviott SD, Schechter M, Goodrich EL, Yanuv I, Rozenberg A, Murphy SA, Zelniker TA, Langkilde AM, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Wilding JPH, McGuire DK, Bhatt DL, Leiter LA, Cahn A, Dwyer JP, Heerspink HJL, Sabatine MS. Dapagliflozin and Prevention of Kidney Disease Among Patients With Type 2 Diabetes: Post Hoc Analyses From the DECLARE-TIMI 58 Trial. Diabetes Care. 2022 Oct 1;45(10):2350-2359. doi: 10.2337/dc22-0382. Oyama K, Raz I, Cahn A, Goodrich EL, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Mosenzon O, Sabatine MS, Wiviott SD. Efficacy and Safety of Dapagliflozin According to Background Use of Cardiovascular Medications in Patients With Type 2 Diabetes: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2022 Sep 1;7(9):914-923. doi: 10.1001/jamacardio.2022.2006. Furtado RHM, Raz I, Goodrich EL, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Aylward P, Dalby AJ, Dellborg M, Dimulescu D, Nicolau JC, Oude Ophuis AJM, Cahn A, Mosenzon O, Gause-Nilsson I, Langkilde AM, Sabatine MS, Wiviott SD. Efficacy and Safety of Dapagliflozin in Type 2 Diabetes According to Baseline Blood Pressure: Observations From DECLARE-TIMI 58 Trial. Circulation. 2022 May 24;145(21):1581-1591. doi: 10.1161/CIRCULATIONAHA.121.058103. Epub 2022 May 5. Cahn A, Wiviott SD, Mosenzon O, Goodrich EL, Murphy SA, Yanuv I, Rozenberg A, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Langkilde AM, Sabatine MS, Raz I. Association of Baseline HbA1c With Cardiovascular and Renal Outcomes: Analyses From DECLARE-TIMI 58. Diabetes Care. 2022 Apr 1;45(4):938-946. doi: 10.2337/dc21-1744. Oyama K, Raz I, Cahn A, Kuder J, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Park KS, Goudev A, Diaz R, Spinar J, Gause-Nilsson IAM, Mosenzon O, Sabatine MS, Wiviott SD. Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE-TIMI 58 trial. Eur Heart J. 2022 Aug 14;43(31):2958-2967. doi: 10.1093/eurheartj/ehab530. Mosenzon O, Wiviott SD, Heerspink HJL, Dwyer JP, Cahn A, Goodrich EL, Rozenberg A, Schechter M, Yanuv I, Murphy SA, Zelniker TA, Gause-Nilsson IAM, Langkilde AM, Fredriksson M, Johansson PA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Sabatine MS, Raz I. The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58. Diabetes Care. 2021 Aug;44(8):1805-1815. doi: 10.2337/dc21-0076. Epub 2021 Jul 7. Cherney DZI, Dagogo-Jack S, McGuire DK, Cosentino F, Pratley R, Shih WJ, Frederich R, Maldonado M, Liu J, Wang S, Cannon CP; VERTIS CV Investigators. Kidney outcomes using a sustained >/=40% decline in eGFR: A meta-analysis of SGLT2 inhibitor trials. Clin Cardiol. 2021 Aug;44(8):1139-1143. doi: 10.1002/clc.23665. Epub 2021 Jun 15. Zelniker TA, Raz I, Mosenzon O, Dwyer JP, Heerspink HHJL, Cahn A, Goodrich EL, Im K, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson I, Langkilde AM, Sabatine MS, Wiviott SD. Effect of Dapagliflozin on Cardiovascular Outcomes According to Baseline Kidney Function and Albuminuria Status in Patients With Type 2 Diabetes: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2021 Jul 1;6(7):801-810. doi: 10.1001/jamacardio.2021.0660. Cahn A, Raz I, Leiter LA, Mosenzon O, Murphy SA, Goodrich EL, Yanuv I, Rozenberg A, Bhatt DL, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Langkilde AM, Sabatine MS, Wiviott SD. Cardiovascular, Renal, and Metabolic Outcomes of Dapagliflozin Versus Placebo in a Primary Cardiovascular Prevention Cohort: Analyses From DECLARE-TIMI 58. Diabetes Care. 2021 May;44(5):1159-1167. doi: 10.2337/dc20-2492. Epub 2021 Mar 2. O'Donoghue ML, Kato ET, Mosenzon O, Murphy SA, Cahn A, Herrera M, Tankova T, Smahelova A, Merlini P, Gause-Nilsson I, Langkilde AM, McGuire DK, Wilding JPH, Leiter LA, Bhatt DL, Raz I, Sabatine MS, Wiviott SD. The efficacy and safety of dapagliflozin in women and men with type 2 diabetes mellitus. Diabetologia. 2021 Jun;64(6):1226-1234. doi: 10.1007/s00125-021-05399-2. Epub 2021 Feb 20. Bonaca MP, Wiviott SD, Zelniker TA, Mosenzon O, Bhatt DL, Leiter LA, McGuire DK, Goodrich EL, De Mendonca Furtado RH, Wilding JPH, Cahn A, Gause-Nilsson IAM, Johanson P, Fredriksson M, Johansson PA, Langkilde AM, Raz I, Sabatine MS. Dapagliflozin and Cardiac, Kidney, and Limb Outcomes in Patients With and Without Peripheral Artery Disease in DECLARE-TIMI 58. Circulation. 2020 Aug 25;142(8):734-747. doi: 10.1161/CIRCULATIONAHA.119.044775. Epub 2020 Aug 3. Zelniker TA, Bonaca MP, Furtado RHM, Mosenzon O, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Budaj A, Kiss RG, Padilla F, Gause-Nilsson I, Langkilde AM, Raz I, Sabatine MS, Wiviott SD. Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial. Circulation. 2020 Apr 14;141(15):1227-1234. doi: 10.1161/CIRCULATIONAHA.119.044183. Epub 2020 Jan 27. Cahn A, Mosenzon O, Wiviott SD, Rozenberg A, Yanuv I, Goodrich EL, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS, Raz I. Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. Diabetes Care. 2020 Feb;43(2):468-475. doi: 10.2337/dc19-1476. Epub 2019 Dec 16. Berg DD, Wiviott SD, Scirica BM, Gurmu Y, Mosenzon O, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Johanson P, Johansson PA, Langkilde AM, Raz I, Braunwald E, Sabatine MS. Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes Mellitus. Circulation. 2019 Nov 5;140(19):1569-1577. doi: 10.1161/CIRCULATIONAHA.119.042685. Epub 2019 Aug 31. Mosenzon O, Wiviott SD, Cahn A, Rozenberg A, Yanuv I, Goodrich EL, Murphy SA, Heerspink HJL, Zelniker TA, Dwyer JP, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Kato ET, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS, Raz I. Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial. Lancet Diabetes Endocrinol. 2019 Aug;7(8):606-617. doi: 10.1016/S2213-8587(19)30180-9. Epub 2019 Jun 10. Erratum In: Lancet Diabetes Endocrinol. 2019 Aug;7(8):e20. doi: 10.1016/S2213-8587(19)30221-9. Furtado RHM, Bonaca MP, Raz I, Zelniker TA, Mosenzon O, Cahn A, Kuder J, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Nicolau JC, Gause-Nilsson IAM, Fredriksson M, Langkilde AM, Sabatine MS, Wiviott SD. Dapagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Previous Myocardial Infarction. Circulation. 2019 May 28;139(22):2516-2527. doi: 10.1161/CIRCULATIONAHA.119.039996. Epub 2019 Mar 18. Kato ET, Silverman MG, Mosenzon O, Zelniker TA, Cahn A, Furtado RHM, Kuder J, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Bonaca MP, Ruff CT, Desai AS, Goto S, Johansson PA, Gause-Nilsson I, Johanson P, Langkilde AM, Raz I, Sabatine MS, Wiviott SD. Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus. Circulation. 2019 May 28;139(22):2528-2536. doi: 10.1161/CIRCULATIONAHA.119.040130. Epub 2019 Mar 18. Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS; DECLARE-TIMI 58 Investigators. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019 Jan 24;380(4):347-357. doi: 10.1056/NEJMoa1812389. Epub 2018 Nov 10. Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Bansilal S, Bhatt DL, Leiter LA, McGuire DK, Wilding JP, Gause-Nilsson IA, Langkilde AM, Johansson PA, Sabatine MS. The design and rationale for the Dapagliflozin Effect on Cardiovascular Events (DECLARE)-TIMI 58 Trial. Am Heart J. 2018 Jun;200:83-89. doi: 10.1016/j.ahj.2018.01.012. Epub 2018 Feb 7. Wittbrodt ET, Eudicone JM, Bell KF, Enhoffer DM, Latham K, Green JB. Eligibility varies among the 4 sodium-glucose cotransporter-2 inhibitor cardiovascular outcomes trials: implications for the general type 2 diabetes US population. Am J Manag Care. 2018 Apr;24(8 Suppl):S138-S145. Bloch MJ. Blood pressure effects of SGLT2 inhibitors make them an attractive option in diabetic patients with hypertension. J Am Soc Hypertens. 2016 Mar;10(3):186-7. doi: 10.1016/j.jash.2016.01.001. No abstract available. Leiter LA, Cefalu WT, de Bruin TW, Xu J, Parikh S, Johnsson E, Gause-Nilsson I. Long-term maintenance of efficacy of dapagliflozin in patients with type 2 diabetes mellitus and cardiovascular disease. Diabetes Obes Metab. 2016 Aug;18(8):766-74. doi: 10.1111/dom.12666. Epub 2016 May 12.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Anna Maria Langkilde, MD
Query!
Address
0
0
AstraZeneca Sweden
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
Type
Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/34/NCT01730534/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/34/NCT01730534/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT01730534
Download to PDF