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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT02111564
Registration number
NCT02111564
Ethics application status
Date submitted
31/03/2014
Date registered
11/04/2014
Date last updated
25/11/2019
Titles & IDs
Public title
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
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Scientific title
Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk
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Secondary ID [1]
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0
2014-000305-13
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Secondary ID [2]
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0
CR103834
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Universal Trial Number (UTN)
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Trial acronym
MARINER
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Heart Failure
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Respiratory Insufficiency
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0
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Stroke Acute
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0
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Infectious Diseases
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0
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Rheumatic Diseases
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0
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Condition category
Condition code
Infection
0
0
0
0
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Studies of infection and infectious agents
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Infection
0
0
0
0
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Other infectious diseases
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Infection
0
0
0
0
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Sexually transmitted infections
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Inflammatory and Immune System
0
0
0
0
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Rheumatoid arthritis
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Musculoskeletal
0
0
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0
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Other muscular and skeletal disorders
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Respiratory
0
0
0
0
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Other respiratory disorders / diseases
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Cardiovascular
0
0
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0
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Coronary heart disease
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Cardiovascular
0
0
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0
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Other cardiovascular diseases
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Skin
0
0
0
0
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Other skin conditions
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban, 10 mg
Treatment: Drugs - Rivaroxaban, 7.5 mg
Treatment: Drugs - Placebo
Experimental: Rivaroxaban - Each patient will receive either 10 mg or 7.5 mg rivaroxaban tablet once daily orally (by mouth) for 45 days. The dosing will depend on a creatinine clearance at screening.
Placebo comparator: Placebo - Each patient will receive matching placebo tablet once daily orally (by mouth) for 45 days.
Treatment: Drugs: Rivaroxaban, 10 mg
Patients, randomly allocated to the rivaroxaban arm, with a creatinine clearance at screening greater than or equal to (\>=)50 mL/min will receive 10 mg rivaroxaban tablet with or without food.
Treatment: Drugs: Rivaroxaban, 7.5 mg
Patients, randomly allocated to the rivaroxaban arm, with a creatinine clearance at screening from \>=30 to less than (\<)50 mL/min will receive 7.5 mg rivaroxaban tablet with or without food.
Treatment: Drugs: Placebo
All patients, randomly allocated to the placebo arm, will receive one placebo tablet with or without food.
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Time From Randomization to First Occurrence of Composite of All Symptomatic Venous Thromboembolism (VTE) and VTE Related Death Adjudicated by Clinical Event Committee (CEC)
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Assessment method [1]
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Symptomatic VTE included lower extremity deep vein thrombosis (DVT) and non-fatal pulmonary embolism (PE). Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [1]
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Up to Day 45
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Primary outcome [2]
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Event Rate Based on Time From Randomization to the First Occurrence of Major Bleeding Adjudicated by CEC
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Assessment method [2]
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A major bleeding event was defined using validated International Society on Thrombosis and Haemostasis (ISTH) bleeding criteria. A major bleeding event was defined as overt bleeding that was associated with a fall in hemoglobin of 2 gram per deciliter (g/dL) or more, or a transfusion of 2 or more units of packed red blood cells or whole blood, or a critical site defined as intracranial, intraspinal, intraocular, pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal, or a fatal outcome. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or last dose + 2 days.
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Timepoint [2]
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From randomization to 2 days after the last dose (Day 45)
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Secondary outcome [1]
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Event Rate Based on Time From Randomization to First Occurrence of VTE-Related Death Adjudicated by CEC
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Assessment method [1]
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Event rate based on time from randomization to first occurrence of VTE-related death (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [1]
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0
Up to Day 45
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Secondary outcome [2]
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Event Rate Based on Time From Randomization to the First Occurrence of a Symptomatic Venous Thromboembolism Event (VTE) Adjudicated by CEC
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Assessment method [2]
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Event rate based on time from randomization to the first occurrence of a symptomatic VTE (adjudicated by CEC) was assessed. Symptomatic VTE included lower extremity DVT and non-fatal PE. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [2]
0
0
Up to Day 45
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Secondary outcome [3]
0
0
Event Rate Based on Time From Randomization to the First Occurrence of a Composite of Symptomatic VTE and All-Cause Mortality (ACM) Adjudicated by CEC
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Assessment method [3]
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Event rate based on time from randomization to the first occurrence of a composite of symptomatic VTE and ACM (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [3]
0
0
Up to Day 45
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Secondary outcome [4]
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Event Rate Based on Time From Randomization to the First Occurrence of a Composite of Symptomatic VTE, Myocardial Infarction (MI), Non-Hemorrhagic Stroke, and Cardiovascular (CV) Death Adjudicated by CEC
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Assessment method [4]
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Event rate based on time from randomization to the first occurrence of a composite of symptomatic VTE (lower extremity DVT and non-fatal PE), MI, non-hemorrhagic stroke, and CV death (death due to a known CV cause and death in which a CV cause cannot be ruled out; by this definition, a VTE-related death was considered a CV death) as adjudicated by CEC was reported. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [4]
0
0
Up to Day 45
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Secondary outcome [5]
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Event Rate Based on Time From Randomization to First Occurrence of All-Cause Mortality (ACM) Adjudicated by CEC
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Assessment method [5]
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Event rate based on time from randomization to first occurrence of ACM (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
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Timepoint [5]
0
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Up to Day 45
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Eligibility
Key inclusion criteria
Key
* The duration of the index hospitalization must have been at least 3 and no more than 10 consecutive days
* Must meet venous thromboembolism (VTE) risk criteria with a total modified Improve VTE Risk Score of: greater than or equal 4, or 3 with D-dimer > 2* upper limit of normal (ULN), or 2 with D-dimer > 2*ULN
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Minimum age
40
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Any serious bleeding within 3 months prior to randomization or occurring during index hospitalization
* Serious trauma (including head trauma) within 4 weeks before randomization
* History of hemorrhagic stroke at any time in the past
* Any medical condition that requires chronic use of any parenteral or oral anticoagulation
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Study design
Purpose of the study
Prevention
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
7/01/2014
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
3/05/2018
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Sample size
Target
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Accrual to date
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Final
12024
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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- Bedford Park
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Recruitment hospital [2]
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- Box Hill
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Recruitment hospital [3]
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- Caboolture
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Recruitment hospital [4]
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- Cairns
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Recruitment hospital [5]
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- Chermside
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Recruitment hospital [6]
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- East Saint Kilda
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Recruitment hospital [7]
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- Kogarah
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Recruitment hospital [8]
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- Launceston
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Recruitment hospital [9]
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- Lismore
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Recruitment hospital [10]
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- Meadowbrook
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Recruitment hospital [11]
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- Milton
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Recruitment hospital [12]
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- Nedlands
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Recruitment hospital [13]
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- Parkwood
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Recruitment hospital [14]
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- Penrith
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Recruitment hospital [15]
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- Redcliffe
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Recruitment hospital [16]
0
0
- South Brisbane
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Recruitment hospital [17]
0
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- Sydney
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Recruitment hospital [18]
0
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- VIC, Parkville
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Recruitment postcode(s) [1]
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- Bedford Park
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Recruitment postcode(s) [2]
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0
- Box Hill
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Recruitment postcode(s) [3]
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0
- Caboolture
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Recruitment postcode(s) [4]
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- Cairns
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Recruitment postcode(s) [5]
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- Chermside
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Recruitment postcode(s) [6]
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- East Saint Kilda
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Recruitment postcode(s) [7]
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- Kogarah
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Recruitment postcode(s) [8]
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- Launceston
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Recruitment postcode(s) [9]
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- Lismore
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Recruitment postcode(s) [10]
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- Meadowbrook
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Recruitment postcode(s) [11]
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0
- Milton
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Recruitment postcode(s) [12]
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- Nedlands
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Recruitment postcode(s) [13]
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0
- Parkwood
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Recruitment postcode(s) [14]
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0
- Penrith
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Recruitment postcode(s) [15]
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- Redcliffe
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Recruitment postcode(s) [16]
0
0
- South Brisbane
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Recruitment postcode(s) [17]
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- Sydney
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Recruitment postcode(s) [18]
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- VIC, Parkville
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Recruitment outside Australia
Country [1]
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United States of America
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State/province [1]
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Alabama
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United States of America
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Arizona
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United States of America
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State/province [3]
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Arkansas
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United States of America
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California
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United States of America
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Colorado
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United States of America
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State/province [6]
0
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Connecticut
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Country [7]
0
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United States of America
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State/province [7]
0
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District of Columbia
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0
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United States of America
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State/province [8]
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Florida
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United States of America
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State/province [9]
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Georgia
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United States of America
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State/province [10]
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Idaho
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United States of America
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Illinois
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United States of America
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Indiana
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Iowa
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Kansas
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Louisiana
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Maine
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Maryland
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Massachusetts
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Michigan
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Minnesota
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Missouri
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North Carolina
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Ohio
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Oklahoma
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Pennsylvania
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Rhode Island
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South Carolina
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Tennessee
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Texas
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Virginia
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Washington
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West Virginia
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Wisconsin
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Argentina
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Bahia Blanca
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Argentina
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Buenos Aires
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Argentina
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Ciudad de Buenos Aires
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Argentina
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Cordoba
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Argentina
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Coronel Suarez
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Argentina
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Corrientes
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Argentina
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Córdoba
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Argentina
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Esperanza
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Argentina
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La Plata
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Argentina
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Merlo
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Argentina
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Moron
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Argentina
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Munro
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Argentina
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Rosario
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Argentina
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Santa Fe
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Argentina
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Santa Fé
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Argentina
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Tucuman
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Austria
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Feldkirch
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Austria
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Graz
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Austria
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Linz
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Austria
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Salzburg
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Austria
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Wien
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Belarus
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Gomel
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Belarus
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Grodno
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Belarus
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Minsk
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Belarus
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Mogilev
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Belarus
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Vitebsk
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Belarus
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Vychulki, Brest Region, Brest
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Bosnia and Herzegovina
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Banja Luka
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Bosnia and Herzegovina
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Bihac
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Bosnia and Herzegovina
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Foca
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Bosnia and Herzegovina
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Mostar
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Bosnia and Herzegovina
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Sarajevo
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Bosnia and Herzegovina
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Tuzla
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Bosnia and Herzegovina
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Zenica
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Brazil
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Belo Horizonte
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Brazil
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Blumenau
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Brazil
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Brasília
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Brazil
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Campina Grande do Sul
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Brazil
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Campinas
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0
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Brazil
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Canoas
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Brazil
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Curitiba
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Brazil
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Itajaí
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Brazil
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Natal
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Brazil
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Passo Fundo
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Brazil
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Porto Alegre
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Brazil
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Recife
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Brazil
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Ribeirão Preto
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Brazil
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Salvador
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Brazil
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San Paulo
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Brazil
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Santo André
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Brazil
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Sao Paulo
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Brazil
Query!
State/province [91]
0
0
São José Do Rio Preto
Query!
Country [92]
0
0
Brazil
Query!
State/province [92]
0
0
São Paulo
Query!
Country [93]
0
0
Brazil
Query!
State/province [93]
0
0
Votuporanga
Query!
Country [94]
0
0
Bulgaria
Query!
State/province [94]
0
0
Blagoevgrad
Query!
Country [95]
0
0
Bulgaria
Query!
State/province [95]
0
0
Burgas
Query!
Country [96]
0
0
Bulgaria
Query!
State/province [96]
0
0
Dimitrovgrad
Query!
Country [97]
0
0
Bulgaria
Query!
State/province [97]
0
0
Gabrovo
Query!
Country [98]
0
0
Bulgaria
Query!
State/province [98]
0
0
Kozlodui
Query!
Country [99]
0
0
Bulgaria
Query!
State/province [99]
0
0
Lom
Query!
Country [100]
0
0
Bulgaria
Query!
State/province [100]
0
0
Lovech
Query!
Country [101]
0
0
Bulgaria
Query!
State/province [101]
0
0
Montana
Query!
Country [102]
0
0
Bulgaria
Query!
State/province [102]
0
0
Pernik
Query!
Country [103]
0
0
Bulgaria
Query!
State/province [103]
0
0
Pleven
Query!
Country [104]
0
0
Bulgaria
Query!
State/province [104]
0
0
Plovdiv
Query!
Country [105]
0
0
Bulgaria
Query!
State/province [105]
0
0
Razlog
Query!
Country [106]
0
0
Bulgaria
Query!
State/province [106]
0
0
Ruse
Query!
Country [107]
0
0
Bulgaria
Query!
State/province [107]
0
0
Sandanski
Query!
Country [108]
0
0
Bulgaria
Query!
State/province [108]
0
0
Sliven
Query!
Country [109]
0
0
Bulgaria
Query!
State/province [109]
0
0
Sofia
Query!
Country [110]
0
0
Bulgaria
Query!
State/province [110]
0
0
Veliko Tarnovo
Query!
Country [111]
0
0
Bulgaria
Query!
State/province [111]
0
0
Vidin
Query!
Country [112]
0
0
Canada
Query!
State/province [112]
0
0
Alberta
Query!
Country [113]
0
0
Canada
Query!
State/province [113]
0
0
New Brunswick
Query!
Country [114]
0
0
Canada
Query!
State/province [114]
0
0
Ontario
Query!
Country [115]
0
0
Canada
Query!
State/province [115]
0
0
Quebec
Query!
Country [116]
0
0
Colombia
Query!
State/province [116]
0
0
Armenia
Query!
Country [117]
0
0
Colombia
Query!
State/province [117]
0
0
Barranquilla
Query!
Country [118]
0
0
Colombia
Query!
State/province [118]
0
0
Bogota
Query!
Country [119]
0
0
Colombia
Query!
State/province [119]
0
0
Bogotá
Query!
Country [120]
0
0
Colombia
Query!
State/province [120]
0
0
Cali
Query!
Country [121]
0
0
Colombia
Query!
State/province [121]
0
0
Chia
Query!
Country [122]
0
0
Colombia
Query!
State/province [122]
0
0
Floridablanca
Query!
Country [123]
0
0
Colombia
Query!
State/province [123]
0
0
Medellin
Query!
Country [124]
0
0
Colombia
Query!
State/province [124]
0
0
Medellín
Query!
Country [125]
0
0
Colombia
Query!
State/province [125]
0
0
Villavicencio
Query!
Country [126]
0
0
Croatia
Query!
State/province [126]
0
0
Cakovec
Query!
Country [127]
0
0
Croatia
Query!
State/province [127]
0
0
Karlovac
Query!
Country [128]
0
0
Croatia
Query!
State/province [128]
0
0
Krapinske Toplice
Query!
Country [129]
0
0
Croatia
Query!
State/province [129]
0
0
Osijek
Query!
Country [130]
0
0
Croatia
Query!
State/province [130]
0
0
Pula
Query!
Country [131]
0
0
Croatia
Query!
State/province [131]
0
0
Rijeka
Query!
Country [132]
0
0
Croatia
Query!
State/province [132]
0
0
Sibenik
Query!
Country [133]
0
0
Croatia
Query!
State/province [133]
0
0
Virovitica
Query!
Country [134]
0
0
Croatia
Query!
State/province [134]
0
0
Zabok
Query!
Country [135]
0
0
Croatia
Query!
State/province [135]
0
0
Zadar
Query!
Country [136]
0
0
Croatia
Query!
State/province [136]
0
0
Zagreb
Query!
Country [137]
0
0
Czechia
Query!
State/province [137]
0
0
Boskovice
Query!
Country [138]
0
0
Czechia
Query!
State/province [138]
0
0
Brno
Query!
Country [139]
0
0
Czechia
Query!
State/province [139]
0
0
Cesky Krumlov
Query!
Country [140]
0
0
Czechia
Query!
State/province [140]
0
0
Jablonec Na Nisou
Query!
Country [141]
0
0
Czechia
Query!
State/province [141]
0
0
Karvina
Query!
Country [142]
0
0
Czechia
Query!
State/province [142]
0
0
Kladno
Query!
Country [143]
0
0
Czechia
Query!
State/province [143]
0
0
Krnov
Query!
Country [144]
0
0
Czechia
Query!
State/province [144]
0
0
Kyjov
Query!
Country [145]
0
0
Czechia
Query!
State/province [145]
0
0
Liberec
Query!
Country [146]
0
0
Czechia
Query!
State/province [146]
0
0
Litomysl
Query!
Country [147]
0
0
Czechia
Query!
State/province [147]
0
0
Mestec Kralove
Query!
Country [148]
0
0
Czechia
Query!
State/province [148]
0
0
Nove Mesto na Morave
Query!
Country [149]
0
0
Czechia
Query!
State/province [149]
0
0
Nymburk N/a
Query!
Country [150]
0
0
Czechia
Query!
State/province [150]
0
0
Olomouc
Query!
Country [151]
0
0
Czechia
Query!
State/province [151]
0
0
Opava
Query!
Country [152]
0
0
Czechia
Query!
State/province [152]
0
0
Ostrava
Query!
Country [153]
0
0
Czechia
Query!
State/province [153]
0
0
Pardubice
Query!
Country [154]
0
0
Czechia
Query!
State/province [154]
0
0
Praha 10
Query!
Country [155]
0
0
Czechia
Query!
State/province [155]
0
0
Praha 2
Query!
Country [156]
0
0
Czechia
Query!
State/province [156]
0
0
Praha 4
Query!
Country [157]
0
0
Czechia
Query!
State/province [157]
0
0
Praha 5
Query!
Country [158]
0
0
Czechia
Query!
State/province [158]
0
0
Praha 8
Query!
Country [159]
0
0
Czechia
Query!
State/province [159]
0
0
Pribram
Query!
Country [160]
0
0
Czechia
Query!
State/province [160]
0
0
Písek
Query!
Country [161]
0
0
Czechia
Query!
State/province [161]
0
0
Slany
Query!
Country [162]
0
0
Czechia
Query!
State/province [162]
0
0
Sternberk
Query!
Country [163]
0
0
Czechia
Query!
State/province [163]
0
0
Svitavy
Query!
Country [164]
0
0
Czechia
Query!
State/province [164]
0
0
Teplice
Query!
Country [165]
0
0
Czechia
Query!
State/province [165]
0
0
Trinec
Query!
Country [166]
0
0
Czechia
Query!
State/province [166]
0
0
Trutnov
Query!
Country [167]
0
0
Czechia
Query!
State/province [167]
0
0
Uherske Hradiste
Query!
Country [168]
0
0
Czechia
Query!
State/province [168]
0
0
Usti Nad Labem
Query!
Country [169]
0
0
Czechia
Query!
State/province [169]
0
0
Usti nad Orlici
Query!
Country [170]
0
0
Czechia
Query!
State/province [170]
0
0
Zlin
Query!
Country [171]
0
0
Denmark
Query!
State/province [171]
0
0
Aalborg
Query!
Country [172]
0
0
Denmark
Query!
State/province [172]
0
0
Copenhagen
Query!
Country [173]
0
0
Denmark
Query!
State/province [173]
0
0
Esbjerg
Query!
Country [174]
0
0
Denmark
Query!
State/province [174]
0
0
Frederiksberg
Query!
Country [175]
0
0
Denmark
Query!
State/province [175]
0
0
Hellerup
Query!
Country [176]
0
0
Denmark
Query!
State/province [176]
0
0
Hilleroed
Query!
Country [177]
0
0
Denmark
Query!
State/province [177]
0
0
Hvidovre
Query!
Country [178]
0
0
Denmark
Query!
State/province [178]
0
0
København S
Query!
Country [179]
0
0
Denmark
Query!
State/province [179]
0
0
Roskilde
Query!
Country [180]
0
0
Estonia
Query!
State/province [180]
0
0
Tallinn
Query!
Country [181]
0
0
Georgia
Query!
State/province [181]
0
0
Batumi
Query!
Country [182]
0
0
Georgia
Query!
State/province [182]
0
0
Kutaisi
Query!
Country [183]
0
0
Georgia
Query!
State/province [183]
0
0
Marneuli
Query!
Country [184]
0
0
Georgia
Query!
State/province [184]
0
0
Rustavi
Query!
Country [185]
0
0
Georgia
Query!
State/province [185]
0
0
T'bilisi
Query!
Country [186]
0
0
Georgia
Query!
State/province [186]
0
0
Tbilisi
Query!
Country [187]
0
0
Georgia
Query!
State/province [187]
0
0
Telavi
Query!
Country [188]
0
0
Germany
Query!
State/province [188]
0
0
Berlin
Query!
Country [189]
0
0
Germany
Query!
State/province [189]
0
0
Coburg
Query!
Country [190]
0
0
Germany
Query!
State/province [190]
0
0
Dresden
Query!
Country [191]
0
0
Germany
Query!
State/province [191]
0
0
Esslingen
Query!
Country [192]
0
0
Germany
Query!
State/province [192]
0
0
Frankfurt
Query!
Country [193]
0
0
Germany
Query!
State/province [193]
0
0
Heidelberg
Query!
Country [194]
0
0
Germany
Query!
State/province [194]
0
0
Jülich
Query!
Country [195]
0
0
Germany
Query!
State/province [195]
0
0
Karlsbad
Query!
Country [196]
0
0
Germany
Query!
State/province [196]
0
0
Leipzig
Query!
Country [197]
0
0
Germany
Query!
State/province [197]
0
0
Limburg
Query!
Country [198]
0
0
Germany
Query!
State/province [198]
0
0
Mannheim
Query!
Country [199]
0
0
Germany
Query!
State/province [199]
0
0
Minden
Query!
Country [200]
0
0
Germany
Query!
State/province [200]
0
0
Mönchengladbach
Query!
Country [201]
0
0
Germany
Query!
State/province [201]
0
0
Neuwied
Query!
Country [202]
0
0
Germany
Query!
State/province [202]
0
0
Troisdorf
Query!
Country [203]
0
0
Germany
Query!
State/province [203]
0
0
Witten
Query!
Country [204]
0
0
Greece
Query!
State/province [204]
0
0
Achaïa
Query!
Country [205]
0
0
Greece
Query!
State/province [205]
0
0
Alexandroupolis
Query!
Country [206]
0
0
Greece
Query!
State/province [206]
0
0
Athens
Query!
Country [207]
0
0
Greece
Query!
State/province [207]
0
0
Heraklion
Query!
Country [208]
0
0
Greece
Query!
State/province [208]
0
0
Ioannina
Query!
Country [209]
0
0
Greece
Query!
State/province [209]
0
0
Kifisia, Athens
Query!
Country [210]
0
0
Greece
Query!
State/province [210]
0
0
Magoula
Query!
Country [211]
0
0
Greece
Query!
State/province [211]
0
0
Patra
Query!
Country [212]
0
0
Greece
Query!
State/province [212]
0
0
Thessalonikis
Query!
Country [213]
0
0
Greece
Query!
State/province [213]
0
0
Thessaloniki
Query!
Country [214]
0
0
Greece
Query!
State/province [214]
0
0
Voula
Query!
Country [215]
0
0
Hungary
Query!
State/province [215]
0
0
Ajka
Query!
Country [216]
0
0
Hungary
Query!
State/province [216]
0
0
Baja
Query!
Country [217]
0
0
Hungary
Query!
State/province [217]
0
0
Balassagyarmat
Query!
Country [218]
0
0
Hungary
Query!
State/province [218]
0
0
Berettyóújfalú
Query!
Country [219]
0
0
Hungary
Query!
State/province [219]
0
0
Budapest
Query!
Country [220]
0
0
Hungary
Query!
State/province [220]
0
0
Cegléd
Query!
Country [221]
0
0
Hungary
Query!
State/province [221]
0
0
Debrecen
Query!
Country [222]
0
0
Hungary
Query!
State/province [222]
0
0
Eger
Query!
Country [223]
0
0
Hungary
Query!
State/province [223]
0
0
Farkasgyepü
Query!
Country [224]
0
0
Hungary
Query!
State/province [224]
0
0
Gyula
Query!
Country [225]
0
0
Hungary
Query!
State/province [225]
0
0
Gyõr
Query!
Country [226]
0
0
Hungary
Query!
State/province [226]
0
0
Gödöllo
Query!
Country [227]
0
0
Hungary
Query!
State/province [227]
0
0
Hodmezovasarhely
Query!
Country [228]
0
0
Hungary
Query!
State/province [228]
0
0
Kalocsa
Query!
Country [229]
0
0
Hungary
Query!
State/province [229]
0
0
Kaposvar
Query!
Country [230]
0
0
Hungary
Query!
State/province [230]
0
0
Kecskemet N/a
Query!
Country [231]
0
0
Hungary
Query!
State/province [231]
0
0
Kecskemet
Query!
Country [232]
0
0
Hungary
Query!
State/province [232]
0
0
Keszthely
Query!
Country [233]
0
0
Hungary
Query!
State/province [233]
0
0
Kistarcsa
Query!
Country [234]
0
0
Hungary
Query!
State/province [234]
0
0
Komarom
Query!
Country [235]
0
0
Hungary
Query!
State/province [235]
0
0
Miskolc
Query!
Country [236]
0
0
Hungary
Query!
State/province [236]
0
0
Nagykanizsa
Query!
Country [237]
0
0
Hungary
Query!
State/province [237]
0
0
Orosháza
Query!
Country [238]
0
0
Hungary
Query!
State/province [238]
0
0
Pecs
Query!
Country [239]
0
0
Hungary
Query!
State/province [239]
0
0
Pécs
Query!
Country [240]
0
0
Hungary
Query!
State/province [240]
0
0
Szeged
Query!
Country [241]
0
0
Hungary
Query!
State/province [241]
0
0
Szekesfehervar
Query!
Country [242]
0
0
Hungary
Query!
State/province [242]
0
0
Szekszárd
Query!
Country [243]
0
0
Hungary
Query!
State/province [243]
0
0
Szentes
Query!
Country [244]
0
0
Hungary
Query!
State/province [244]
0
0
Szolnok
Query!
Country [245]
0
0
Hungary
Query!
State/province [245]
0
0
Szombathely
Query!
Country [246]
0
0
Hungary
Query!
State/province [246]
0
0
Székesfehérvár
Query!
Country [247]
0
0
Hungary
Query!
State/province [247]
0
0
Sátoraljaújhely
Query!
Country [248]
0
0
Hungary
Query!
State/province [248]
0
0
Zalaegerszeg
Query!
Country [249]
0
0
Israel
Query!
State/province [249]
0
0
Beersheba
Query!
Country [250]
0
0
Israel
Query!
State/province [250]
0
0
Hadera
Query!
Country [251]
0
0
Israel
Query!
State/province [251]
0
0
Haifa
Query!
Country [252]
0
0
Israel
Query!
State/province [252]
0
0
Holon
Query!
Country [253]
0
0
Israel
Query!
State/province [253]
0
0
Jerusalem
Query!
Country [254]
0
0
Israel
Query!
State/province [254]
0
0
Kfar-Saba
Query!
Country [255]
0
0
Israel
Query!
State/province [255]
0
0
Modi'in
Query!
Country [256]
0
0
Israel
Query!
State/province [256]
0
0
Nahariya
Query!
Country [257]
0
0
Israel
Query!
State/province [257]
0
0
Petah Tikva
Query!
Country [258]
0
0
Israel
Query!
State/province [258]
0
0
Petah Tiqwa
Query!
Country [259]
0
0
Israel
Query!
State/province [259]
0
0
Rehovot
Query!
Country [260]
0
0
Israel
Query!
State/province [260]
0
0
Safed
Query!
Country [261]
0
0
Israel
Query!
State/province [261]
0
0
Tel-Hashomer
Query!
Country [262]
0
0
Israel
Query!
State/province [262]
0
0
Tiberias
Query!
Country [263]
0
0
Israel
Query!
State/province [263]
0
0
Zefat
Query!
Country [264]
0
0
Latvia
Query!
State/province [264]
0
0
Balvi
Query!
Country [265]
0
0
Latvia
Query!
State/province [265]
0
0
Daugavpils
Query!
Country [266]
0
0
Latvia
Query!
State/province [266]
0
0
Jekabpils
Query!
Country [267]
0
0
Latvia
Query!
State/province [267]
0
0
Jelgava
Query!
Country [268]
0
0
Latvia
Query!
State/province [268]
0
0
Kraslavas Aprinkis
Query!
Country [269]
0
0
Latvia
Query!
State/province [269]
0
0
Kuldiga
Query!
Country [270]
0
0
Latvia
Query!
State/province [270]
0
0
Liepaja
Query!
Country [271]
0
0
Latvia
Query!
State/province [271]
0
0
Riga
Query!
Country [272]
0
0
Latvia
Query!
State/province [272]
0
0
Ventspils
Query!
Country [273]
0
0
Lithuania
Query!
State/province [273]
0
0
Kaunas
Query!
Country [274]
0
0
Lithuania
Query!
State/province [274]
0
0
Klaipeda
Query!
Country [275]
0
0
Lithuania
Query!
State/province [275]
0
0
Panevezys
Query!
Country [276]
0
0
Lithuania
Query!
State/province [276]
0
0
Siauliai
Query!
Country [277]
0
0
Lithuania
Query!
State/province [277]
0
0
Taurage
Query!
Country [278]
0
0
Lithuania
Query!
State/province [278]
0
0
Utena
Query!
Country [279]
0
0
Lithuania
Query!
State/province [279]
0
0
Vilniaus Apskritis
Query!
Country [280]
0
0
Lithuania
Query!
State/province [280]
0
0
Vilnius
Query!
Country [281]
0
0
Mexico
Query!
State/province [281]
0
0
Aguascalientes
Query!
Country [282]
0
0
Mexico
Query!
State/province [282]
0
0
Cuernavaca
Query!
Country [283]
0
0
Mexico
Query!
State/province [283]
0
0
Guadalajara
Query!
Country [284]
0
0
Mexico
Query!
State/province [284]
0
0
Merida
Query!
Country [285]
0
0
Mexico
Query!
State/province [285]
0
0
Monterrey
Query!
Country [286]
0
0
Mexico
Query!
State/province [286]
0
0
San Pedro Garza Garcia
Query!
Country [287]
0
0
Netherlands
Query!
State/province [287]
0
0
Alkmaar
Query!
Country [288]
0
0
Netherlands
Query!
State/province [288]
0
0
Almelo
Query!
Country [289]
0
0
Netherlands
Query!
State/province [289]
0
0
Amsterdam
Query!
Country [290]
0
0
Netherlands
Query!
State/province [290]
0
0
Arnhem
Query!
Country [291]
0
0
Netherlands
Query!
State/province [291]
0
0
Den Haag
Query!
Country [292]
0
0
Netherlands
Query!
State/province [292]
0
0
Harderwijk
Query!
Country [293]
0
0
Netherlands
Query!
State/province [293]
0
0
Heerlen
Query!
Country [294]
0
0
Netherlands
Query!
State/province [294]
0
0
Hoorn
Query!
Country [295]
0
0
Netherlands
Query!
State/province [295]
0
0
Maastricht
Query!
Country [296]
0
0
Netherlands
Query!
State/province [296]
0
0
Nieuwegein
Query!
Country [297]
0
0
Netherlands
Query!
State/province [297]
0
0
s-Hertogenbosch
Query!
Country [298]
0
0
Netherlands
Query!
State/province [298]
0
0
Sittard-Geleen
Query!
Country [299]
0
0
Netherlands
Query!
State/province [299]
0
0
Sneek
Query!
Country [300]
0
0
Netherlands
Query!
State/province [300]
0
0
Tilburg
Query!
Country [301]
0
0
Netherlands
Query!
State/province [301]
0
0
Veldhoven
Query!
Country [302]
0
0
Netherlands
Query!
State/province [302]
0
0
Zutphen
Query!
Country [303]
0
0
Netherlands
Query!
State/province [303]
0
0
Zwolle
Query!
Country [304]
0
0
North Macedonia
Query!
State/province [304]
0
0
Bitola
Query!
Country [305]
0
0
North Macedonia
Query!
State/province [305]
0
0
Ohrid
Query!
Country [306]
0
0
North Macedonia
Query!
State/province [306]
0
0
Skopje
Query!
Country [307]
0
0
North Macedonia
Query!
State/province [307]
0
0
Struga
Query!
Country [308]
0
0
North Macedonia
Query!
State/province [308]
0
0
Štip
Query!
Country [309]
0
0
Peru
Query!
State/province [309]
0
0
Callao
Query!
Country [310]
0
0
Peru
Query!
State/province [310]
0
0
Lima
Query!
Country [311]
0
0
Poland
Query!
State/province [311]
0
0
Bialystok
Query!
Country [312]
0
0
Poland
Query!
State/province [312]
0
0
Bielsko-Biala
Query!
Country [313]
0
0
Poland
Query!
State/province [313]
0
0
Bydgoszcz
Query!
Country [314]
0
0
Poland
Query!
State/province [314]
0
0
Bystra
Query!
Country [315]
0
0
Poland
Query!
State/province [315]
0
0
Czeladz
Query!
Country [316]
0
0
Poland
Query!
State/province [316]
0
0
Gdynia
Query!
Country [317]
0
0
Poland
Query!
State/province [317]
0
0
Kielce
Query!
Country [318]
0
0
Poland
Query!
State/province [318]
0
0
Klodzko
Query!
Country [319]
0
0
Poland
Query!
State/province [319]
0
0
Krakow
Query!
Country [320]
0
0
Poland
Query!
State/province [320]
0
0
Kraków
Query!
Country [321]
0
0
Poland
Query!
State/province [321]
0
0
Leczna
Query!
Country [322]
0
0
Poland
Query!
State/province [322]
0
0
Lodz
Query!
Country [323]
0
0
Poland
Query!
State/province [323]
0
0
Lublin
Query!
Country [324]
0
0
Poland
Query!
State/province [324]
0
0
Olawa
Query!
Country [325]
0
0
Poland
Query!
State/province [325]
0
0
Ostroleka
Query!
Country [326]
0
0
Poland
Query!
State/province [326]
0
0
Ostrow Mazowiecka
Query!
Country [327]
0
0
Poland
Query!
State/province [327]
0
0
Pabianice
Query!
Country [328]
0
0
Poland
Query!
State/province [328]
0
0
Plock
Query!
Country [329]
0
0
Poland
Query!
State/province [329]
0
0
Poznan
Query!
Country [330]
0
0
Poland
Query!
State/province [330]
0
0
Proszowice
Query!
Country [331]
0
0
Poland
Query!
State/province [331]
0
0
Pulawy
Query!
Country [332]
0
0
Poland
Query!
State/province [332]
0
0
Rabka-Zdroj
Query!
Country [333]
0
0
Poland
Query!
State/province [333]
0
0
Siedlce
Query!
Country [334]
0
0
Poland
Query!
State/province [334]
0
0
Sopot,Gdynia
Query!
Country [335]
0
0
Poland
Query!
State/province [335]
0
0
Sosnowiec
Query!
Country [336]
0
0
Poland
Query!
State/province [336]
0
0
Szczecin
Query!
Country [337]
0
0
Poland
Query!
State/province [337]
0
0
Tarn W N/a
Query!
Country [338]
0
0
Poland
Query!
State/province [338]
0
0
Torun
Query!
Country [339]
0
0
Poland
Query!
State/province [339]
0
0
Warszawa N/a
Query!
Country [340]
0
0
Poland
Query!
State/province [340]
0
0
Warszawa
Query!
Country [341]
0
0
Poland
Query!
State/province [341]
0
0
Wegrow
Query!
Country [342]
0
0
Poland
Query!
State/province [342]
0
0
Wroclaw
Query!
Country [343]
0
0
Portugal
Query!
State/province [343]
0
0
Braga
Query!
Country [344]
0
0
Portugal
Query!
State/province [344]
0
0
Coimbra
Query!
Country [345]
0
0
Portugal
Query!
State/province [345]
0
0
Covilhã
Query!
Country [346]
0
0
Portugal
Query!
State/province [346]
0
0
Figueira da Foz
Query!
Country [347]
0
0
Portugal
Query!
State/province [347]
0
0
Guimarães
Query!
Country [348]
0
0
Portugal
Query!
State/province [348]
0
0
Lisboa
Query!
Country [349]
0
0
Portugal
Query!
State/province [349]
0
0
Porto
Query!
Country [350]
0
0
Portugal
Query!
State/province [350]
0
0
Vila Nova de Gaia
Query!
Country [351]
0
0
Puerto Rico
Query!
State/province [351]
0
0
San Juan
Query!
Country [352]
0
0
Romania
Query!
State/province [352]
0
0
Bacau
Query!
Country [353]
0
0
Romania
Query!
State/province [353]
0
0
Baia Mare
Query!
Country [354]
0
0
Romania
Query!
State/province [354]
0
0
Braila
Query!
Country [355]
0
0
Romania
Query!
State/province [355]
0
0
Brasov
Query!
Country [356]
0
0
Romania
Query!
State/province [356]
0
0
Bucuresti
Query!
Country [357]
0
0
Romania
Query!
State/province [357]
0
0
Cluj-Napoca
Query!
Country [358]
0
0
Romania
Query!
State/province [358]
0
0
Craiova
Query!
Country [359]
0
0
Romania
Query!
State/province [359]
0
0
Focsani
Query!
Country [360]
0
0
Romania
Query!
State/province [360]
0
0
Iasi
Query!
Country [361]
0
0
Romania
Query!
State/province [361]
0
0
Oradea
Query!
Country [362]
0
0
Romania
Query!
State/province [362]
0
0
Pitesti
Query!
Country [363]
0
0
Romania
Query!
State/province [363]
0
0
Tg Mures
Query!
Country [364]
0
0
Romania
Query!
State/province [364]
0
0
Timisoara
Query!
Country [365]
0
0
Russian Federation
Query!
State/province [365]
0
0
Arkhangelsk
Query!
Country [366]
0
0
Russian Federation
Query!
State/province [366]
0
0
Chelyabinsk
Query!
Country [367]
0
0
Russian Federation
Query!
State/province [367]
0
0
Ekaterinburg
Query!
Country [368]
0
0
Russian Federation
Query!
State/province [368]
0
0
Irkutsk
Query!
Country [369]
0
0
Russian Federation
Query!
State/province [369]
0
0
Kazan
Query!
Country [370]
0
0
Russian Federation
Query!
State/province [370]
0
0
Kemerovo
Query!
Country [371]
0
0
Russian Federation
Query!
State/province [371]
0
0
Krasnodar
Query!
Country [372]
0
0
Russian Federation
Query!
State/province [372]
0
0
Krasnoyarsk
Query!
Country [373]
0
0
Russian Federation
Query!
State/province [373]
0
0
Moscow
Query!
Country [374]
0
0
Russian Federation
Query!
State/province [374]
0
0
Moskva
Query!
Country [375]
0
0
Russian Federation
Query!
State/province [375]
0
0
Novosibirsk
Query!
Country [376]
0
0
Russian Federation
Query!
State/province [376]
0
0
Orenburg
Query!
Country [377]
0
0
Russian Federation
Query!
State/province [377]
0
0
Penza
Query!
Country [378]
0
0
Russian Federation
Query!
State/province [378]
0
0
Rostov on Don
Query!
Country [379]
0
0
Russian Federation
Query!
State/province [379]
0
0
Saint Petersburg
Query!
Country [380]
0
0
Russian Federation
Query!
State/province [380]
0
0
Saint-Petersburg
Query!
Country [381]
0
0
Russian Federation
Query!
State/province [381]
0
0
Saratov
Query!
Country [382]
0
0
Russian Federation
Query!
State/province [382]
0
0
Smolensk
Query!
Country [383]
0
0
Russian Federation
Query!
State/province [383]
0
0
St. Petersburg
Query!
Country [384]
0
0
Russian Federation
Query!
State/province [384]
0
0
Tomsk
Query!
Country [385]
0
0
Russian Federation
Query!
State/province [385]
0
0
Ulyanovsk
Query!
Country [386]
0
0
Russian Federation
Query!
State/province [386]
0
0
Vsevolzhsk
Query!
Country [387]
0
0
Russian Federation
Query!
State/province [387]
0
0
Yaroslavl
Query!
Country [388]
0
0
Serbia
Query!
State/province [388]
0
0
Belgrade
Query!
Country [389]
0
0
Serbia
Query!
State/province [389]
0
0
Beograd
Query!
Country [390]
0
0
Serbia
Query!
State/province [390]
0
0
Cacak
Query!
Country [391]
0
0
Serbia
Query!
State/province [391]
0
0
Cuprija
Query!
Country [392]
0
0
Serbia
Query!
State/province [392]
0
0
Dedinje
Query!
Country [393]
0
0
Serbia
Query!
State/province [393]
0
0
Kragujevac
Query!
Country [394]
0
0
Serbia
Query!
State/province [394]
0
0
Leskovac
Query!
Country [395]
0
0
Serbia
Query!
State/province [395]
0
0
Nis
Query!
Country [396]
0
0
Serbia
Query!
State/province [396]
0
0
Novi Sad
Query!
Country [397]
0
0
Serbia
Query!
State/province [397]
0
0
Sabac
Query!
Country [398]
0
0
Serbia
Query!
State/province [398]
0
0
Smederevo
Query!
Country [399]
0
0
Serbia
Query!
State/province [399]
0
0
Sremska Kamenica
Query!
Country [400]
0
0
Serbia
Query!
State/province [400]
0
0
Subotica
Query!
Country [401]
0
0
Serbia
Query!
State/province [401]
0
0
Valjevo
Query!
Country [402]
0
0
Serbia
Query!
State/province [402]
0
0
Vranje
Query!
Country [403]
0
0
Serbia
Query!
State/province [403]
0
0
Zajecar
Query!
Country [404]
0
0
Slovakia
Query!
State/province [404]
0
0
Kosice
Query!
Country [405]
0
0
Slovakia
Query!
State/province [405]
0
0
Martin
Query!
Country [406]
0
0
Slovakia
Query!
State/province [406]
0
0
Nitra
Query!
Country [407]
0
0
South Africa
Query!
State/province [407]
0
0
Bellville
Query!
Country [408]
0
0
South Africa
Query!
State/province [408]
0
0
Bloemfontein
Query!
Country [409]
0
0
South Africa
Query!
State/province [409]
0
0
Cape Town
Query!
Country [410]
0
0
South Africa
Query!
State/province [410]
0
0
Durban Kwa Zulu Natal
Query!
Country [411]
0
0
South Africa
Query!
State/province [411]
0
0
Durban
Query!
Country [412]
0
0
South Africa
Query!
State/province [412]
0
0
Gatesville Cape Town
Query!
Country [413]
0
0
South Africa
Query!
State/province [413]
0
0
Groenkloof, Pretoria
Query!
Country [414]
0
0
South Africa
Query!
State/province [414]
0
0
Johannesburg
Query!
Country [415]
0
0
South Africa
Query!
State/province [415]
0
0
Kempton Park
Query!
Country [416]
0
0
South Africa
Query!
State/province [416]
0
0
Kuils River
Query!
Country [417]
0
0
South Africa
Query!
State/province [417]
0
0
Pretoria
Query!
Country [418]
0
0
South Africa
Query!
State/province [418]
0
0
Somerset West
Query!
Country [419]
0
0
South Africa
Query!
State/province [419]
0
0
Stellenbosch
Query!
Country [420]
0
0
South Africa
Query!
State/province [420]
0
0
Worcester
Query!
Country [421]
0
0
Spain
Query!
State/province [421]
0
0
Alcalá de Henares
Query!
Country [422]
0
0
Spain
Query!
State/province [422]
0
0
Alicante
Query!
Country [423]
0
0
Spain
Query!
State/province [423]
0
0
Almeria
Query!
Country [424]
0
0
Spain
Query!
State/province [424]
0
0
Alzira
Query!
Country [425]
0
0
Spain
Query!
State/province [425]
0
0
Aranjuez
Query!
Country [426]
0
0
Spain
Query!
State/province [426]
0
0
Avila
Query!
Country [427]
0
0
Spain
Query!
State/province [427]
0
0
Balea
Query!
Country [428]
0
0
Spain
Query!
State/province [428]
0
0
Barcelona
Query!
Country [429]
0
0
Spain
Query!
State/province [429]
0
0
Burgos
Query!
Country [430]
0
0
Spain
Query!
State/province [430]
0
0
Cartagena
Query!
Country [431]
0
0
Spain
Query!
State/province [431]
0
0
Cáceres
Query!
Country [432]
0
0
Spain
Query!
State/province [432]
0
0
Don Benito
Query!
Country [433]
0
0
Spain
Query!
State/province [433]
0
0
Elche
Query!
Country [434]
0
0
Spain
Query!
State/province [434]
0
0
Getafe
Query!
Country [435]
0
0
Spain
Query!
State/province [435]
0
0
Granada
Query!
Country [436]
0
0
Spain
Query!
State/province [436]
0
0
Huelva N/a
Query!
Country [437]
0
0
Spain
Query!
State/province [437]
0
0
La Laguna
Query!
Country [438]
0
0
Spain
Query!
State/province [438]
0
0
Las Palmas de Gran Canaria
Query!
Country [439]
0
0
Spain
Query!
State/province [439]
0
0
Logroño
Query!
Country [440]
0
0
Spain
Query!
State/province [440]
0
0
Madrid
Query!
Country [441]
0
0
Spain
Query!
State/province [441]
0
0
Majadahonda-Madrid
Query!
Country [442]
0
0
Spain
Query!
State/province [442]
0
0
Malaga
Query!
Country [443]
0
0
Spain
Query!
State/province [443]
0
0
Murcia
Query!
Country [444]
0
0
Spain
Query!
State/province [444]
0
0
Móstoles
Query!
Country [445]
0
0
Spain
Query!
State/province [445]
0
0
Olot
Query!
Country [446]
0
0
Spain
Query!
State/province [446]
0
0
Oviedo
Query!
Country [447]
0
0
Spain
Query!
State/province [447]
0
0
Palma de Mallorca
Query!
Country [448]
0
0
Spain
Query!
State/province [448]
0
0
Pamplona
Query!
Country [449]
0
0
Spain
Query!
State/province [449]
0
0
Sabadell
Query!
Country [450]
0
0
Spain
Query!
State/province [450]
0
0
San Sebastian de los Reyes
Query!
Country [451]
0
0
Spain
Query!
State/province [451]
0
0
Sanchinarro
Query!
Country [452]
0
0
Spain
Query!
State/province [452]
0
0
Sant Boi de Llobregat
Query!
Country [453]
0
0
Spain
Query!
State/province [453]
0
0
Sant Joan d'Alacant
Query!
Country [454]
0
0
Spain
Query!
State/province [454]
0
0
Santander N/a
Query!
Country [455]
0
0
Spain
Query!
State/province [455]
0
0
Sarrià
Query!
Country [456]
0
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Spain
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Sevilla
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Spain
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Valencia
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Spain
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Turkey
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Istanbul
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Turkey
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Rize
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Janssen Research & Development, LLC
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Summary
Brief summary
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban compared with placebo in the prevention of symptomatic venous thromboembolism (VTE) events and VTE-related death post-hospital discharge in high-risk, medically ill patients.
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Trial website
https://clinicaltrials.gov/study/NCT02111564
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Trial related presentations / publications
Raskob GE, Spyropoulos AC, Zrubek J, Ageno W, Albers G, Elliott CG, Halperin J, Haskell L, Hiatt WR, Maynard GA, Peters G, Spiro T, Steg PG, Suh EY, Weitz JI. The MARINER trial of rivaroxaban after hospital discharge for medical patients at high risk of VTE. Design, rationale, and clinical implications. Thromb Haemost. 2016 Jun 2;115(6):1240-8. doi: 10.1160/TH15-09-0756. Epub 2016 Feb 4. Raskob GE, Ageno W, Albers G, Elliott CG, Halperin J, Maynard G, Steg PG, Weitz JI, Albanese J, Yuan Z, Levitan B, Lu W, Suh EY, Spiro T, Lipardi C, Barnathan ES, Spyropoulos AC. Benefit-Risk Assessment of Rivaroxaban for Extended Thromboprophylaxis After Hospitalization for Medical Illness. J Am Heart Assoc. 2022 Oct 18;11(20):e026229. doi: 10.1161/JAHA.122.026229. Epub 2022 Oct 7. Spyropoulos AC, Raskob GE, Cohen AT, Ageno W, Weitz JI, Spiro TE, Lu W, Lipardi C, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard G, Steg PG, Sugarmann C, Barnathan ES. Association of Bleeding Severity With Mortality in Extended Thromboprophylaxis of Medically Ill Patients in the MAGELLAN and MARINER Trials. Circulation. 2022 May 10;145(19):1471-1479. doi: 10.1161/CIRCULATIONAHA.121.057847. Epub 2022 Apr 7. Raskob GE, Spyropoulos AC, Spiro TE, Lu W, Yuan Z, Levitan B, Suh E, Barnathan ES. Benefit-Risk of Rivaroxaban for Extended Thromboprophylaxis After Hospitalization for Medical Illness: Pooled Analysis From MAGELLAN and MARINER. J Am Heart Assoc. 2021 Nov 16;10(22):e021579. doi: 10.1161/JAHA.121.021579. Epub 2021 Nov 10. Jamil A, Jamil U, Singh K, Khan F, Chi G. Extended Thromboprophylaxis With Betrixaban or Rivaroxaban for Acutely Ill Hospitalized Medical Patients: Meta-Analysis of Prespecified Subgroups. Crit Pathw Cardiol. 2021 Mar 1;20(1):16-24. doi: 10.1097/HPC.0000000000000232. Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Lu W, Spiro TE, Barnathan ES, Raskob GE. Post-Discharge Prophylaxis With Rivaroxaban Reduces Fatal and Major Thromboembolic Events in Medically Ill Patients. J Am Coll Cardiol. 2020 Jun 30;75(25):3140-3147. doi: 10.1016/j.jacc.2020.04.071. Weitz JI, Raskob GE, Spyropoulos AC, Spiro TE, De Sanctis Y, Xu J, Lu W, Suh E, Argenti D, Yang H, Albanese J, Lipardi C, Barnathan ES. Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients with Renal Impairment: Insights from the MAGELLAN and MARINER Trials. Thromb Haemost. 2020 Mar;120(3):515-524. doi: 10.1055/s-0039-1701009. Epub 2020 Jan 23. Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE; MARINER Investigators. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. N Engl J Med. 2018 Sep 20;379(12):1118-1127. doi: 10.1056/NEJMoa1805090. Epub 2018 Aug 26.
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Public notes
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Contacts
Principal investigator
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Janssen Research & Development, LLC Clinical Trial
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Janssen Research & Development, LLC
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No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
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Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/64/NCT02111564/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/64/NCT02111564/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results not provided in
https://clinicaltrials.gov/study/NCT02111564
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