Trial Review

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/ct2/show/NCT02268786




Registration number
NCT02268786
Ethics application status
Date submitted
15/10/2014
Date registered
20/10/2014
Date last updated
13/05/2020

Titles & IDs
Public title
Single Embryo TrAnsfeR of Euploid Embryo
Scientific title
Prospective, Multi-center, Randomized Controlled Trial Comparing Pregnancy Outcomes Following Selection and Single Embryo Transfer (SET) Based on Preimplantation Genetic Screening (PGS) by Next Generation Sequencing (NGS) Versus Standard Morphological Assessment
Secondary ID [1] 0 0
RGH-001
Universal Trial Number (UTN)
Trial acronym
STAR
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Infertility 0 0
Aneuploidy 0 0
Condition category
Condition code
Human Genetics and Inherited Disorders 0 0 0 0
Other human genetics and inherited disorders

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Other interventions - Preimplantation Genetic Screening by NGS

Experimental: Group A - Intent to transfer single euploid embryo based on NGS testing (VeriSeq™ PGS) of biopsied blastocysts

No Intervention: Group B - Intent to transfer single embryo based on morphological assessment according to the Gardner scoring system (no PGS)


Other interventions: Preimplantation Genetic Screening by NGS
The VeriSeq PGS takes advantage of next-generation sequencing (NGS) technology to provide comprehensive, accurate screening of all 24 chromosomes for selection of euploid embryos.
Intervention code [1] 0 0
Other interventions
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Ongoing Pregnancy
Timepoint [1] 0 0
Gestational Age of 20 Weeks

Eligibility
Key inclusion criteria
- Patient undergoing IVF

- At least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development
Minimum age
25 Years
Maximum age
40 Years
Sex
Females
Can healthy volunteers participate?
No
Key exclusion criteria
- History of more than two prior implantation failure following IVF

- History of more than one miscarriage of viable pregnancy

- One or both partners known to be carrier(s) of a chromosomal abnormality

- Known genetic carrier couple and/or one or both partners carrier of a known autosomal
dominant disorder

- Any other non-study related preimplantation genetic testing

- Use of donor oocytes

- Use of gestational carrier (surrogate or donor egg recipient).

- Severe oligospermia (<1,000,000 sperm/ml); Surgical Sperm Retrieval for reasons other
than post-vasectomy and CAVD

- Low ovarian reserve with (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and/or
(AMH) <7 pmol/L (or <1 ng/ml)

- Gender selection cycles

- Concurrent participation in another clinical trial

Study design
Purpose of the study
Screening
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s


Intervention assignment
Parallel
Other design features
Phase
Not Applicable
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
1/09/2014
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
31/12/2016
Sample size
Target
Accrual to date
Final
661
Recruitment in Australia
Recruitment state(s)
VIC
Recruitment hospital [1] 0 0
Melbourne IVF - Melbourne
Recruitment postcode(s) [1] 0 0
3002 - Melbourne
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Arizona
Country [2] 0 0
United States of America
State/province [2] 0 0
California
Country [3] 0 0
United States of America
State/province [3] 0 0
Colorado
Country [4] 0 0
United States of America
State/province [4] 0 0
Delaware
Country [5] 0 0
United States of America
State/province [5] 0 0
Florida
Country [6] 0 0
United States of America
State/province [6] 0 0
Georgia
Country [7] 0 0
United States of America
State/province [7] 0 0
Hawaii
Country [8] 0 0
United States of America
State/province [8] 0 0
Illinois
Country [9] 0 0
United States of America
State/province [9] 0 0
Massachusetts
Country [10] 0 0
United States of America
State/province [10] 0 0
Michigan
Country [11] 0 0
United States of America
State/province [11] 0 0
New Jersey
Country [12] 0 0
United States of America
State/province [12] 0 0
Pennsylvania
Country [13] 0 0
United States of America
State/province [13] 0 0
Texas
Country [14] 0 0
United States of America
State/province [14] 0 0
Utah
Country [15] 0 0
United States of America
State/province [15] 0 0
Washington
Country [16] 0 0
Canada
State/province [16] 0 0
British Columbia
Country [17] 0 0
Canada
State/province [17] 0 0
Ontario
Country [18] 0 0
United Kingdom
State/province [18] 0 0
Greater London
Country [19] 0 0
United Kingdom
State/province [19] 0 0
Greater Manchester
Country [20] 0 0
United Kingdom
State/province [20] 0 0
Oxfordshire
Country [21] 0 0
United Kingdom
State/province [21] 0 0
London
Country [22] 0 0
United Kingdom
State/province [22] 0 0
Oxford

Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Name
Illumina, Inc.
Address
Country
Other collaborator category [1] 0 0
Commercial sector/Industry
Name [1] 0 0
Reprogenetics
Address [1] 0 0
Country [1] 0 0
Other collaborator category [2] 0 0
Other
Name [2] 0 0
Genesis Genetics
Address [2] 0 0
Country [2] 0 0

Ethics approval
Ethics application status

Summary
Brief summary
The purpose of the current study is to evaluate the effect of preimplantation genetic
screening (PGS) by next generation sequencing (NGS) compared to standard morphological
assessment of embryos on pregnancy rates through a randomized controlled trial (RCT). All
embryos will be vitrified and a single embryo transfer (SET) will be performed with either
screened or unscreened embryos depending on randomization.
Trial website
https://clinicaltrials.gov/ct2/show/NCT02268786
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries



Summary Results

For IPD and results data, please see https://clinicaltrials.gov/ct2/show/NCT02268786