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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01877915
Registration number
NCT01877915
Ethics application status
Date submitted
12/06/2013
Date registered
14/06/2013
Date last updated
10/05/2019
Titles & IDs
Public title
A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure
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Scientific title
A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Heart Failure and Significant Coronary Artery Disease Following an Episode of Decompensated Heart Failure
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Secondary ID [1]
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0
RIVAROXHFA3001
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Secondary ID [2]
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CR101940
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Universal Trial Number (UTN)
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Trial acronym
COMMANDER HF
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Heart Failure
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0
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Coronary Artery Disease
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Condition category
Condition code
Cardiovascular
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Coronary heart disease
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Cardiovascular
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0
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Other cardiovascular diseases
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban
Treatment: Drugs - Placebo
Other interventions - Standard of care for heart failure and coronary artery disease
Experimental: Rivaroxaban 2.5 mg - Each participant will receive 2.5 mg of rivaroxaban twice daily with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).
Placebo comparator: Placebo - Each participant will receive matching placebo twice daily with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).
Treatment: Drugs: Rivaroxaban
Each participant, randomly allocated to the rivaroxaban arm, will receive one 2.5 mg tablet of rivaroxaban orally (by mouth) twice daily (once in the morning and once in the evening at approximately the same time each day) until the global treatment end date (GTED) (defined as the date when 1200 primary efficacy outcome events have occurred). Rivaroxaban will be given with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).
Treatment: Drugs: Placebo
Each participant, randomly allocated to the placebo arm, will receive one matching placebo tablet orally twice daily (once in the morning and once in the evening at approximately the same time each day) until the GTED. Placebo will be given with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).
Other interventions: Standard of care for heart failure and coronary artery disease
Each participant's standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician) should be continued throughout the study.
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Intervention code [1]
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Treatment: Drugs
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Intervention code [2]
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Other interventions
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Event Rate of All-Cause Mortality, Myocardial Infarction (MI), or Stroke
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Assessment method [1]
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Event Rate of all-cause mortality (ACM), MI, or stroke were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 patient \[pt\]-year \[yr\]) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [1]
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Up to Global treatment end date (approximately 54 months)
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Primary outcome [2]
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Event Rate of Either Fatal Bleeding or Bleeding Into a Critical Space With Potential for Permanent Disability
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Assessment method [2]
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Event rate of either fatal bleeding or bleeding into critical space with potential for permanent disability were assessed. Fatal bleeding event was death within 7 days after a bleeding event which required hospitalization or met International Society on Thrombosis and Haemostasis(ISTH) major bleeding definition criteria. Fatal bleeding events included those met criteria in 3 categories: 1: Any ISTH major bleeding event consider primary cause of death by investigator; 2: Any ISTH major bleeding event not considered to be primary cause of death by investigator but resulted in death within 7 days;3: Any bleeding event resulted in hospital stay and death within 7 days. Bleeding into critical space with potential for permanent disability included 7 critical spaces: intracranial, intraspinal, intraocular. Event rate estimated based on time to first occurrence of event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [2]
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Up to 227 Weeks
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Secondary outcome [1]
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Event Rate of Cardio Vascular Death or Re-Hospitalization for Worsening of Heart Failure (RHHF)
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Assessment method [1]
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Event rate of cardio vascular (CV) death or re-hospitalization for worsening of heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [1]
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Up to Global treatment end date (approximately 54 months)
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Secondary outcome [2]
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Event Rate of Cardio Vascular Death
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Assessment method [2]
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Event rate of cardio vascular death were assessed. CV death included deaths due to spontaneous bleeding, MI, stroke, worsening HF and arrhythmias, death due to CV procedures and sudden death. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [2]
0
0
Up to Global treatment end date (approximately 54 months)
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Secondary outcome [3]
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Event Rate of Re-Hospitalization for Worsening of Heart Failure
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Assessment method [3]
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Event rate of re-hospitalization for worsening of heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [3]
0
0
Up to Global treatment end date (approximately 54 months)
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Secondary outcome [4]
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Event Rate of Re-Hospitalization for Cardio Vascular Events (RHCV)
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Assessment method [4]
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Event rate due to cardio vascular events were assessed. Hospitalization for a CV Event required that participants be hospitalized (in-patient or emergency department) for greater than 24 hours and must have met the following criterion:Discharge summary with primary reason for admission listed as CV in nature (example, bleeding, arrhythmia, ACS, MI) other than HF which was captured in the HF re-hospitalization. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [4]
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Up to Global treatment end date (approximately 54 months)
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Secondary outcome [5]
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Event Rate of All-Cause Mortality (ACM) or Re-Hospitalization for Worsening Heart Failure
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Assessment method [5]
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Event rate of all-Cause Mortality (ACM) or re-Hospitalization for worsening heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [5]
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0
Up to Global treatment end date (approximately 54 months)
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Secondary outcome [6]
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Event Rate of Bleeding Events That Requiring Hospitalization
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Assessment method [6]
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Event rate of bleeding events and required Hospitalization were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [6]
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Up to 227 Weeks
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Secondary outcome [7]
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Event Rate of International Society on Thrombosis and Haemostasis (ISTH) Major Bleeding Event
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Assessment method [7]
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Event rate of ISTH major bleeding event were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100\*n/(total risk exposure), where n is the number of events.
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Timepoint [7]
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Up to 227 Weeks
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Eligibility
Key inclusion criteria
* Must have symptomatic heart failure for at least 3 months prior to Screening
* Participants must have an episode of decompensated heart failure (index event) requiring (a) an overnight stay [that is, staying past midnight] in a hospital, emergency department, or medical facility with the capability of treating with intravenous medications and observing heart failure patients before randomization or (b) an unscheduled outpatient visit to a heart failure management center, where parenteral therapy is required for heart failure stabilization. An episode of decompensated heart failure is defined as symptoms of worsening dyspnea or fatigue, objective signs of congestion such as peripheral edema or ascites, and/or adjustment of pre-hospitalization/outpatient visit heart failure medications. Participants are eligible for randomization at discharge from the facility treating the index event and up to 30 days after discharge if they are in stable condition
* Must have a documented left ventricular ejection fraction (LVEF) of less than or equal to 40 percent (%) within 1 year before randomization
* Must have evidence of significant coronary artery disease
* Must be medically stable in terms of their heart failure clinical status at the time of randomization
* Must have a brain natriuretic peptide (BNP) level greater than or equal to (>=) 200 picogram per milliliter (pg/mL) or N-terminal-proBNP (NT-proBNP) level >=800 pg/mL (preferred assay) during the Screening period and before randomization
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Minimum age
18
Years
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Maximum age
95
Years
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Any condition that, in the opinion of the investigator, contraindicates anticoagulant therapy or would have an unacceptable risk of bleeding, such as, but not limited to, active internal bleeding, clinically significant bleeding, bleeding at a noncompressible site, or bleeding diathesis within 28 days of randomization
* Severe concomitant disease such as (a) atrial fibrillation (AFib) or another condition that requires chronic anticoagulation (participants with isolated transient AFib may be allowed at the discretion of the treating physician investigator) and (b) Documented acute myocardial infarction (MI) during index event
* Prior stroke within 90 days of randomization
* Has been hospitalized for longer than 21 days during the index event
* Planned intermittent outpatient treatment with positive inotropic drugs administered intravenously
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
10/09/2013
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
19/04/2018
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Sample size
Target
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Accrual to date
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Final
5081
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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- Bedford
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Recruitment hospital [2]
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- Cairns
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- Concord
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Recruitment hospital [4]
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- Darlinghurst
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- Hobart
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- Launceston
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- Perth
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Recruitment hospital [8]
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- Sydney
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Recruitment hospital [9]
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- Wollongong
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Recruitment hospital [10]
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- Woolloongabba
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Recruitment postcode(s) [1]
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- Bedford
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- Cairns
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- Concord
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Recruitment postcode(s) [4]
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- Darlinghurst
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- Hobart
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Recruitment postcode(s) [6]
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- Launceston
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- Perth
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Recruitment postcode(s) [8]
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- Sydney
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Recruitment postcode(s) [9]
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- Wollongong
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Recruitment postcode(s) [10]
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- Woolloongabba
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Recruitment outside Australia
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United States of America
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Alabama
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Alaska
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Colorado
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Connecticut
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Florida
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Georgia
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Illinois
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Indiana
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Caba
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Ciudad Autonoma de Buenos Aires
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Tucuman
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Vicente Lopez
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Brazil
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Blumenal
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Bulgaria
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Blagoevgrad
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Stara Zagora
Query!
Country [91]
0
0
Bulgaria
Query!
State/province [91]
0
0
Varna
Query!
Country [92]
0
0
Bulgaria
Query!
State/province [92]
0
0
Veliko Tarnovo
Query!
Country [93]
0
0
Canada
Query!
State/province [93]
0
0
Alberta
Query!
Country [94]
0
0
Canada
Query!
State/province [94]
0
0
British Columbia
Query!
Country [95]
0
0
Canada
Query!
State/province [95]
0
0
Newfoundland and Labrador
Query!
Country [96]
0
0
Canada
Query!
State/province [96]
0
0
Nova Scotia
Query!
Country [97]
0
0
Canada
Query!
State/province [97]
0
0
Ontario
Query!
Country [98]
0
0
Canada
Query!
State/province [98]
0
0
Quebec
Query!
Country [99]
0
0
China
Query!
State/province [99]
0
0
Baotou
Query!
Country [100]
0
0
China
Query!
State/province [100]
0
0
Beijing
Query!
Country [101]
0
0
China
Query!
State/province [101]
0
0
Changchun
Query!
Country [102]
0
0
China
Query!
State/province [102]
0
0
Changsha
Query!
Country [103]
0
0
China
Query!
State/province [103]
0
0
Chengdu
Query!
Country [104]
0
0
China
Query!
State/province [104]
0
0
Daqing
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Guangzhou
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Haikou
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Hangzhou
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Hunan
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Jinan
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Jining
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Lanzhou
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Nanchang
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Nanjing
Query!
Country [114]
0
0
China
Query!
State/province [114]
0
0
Nanning
Query!
Country [115]
0
0
China
Query!
State/province [115]
0
0
Qingdao
Query!
Country [116]
0
0
China
Query!
State/province [116]
0
0
Shanghai
Query!
Country [117]
0
0
China
Query!
State/province [117]
0
0
Shenyang
Query!
Country [118]
0
0
China
Query!
State/province [118]
0
0
Shijiazhuang
Query!
Country [119]
0
0
China
Query!
State/province [119]
0
0
Suzhou
Query!
Country [120]
0
0
China
Query!
State/province [120]
0
0
Taiyuan
Query!
Country [121]
0
0
China
Query!
State/province [121]
0
0
Tianjin
Query!
Country [122]
0
0
China
Query!
State/province [122]
0
0
Wuhan
Query!
Country [123]
0
0
China
Query!
State/province [123]
0
0
Xi'an
Query!
Country [124]
0
0
China
Query!
State/province [124]
0
0
Xian
Query!
Country [125]
0
0
China
Query!
State/province [125]
0
0
Yang Zhou
Query!
Country [126]
0
0
China
Query!
State/province [126]
0
0
Yichang
Query!
Country [127]
0
0
Czechia
Query!
State/province [127]
0
0
Brno
Query!
Country [128]
0
0
Czechia
Query!
State/province [128]
0
0
Hodonín
Query!
Country [129]
0
0
Czechia
Query!
State/province [129]
0
0
Hradec Králové
Query!
Country [130]
0
0
Czechia
Query!
State/province [130]
0
0
Hranice
Query!
Country [131]
0
0
Czechia
Query!
State/province [131]
0
0
Karlovy Vary
Query!
Country [132]
0
0
Czechia
Query!
State/province [132]
0
0
Kladno
Query!
Country [133]
0
0
Czechia
Query!
State/province [133]
0
0
Kolín
Query!
Country [134]
0
0
Czechia
Query!
State/province [134]
0
0
Litomyšl
Query!
Country [135]
0
0
Czechia
Query!
State/province [135]
0
0
Mladá Boleslav
Query!
Country [136]
0
0
Czechia
Query!
State/province [136]
0
0
Olomouc
Query!
Country [137]
0
0
Czechia
Query!
State/province [137]
0
0
Plze?-Bory
Query!
Country [138]
0
0
Czechia
Query!
State/province [138]
0
0
Praha 10
Query!
Country [139]
0
0
Czechia
Query!
State/province [139]
0
0
Praha 8 - Libe?
Query!
Country [140]
0
0
Czechia
Query!
State/province [140]
0
0
Praha
Query!
Country [141]
0
0
Czechia
Query!
State/province [141]
0
0
Slany
Query!
Country [142]
0
0
Czechia
Query!
State/province [142]
0
0
Teplice
Query!
Country [143]
0
0
Czechia
Query!
State/province [143]
0
0
Uherské Hradišt?
Query!
Country [144]
0
0
Czechia
Query!
State/province [144]
0
0
Valašské Mezi?í?í
Query!
Country [145]
0
0
Denmark
Query!
State/province [145]
0
0
Esbjerg
Query!
Country [146]
0
0
Denmark
Query!
State/province [146]
0
0
Herlev
Query!
Country [147]
0
0
Denmark
Query!
State/province [147]
0
0
Hjørring
Query!
Country [148]
0
0
Denmark
Query!
State/province [148]
0
0
Hvidovre
Query!
Country [149]
0
0
Denmark
Query!
State/province [149]
0
0
Køge
Query!
Country [150]
0
0
Estonia
Query!
State/province [150]
0
0
Tallinn
Query!
Country [151]
0
0
France
Query!
State/province [151]
0
0
Besancon
Query!
Country [152]
0
0
France
Query!
State/province [152]
0
0
Bron Cedex
Query!
Country [153]
0
0
France
Query!
State/province [153]
0
0
Chambray-Lès-Tours
Query!
Country [154]
0
0
France
Query!
State/province [154]
0
0
Corbeil Essonnes
Query!
Country [155]
0
0
France
Query!
State/province [155]
0
0
Lille
Query!
Country [156]
0
0
France
Query!
State/province [156]
0
0
Montpellier
Query!
Country [157]
0
0
France
Query!
State/province [157]
0
0
Nantes
Query!
Country [158]
0
0
France
Query!
State/province [158]
0
0
Nice
Query!
Country [159]
0
0
France
Query!
State/province [159]
0
0
Pau
Query!
Country [160]
0
0
France
Query!
State/province [160]
0
0
Rouen
Query!
Country [161]
0
0
France
Query!
State/province [161]
0
0
Toulouse
Query!
Country [162]
0
0
France
Query!
State/province [162]
0
0
Vandoeuvre-les-nancy
Query!
Country [163]
0
0
Germany
Query!
State/province [163]
0
0
Berlin
Query!
Country [164]
0
0
Germany
Query!
State/province [164]
0
0
Bielefeld
Query!
Country [165]
0
0
Germany
Query!
State/province [165]
0
0
Bonn
Query!
Country [166]
0
0
Germany
Query!
State/province [166]
0
0
Coburg
Query!
Country [167]
0
0
Germany
Query!
State/province [167]
0
0
Dresden
Query!
Country [168]
0
0
Germany
Query!
State/province [168]
0
0
Halle
Query!
Country [169]
0
0
Germany
Query!
State/province [169]
0
0
Hamburg
Query!
Country [170]
0
0
Germany
Query!
State/province [170]
0
0
Heidelberg
Query!
Country [171]
0
0
Germany
Query!
State/province [171]
0
0
Konstanz
Query!
Country [172]
0
0
Germany
Query!
State/province [172]
0
0
Langen
Query!
Country [173]
0
0
Germany
Query!
State/province [173]
0
0
Leipzig
Query!
Country [174]
0
0
Germany
Query!
State/province [174]
0
0
Ludwigshafen
Query!
Country [175]
0
0
Germany
Query!
State/province [175]
0
0
Magdeburg
Query!
Country [176]
0
0
Germany
Query!
State/province [176]
0
0
Mainz
Query!
Country [177]
0
0
Germany
Query!
State/province [177]
0
0
Markkleeberg
Query!
Country [178]
0
0
Germany
Query!
State/province [178]
0
0
Papenburg
Query!
Country [179]
0
0
Germany
Query!
State/province [179]
0
0
Stuttgart
Query!
Country [180]
0
0
Germany
Query!
State/province [180]
0
0
Ulm
Query!
Country [181]
0
0
Germany
Query!
State/province [181]
0
0
Witten
Query!
Country [182]
0
0
Greece
Query!
State/province [182]
0
0
Athens
Query!
Country [183]
0
0
Greece
Query!
State/province [183]
0
0
Heraklion -Crete
Query!
Country [184]
0
0
Greece
Query!
State/province [184]
0
0
Larisa
Query!
Country [185]
0
0
Greece
Query!
State/province [185]
0
0
Thessalonikis
Query!
Country [186]
0
0
Greece
Query!
State/province [186]
0
0
Voula
Query!
Country [187]
0
0
Hungary
Query!
State/province [187]
0
0
Balatonfüred
Query!
Country [188]
0
0
Hungary
Query!
State/province [188]
0
0
Berettyóújfalu
Query!
Country [189]
0
0
Hungary
Query!
State/province [189]
0
0
Budapest
Query!
Country [190]
0
0
Hungary
Query!
State/province [190]
0
0
Gyor
Query!
Country [191]
0
0
Hungary
Query!
State/province [191]
0
0
Miskolc
Query!
Country [192]
0
0
Hungary
Query!
State/province [192]
0
0
Nagykanizsa
Query!
Country [193]
0
0
Hungary
Query!
State/province [193]
0
0
Szekszárd
Query!
Country [194]
0
0
Hungary
Query!
State/province [194]
0
0
Szolnok
Query!
Country [195]
0
0
Hungary
Query!
State/province [195]
0
0
Székesfehérvár
Query!
Country [196]
0
0
Hungary
Query!
State/province [196]
0
0
Zalaegerszeg
Query!
Country [197]
0
0
Japan
Query!
State/province [197]
0
0
Aichi
Query!
Country [198]
0
0
Japan
Query!
State/province [198]
0
0
Chiba
Query!
Country [199]
0
0
Japan
Query!
State/province [199]
0
0
Chikushino-shi
Query!
Country [200]
0
0
Japan
Query!
State/province [200]
0
0
Ehime
Query!
Country [201]
0
0
Japan
Query!
State/province [201]
0
0
Fukuoka
Query!
Country [202]
0
0
Japan
Query!
State/province [202]
0
0
Gifu
Query!
Country [203]
0
0
Japan
Query!
State/province [203]
0
0
Gunma
Query!
Country [204]
0
0
Japan
Query!
State/province [204]
0
0
Hatsukaichi
Query!
Country [205]
0
0
Japan
Query!
State/province [205]
0
0
Hitachi
Query!
Country [206]
0
0
Japan
Query!
State/province [206]
0
0
Hokkaido
Query!
Country [207]
0
0
Japan
Query!
State/province [207]
0
0
Hyogo
Query!
Country [208]
0
0
Japan
Query!
State/province [208]
0
0
Ibaraki
Query!
Country [209]
0
0
Japan
Query!
State/province [209]
0
0
Ishikawa
Query!
Country [210]
0
0
Japan
Query!
State/province [210]
0
0
Izumo
Query!
Country [211]
0
0
Japan
Query!
State/province [211]
0
0
Kagawa
Query!
Country [212]
0
0
Japan
Query!
State/province [212]
0
0
Kahoku-District
Query!
Country [213]
0
0
Japan
Query!
State/province [213]
0
0
Kanagawa
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Kobe-shi
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Komatsushima-shi
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Koshigaya-shi
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Kumamoto
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Kyoto
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Miyazaki
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Nagano-shi
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Nagano
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Nagasaki
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Nagoya
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Niigata
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Oita
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Okayama
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Okinawa
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Osaka-shi
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Osaka
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Saga
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Saitama
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Sapporo
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Sendai
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Shiga
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Shimane
Query!
Country [236]
0
0
Japan
Query!
State/province [236]
0
0
Shizuoka
Query!
Country [237]
0
0
Japan
Query!
State/province [237]
0
0
Tachikawa
Query!
Country [238]
0
0
Japan
Query!
State/province [238]
0
0
Takaraduka
Query!
Country [239]
0
0
Japan
Query!
State/province [239]
0
0
Tochigi
Query!
Country [240]
0
0
Japan
Query!
State/province [240]
0
0
Tokushima
Query!
Country [241]
0
0
Japan
Query!
State/province [241]
0
0
Tokyo
Query!
Country [242]
0
0
Japan
Query!
State/province [242]
0
0
Toyama
Query!
Country [243]
0
0
Japan
Query!
State/province [243]
0
0
Toyoake
Query!
Country [244]
0
0
Japan
Query!
State/province [244]
0
0
Tsu
Query!
Country [245]
0
0
Japan
Query!
State/province [245]
0
0
Wakayama
Query!
Country [246]
0
0
Japan
Query!
State/province [246]
0
0
Yamaguchi
Query!
Country [247]
0
0
Japan
Query!
State/province [247]
0
0
Yatsushiro
Query!
Country [248]
0
0
Japan
Query!
State/province [248]
0
0
Yokohama
Query!
Country [249]
0
0
Japan
Query!
State/province [249]
0
0
Yonago
Query!
Country [250]
0
0
Korea, Republic of
Query!
State/province [250]
0
0
Busan
Query!
Country [251]
0
0
Korea, Republic of
Query!
State/province [251]
0
0
Cheongju
Query!
Country [252]
0
0
Korea, Republic of
Query!
State/province [252]
0
0
Daegu
Query!
Country [253]
0
0
Korea, Republic of
Query!
State/province [253]
0
0
Daejeon
Query!
Country [254]
0
0
Korea, Republic of
Query!
State/province [254]
0
0
Gwangju
Query!
Country [255]
0
0
Korea, Republic of
Query!
State/province [255]
0
0
Seongnam-si
Query!
Country [256]
0
0
Korea, Republic of
Query!
State/province [256]
0
0
Seoul
Query!
Country [257]
0
0
Korea, Republic of
Query!
State/province [257]
0
0
Wonju
Query!
Country [258]
0
0
Latvia
Query!
State/province [258]
0
0
Daugavpils
Query!
Country [259]
0
0
Latvia
Query!
State/province [259]
0
0
Kuldiga
Query!
Country [260]
0
0
Latvia
Query!
State/province [260]
0
0
Liepaja
Query!
Country [261]
0
0
Latvia
Query!
State/province [261]
0
0
Riga
Query!
Country [262]
0
0
Latvia
Query!
State/province [262]
0
0
Sigulda
Query!
Country [263]
0
0
Latvia
Query!
State/province [263]
0
0
Ventspils
Query!
Country [264]
0
0
Lithuania
Query!
State/province [264]
0
0
Alytus
Query!
Country [265]
0
0
Lithuania
Query!
State/province [265]
0
0
Kaunas
Query!
Country [266]
0
0
Lithuania
Query!
State/province [266]
0
0
Klaipeda
Query!
Country [267]
0
0
Lithuania
Query!
State/province [267]
0
0
Panevezys
Query!
Country [268]
0
0
Lithuania
Query!
State/province [268]
0
0
Siauliai
Query!
Country [269]
0
0
Lithuania
Query!
State/province [269]
0
0
Vilnius
Query!
Country [270]
0
0
Malaysia
Query!
State/province [270]
0
0
Cheras
Query!
Country [271]
0
0
Malaysia
Query!
State/province [271]
0
0
Johor Bahru
Query!
Country [272]
0
0
Malaysia
Query!
State/province [272]
0
0
Kota Kinabalu
Query!
Country [273]
0
0
Malaysia
Query!
State/province [273]
0
0
Kuala Lumpur
Query!
Country [274]
0
0
Malaysia
Query!
State/province [274]
0
0
Kuching
Query!
Country [275]
0
0
Malaysia
Query!
State/province [275]
0
0
Penang
Query!
Country [276]
0
0
Malaysia
Query!
State/province [276]
0
0
Selangor
Query!
Country [277]
0
0
Malaysia
Query!
State/province [277]
0
0
Selayang
Query!
Country [278]
0
0
Mexico
Query!
State/province [278]
0
0
Aguascalientes
Query!
Country [279]
0
0
Mexico
Query!
State/province [279]
0
0
Benito Juárez
Query!
Country [280]
0
0
Mexico
Query!
State/province [280]
0
0
Chihuahua
Query!
Country [281]
0
0
Mexico
Query!
State/province [281]
0
0
Culiacan
Query!
Country [282]
0
0
Mexico
Query!
State/province [282]
0
0
Durango
Query!
Country [283]
0
0
Mexico
Query!
State/province [283]
0
0
Guadalajara
Query!
Country [284]
0
0
Mexico
Query!
State/province [284]
0
0
León
Query!
Country [285]
0
0
Mexico
Query!
State/province [285]
0
0
Mexico City
Query!
Country [286]
0
0
Mexico
Query!
State/province [286]
0
0
Mexico
Query!
Country [287]
0
0
Mexico
Query!
State/province [287]
0
0
Oaxaca
Query!
Country [288]
0
0
Mexico
Query!
State/province [288]
0
0
Pachuca
Query!
Country [289]
0
0
Mexico
Query!
State/province [289]
0
0
Puebla
Query!
Country [290]
0
0
Mexico
Query!
State/province [290]
0
0
Queretaro
Query!
Country [291]
0
0
Mexico
Query!
State/province [291]
0
0
San Luis Potosí
Query!
Country [292]
0
0
Mexico
Query!
State/province [292]
0
0
Tampico
Query!
Country [293]
0
0
Mexico
Query!
State/province [293]
0
0
Veracruz
Query!
Country [294]
0
0
Netherlands
Query!
State/province [294]
0
0
Almere
Query!
Country [295]
0
0
Netherlands
Query!
State/province [295]
0
0
Amsterdam
Query!
Country [296]
0
0
Netherlands
Query!
State/province [296]
0
0
Blaricum
Query!
Country [297]
0
0
Netherlands
Query!
State/province [297]
0
0
Breda
Query!
Country [298]
0
0
Netherlands
Query!
State/province [298]
0
0
Deventer
Query!
Country [299]
0
0
Netherlands
Query!
State/province [299]
0
0
Doetinchem
Query!
Country [300]
0
0
Netherlands
Query!
State/province [300]
0
0
Ede
Query!
Country [301]
0
0
Netherlands
Query!
State/province [301]
0
0
Groningen
Query!
Country [302]
0
0
Netherlands
Query!
State/province [302]
0
0
Heerlen
Query!
Country [303]
0
0
Netherlands
Query!
State/province [303]
0
0
Helmond
Query!
Country [304]
0
0
Netherlands
Query!
State/province [304]
0
0
Maastricht
Query!
Country [305]
0
0
Netherlands
Query!
State/province [305]
0
0
Meppel
Query!
Country [306]
0
0
Netherlands
Query!
State/province [306]
0
0
Tilburg
Query!
Country [307]
0
0
Poland
Query!
State/province [307]
0
0
Bedzin
Query!
Country [308]
0
0
Poland
Query!
State/province [308]
0
0
Gdynia
Query!
Country [309]
0
0
Poland
Query!
State/province [309]
0
0
Gliwice
Query!
Country [310]
0
0
Poland
Query!
State/province [310]
0
0
Grodzisk Mazowiecki
Query!
Country [311]
0
0
Poland
Query!
State/province [311]
0
0
Inowroclaw
Query!
Country [312]
0
0
Poland
Query!
State/province [312]
0
0
Katowice
Query!
Country [313]
0
0
Poland
Query!
State/province [313]
0
0
Kielce
Query!
Country [314]
0
0
Poland
Query!
State/province [314]
0
0
Krakow
Query!
Country [315]
0
0
Poland
Query!
State/province [315]
0
0
Kraków
Query!
Country [316]
0
0
Poland
Query!
State/province [316]
0
0
Kutno
Query!
Country [317]
0
0
Poland
Query!
State/province [317]
0
0
Lodz
Query!
Country [318]
0
0
Poland
Query!
State/province [318]
0
0
Lubin
Query!
Country [319]
0
0
Poland
Query!
State/province [319]
0
0
Lublin
Query!
Country [320]
0
0
Poland
Query!
State/province [320]
0
0
Myslenice
Query!
Country [321]
0
0
Poland
Query!
State/province [321]
0
0
Olsztyn
Query!
Country [322]
0
0
Poland
Query!
State/province [322]
0
0
Ostroleka
Query!
Country [323]
0
0
Poland
Query!
State/province [323]
0
0
Ostrowiec Swietokrzyski
Query!
Country [324]
0
0
Poland
Query!
State/province [324]
0
0
Oswiecim
Query!
Country [325]
0
0
Poland
Query!
State/province [325]
0
0
Plock
Query!
Country [326]
0
0
Poland
Query!
State/province [326]
0
0
Pulawy
Query!
Country [327]
0
0
Poland
Query!
State/province [327]
0
0
Rabka-Zdrój
Query!
Country [328]
0
0
Poland
Query!
State/province [328]
0
0
Skierniewice
Query!
Country [329]
0
0
Poland
Query!
State/province [329]
0
0
Starogard Gdanski
Query!
Country [330]
0
0
Poland
Query!
State/province [330]
0
0
Szczecin
Query!
Country [331]
0
0
Poland
Query!
State/province [331]
0
0
Torun
Query!
Country [332]
0
0
Poland
Query!
State/province [332]
0
0
Warszawa
Query!
Country [333]
0
0
Poland
Query!
State/province [333]
0
0
Wloclawek
Query!
Country [334]
0
0
Poland
Query!
State/province [334]
0
0
Wroclaw
Query!
Country [335]
0
0
Poland
Query!
State/province [335]
0
0
Zabrze
Query!
Country [336]
0
0
Poland
Query!
State/province [336]
0
0
Zamosc
Query!
Country [337]
0
0
Poland
Query!
State/province [337]
0
0
Lódz
Query!
Country [338]
0
0
Portugal
Query!
State/province [338]
0
0
Almada
Query!
Country [339]
0
0
Portugal
Query!
State/province [339]
0
0
Aveiro
Query!
Country [340]
0
0
Portugal
Query!
State/province [340]
0
0
Braga
Query!
Country [341]
0
0
Portugal
Query!
State/province [341]
0
0
Carnaxide
Query!
Country [342]
0
0
Portugal
Query!
State/province [342]
0
0
Coimbra
Query!
Country [343]
0
0
Portugal
Query!
State/province [343]
0
0
Covilhã
Query!
Country [344]
0
0
Portugal
Query!
State/province [344]
0
0
Leiria
Query!
Country [345]
0
0
Portugal
Query!
State/province [345]
0
0
Lisboa
Query!
Country [346]
0
0
Portugal
Query!
State/province [346]
0
0
Matosinhos
Query!
Country [347]
0
0
Portugal
Query!
State/province [347]
0
0
Viana do Castelo
Query!
Country [348]
0
0
Portugal
Query!
State/province [348]
0
0
Vila Real
Query!
Country [349]
0
0
Romania
Query!
State/province [349]
0
0
Bacau
Query!
Country [350]
0
0
Romania
Query!
State/province [350]
0
0
Baia Mare
Query!
Country [351]
0
0
Romania
Query!
State/province [351]
0
0
Braila
Query!
Country [352]
0
0
Romania
Query!
State/province [352]
0
0
Brasov
Query!
Country [353]
0
0
Romania
Query!
State/province [353]
0
0
Bucharest
Query!
Country [354]
0
0
Romania
Query!
State/province [354]
0
0
Bucuresti
Query!
Country [355]
0
0
Romania
Query!
State/province [355]
0
0
Buzau
Query!
Country [356]
0
0
Romania
Query!
State/province [356]
0
0
Cluj Napoca
Query!
Country [357]
0
0
Romania
Query!
State/province [357]
0
0
Cluj-Napoca
Query!
Country [358]
0
0
Romania
Query!
State/province [358]
0
0
Craiova
Query!
Country [359]
0
0
Romania
Query!
State/province [359]
0
0
Focsani
Query!
Country [360]
0
0
Romania
Query!
State/province [360]
0
0
Galati
Query!
Country [361]
0
0
Romania
Query!
State/province [361]
0
0
Iasi
Query!
Country [362]
0
0
Romania
Query!
State/province [362]
0
0
Oradea
Query!
Country [363]
0
0
Romania
Query!
State/province [363]
0
0
Pitesti
Query!
Country [364]
0
0
Romania
Query!
State/province [364]
0
0
Sibiu
Query!
Country [365]
0
0
Romania
Query!
State/province [365]
0
0
Targu Mures
Query!
Country [366]
0
0
Romania
Query!
State/province [366]
0
0
Targu-Mures
Query!
Country [367]
0
0
Romania
Query!
State/province [367]
0
0
Timisoara
Query!
Country [368]
0
0
Russian Federation
Query!
State/province [368]
0
0
Arkhangelsk
Query!
Country [369]
0
0
Russian Federation
Query!
State/province [369]
0
0
Barnaul
Query!
Country [370]
0
0
Russian Federation
Query!
State/province [370]
0
0
Chita
Query!
Country [371]
0
0
Russian Federation
Query!
State/province [371]
0
0
Ekaterinburg
Query!
Country [372]
0
0
Russian Federation
Query!
State/province [372]
0
0
Ivanovo
Query!
Country [373]
0
0
Russian Federation
Query!
State/province [373]
0
0
Izhevsk
Query!
Country [374]
0
0
Russian Federation
Query!
State/province [374]
0
0
Kaluga
Query!
Country [375]
0
0
Russian Federation
Query!
State/province [375]
0
0
Kemerovo
Query!
Country [376]
0
0
Russian Federation
Query!
State/province [376]
0
0
Kirov
Query!
Country [377]
0
0
Russian Federation
Query!
State/province [377]
0
0
Krasnoyarsk
Query!
Country [378]
0
0
Russian Federation
Query!
State/province [378]
0
0
Kursk
Query!
Country [379]
0
0
Russian Federation
Query!
State/province [379]
0
0
Moscow, Zelenograd
Query!
Country [380]
0
0
Russian Federation
Query!
State/province [380]
0
0
Moscow
Query!
Country [381]
0
0
Russian Federation
Query!
State/province [381]
0
0
Nizhniy Novgorod
Query!
Country [382]
0
0
Russian Federation
Query!
State/province [382]
0
0
Nizhny Novgorod
Query!
Country [383]
0
0
Russian Federation
Query!
State/province [383]
0
0
Novosibirsk
Query!
Country [384]
0
0
Russian Federation
Query!
State/province [384]
0
0
Orenburg
Query!
Country [385]
0
0
Russian Federation
Query!
State/province [385]
0
0
Perm
Query!
Country [386]
0
0
Russian Federation
Query!
State/province [386]
0
0
Rostov on Don
Query!
Country [387]
0
0
Russian Federation
Query!
State/province [387]
0
0
Ryazan
Query!
Country [388]
0
0
Russian Federation
Query!
State/province [388]
0
0
Saint Petersburg
Query!
Country [389]
0
0
Russian Federation
Query!
State/province [389]
0
0
Samara
Query!
Country [390]
0
0
Russian Federation
Query!
State/province [390]
0
0
Saratov
Query!
Country [391]
0
0
Russian Federation
Query!
State/province [391]
0
0
Syktyvkar
Query!
Country [392]
0
0
Russian Federation
Query!
State/province [392]
0
0
Tomsk
Query!
Country [393]
0
0
Russian Federation
Query!
State/province [393]
0
0
Tyumen
Query!
Country [394]
0
0
Russian Federation
Query!
State/province [394]
0
0
Voronezh
Query!
Country [395]
0
0
Russian Federation
Query!
State/province [395]
0
0
Yaroslavl
Query!
Country [396]
0
0
Slovakia
Query!
State/province [396]
0
0
Banska Bystrica
Query!
Country [397]
0
0
Slovakia
Query!
State/province [397]
0
0
Bardejov
Query!
Country [398]
0
0
Slovakia
Query!
State/province [398]
0
0
Kosice
Query!
Country [399]
0
0
Slovakia
Query!
State/province [399]
0
0
Lucenec
Query!
Country [400]
0
0
Slovakia
Query!
State/province [400]
0
0
Moldava nad Bodvou
Query!
Country [401]
0
0
Slovakia
Query!
State/province [401]
0
0
Nitra
Query!
Country [402]
0
0
Slovakia
Query!
State/province [402]
0
0
Povazska Bystrica
Query!
Country [403]
0
0
Slovakia
Query!
State/province [403]
0
0
Svidnik
Query!
Country [404]
0
0
South Africa
Query!
State/province [404]
0
0
Bloemfontein
Query!
Country [405]
0
0
South Africa
Query!
State/province [405]
0
0
Cape Town
Query!
Country [406]
0
0
South Africa
Query!
State/province [406]
0
0
Centurion
Query!
Country [407]
0
0
South Africa
Query!
State/province [407]
0
0
Durban
Query!
Country [408]
0
0
South Africa
Query!
State/province [408]
0
0
Pinelands
Query!
Country [409]
0
0
South Africa
Query!
State/province [409]
0
0
Pretoria
Query!
Country [410]
0
0
South Africa
Query!
State/province [410]
0
0
Tongaat
Query!
Country [411]
0
0
Spain
Query!
State/province [411]
0
0
A Coruña
Query!
Country [412]
0
0
Spain
Query!
State/province [412]
0
0
Alicante
Query!
Country [413]
0
0
Spain
Query!
State/province [413]
0
0
Almería
Query!
Country [414]
0
0
Spain
Query!
State/province [414]
0
0
Avila
Query!
Country [415]
0
0
Spain
Query!
State/province [415]
0
0
Barcelona
Query!
Country [416]
0
0
Spain
Query!
State/province [416]
0
0
Burgos
Query!
Country [417]
0
0
Spain
Query!
State/province [417]
0
0
Cáceres
Query!
Country [418]
0
0
Spain
Query!
State/province [418]
0
0
Elche
Query!
Country [419]
0
0
Spain
Query!
State/province [419]
0
0
Granada
Query!
Country [420]
0
0
Spain
Query!
State/province [420]
0
0
La Coruña
Query!
Country [421]
0
0
Spain
Query!
State/province [421]
0
0
Lorca
Query!
Country [422]
0
0
Spain
Query!
State/province [422]
0
0
Madrid
Query!
Country [423]
0
0
Spain
Query!
State/province [423]
0
0
Majadahonda
Query!
Country [424]
0
0
Spain
Query!
State/province [424]
0
0
Murcia
Query!
Country [425]
0
0
Spain
Query!
State/province [425]
0
0
Olot
Query!
Country [426]
0
0
Spain
Query!
State/province [426]
0
0
Orihuela
Query!
Country [427]
0
0
Spain
Query!
State/province [427]
0
0
Palma de Mallorca
Query!
Country [428]
0
0
Spain
Query!
State/province [428]
0
0
San Juan
Query!
Country [429]
0
0
Spain
Query!
State/province [429]
0
0
Sanlúcar de Barrameda
Query!
Country [430]
0
0
Spain
Query!
State/province [430]
0
0
Sant Joan Despí
Query!
Country [431]
0
0
Spain
Query!
State/province [431]
0
0
Santander
Query!
Country [432]
0
0
Spain
Query!
State/province [432]
0
0
Sevilla
Query!
Country [433]
0
0
Spain
Query!
State/province [433]
0
0
Terrassa
Query!
Country [434]
0
0
Spain
Query!
State/province [434]
0
0
Torrevieja
Query!
Country [435]
0
0
Spain
Query!
State/province [435]
0
0
Valencia
Query!
Country [436]
0
0
Spain
Query!
State/province [436]
0
0
Vigo
Query!
Country [437]
0
0
Spain
Query!
State/province [437]
0
0
Viladecans
Query!
Country [438]
0
0
Sweden
Query!
State/province [438]
0
0
Falun
Query!
Country [439]
0
0
Sweden
Query!
State/province [439]
0
0
Jönköping
Query!
Country [440]
0
0
Sweden
Query!
State/province [440]
0
0
Ljungby
Query!
Country [441]
0
0
Sweden
Query!
State/province [441]
0
0
Stockholm
Query!
Country [442]
0
0
Sweden
Query!
State/province [442]
0
0
Uppsala
Query!
Country [443]
0
0
Turkey
Query!
State/province [443]
0
0
Ankara
Query!
Country [444]
0
0
Turkey
Query!
State/province [444]
0
0
Bursa
Query!
Country [445]
0
0
Turkey
Query!
State/province [445]
0
0
Diyarbakir
Query!
Country [446]
0
0
Turkey
Query!
State/province [446]
0
0
Eskisehir
Query!
Country [447]
0
0
Turkey
Query!
State/province [447]
0
0
Istanbul
Query!
Country [448]
0
0
Turkey
Query!
State/province [448]
0
0
Kahramanmaras
Query!
Country [449]
0
0
Turkey
Query!
State/province [449]
0
0
Kocaeli
Query!
Country [450]
0
0
Turkey
Query!
State/province [450]
0
0
Konya
Query!
Country [451]
0
0
Turkey
Query!
State/province [451]
0
0
Kirikkale
Query!
Country [452]
0
0
Turkey
Query!
State/province [452]
0
0
Mersin
Query!
Country [453]
0
0
Turkey
Query!
State/province [453]
0
0
Sivas
Query!
Country [454]
0
0
Ukraine
Query!
State/province [454]
0
0
Cherkassy
Query!
Country [455]
0
0
Ukraine
Query!
State/province [455]
0
0
Cherkasy
Query!
Country [456]
0
0
Ukraine
Query!
State/province [456]
0
0
Dnipro
Query!
Country [457]
0
0
Ukraine
Query!
State/province [457]
0
0
Donetsk
Query!
Country [458]
0
0
Ukraine
Query!
State/province [458]
0
0
Kharkiv
Query!
Country [459]
0
0
Ukraine
Query!
State/province [459]
0
0
Kyiv
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Janssen Research & Development, LLC
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Bayer
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Summary
Brief summary
The purpose of this study is to assess the effectiveness and safety of rivaroxaban compared with placebo (inactive medication), in reducing the risk of death, myocardial infarction or stroke in participants with heart failure and significant coronary artery disease following an episode of decompensated heart failure.
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Trial website
https://clinicaltrials.gov/study/NCT01877915
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Trial related presentations / publications
Ferreira JP, Cleland JG, Lam CSP, Anker SD, Mehra MR, van Veldhuisen DJ, Byra WM, La Police DA, Pitt B, Greenberg B, Zannad F. Heart failure re-hospitalizations and subsequent fatal events in coronary artery disease: insights from COMMANDER-HF, EPHESUS, and EXAMINE. Clin Res Cardiol. 2021 Oct;110(10):1554-1563. doi: 10.1007/s00392-021-01830-1. Epub 2021 Mar 8. Ferreira JP, Cleland JGF, Lam CSP, van Veldhuisen DJ, Byra WM, La Police DA, Anker SD, Mehra MR, Leroy C, Eschwege V, Toussaint-Hacquard M, Rossignol P, Greenberg B, Zannad F. Impact of Geographic Region on the COMMANDER-HF Trial. JACC Heart Fail. 2021 Mar;9(3):201-211. doi: 10.1016/j.jchf.2020.11.007. Epub 2021 Feb 3. Cunningham JW, Ferreira JP, Deng H, Anker SD, Byra WM, Cleland JGF, Gheorghiade M, Lam CSP, La Police D, Mehra MR, Neaton JD, Spiro TE, van Veldhuisen DJ, Greenberg B, Zannad F. Natriuretic Peptide-Based Inclusion Criteria in a Heart Failure Clinical Trial: Insights From COMMANDER HF. JACC Heart Fail. 2020 May;8(5):359-368. doi: 10.1016/j.jchf.2019.12.009. Epub 2020 Mar 11. Mehra MR, Vaduganathan M, Fu M, Ferreira JP, Anker SD, Cleland JGF, Lam CSP, van Veldhuisen DJ, Byra WM, Spiro TE, Deng H, Zannad F, Greenberg B. A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial. Eur Heart J. 2019 Nov 21;40(44):3593-3602. doi: 10.1093/eurheartj/ehz427. Greenberg B, Neaton JD, Anker SD, Byra WM, Cleland JGF, Deng H, Fu M, La Police DA, Lam CSP, Mehra MR, Nessel CC, Spiro TE, van Veldhuisen DJ, Vanden Boom CM, Zannad F. Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial. JAMA Cardiol. 2019 Jun 1;4(6):515-523. doi: 10.1001/jamacardio.2019.1049. Zannad F, Anker SD, Byra WM, Cleland JGF, Fu M, Gheorghiade M, Lam CSP, Mehra MR, Neaton JD, Nessel CC, Spiro TE, van Veldhuisen DJ, Greenberg B; COMMANDER HF Investigators. Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease. N Engl J Med. 2018 Oct 4;379(14):1332-1342. doi: 10.1056/NEJMoa1808848. Epub 2018 Aug 27.
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Public notes
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Contacts
Principal investigator
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Janssen Research & Development, LLC Clinical Trial
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Janssen Research & Development, LLC
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No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
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Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/15/NCT01877915/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/15/NCT01877915/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results not provided in
https://clinicaltrials.gov/study/NCT01877915
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