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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT03473223




Registration number
NCT03473223
Ethics application status
Date submitted
14/03/2018
Date registered
22/03/2018

Titles & IDs
Public title
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
Scientific title
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome
Secondary ID [1] 0 0
2017-000996-98
Secondary ID [2] 0 0
CSL112_3001
Universal Trial Number (UTN)
Trial acronym
AEGIS-II
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Coronary heart disease
Other 0 0 0 0
Research that is not of generic health relevance and not applicable to specific health categories listed above

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Other - Apolipoprotein A-I [human] (apoA-I)
Other interventions - Placebo

Experimental: CSL112 - Apolipoprotein A-I \[human\]

Placebo comparator: Placebo - 25% albumin solution diluted to 4.4%


Treatment: Other: Apolipoprotein A-I [human] (apoA-I)
Apolipoprotein A-I \[human\] (apoA-I) purified from human plasma for intravenous administration

Other interventions: Placebo
25% albumin solution diluted to 4.4%
Intervention code [1] 0 0
Treatment: Other
Intervention code [2] 0 0
Other interventions
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Number of Participants With First Occurrence of Any Component of Composite MACE (CV Death, MI, or Stroke)
Timepoint [1] 0 0
From the time of randomization through 90 days
Secondary outcome [1] 0 0
Total Number of Hospitalizations for Coronary, Cerebral, and Peripheral Ischemia
Timepoint [1] 0 0
From the time of randomization through 90 days
Secondary outcome [2] 0 0
Number of Participants With First Occurrence of CV Death, MI, or Stroke
Timepoint [2] 0 0
From the time of randomization through 180 days
Secondary outcome [3] 0 0
Number of Participants With First Occurrence of CV Death, MI, or Stroke
Timepoint [3] 0 0
From the time of randomization through 365 days
Secondary outcome [4] 0 0
Number of Participants With Occurrence of CV Death
Timepoint [4] 0 0
From the time of randomization through 90 days
Secondary outcome [5] 0 0
Number of Participants With First Occurrence of MI
Timepoint [5] 0 0
From the time of randomization through 90 days
Secondary outcome [6] 0 0
Number of Participants With First Occurrence of Stroke
Timepoint [6] 0 0
From the time of randomization through 90 days
Secondary outcome [7] 0 0
Number of Participants With First Occurrence of CV Death, Type 1 MI or Stroke
Timepoint [7] 0 0
From the time of randomization through 90, 180 and 365 days
Secondary outcome [8] 0 0
Number of Participants With Occurrence of All-cause Death
Timepoint [8] 0 0
From the time of randomization through 365 days
Secondary outcome [9] 0 0
Number of Participants With Adverse Events
Timepoint [9] 0 0
From the start of treatment through 90 days
Secondary outcome [10] 0 0
Percentage of Participants With Adverse Events
Timepoint [10] 0 0
From the start of treatment through 90 days
Secondary outcome [11] 0 0
Number of Participants With Treatment-related Adverse Events
Timepoint [11] 0 0
From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Secondary outcome [12] 0 0
Percentage of Participants With Treatment-related Adverse Events
Timepoint [12] 0 0
From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Secondary outcome [13] 0 0
Number of Participants With Serious Adverse Events (SAEs)
Timepoint [13] 0 0
From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Secondary outcome [14] 0 0
Percentage of Participants With SAEs
Timepoint [14] 0 0
From the start of treatment through 379 days (Day 365 + 14 days of follow up)
Secondary outcome [15] 0 0
Number of Participants With a Shift From Baseline to Worst Post-treatment Value in Clinical Laboratory Assessments
Timepoint [15] 0 0
Baseline and 29 days
Secondary outcome [16] 0 0
Percentage of Participants With a Shift From Baseline to Worst Post-treatment Value in Clinical Laboratory Assessments
Timepoint [16] 0 0
Baseline and 29 days
Secondary outcome [17] 0 0
Change From Baseline in Hematology Parameters
Timepoint [17] 0 0
From Baseline to Day 29
Secondary outcome [18] 0 0
Change From Baseline in Hematology Parameter: Hematocrit
Timepoint [18] 0 0
From Baseline to Day 29
Secondary outcome [19] 0 0
Change From Baseline in Hematology Parameter: Hemoglobin
Timepoint [19] 0 0
From Baseline to Day 29
Secondary outcome [20] 0 0
Change From Baseline in Hepatic Parameters
Timepoint [20] 0 0
From Baseline to Day 29
Secondary outcome [21] 0 0
Change From Baseline in Hepatic Parameter: Bilirubin
Timepoint [21] 0 0
From Baseline to Day 29
Secondary outcome [22] 0 0
Change From Baseline in Renal Parameter: Serum Creatinine
Timepoint [22] 0 0
From Baseline to Day 29
Secondary outcome [23] 0 0
Change From Baseline in Renal Parameter: eGFR
Timepoint [23] 0 0
From Baseline to Day 29
Secondary outcome [24] 0 0
Change From Baseline in Renal Parameter: Blood Urea Nitrogen
Timepoint [24] 0 0
From Baseline to Day 29

Eligibility
Key inclusion criteria
* Male or female least 18 years of age
* Evidence of myocardial necrosis, consistent with type I (spontaneous) MI
* No suspicion of acute kidney injury
* Evidence of multivessel coronary artery disease
* Presence of established cardiovascular risk factor(s):

1. Diabetes mellitus on pharmacotherapy OR
2. 2 or more of the following: age = 65 years, prior history of MI, peripheral arterial disease
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Ongoing hemodynamic instability
* Evidence of hepatobiliary disease
* Evidence of severe chronic kidney disease
* Plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index MI
* Known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin

Study design
Purpose of the study
Prevention
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
21/03/2018
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
17/11/2023
Sample size
Target
Accrual to date
Final
18226
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,TazmaniaVIC,WA
Recruitment hospital [1] 0 0
0360087 - Campbelltown Hospital - Campbelltown
Recruitment hospital [2] 0 0
0360069 - Liverpool Hospital - Liverpool
Recruitment hospital [3] 0 0
0360070 - Royal North Shore Hospital - St. Leonards
Recruitment hospital [4] 0 0
0360071 - Wollongong Hospital - Wollongong
Recruitment hospital [5] 0 0
0360063 - Cairns Base Hospital - Cairns
Recruitment hospital [6] 0 0
0360062 - The Prince Charles Hospital - Chermside
Recruitment hospital [7] 0 0
0360061 - Royal Brisbane Hospital - Herston
Recruitment hospital [8] 0 0
0360060 - Gold Coast Hospital - Southport
Recruitment hospital [9] 0 0
0360057 - Royal Adelaide Hospital - Adelaide
Recruitment hospital [10] 0 0
0360032 - Flinders Medical Centre - Bedford Park
Recruitment hospital [11] 0 0
0360055 - Queen Elizabeth Hospital - Woodville South
Recruitment hospital [12] 0 0
0360084 - Royal Hobart Hospital - Hobart
Recruitment hospital [13] 0 0
0360092 - Monash Medical Centre - Clayton
Recruitment hospital [14] 0 0
0360036 - The Northern Hospital - Epping
Recruitment hospital [15] 0 0
0360096 - Peninsula Health - Frankston
Recruitment hospital [16] 0 0
0360076 - Geelong Hospital - Geelong
Recruitment hospital [17] 0 0
0360081 - Peninsula Heart Centre - Langwarrin
Recruitment hospital [18] 0 0
0360073 - The Alfred Hospital - Melbourne
Recruitment hospital [19] 0 0
0360080 - Fiona Stanley Hospital - Murdoch
Recruitment hospital [20] 0 0
0360059 - Royal Perth Hospital - Perth
Recruitment hospital [21] 0 0
0360072 - John Hunter Hospital - New Lambton Heights
Recruitment postcode(s) [1] 0 0
2560 - Campbelltown
Recruitment postcode(s) [2] 0 0
2170 - Liverpool
Recruitment postcode(s) [3] 0 0
2065 - St. Leonards
Recruitment postcode(s) [4] 0 0
2500 - Wollongong
Recruitment postcode(s) [5] 0 0
4870 - Cairns
Recruitment postcode(s) [6] 0 0
4032 - Chermside
Recruitment postcode(s) [7] 0 0
4029 - Herston
Recruitment postcode(s) [8] 0 0
4215 - Southport
Recruitment postcode(s) [9] 0 0
5000 - Adelaide
Recruitment postcode(s) [10] 0 0
5042 - Bedford Park
Recruitment postcode(s) [11] 0 0
5011 - Woodville South
Recruitment postcode(s) [12] 0 0
7001 - Hobart
Recruitment postcode(s) [13] 0 0
3168 - Clayton
Recruitment postcode(s) [14] 0 0
3076 - Epping
Recruitment postcode(s) [15] 0 0
3199 - Frankston
Recruitment postcode(s) [16] 0 0
3320 - Geelong
Recruitment postcode(s) [17] 0 0
3910 - Langwarrin
Recruitment postcode(s) [18] 0 0
3004 - Melbourne
Recruitment postcode(s) [19] 0 0
6150 - Murdoch
Recruitment postcode(s) [20] 0 0
6000 - Perth
Recruitment postcode(s) [21] 0 0
2305 - New Lambton Heights
Recruitment outside Australia
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Chambray Les Tours
Country [178] 0 0
France
State/province [178] 0 0
Corbeil-Essonnes
Country [179] 0 0
France
State/province [179] 0 0
Grenoble
Country [180] 0 0
France
State/province [180] 0 0
Le Coudray
Country [181] 0 0
France
State/province [181] 0 0
Le Plessis-Robinson
Country [182] 0 0
France
State/province [182] 0 0
Lille CEDEX
Country [183] 0 0
France
State/province [183] 0 0
Montauban
Country [184] 0 0
France
State/province [184] 0 0
Montpellier
Country [185] 0 0
France
State/province [185] 0 0
Nantes
Country [186] 0 0
France
State/province [186] 0 0
Nice
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France
State/province [187] 0 0
Nimes
Country [188] 0 0
France
State/province [188] 0 0
Paris
Country [189] 0 0
France
State/province [189] 0 0
Pessac
Country [190] 0 0
France
State/province [190] 0 0
Poitiers
Country [191] 0 0
France
State/province [191] 0 0
Pringy
Country [192] 0 0
France
State/province [192] 0 0
Thionville
Country [193] 0 0
France
State/province [193] 0 0
Toulouse
Country [194] 0 0
Georgia
State/province [194] 0 0
Tbilisi
Country [195] 0 0
Germany
State/province [195] 0 0
Bad Friedrichshall
Country [196] 0 0
Germany
State/province [196] 0 0
Berlin
Country [197] 0 0
Germany
State/province [197] 0 0
Bitburg
Country [198] 0 0
Germany
State/province [198] 0 0
Bonn
Country [199] 0 0
Germany
State/province [199] 0 0
Coburg
Country [200] 0 0
Germany
State/province [200] 0 0
Dresden
Country [201] 0 0
Germany
State/province [201] 0 0
Erfurt
Country [202] 0 0
Germany
State/province [202] 0 0
Essen
Country [203] 0 0
Germany
State/province [203] 0 0
Frankfurt Am Main
Country [204] 0 0
Germany
State/province [204] 0 0
Frankfurt am Main
Country [205] 0 0
Germany
State/province [205] 0 0
Freiburg im Breisgau
Country [206] 0 0
Germany
State/province [206] 0 0
Hamburg
Country [207] 0 0
Germany
State/province [207] 0 0
Jena
Country [208] 0 0
Germany
State/province [208] 0 0
Kassel
Country [209] 0 0
Germany
State/province [209] 0 0
Langen
Country [210] 0 0
Germany
State/province [210] 0 0
Ludwigshafen
Country [211] 0 0
Germany
State/province [211] 0 0
Mainz
Country [212] 0 0
Germany
State/province [212] 0 0
Rüsselsheim am Main
Country [213] 0 0
Germany
State/province [213] 0 0
Witten
Country [214] 0 0
Greece
State/province [214] 0 0
Athens
Country [215] 0 0
Greece
State/province [215] 0 0
Chaidari
Country [216] 0 0
Greece
State/province [216] 0 0
Chortiátis
Country [217] 0 0
Greece
State/province [217] 0 0
Ioannina
Country [218] 0 0
Greece
State/province [218] 0 0
Larissa
Country [219] 0 0
Greece
State/province [219] 0 0
Patra
Country [220] 0 0
Greece
State/province [220] 0 0
Piraeus
Country [221] 0 0
Greece
State/province [221] 0 0
Thessaloniki
Country [222] 0 0
Hong Kong
State/province [222] 0 0
Kowloon
Country [223] 0 0
Hong Kong
State/province [223] 0 0
Kwai Chung
Country [224] 0 0
Hong Kong
State/province [224] 0 0
Sha Tin
Country [225] 0 0
Hungary
State/province [225] 0 0
Budapest
Country [226] 0 0
Hungary
State/province [226] 0 0
Debrecen
Country [227] 0 0
Hungary
State/province [227] 0 0
Dombóvár
Country [228] 0 0
Hungary
State/province [228] 0 0
Gyula
Country [229] 0 0
Hungary
State/province [229] 0 0
Gyor
Country [230] 0 0
Hungary
State/province [230] 0 0
Kaposvár
Country [231] 0 0
Hungary
State/province [231] 0 0
Kecskemét
Country [232] 0 0
Hungary
State/province [232] 0 0
Nyíregyháza
Country [233] 0 0
Hungary
State/province [233] 0 0
Szeged
Country [234] 0 0
Hungary
State/province [234] 0 0
Szekszárd
Country [235] 0 0
Hungary
State/province [235] 0 0
Szolnok
Country [236] 0 0
Hungary
State/province [236] 0 0
Székesfehérvár
Country [237] 0 0
Hungary
State/province [237] 0 0
Zalaegerszeg
Country [238] 0 0
Israel
State/province [238] 0 0
Afula
Country [239] 0 0
Israel
State/province [239] 0 0
Ashkelon
Country [240] 0 0
Israel
State/province [240] 0 0
Be'er Ya'aqov
Country [241] 0 0
Israel
State/province [241] 0 0
Beer Sheva
Country [242] 0 0
Israel
State/province [242] 0 0
Hadera
Country [243] 0 0
Israel
State/province [243] 0 0
Haifa
Country [244] 0 0
Israel
State/province [244] 0 0
Jerusalem
Country [245] 0 0
Israel
State/province [245] 0 0
Kfar Saba
Country [246] 0 0
Israel
State/province [246] 0 0
Nahariya
Country [247] 0 0
Israel
State/province [247] 0 0
Nazareth
Country [248] 0 0
Israel
State/province [248] 0 0
Petah Tiqva
Country [249] 0 0
Israel
State/province [249] 0 0
Ramat Gan
Country [250] 0 0
Israel
State/province [250] 0 0
Rehovot
Country [251] 0 0
Israel
State/province [251] 0 0
Safed
Country [252] 0 0
Israel
State/province [252] 0 0
Tel Aviv-Yafo
Country [253] 0 0
Italy
State/province [253] 0 0
Bergamo
Country [254] 0 0
Italy
State/province [254] 0 0
Brescia
Country [255] 0 0
Italy
State/province [255] 0 0
Busto Arsizio
Country [256] 0 0
Italy
State/province [256] 0 0
Caserta
Country [257] 0 0
Italy
State/province [257] 0 0
Catanzaro
Country [258] 0 0
Italy
State/province [258] 0 0
Firenze
Country [259] 0 0
Italy
State/province [259] 0 0
Milano
Country [260] 0 0
Italy
State/province [260] 0 0
Napoli
Country [261] 0 0
Italy
State/province [261] 0 0
Osio Sotto
Country [262] 0 0
Italy
State/province [262] 0 0
Palermo
Country [263] 0 0
Italy
State/province [263] 0 0
Pavia
Country [264] 0 0
Italy
State/province [264] 0 0
Roma
Country [265] 0 0
Italy
State/province [265] 0 0
Rozzano
Country [266] 0 0
Japan
State/province [266] 0 0
Okayama
Country [267] 0 0
Japan
State/province [267] 0 0
Adachi-Ku
Country [268] 0 0
Japan
State/province [268] 0 0
Amagasaki-Shi
Country [269] 0 0
Japan
State/province [269] 0 0
Aoba-Ku
Country [270] 0 0
Japan
State/province [270] 0 0
Asahi-Shi
Country [271] 0 0
Japan
State/province [271] 0 0
Fuchu-Shi
Country [272] 0 0
Japan
State/province [272] 0 0
Fukuoka-Shi
Country [273] 0 0
Japan
State/province [273] 0 0
Itabashi-Ku
Country [274] 0 0
Japan
State/province [274] 0 0
Izunokuni-Shi
Country [275] 0 0
Japan
State/province [275] 0 0
Kanazawa-Shi
Country [276] 0 0
Japan
State/province [276] 0 0
Kasuga-Shi
Country [277] 0 0
Japan
State/province [277] 0 0
Kisarazu-Shi
Country [278] 0 0
Japan
State/province [278] 0 0
Kochi-Shi
Country [279] 0 0
Japan
State/province [279] 0 0
Kumamoto-Shi
Country [280] 0 0
Japan
State/province [280] 0 0
Kurume-Shi
Country [281] 0 0
Japan
State/province [281] 0 0
Kusatsu-Shi
Country [282] 0 0
Japan
State/province [282] 0 0
Matsusaka-Shi
Country [283] 0 0
Japan
State/province [283] 0 0
Matsuyama-Shi
Country [284] 0 0
Japan
State/province [284] 0 0
Meguro-ku
Country [285] 0 0
Japan
State/province [285] 0 0
Miyazaki-Shi
Country [286] 0 0
Japan
State/province [286] 0 0
Sapporo-Shi
Country [287] 0 0
Japan
State/province [287] 0 0
Sendai-Shi
Country [288] 0 0
Japan
State/province [288] 0 0
Seto-Shi
Country [289] 0 0
Japan
State/province [289] 0 0
Shinjuku-Ku
Country [290] 0 0
Japan
State/province [290] 0 0
Shizuoka-Shi
Country [291] 0 0
Japan
State/province [291] 0 0
Suita-Shi
Country [292] 0 0
Japan
State/province [292] 0 0
Takamatsu-Shi
Country [293] 0 0
Japan
State/province [293] 0 0
Tomakomai-Shi
Country [294] 0 0
Japan
State/province [294] 0 0
Urayasu-Shi
Country [295] 0 0
Japan
State/province [295] 0 0
Yokohama-Shi
Country [296] 0 0
Korea, Republic of
State/province [296] 0 0
Dongdaemun-gu
Country [297] 0 0
Korea, Republic of
State/province [297] 0 0
Gangdong-gu
Country [298] 0 0
Korea, Republic of
State/province [298] 0 0
Gangwon-do
Country [299] 0 0
Korea, Republic of
State/province [299] 0 0
Gyeonggi-do
Country [300] 0 0
Korea, Republic of
State/province [300] 0 0
Gyeongsangnam-do
Country [301] 0 0
Korea, Republic of
State/province [301] 0 0
Jongro-gu
Country [302] 0 0
Korea, Republic of
State/province [302] 0 0
Seongbuk-gu
Country [303] 0 0
Korea, Republic of
State/province [303] 0 0
Cheongju
Country [304] 0 0
Korea, Republic of
State/province [304] 0 0
Gangdong
Country [305] 0 0
Korea, Republic of
State/province [305] 0 0
Junggu
Country [306] 0 0
Korea, Republic of
State/province [306] 0 0
Seoul
Country [307] 0 0
Korea, Republic of
State/province [307] 0 0
Suwon
Country [308] 0 0
Korea, Republic of
State/province [308] 0 0
Yeongdeungpo-dong
Country [309] 0 0
Latvia
State/province [309] 0 0
Daugavpils
Country [310] 0 0
Latvia
State/province [310] 0 0
Liepaja
Country [311] 0 0
Latvia
State/province [311] 0 0
Riga
Country [312] 0 0
Latvia
State/province [312] 0 0
Valmiera
Country [313] 0 0
Lithuania
State/province [313] 0 0
Kaunas
Country [314] 0 0
Lithuania
State/province [314] 0 0
Klaipeda
Country [315] 0 0
Lithuania
State/province [315] 0 0
Panevežys
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Lithuania
State/province [316] 0 0
Vilnius
Country [317] 0 0
Lithuania
State/province [317] 0 0
Šiauliai
Country [318] 0 0
Malaysia
State/province [318] 0 0
Sabah
Country [319] 0 0
Malaysia
State/province [319] 0 0
Kota Bharu
Country [320] 0 0
Malaysia
State/province [320] 0 0
Kuala Lumpur
Country [321] 0 0
Malaysia
State/province [321] 0 0
Kuantan
Country [322] 0 0
Malaysia
State/province [322] 0 0
Kuching
Country [323] 0 0
Malaysia
State/province [323] 0 0
Pulau Pinang
Country [324] 0 0
Malaysia
State/province [324] 0 0
Sungai Buloh
Country [325] 0 0
Mexico
State/province [325] 0 0
Jalisco
Country [326] 0 0
Mexico
State/province [326] 0 0
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Country [327] 0 0
Mexico
State/province [327] 0 0
Chihuahua
Country [328] 0 0
Mexico
State/province [328] 0 0
Culiacán
Country [329] 0 0
Mexico
State/province [329] 0 0
Guadalajara
Country [330] 0 0
Mexico
State/province [330] 0 0
Mazatlán
Country [331] 0 0
Mexico
State/province [331] 0 0
Mexico City
Country [332] 0 0
Mexico
State/province [332] 0 0
Mexico
Country [333] 0 0
Mexico
State/province [333] 0 0
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Country [334] 0 0
Mexico
State/province [334] 0 0
Morelia
Country [335] 0 0
Mexico
State/province [335] 0 0
Puebla
Country [336] 0 0
Mexico
State/province [336] 0 0
Querétaro
Country [337] 0 0
Mexico
State/province [337] 0 0
San Luis Potosi
Country [338] 0 0
Mexico
State/province [338] 0 0
San Luis Potosí
Country [339] 0 0
Mexico
State/province [339] 0 0
Torreón
Country [340] 0 0
Mexico
State/province [340] 0 0
Xalapa
Country [341] 0 0
Netherlands
State/province [341] 0 0
Alkmaar
Country [342] 0 0
Netherlands
State/province [342] 0 0
Amersfoort
Country [343] 0 0
Netherlands
State/province [343] 0 0
Amsterdam
Country [344] 0 0
Netherlands
State/province [344] 0 0
Breda
Country [345] 0 0
Netherlands
State/province [345] 0 0
Deventer
Country [346] 0 0
Netherlands
State/province [346] 0 0
Ede
Country [347] 0 0
Netherlands
State/province [347] 0 0
Eindhoven
Country [348] 0 0
Netherlands
State/province [348] 0 0
Enschede
Country [349] 0 0
Netherlands
State/province [349] 0 0
Goes
Country [350] 0 0
Netherlands
State/province [350] 0 0
Gouda
Country [351] 0 0
Netherlands
State/province [351] 0 0
Haarlem
Country [352] 0 0
Netherlands
State/province [352] 0 0
Harderwijk
Country [353] 0 0
Netherlands
State/province [353] 0 0
Heerlen
Country [354] 0 0
Netherlands
State/province [354] 0 0
Hoorn
Country [355] 0 0
Netherlands
State/province [355] 0 0
Leeuwarden
Country [356] 0 0
Netherlands
State/province [356] 0 0
Leiden
Country [357] 0 0
Netherlands
State/province [357] 0 0
Nijmegen
Country [358] 0 0
Netherlands
State/province [358] 0 0
Rotterdam
Country [359] 0 0
Netherlands
State/province [359] 0 0
Sneek
Country [360] 0 0
Netherlands
State/province [360] 0 0
Tiel
Country [361] 0 0
Netherlands
State/province [361] 0 0
Tilburg
Country [362] 0 0
Netherlands
State/province [362] 0 0
Utrecht
Country [363] 0 0
Netherlands
State/province [363] 0 0
Venlo
Country [364] 0 0
Netherlands
State/province [364] 0 0
Zutphen
Country [365] 0 0
New Zealand
State/province [365] 0 0
Auckland
Country [366] 0 0
New Zealand
State/province [366] 0 0
Wellington
Country [367] 0 0
New Zealand
State/province [367] 0 0
Christchurch
Country [368] 0 0
New Zealand
State/province [368] 0 0
Dunedin
Country [369] 0 0
New Zealand
State/province [369] 0 0
Hamilton
Country [370] 0 0
New Zealand
State/province [370] 0 0
New Plymouth
Country [371] 0 0
Norway
State/province [371] 0 0
Lørenskog
Country [372] 0 0
Norway
State/province [372] 0 0
Oslo
Country [373] 0 0
Norway
State/province [373] 0 0
Skien
Country [374] 0 0
Norway
State/province [374] 0 0
Stavanger
Country [375] 0 0
Peru
State/province [375] 0 0
Lima
Country [376] 0 0
Poland
State/province [376] 0 0
Bielsko-Biala
Country [377] 0 0
Poland
State/province [377] 0 0
Bydgoszcz
Country [378] 0 0
Poland
State/province [378] 0 0
Chrzanow
Country [379] 0 0
Poland
State/province [379] 0 0
Dabrowa Górnicza
Country [380] 0 0
Poland
State/province [380] 0 0
Grodzisk Mazowiecki
Country [381] 0 0
Poland
State/province [381] 0 0
Kedzierzyn-Kozle
Country [382] 0 0
Poland
State/province [382] 0 0
Krakow
Country [383] 0 0
Poland
State/province [383] 0 0
Kraków
Country [384] 0 0
Poland
State/province [384] 0 0
Krosno
Country [385] 0 0
Poland
State/province [385] 0 0
Lublin
Country [386] 0 0
Poland
State/province [386] 0 0
Nowa Sól
Country [387] 0 0
Poland
State/province [387] 0 0
Oswiecim
Country [388] 0 0
Poland
State/province [388] 0 0
Pinczów
Country [389] 0 0
Poland
State/province [389] 0 0
Pulawy
Country [390] 0 0
Poland
State/province [390] 0 0
Sztum
Country [391] 0 0
Poland
State/province [391] 0 0
Torun
Country [392] 0 0
Poland
State/province [392] 0 0
Tychy
Country [393] 0 0
Poland
State/province [393] 0 0
Walbrzych
Country [394] 0 0
Poland
State/province [394] 0 0
Warszawa
Country [395] 0 0
Poland
State/province [395] 0 0
Zgierz
Country [396] 0 0
Poland
State/province [396] 0 0
Swidnica
Country [397] 0 0
Portugal
State/province [397] 0 0
Almada
Country [398] 0 0
Portugal